CO6801719A2 - Forma cristalina de un inhibidor de la interacción de mdm2/4 y p53 - Google Patents
Forma cristalina de un inhibidor de la interacción de mdm2/4 y p53Info
- Publication number
- CO6801719A2 CO6801719A2 CO13128275A CO13128275A CO6801719A2 CO 6801719 A2 CO6801719 A2 CO 6801719A2 CO 13128275 A CO13128275 A CO 13128275A CO 13128275 A CO13128275 A CO 13128275A CO 6801719 A2 CO6801719 A2 CO 6801719A2
- Authority
- CO
- Colombia
- Prior art keywords
- mdm2
- crystal form
- interaction inhibitor
- inhibitor
- interaction
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010078927 | 2010-11-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6801719A2 true CO6801719A2 (es) | 2013-11-29 |
Family
ID=45093718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO13128275A CO6801719A2 (es) | 2010-11-19 | 2013-05-24 | Forma cristalina de un inhibidor de la interacción de mdm2/4 y p53 |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US9073898B2 (es) |
| EP (1) | EP2640467B1 (es) |
| JP (1) | JP5667308B2 (es) |
| KR (1) | KR101561750B1 (es) |
| AR (1) | AR083905A1 (es) |
| AU (1) | AU2011331095B2 (es) |
| BR (1) | BR112013011966A2 (es) |
| CA (1) | CA2816810A1 (es) |
| CO (1) | CO6801719A2 (es) |
| CU (1) | CU24130B1 (es) |
| CY (1) | CY1116002T1 (es) |
| DK (1) | DK2640467T3 (es) |
| EC (1) | ECSP13012628A (es) |
| ES (1) | ES2528376T3 (es) |
| GT (1) | GT201300132A (es) |
| HK (1) | HK1184091A1 (es) |
| HR (1) | HRP20150231T1 (es) |
| IL (1) | IL226182A0 (es) |
| MA (1) | MA34666B1 (es) |
| ME (1) | ME02099B (es) |
| MX (1) | MX336634B (es) |
| MY (1) | MY160880A (es) |
| NZ (1) | NZ610296A (es) |
| PE (1) | PE20140420A1 (es) |
| PL (1) | PL2640467T3 (es) |
| PT (1) | PT2640467E (es) |
| RS (1) | RS53770B1 (es) |
| RU (1) | RU2013127661A (es) |
| SG (1) | SG190186A1 (es) |
| SI (1) | SI2640467T1 (es) |
| SM (1) | SMT201500059B (es) |
| TW (1) | TWI520950B (es) |
| WO (1) | WO2012066095A1 (es) |
| ZA (1) | ZA201303155B (es) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5649825B2 (ja) | 2007-01-31 | 2015-01-07 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | 安定化させたｐ５３ペプチドおよびその使用法 |
| KR20160061439A (ko) | 2007-03-28 | 2016-05-31 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 스티칭된 폴리펩티드 |
| US8440693B2 (en) | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
| KR102104762B1 (ko) | 2010-08-13 | 2020-04-24 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
| KR20140100937A (ko) | 2011-10-18 | 2014-08-18 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
| US9408885B2 (en) * | 2011-12-01 | 2016-08-09 | Vib Vzw | Combinations of therapeutic agents for treating melanoma |
| CN104144695A (zh) | 2012-02-15 | 2014-11-12 | 爱勒让治疗公司 | 三唑交联的和硫醚交联的拟肽大环化合物 |
| CN107216380A (zh) | 2012-02-15 | 2017-09-29 | 爱勒让治疗公司 | 拟肽大环化合物 |
| EP2855483B1 (en) | 2012-05-24 | 2017-10-25 | Novartis AG | Pyrrolopyrrolidinone compounds |
| KR20150082307A (ko) | 2012-11-01 | 2015-07-15 | 에일러론 테라퓨틱스 인코포레이티드 | 이치환 아미노산 및 이의 제조 및 사용 방법 |
| WO2014115077A1 (en) | 2013-01-22 | 2014-07-31 | Novartis Ag | Substituted purinone compounds |
| EP2948453B1 (en) | 2013-01-22 | 2017-08-02 | Novartis AG | Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the p53/mdm2 interaction |
| EP3004109A1 (en) | 2013-05-27 | 2016-04-13 | Novartis AG | Imidazopyrrolidinone derivatives and their use in the treatment of disease |
| US9624247B2 (en) | 2013-05-28 | 2017-04-18 | Novartis Ag | Pyrazolo-pyrrolidin-4-one derivatives as bet inhibitors and their use in the treatment of disease |
| US9714249B2 (en) | 2013-05-28 | 2017-07-25 | Novartis Ag | Pyrazolo-pyrrolidin-4-one derivatives and their use in the treatment of disease |
| JP2016537384A (ja) | 2013-11-21 | 2016-12-01 | ノバルティス アーゲー | ピロロピロロン誘導体およびｂｅｔ阻害剤としてのその使用 |
| CN105848656B (zh) * | 2013-12-23 | 2019-10-25 | 诺华股份有限公司 | 药物组合 |
| US20160339023A1 (en) * | 2013-12-23 | 2016-11-24 | Fang Li | Pharmaceutical Combinations |
| BR112017005598A2 (pt) | 2014-09-24 | 2017-12-12 | Aileron Therapeutics Inc | macrociclos peptidomiméticos e usos dos mesmos |
| SG10201902598VA (en) | 2014-09-24 | 2019-04-29 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and formulations thereof |
| EP3294318A4 (en) | 2015-03-20 | 2019-04-03 | Aileron Therapeutics, Inc. | PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF |
| TWI750129B (zh) | 2015-08-03 | 2021-12-21 | 瑞士商諾華公司 | 作為血液學毒性生物標記之ｇｄｆ-１５ |
| WO2017037586A1 (en) * | 2015-08-28 | 2017-03-09 | Novartis Ag | Combination therapy using pi3k inhbitor and mdm2 inhibitor |
| RU2740091C2 (ru) | 2015-08-28 | 2021-01-11 | Новартис Аг | Ингибиторы mdm2 и их комбинации |
| WO2017044633A1 (en) | 2015-09-10 | 2017-03-16 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles as modulators of mcl-1 |
| KR101838687B1 (ko) | 2016-01-26 | 2018-03-15 | 한국생명공학연구원 | 나노포어를 이용한 단백질-단백질 상호작용 저해제 스크리닝 방법 |
| WO2017201449A1 (en) | 2016-05-20 | 2017-11-23 | Genentech, Inc. | Protac antibody conjugates and methods of use |
| SI3541387T1 (sl) | 2016-11-15 | 2021-08-31 | Novartis Ag | Odmerek in režim za zaviralce interakcije HDM2-P53 |
| WO2018092064A1 (en) | 2016-11-18 | 2018-05-24 | Novartis Ag | Combinations of mdm2 inhibitors and bcl-xl inhibitors |
| WO2018111902A1 (en) | 2016-12-12 | 2018-06-21 | Multivir Inc. | Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases |
| US11413284B2 (en) | 2017-09-12 | 2022-08-16 | Novartis Ag | Protein kinase C inhibitors for treatment of uveal melanoma |
| EP3694518A1 (en) | 2017-10-12 | 2020-08-19 | Novartis AG | Combinations of mdm2 inhibitors with inhibitors of erk for treating cancers |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3829420A (en) | 1970-07-13 | 1974-08-13 | Sumitomo Chemical Co | 3,4-dihydro-2(1h)-quinazolinones and preparation thereof |
| US4099002A (en) | 1970-12-23 | 1978-07-04 | Sumitomo Chemical Company, Limited | Quinazolinone derivatives and a process for production thereof |
| JPS4822715B1 (es) | 1970-12-28 | 1973-07-07 | ||
| JPS5427356B2 (es) | 1972-03-31 | 1979-09-10 | ||
| GB1524747A (en) | 1976-05-11 | 1978-09-13 | Ici Ltd | Polypeptide |
| US4258187A (en) | 1977-06-16 | 1981-03-24 | E. I. Du Pont De Nemours And Company | Process for preparing quinazolinone oxides |
| US4335127A (en) | 1979-01-08 | 1982-06-15 | Janssen Pharmaceutica, N.V. | Piperidinylalkyl quinazoline compounds, composition and method of use |
| ATE28864T1 (de) | 1982-07-23 | 1987-08-15 | Ici Plc | Amide-derivate. |
| GB8327256D0 (en) | 1983-10-12 | 1983-11-16 | Ici Plc | Steroid derivatives |
| DE3420799A1 (de) | 1984-06-04 | 1985-12-05 | Bayer Ag, 5090 Leverkusen | Chromogene 4,4-diaryl-dihydrochinazolone, ihre herstellung und verwendung |
| US5093330A (en) | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| US5010099A (en) | 1989-08-11 | 1991-04-23 | Harbor Branch Oceanographic Institution, Inc. | Discodermolide compounds, compositions containing same and method of preparation and use |
| US5395855A (en) | 1990-05-07 | 1995-03-07 | Ciba-Geigy Corporation | Hydrazones |
| NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
| WO1993004047A1 (en) | 1991-08-16 | 1993-03-04 | Merck & Co., Inc. | Quinazoline derivatives as inhibitors of hiv reverse transcriptase |
| GB9300059D0 (en) | 1992-01-20 | 1993-03-03 | Zeneca Ltd | Quinazoline derivatives |
| TW225528B (es) | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| DE69233739D1 (de) | 1992-10-28 | 2008-08-07 | Genentech Inc | Verwendung von Antagonisten des Zellwachstumsfaktors VEGF |
| GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
| EP0817775B1 (en) | 1995-03-30 | 2001-09-12 | Pfizer Inc. | Quinazoline derivatives |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| US5843901A (en) | 1995-06-07 | 1998-12-01 | Advanced Research & Technology Institute | LHRH antagonist peptides |
| CZ1598A3 (cs) | 1995-07-06 | 1998-04-15 | Novartis Ag | Pyrrolopyrimidiny a způsoby jejich přípravy |
| US5760041A (en) | 1996-02-05 | 1998-06-02 | American Cyanamid Company | 4-aminoquinazoline EGFR Inhibitors |
| GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| DK0892789T4 (da) | 1996-04-12 | 2010-04-06 | Warner Lambert Co | Irreversible inhibitorer af tyrosin kinaser |
| BR9709959A (pt) | 1996-06-24 | 2000-05-09 | Pfizer | Derivados tricìclicos de fenilamino substituìdo para o tratamento de doenças hiperproliferativas |
| WO1998001467A2 (en) | 1996-07-05 | 1998-01-15 | Novartis Ag | Inhibitors of the interaction between p53 and mdm2 |
| NZ334821A (en) | 1996-08-30 | 2000-12-22 | Novartis Ag | Method for producing epothilones |
| DE938597T1 (de) | 1996-09-06 | 2000-03-09 | Obducat Ab | Verfahren für das anisotrope ätzen von strukturen in leitende materialien |
| DE19638745C2 (de) | 1996-09-11 | 2001-05-10 | Schering Ag | Monoklonale Antikörper gegen die extrazelluläre Domäne des menschlichen VEGF - Rezeptorproteins (KDR) |
| WO1998010767A2 (en) | 1996-09-13 | 1998-03-19 | Sugen, Inc. | Use of quinazoline derivatives for the manufacture of a medicament in the treatment of hyperproliferative skin disorders |
| EP0837063A1 (en) | 1996-10-17 | 1998-04-22 | Pfizer Inc. | 4-Aminoquinazoline derivatives |
| NZ335383A (en) | 1996-11-18 | 2000-10-27 | Biotechnolog Forschung Gmbh | Epothilone C,D,E and F for plant protection and cytostatic effects shown in kidney cells |
| US6441186B1 (en) | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
| CO4950519A1 (es) | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| CO4940418A1 (es) | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
| GB9721069D0 (en) | 1997-10-03 | 1997-12-03 | Pharmacia & Upjohn Spa | Polymeric derivatives of camptothecin |
| US6194181B1 (en) | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
| NZ506742A (en) | 1998-02-25 | 2003-09-26 | Sloan Kettering Inst Cancer | Synthesis of desoxyepothilones and hydroxy acid derivative intermediates |
| JP4516690B2 (ja) | 1998-08-11 | 2010-08-04 | ノバルティス アーゲー | 血管形成阻害活性を有するイソキノリン誘導体 |
| GB9824579D0 (en) | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
| UA71587C2 (uk) | 1998-11-10 | 2004-12-15 | Шерінг Акцієнгезелльшафт | Аміди антранілової кислоти та їхнє застосування як лікарських засобів |
| CA2350189A1 (en) | 1998-11-20 | 2000-06-02 | Kosan Biosciences, Inc. | Recombinant methods and materials for producing epothilone and epothilone derivatives |
| CA2355976C (en) | 1998-12-22 | 2012-07-17 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists and uses thereof |
| ES2265929T3 (es) | 1999-03-30 | 2007-03-01 | Novartis Ag | Derivados de ftalazina para el tratamiento de enfermedades inflamatorias. |
| WO2000066560A1 (en) | 1999-05-04 | 2000-11-09 | American Home Products Corporation | Quinazolinone and benzoxazine derivatives as progesterone receptor modulators |
| JP2001302515A (ja) | 2000-04-18 | 2001-10-31 | Sumitomo Pharmaceut Co Ltd | ポリ（ａｄｐ−リボース）ポリメラーゼ阻害剤 |
| PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| TWI238824B (en) | 2001-05-14 | 2005-09-01 | Novartis Ag | 4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives |
| GB0119249D0 (en) | 2001-08-07 | 2001-10-03 | Novartis Ag | Organic compounds |
| AU2003214873A1 (en) | 2002-01-18 | 2003-09-02 | Ceretek Llc | Methods of treating conditions associated with an edg receptor |
| WO2003095625A2 (en) | 2002-05-13 | 2003-11-20 | 3-Dimensional Pharmaceuticals, Inc. | Method for cytoprotection through mdm2 and hdm2 inhibition |
| US7119111B2 (en) | 2002-05-29 | 2006-10-10 | Amgen, Inc. | 2-oxo-1,3,4-trihydroquinazolinyl derivatives and methods of use |
| US20040213264A1 (en) | 2003-04-25 | 2004-10-28 | Nortel Networks Limited | Service class and destination dominance traffic management |
| EP1657238A4 (en) | 2003-08-22 | 2008-12-03 | Takeda Pharmaceutical | MERGED PYRIMIDINE DERIVATIVE AND USE THEREOF |
| SI1663185T1 (sl) | 2003-09-22 | 2009-04-30 | Onepharm Res & Dev Gmbh | Preprečevanje in zdravljenje z vnetjem inducirane in/ali imunsko posredovane izgube kosti |
| GB0419481D0 (en) | 2004-09-02 | 2004-10-06 | Cancer Rec Tech Ltd | Isoindolin-1-one derivatives |
| US20080153791A1 (en) | 2005-03-18 | 2008-06-26 | Onpharm Gmbh | 11Beta -Hydroxysteroid Dehydrogenases |
| US7576082B2 (en) | 2005-06-24 | 2009-08-18 | Hoffman-La Roche Inc. | Oxindole derivatives |
| DE102006016426A1 (de) | 2006-04-07 | 2007-10-11 | Merck Patent Gmbh | Neuartige Cyclobutyl-Verbindungen als Kinase-Inhibitoren |
| US8367699B2 (en) | 2006-09-15 | 2013-02-05 | Nexuspharma, Inc. | Tetrahydro-isoquinolines |
| US8440693B2 (en) * | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
-
2010
- 2010-12-21 CU CU2012000098A patent/CU24130B1/es active IP Right Grant
-
2011
- 2011-11-17 NZ NZ610296A patent/NZ610296A/en not_active IP Right Cessation
- 2011-11-17 PT PT11790916T patent/PT2640467E/pt unknown
- 2011-11-17 AU AU2011331095A patent/AU2011331095B2/en not_active Ceased
- 2011-11-17 MX MX2013005631A patent/MX336634B/es unknown
- 2011-11-17 PE PE2013001210A patent/PE20140420A1/es not_active Application Discontinuation
- 2011-11-17 EP EP11790916.8A patent/EP2640467B1/en active Active
- 2011-11-17 DK DK11790916.8T patent/DK2640467T3/en active
- 2011-11-17 WO PCT/EP2011/070385 patent/WO2012066095A1/en active Application Filing
- 2011-11-17 US US13/988,227 patent/US9073898B2/en not_active Expired - Fee Related
- 2011-11-17 RS RS20150050A patent/RS53770B1/en unknown
- 2011-11-17 RU RU2013127661/04A patent/RU2013127661A/ru not_active Application Discontinuation
- 2011-11-17 ME MEP-2015-12A patent/ME02099B/me unknown
- 2011-11-17 AR ARP110104289A patent/AR083905A1/es unknown
- 2011-11-17 CA CA2816810A patent/CA2816810A1/en not_active Abandoned
- 2011-11-17 PL PL11790916T patent/PL2640467T3/pl unknown
- 2011-11-17 KR KR1020137015727A patent/KR101561750B1/ko not_active IP Right Cessation
- 2011-11-17 MY MYPI2013001567A patent/MY160880A/en unknown
- 2011-11-17 SI SI201130417T patent/SI2640467T1/sl unknown
- 2011-11-17 US US13/298,351 patent/US8969351B2/en not_active Expired - Fee Related
- 2011-11-17 SG SG2013034988A patent/SG190186A1/en unknown
- 2011-11-17 JP JP2013539265A patent/JP5667308B2/ja not_active Expired - Fee Related
- 2011-11-17 ES ES11790916.8T patent/ES2528376T3/es active Active
- 2011-11-17 BR BR112013011966A patent/BR112013011966A2/pt not_active IP Right Cessation
- 2011-11-18 TW TW100142392A patent/TWI520950B/zh not_active IP Right Cessation
-
2013
- 2013-04-30 ZA ZA2013/03155A patent/ZA201303155B/en unknown
- 2013-05-06 IL IL226182A patent/IL226182A0/en unknown
- 2013-05-14 MA MA35904A patent/MA34666B1/fr unknown
- 2013-05-17 GT GT201300132A patent/GT201300132A/es unknown
- 2013-05-17 EC ECSP13012628 patent/ECSP13012628A/es unknown
- 2013-05-24 CO CO13128275A patent/CO6801719A2/es not_active Application Discontinuation
- 2013-10-11 HK HK13111501.4A patent/HK1184091A1/xx not_active IP Right Cessation
-
2015
- 2015-02-12 CY CY20151100140T patent/CY1116002T1/el unknown
- 2015-02-27 HR HRP20150231AT patent/HRP20150231T1/hr unknown
- 2015-03-10 SM SM201500059T patent/SMT201500059B/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO6801719A2 (es) | Forma cristalina de un inhibidor de la interacción de mdm2/4 y p53 | |
| SMT201600181B (it) | Composti antiparassitari di diidroazolo e composizioni che li comprendono | |
| SMT201600135B (it) | Nuovi inibitori della s-nitrosoglutatione riduttasi | |
| DK3400944T3 (da) | Ibat-inhibitorer til behandling af leversygdomme | |
| SMT201500271B (it) | Inibitori di neprilisina | |
| BR112012017441A2 (pt) | compostos e métodos | |
| SMT201600272B (it) | Diidropiridinoni e piperidinoni arilici come inibitori di mgat2 | |
| DK2594567T3 (da) | Heterocykliske alkynylbenzenforbindelser og anvendelser deraf | |
| BR112013013663A2 (pt) | ácidos 1-benzilcicloalquilcarboxílicos substituídos e sua utilização | |
| DK3178818T3 (da) | Pyrazolylquinoxalinkinasehæmmere | |
| BR112012027165A2 (pt) | composição e artigo | |
| SMT201600127B (it) | Forma cristallina di (r)-7-cloro-n-(chinuclidin- 3-il)benzo[b]tiofen-2-carbossamide cloridrato monoidrato | |
| IT1404856B1 (it) | Copricapo stirabile e suo procedimento di fabbricazione | |
| BR112012028633A2 (pt) | composição reticulada e artigo | |
| DK2642992T3 (da) | Forbindelser og anvendelse deraf | |
| FI20106181A0 (fi) | Menetelmä substraatin muodostamiseksi ja substraatti | |
| BR112012021749A2 (pt) | processos e compostos | |
| IT1404249B1 (it) | Parete di banchina e procedimento per la sua realizzazione | |
| FR2955473B1 (fr) | Structure de presentoir | |
| BR112013012958A2 (pt) | inibidores integrin ligado com quinase | |
| ES1074944Y (es) | Envase monodosis para dentifricos y similares | |
| ITMI20100187U1 (it) | Eurobox - portamonete -contamonete per 1 euro e 2 euro | |
| FIU20114101U0 (fi) | Seinäelementti ja seinärakenne | |
| UA21308S (uk) | Розгортка упаковки | |
| UA21432S (uk) | Розгортка упаковки |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |