EA201171010A1 - Производные 6-(6-o-циклоалкил- или 6-nh-циклоалкилтриазолопиридазинсульфанил)бензотиазолов и бензимидазолов: способ получения, применение в качестве лекарственных средств и применение в качестве ингибиторов met - Google Patents
Производные 6-(6-o-циклоалкил- или 6-nh-циклоалкилтриазолопиридазинсульфанил)бензотиазолов и бензимидазолов: способ получения, применение в качестве лекарственных средств и применение в качестве ингибиторов metInfo
- Publication number
- EA201171010A1 EA201171010A1 EA201171010A EA201171010A EA201171010A1 EA 201171010 A1 EA201171010 A1 EA 201171010A1 EA 201171010 A EA201171010 A EA 201171010A EA 201171010 A EA201171010 A EA 201171010A EA 201171010 A1 EA201171010 A1 EA 201171010A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- correls
- correling
- cycloalkyl
- cycloalkyltriazolephenyl
- correle
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Изобретение относится к новым соединениям формулы (I), в которойозначает простую или двойную связь; Ra означает -O-циклоалкил или -NH-циклоалкил; Х означает S, SO или SO; А означает NH или S; W означает Н, алкил или COR, где R означает циклоалкил; алкил; алкокси; O-фенил; -O-(CH)-фенил, где n=1-4; или NR1R2, где R1 означает Н или алкил и R2 означает Н, циклоалкил, гетероциклоалкил или алкил; или R1, R2 образуют вместе с N цикл, необязательно содержащий О, S, N и/или NH; причем все эти радикалы необязательно замещены; эти соединения, находящиеся во всех изомерных формах и в виде солей, используются в качестве лекарственных средств, в частности в качестве ингибиторов MET.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0900510A FR2941949B1 (fr) | 2009-02-06 | 2009-02-06 | Derives de 6-(6-o-cycloalkyl ou 6-nh-cycloalkyl- triazolopyridazine-sulfanyl)benzothiazoles et benzimidazoles preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
PCT/FR2010/050177 WO2010089506A1 (fr) | 2009-02-06 | 2010-02-04 | Derives de 6-(6-o-cycloalkyl ou 6-nh-cycloalkyl-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201171010A1 true EA201171010A1 (ru) | 2012-03-30 |
Family
ID=40863635
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201171010A EA201171010A1 (ru) | 2009-02-06 | 2010-02-04 | Производные 6-(6-o-циклоалкил- или 6-nh-циклоалкилтриазолопиридазинсульфанил)бензотиазолов и бензимидазолов: способ получения, применение в качестве лекарственных средств и применение в качестве ингибиторов met |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP2393790A1 (ru) |
JP (1) | JP2012517407A (ru) |
KR (1) | KR20110126660A (ru) |
CN (1) | CN102388029A (ru) |
AR (1) | AR075248A1 (ru) |
AU (1) | AU2010212231A1 (ru) |
BR (1) | BRPI1011354A2 (ru) |
CA (1) | CA2751525A1 (ru) |
CO (1) | CO6400222A2 (ru) |
EA (1) | EA201171010A1 (ru) |
FR (1) | FR2941949B1 (ru) |
IL (1) | IL214407A0 (ru) |
MA (1) | MA33102B1 (ru) |
MX (1) | MX2011008312A (ru) |
SG (1) | SG173558A1 (ru) |
TW (1) | TW201040187A (ru) |
UY (1) | UY32419A (ru) |
WO (1) | WO2010089506A1 (ru) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2755976B1 (en) | 2011-09-15 | 2018-07-18 | Novartis AG | 6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyridines as c-met tyrosine kinase inhibitors |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1298125A1 (en) | 2001-09-26 | 2003-04-02 | Aventis Pharma S.A. | Substituted benzimidazole compounds and their use for the treatment of cancer |
BRPI0619252A2 (pt) * | 2005-11-30 | 2011-09-20 | Vertex Pharma | inibidores de c-met e seus usos |
ZA200804681B (en) * | 2005-11-30 | 2009-11-25 | Vertex Pharma Inc | Inhibitors of C-Met and uses thereof |
ME02736B (me) * | 2005-12-21 | 2017-10-20 | Janssen Pharmaceutica Nv | Triazolopiridazini kao modulatori tirozin kinaze |
WO2007138472A2 (en) * | 2006-05-30 | 2007-12-06 | Pfizer Products Inc. | Triazolopyridazine derivatives |
PE20121506A1 (es) * | 2006-07-14 | 2012-11-26 | Amgen Inc | Compuestos triazolopiridinas como inhibidores de c-met |
KR20090071612A (ko) * | 2006-10-23 | 2009-07-01 | 에스지엑스 파마슈티컬스, 인코포레이티드 | 단백질 키나제 조정제로서의 바이시클릭 트리아졸 |
PA8792501A1 (es) * | 2007-08-09 | 2009-04-23 | Sanofi Aventis | Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol,su procedimiento de preparación,su aplicación como medicamentos,composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met. |
-
2009
- 2009-02-06 FR FR0900510A patent/FR2941949B1/fr not_active Expired - Fee Related
-
2010
- 2010-02-04 MX MX2011008312A patent/MX2011008312A/es not_active Application Discontinuation
- 2010-02-04 EA EA201171010A patent/EA201171010A1/ru unknown
- 2010-02-04 BR BRPI1011354A patent/BRPI1011354A2/pt not_active IP Right Cessation
- 2010-02-04 KR KR1020117020676A patent/KR20110126660A/ko not_active Application Discontinuation
- 2010-02-04 AU AU2010212231A patent/AU2010212231A1/en not_active Abandoned
- 2010-02-04 CA CA2751525A patent/CA2751525A1/fr not_active Abandoned
- 2010-02-04 WO PCT/FR2010/050177 patent/WO2010089506A1/fr active Application Filing
- 2010-02-04 MA MA34147A patent/MA33102B1/fr unknown
- 2010-02-04 JP JP2011548750A patent/JP2012517407A/ja not_active Withdrawn
- 2010-02-04 EP EP10708277A patent/EP2393790A1/fr not_active Withdrawn
- 2010-02-04 SG SG2011056470A patent/SG173558A1/en unknown
- 2010-02-04 CN CN2010800150530A patent/CN102388029A/zh active Pending
- 2010-02-05 UY UY0001032419A patent/UY32419A/es not_active Application Discontinuation
- 2010-02-05 AR ARP100100316A patent/AR075248A1/es unknown
- 2010-02-05 TW TW099103558A patent/TW201040187A/zh unknown
-
2011
- 2011-08-02 IL IL214407A patent/IL214407A0/en unknown
- 2011-08-05 CO CO11099121A patent/CO6400222A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2012517407A (ja) | 2012-08-02 |
FR2941949B1 (fr) | 2011-04-01 |
MA33102B1 (fr) | 2012-03-01 |
CO6400222A2 (es) | 2012-03-15 |
AU2010212231A1 (en) | 2011-08-25 |
FR2941949A1 (fr) | 2010-08-13 |
TW201040187A (en) | 2010-11-16 |
UY32419A (es) | 2010-09-30 |
KR20110126660A (ko) | 2011-11-23 |
IL214407A0 (en) | 2011-09-27 |
BRPI1011354A2 (pt) | 2019-09-24 |
CA2751525A1 (fr) | 2010-08-12 |
SG173558A1 (en) | 2011-09-29 |
MX2011008312A (es) | 2011-11-02 |
WO2010089506A1 (fr) | 2010-08-12 |
AR075248A1 (es) | 2011-03-16 |
EP2393790A1 (fr) | 2011-12-14 |
CN102388029A (zh) | 2012-03-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1116987T1 (el) | Συμπυκνωμενα ιμιδαζολυλιμιδαζολια ως αντιϊικες ενωσεις | |
EA201301209A1 (ru) | Производные пирролотриазинона в качестве ингибиторов p13k | |
EA201201677A1 (ru) | Производные гетероарилимидазолона в качестве ингибиторов jak | |
EA201200938A1 (ru) | Производные имидазопиридина в качестве ингибиторов jak | |
EA201490474A1 (ru) | Аминохиназолины в качестве ингибиторов киназ | |
EA201001013A1 (ru) | Бис(сульфониламино)производные для применения в терапии | |
EA201300250A1 (ru) | Оксадиазольные ингибиторы продуцирования лейкотриена | |
EA201491824A1 (ru) | Производные бензамида для ингибирования активности abl1, abl2 и bcr-abl1 | |
EA201200741A1 (ru) | Способ получения этексилата дабигатрана | |
IN2014MN02106A (ru) | ||
UA117800C2 (uk) | Похідні урацилу або тиміну для лікування гепатиту с | |
EA201101026A1 (ru) | Ингибиторы бета-секретазы | |
EA201301319A1 (ru) | Производные пиридин-2(1н)-она, применимые в качестве лекарственных средств для лечения миелопролиферативных нарушений, отторжения трансплантата, иммунологически обусловленных и воспалительных заболеваний | |
EA201490596A1 (ru) | Новые производные дигидрохинолин-2-она | |
EA201491362A1 (ru) | Анестезирующие соединения и способы их применения | |
EA201200669A1 (ru) | ПИРИДОПИРИМИДИНОНОВЫЕ ИНГИБИТОРЫ PI3Kα | |
EA201291409A1 (ru) | Производные индолизина, способ их получения и их терапевтическое применение | |
EA200801608A1 (ru) | Производные бензимидазолонкарбоновой кислоты | |
EA201490471A1 (ru) | Пиридазиноновые соединения и их применение в качестве ингибиторов daao | |
EA201492170A1 (ru) | Новые замещенные в цикле n-пиридиниламиды в качестве ингибиторов киназ | |
EA201500298A1 (ru) | Алкоксипиразолы в качестве активаторов растворимой гуанилатциклазы | |
EA201490567A1 (ru) | Новые бициклические производные дигидрохинолин-2-она | |
IN2014MN01521A (ru) | ||
EA201500182A1 (ru) | 4-МЕТИЛ-2,3,5,9,9b-ПЕНТААЗАЦИКЛОПЕНТА[a]НАФТАЛИНЫ | |
EA201190293A1 (ru) | Пролекарства триптолида |