CO6531453A2 - Uso del antagonista del receptor opiaceo para los trastornos del tracto gastrointestinal - Google Patents
Uso del antagonista del receptor opiaceo para los trastornos del tracto gastrointestinalInfo
- Publication number
- CO6531453A2 CO6531453A2 CO12064152A CO12064152A CO6531453A2 CO 6531453 A2 CO6531453 A2 CO 6531453A2 CO 12064152 A CO12064152 A CO 12064152A CO 12064152 A CO12064152 A CO 12064152A CO 6531453 A2 CO6531453 A2 CO 6531453A2
- Authority
- CO
- Colombia
- Prior art keywords
- opioid
- compound
- treating
- administering
- activation
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- 210000001035 gastrointestinal tract Anatomy 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102000003840 Opioid Receptors Human genes 0.000 abstract 2
- 108090000137 Opioid Receptors Proteins 0.000 abstract 2
- 208000030053 Opioid-Induced Constipation Diseases 0.000 abstract 2
- 230000004913 activation Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- ZGCYVRNZWGUXNQ-UHFFFAOYSA-N Bevenopran Chemical compound C=1C=C(OC=2N=CC(=NC=2)C(N)=O)C(OC)=CC=1CNCCC1CCOCC1 ZGCYVRNZWGUXNQ-UHFFFAOYSA-N 0.000 abstract 1
- 206010010774 Constipation Diseases 0.000 abstract 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 abstract 1
- 230000036592 analgesia Effects 0.000 abstract 1
- 230000001079 digestive effect Effects 0.000 abstract 1
- 210000002249 digestive system Anatomy 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 210000005095 gastrointestinal system Anatomy 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- 150000002894 organic compounds Chemical class 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003216 pyrazines Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24361609P | 2009-09-18 | 2009-09-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6531453A2 true CO6531453A2 (es) | 2012-09-28 |
Family
ID=43216894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO12064152A CO6531453A2 (es) | 2009-09-18 | 2012-04-18 | Uso del antagonista del receptor opiaceo para los trastornos del tracto gastrointestinal |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20110071163A1 (https=) |
| EP (1) | EP2477627B1 (https=) |
| JP (1) | JP5797655B2 (https=) |
| KR (1) | KR20120092592A (https=) |
| CN (2) | CN104958298A (https=) |
| AU (1) | AU2010295464B2 (https=) |
| BR (1) | BR112012006069A8 (https=) |
| CA (1) | CA2774021A1 (https=) |
| CL (1) | CL2012000676A1 (https=) |
| CO (1) | CO6531453A2 (https=) |
| HK (1) | HK1210959A1 (https=) |
| IL (1) | IL218679A0 (https=) |
| MX (1) | MX342548B (https=) |
| NZ (1) | NZ598783A (https=) |
| PE (1) | PE20120991A1 (https=) |
| RU (1) | RU2561873C2 (https=) |
| TW (1) | TW201118084A (https=) |
| WO (1) | WO2011035142A1 (https=) |
| ZA (1) | ZA201201954B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014102571A1 (en) * | 2012-12-28 | 2014-07-03 | Instytut Medycyny Doswiadczalnej I Klinicznej Im. Miroslawa Mossakowskiego Polskiej Akademii Nauk | Peptidomimetics and their application |
| TN2018000355A1 (en) | 2016-05-20 | 2020-06-15 | Esteve Pharmaceuticals Sa | Tetrahydropyran and thiopyran derivatives having multimodal activity against pain. |
| CN106117190B (zh) * | 2016-06-21 | 2019-03-29 | 山东川成医药股份有限公司 | 一种倍福普兰的合成方法 |
| CN113573711A (zh) | 2019-01-04 | 2021-10-29 | 伊瑟治疗公司 | 治疗药物或酒精依赖性的方法 |
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| US4191771A (en) * | 1974-09-06 | 1980-03-04 | Eli Lilly And Company | Analgesic method using 1,3,4-trisubstituted-4-arylpiperidines |
| US5166174A (en) * | 1987-01-28 | 1992-11-24 | K.K. Ueno Seiyaku Oyo Kenkyujo | Prostaglandins E and anti-ulcers containing same |
| US5319087A (en) * | 1987-04-16 | 1994-06-07 | Eli Lilly And Company | Piperidine opioid antagonists |
| US5064834A (en) * | 1987-04-16 | 1991-11-12 | Eli Lilly And Company | Piperidine opioid antagonists |
| US4992450A (en) * | 1987-04-16 | 1991-02-12 | Eli Lilly And Company | Piperidine opioid antagonists |
| US4891379A (en) * | 1987-04-16 | 1990-01-02 | Kabushiki Kaisha Kobe Seikosho | Piperidine opioid antagonists |
| US5250542A (en) * | 1991-03-29 | 1993-10-05 | Eli Lilly And Company | Peripherally selective piperidine carboxylate opioid antagonists |
| US5159081A (en) * | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
| US5270328A (en) * | 1991-03-29 | 1993-12-14 | Eli Lilly And Company | Peripherally selective piperidine opioid antagonists |
| US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| EP0759303B1 (en) | 1994-04-22 | 2002-10-16 | Yamanouchi Pharmaceutical Co. Ltd. | Colon-specific drug release system |
| US5378448A (en) * | 1994-06-07 | 1995-01-03 | Lin; Hsing K. | Process for removing selenium from sulfur |
| TW490465B (en) * | 1994-11-24 | 2002-06-11 | Janssen Pharmaceutica Nv | Enterokinetic benzamide, the preparation process and the pharmaceutical compositions thereof |
| EP0827746B1 (en) * | 1996-09-05 | 2002-04-03 | Eli Lilly And Company | Carbazole analogues as selective beta3 adrenergic agonists |
| US6559158B1 (en) * | 1997-11-03 | 2003-05-06 | Ur Labs, Inc. | Use of methylnaltrexone and related compounds to treat chronic opioid use side affects |
| US6022884A (en) * | 1997-11-07 | 2000-02-08 | Amgen Inc. | Substituted pyridine compounds and methods of use |
| JP5068401B2 (ja) | 1998-09-28 | 2012-11-07 | カプスゲル・ベルギウム・ナムローゼ・フェンノートシャップ | Hpmcカプセルを使用する腸及び結腸への送達 |
| US6436959B1 (en) * | 1998-12-23 | 2002-08-20 | Ortho-Mcneil Pharmaceutical, Inc. | 4-[aryl(piperidin-4-yl)]aminobenzamides |
| US6194382B1 (en) * | 1999-03-03 | 2001-02-27 | Albert Einstein College Of Medicine Of Yeshiva University | Method and composition for treating irritable bowel syndrome using low doses of opioid receptor antagonists |
| BRPI0014869B8 (pt) * | 1999-10-15 | 2021-05-25 | Sucampo Ag | prostaglandinas bicíclicas, composições estabilizadas das mesmas, bem como processo para sua estabilização |
| AU776567B2 (en) * | 1999-11-01 | 2004-09-16 | Evans, Brian K | Composition for treatment of constipation and irritable bowel syndrome |
| US6469030B2 (en) * | 1999-11-29 | 2002-10-22 | Adolor Corporation | Methods for the treatment and prevention of ileus |
| US6414016B1 (en) * | 2000-09-05 | 2002-07-02 | Sucampo, A.G. | Anti-constipation composition |
| AU2002227135B2 (en) * | 2000-10-31 | 2008-01-03 | Rensselaer Polytechnic Institute | 8- substituted-2, 6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents |
| EP1420794B1 (en) * | 2001-08-31 | 2017-12-27 | Sucampo AG | Prostaglandin analogs as chloride channel openers |
| ES2654819T3 (es) * | 2001-10-18 | 2018-02-15 | Nektar Therapeutics | Conjugados poliméricos de antagonistas de opioides |
| AR037524A1 (es) * | 2001-11-14 | 2004-11-17 | Sucampo Ag | Unidad de dosificacion que comprende un analogo de prostaglandina para el tratamiento de la constipacion |
| KR101025633B1 (ko) * | 2002-09-19 | 2011-03-30 | 일라이 릴리 앤드 캄파니 | 오피오이드 수용체 안타고니스트로서의 디아릴 에테르 |
| EP1575596B1 (en) * | 2002-12-27 | 2016-06-22 | Sucampo AG | Derivatives of prostaglandins for treating irritable bowel syndrome and/or functional dyspepsia |
| ATE406360T1 (de) * | 2003-03-07 | 2008-09-15 | Lilly Co Eli | Antagonisten der opioidrezeptoren |
| CA2549009A1 (en) * | 2003-12-12 | 2005-07-07 | Eli Lilly And Company | Opioid receptor antagonists |
| ES2390459T3 (es) * | 2003-12-22 | 2012-11-13 | Eli Lilly And Company | Antagonistas de receptores de opioides |
| ATE399164T1 (de) * | 2004-03-12 | 2008-07-15 | Lilly Co Eli | Antagonisten des opioidrezeptors |
| DE602005022572D1 (de) * | 2004-03-12 | 2010-09-09 | Lilly Co Eli | Antagonisten des opioidrezeptors |
| US8524731B2 (en) * | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| WO2006126529A1 (ja) * | 2005-05-25 | 2006-11-30 | Shionogi & Co., Ltd. | 6,7-不飽和-7-カルバモイル置換モルヒナン誘導体 |
| MX2008009650A (es) * | 2006-01-24 | 2008-11-06 | R Tech Ueno Ltd | Formulacion de capsula de gelatina suave. |
| MY145633A (en) * | 2006-03-01 | 2012-03-15 | Theravance Inc | 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| TWI409067B (zh) * | 2007-02-28 | 2013-09-21 | Theravance Inc | 8-氮雜雙環〔3.2.1〕辛烷化合物之結晶型 |
| EP2214672B1 (en) * | 2007-10-18 | 2012-10-17 | Aiko Biotechnology | Combination analgesic employing opioid and neutral antagonist |
| RU2482107C2 (ru) * | 2007-12-11 | 2013-05-20 | Тереванс, Инк. | Производные 3-карбоксипропил-аминотетралина и родственные соединения в качестве антагонистов mu-опиоидного рецептора |
| JP5650657B2 (ja) * | 2008-12-10 | 2015-01-07 | セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー | 3−カルボキシプロピル−アミノテトラリン化合物の結晶形態 |
| TR201908514T4 (tr) * | 2009-12-04 | 2019-07-22 | Alkermes Pharma Ireland Ltd | İlaç doz aşimi tedavi̇si̇ i̇çi̇n morfi̇nan türevleri̇ |
-
2010
- 2010-09-17 AU AU2010295464A patent/AU2010295464B2/en not_active Ceased
- 2010-09-17 BR BR112012006069A patent/BR112012006069A8/pt not_active Application Discontinuation
- 2010-09-17 TW TW099131769A patent/TW201118084A/zh unknown
- 2010-09-17 WO PCT/US2010/049311 patent/WO2011035142A1/en not_active Ceased
- 2010-09-17 PE PE2012000347A patent/PE20120991A1/es not_active Application Discontinuation
- 2010-09-17 CN CN201510256187.6A patent/CN104958298A/zh active Pending
- 2010-09-17 CN CN2010800522092A patent/CN102695508A/zh active Pending
- 2010-09-17 CA CA2774021A patent/CA2774021A1/en not_active Abandoned
- 2010-09-17 US US12/884,985 patent/US20110071163A1/en not_active Abandoned
- 2010-09-17 KR KR1020127008846A patent/KR20120092592A/ko not_active Ceased
- 2010-09-17 MX MX2012003310A patent/MX342548B/es active IP Right Grant
- 2010-09-17 RU RU2012115450/15A patent/RU2561873C2/ru not_active IP Right Cessation
- 2010-09-17 EP EP10757144.0A patent/EP2477627B1/en not_active Not-in-force
- 2010-09-17 NZ NZ598783A patent/NZ598783A/xx not_active IP Right Cessation
- 2010-09-17 JP JP2012529934A patent/JP5797655B2/ja not_active Expired - Fee Related
-
2012
- 2012-03-15 ZA ZA2012/01954A patent/ZA201201954B/en unknown
- 2012-03-15 IL IL218679A patent/IL218679A0/en unknown
- 2012-03-16 CL CL2012000676A patent/CL2012000676A1/es unknown
- 2012-04-18 CO CO12064152A patent/CO6531453A2/es not_active Application Discontinuation
-
2015
- 2015-12-02 HK HK15111842.0A patent/HK1210959A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201201954B (en) | 2012-11-28 |
| JP2013505260A (ja) | 2013-02-14 |
| NZ598783A (en) | 2013-07-26 |
| MX342548B (es) | 2016-10-04 |
| EP2477627B1 (en) | 2018-08-15 |
| EP2477627A1 (en) | 2012-07-25 |
| AU2010295464A1 (en) | 2012-04-12 |
| PE20120991A1 (es) | 2012-08-01 |
| BR112012006069A8 (pt) | 2017-10-10 |
| IL218679A0 (en) | 2012-05-31 |
| WO2011035142A1 (en) | 2011-03-24 |
| MX2012003310A (es) | 2012-07-17 |
| JP5797655B2 (ja) | 2015-10-21 |
| AU2010295464B2 (en) | 2015-11-26 |
| CN102695508A (zh) | 2012-09-26 |
| TW201118084A (en) | 2011-06-01 |
| HK1210959A1 (en) | 2016-05-13 |
| CN104958298A (zh) | 2015-10-07 |
| RU2012115450A (ru) | 2013-10-27 |
| CL2012000676A1 (es) | 2012-10-19 |
| KR20120092592A (ko) | 2012-08-21 |
| CA2774021A1 (en) | 2011-03-24 |
| RU2561873C2 (ru) | 2015-09-10 |
| BR112012006069A2 (pt) | 2016-03-29 |
| US20110071163A1 (en) | 2011-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |