CO6630104A2 - Derivados de quinolizidina e indolizidina - Google Patents

Derivados de quinolizidina e indolizidina

Info

Publication number
CO6630104A2
CO6630104A2 CO12178886A CO12178886A CO6630104A2 CO 6630104 A2 CO6630104 A2 CO 6630104A2 CO 12178886 A CO12178886 A CO 12178886A CO 12178886 A CO12178886 A CO 12178886A CO 6630104 A2 CO6630104 A2 CO 6630104A2
Authority
CO
Colombia
Prior art keywords
compounds
inhibitors
lower alkyl
quinolizidine
glycine transporter
Prior art date
Application number
CO12178886A
Other languages
English (en)
Inventor
Sabine Kolczewski
Emmanuel Pinard
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44314179&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6630104(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO6630104A2 publication Critical patent/CO6630104A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

La presente invención, se refiere a compuestos de la fórmula general I-A ó I-Ben donde,X, es un enlace o un grupo -CH, R, Ry Rson, de una forma independiente, las unas con respecto a las otras, hidrógeno, alcoxi inferior, alquilo inferior sustituido por halógeno, ó S- alquilo inferior;o a sales de adición de ácidos, farmacéuticamente aceptables, a una mezcla racémica, o sus correspondientes enantiómeros y / o isómeros ópticos de éste.Se ha encontrado el hecho de que, los compuestos de las fórmulas generales I-A y I-B, son buenos inhibidores del transportador de glicina 1 (GlyT-1), y que éstos tienen una buena selectividad a los inhibidores del transportador de glicina 2 (GIyT-2), apropiados en el tratamiento de los trastornos neurológicos y neuropsiquiátricos.
CO12178886A 2010-06-22 2012-10-10 Derivados de quinolizidina e indolizidina CO6630104A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10166776 2010-06-22

Publications (1)

Publication Number Publication Date
CO6630104A2 true CO6630104A2 (es) 2013-03-01

Family

ID=44314179

Family Applications (1)

Application Number Title Priority Date Filing Date
CO12178886A CO6630104A2 (es) 2010-06-22 2012-10-10 Derivados de quinolizidina e indolizidina

Country Status (23)

Country Link
US (1) US8143273B2 (es)
EP (1) EP2585460B1 (es)
JP (1) JP5659299B2 (es)
KR (1) KR101431949B1 (es)
CN (1) CN102947301B (es)
AR (1) AR082766A1 (es)
AU (1) AU2011269147A1 (es)
BR (1) BR112012030886A2 (es)
CA (1) CA2797874C (es)
CL (1) CL2012003553A1 (es)
CO (1) CO6630104A2 (es)
CR (1) CR20120601A (es)
EA (1) EA201291281A1 (es)
ES (1) ES2523572T3 (es)
HK (1) HK1179609A1 (es)
IL (1) IL222602A0 (es)
MA (1) MA34250B1 (es)
MX (1) MX2012013580A (es)
PE (1) PE20130776A1 (es)
SG (1) SG186327A1 (es)
TW (1) TWI412526B (es)
WO (1) WO2011161008A1 (es)
ZA (1) ZA201209089B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2014199960A1 (ja) * 2013-06-10 2017-02-23 大正製薬株式会社 グリシントランスポーター阻害物質
KR102380870B1 (ko) 2019-06-19 2022-03-31 한양대학교 에리카산학협력단 퀴놀리지딘 화합물 및 그 제조방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MC1289A1 (fr) 1978-10-13 1980-07-22 Hoffmann La Roche Phenyl quinolizidines
ZA795318B (en) * 1978-10-13 1980-09-24 Hoffmann La Roche Phenyl quinolizidines
EP0067565A1 (en) * 1981-06-16 1982-12-22 Beecham Group Plc Pharmaceutically active compounds
WO2002024695A2 (en) 2000-09-22 2002-03-28 Ortho Mcneil Pharmaceutical, Inc. Octahydro-indolizines and quinolizines and hexahydro-pyrrolizines
AU2002365132A1 (en) * 2001-10-17 2003-07-15 Bristol-Myers Squibb Company BICYCLIC LACTAM DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-Alpha CONVERTING ENZYME (TACE)
FR2906251B1 (fr) * 2006-09-22 2008-11-07 Sanofi Aventis Sa Derives de pyrrolizine, indolizine et quinolizine, leur preparation et leur application en therapeutique
JP2011524894A (ja) * 2008-06-18 2011-09-08 ファイザー・リミテッド ニコチンアミド誘導体

Also Published As

Publication number Publication date
JP5659299B2 (ja) 2015-01-28
BR112012030886A2 (pt) 2016-11-08
CR20120601A (es) 2013-01-03
EA201291281A1 (ru) 2013-06-28
ZA201209089B (en) 2013-08-28
US20110313165A1 (en) 2011-12-22
IL222602A0 (en) 2012-12-31
MX2012013580A (es) 2013-01-24
US8143273B2 (en) 2012-03-27
CL2012003553A1 (es) 2013-03-22
TW201206928A (en) 2012-02-16
EP2585460A1 (en) 2013-05-01
PE20130776A1 (es) 2013-07-03
TWI412526B (zh) 2013-10-21
CN102947301A (zh) 2013-02-27
CA2797874C (en) 2018-04-24
KR20130028756A (ko) 2013-03-19
HK1179609A1 (en) 2013-10-04
CA2797874A1 (en) 2011-12-29
MA34250B1 (fr) 2013-05-02
ES2523572T3 (es) 2014-11-27
JP2013529609A (ja) 2013-07-22
WO2011161008A1 (en) 2011-12-29
EP2585460B1 (en) 2014-10-01
CN102947301B (zh) 2015-02-11
KR101431949B1 (ko) 2014-08-19
AU2011269147A1 (en) 2012-11-01
SG186327A1 (en) 2013-01-30
AR082766A1 (es) 2013-01-09

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