CO6511200A2 - Proceso para la preparación de derivados de primidinilacetonitrilo e intermediarios para la sintesis de estos - Google Patents

Proceso para la preparación de derivados de primidinilacetonitrilo e intermediarios para la sintesis de estos

Info

Publication number
CO6511200A2
CO6511200A2 CO12035697A CO12035697A CO6511200A2 CO 6511200 A2 CO6511200 A2 CO 6511200A2 CO 12035697 A CO12035697 A CO 12035697A CO 12035697 A CO12035697 A CO 12035697A CO 6511200 A2 CO6511200 A2 CO 6511200A2
Authority
CO
Colombia
Prior art keywords
derivatives
synthesis
preparation
pyrimidinylacetonitrile
general formula
Prior art date
Application number
CO12035697A
Other languages
English (en)
Inventor
Kentaro Kawazoe
Original Assignee
Ihara Chemical Ind Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ihara Chemical Ind Co filed Critical Ihara Chemical Ind Co
Publication of CO6511200A2 publication Critical patent/CO6511200A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/08—Preparation of nitro compounds by substitution of hydrogen atoms by nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Se proporciona un proceso mediante el cual se pueden preparar en forma fácil y eficiente derivados del pirimidinilacetonitrilo, a partir de materia prima disponible industrialmente. También se proporcionan compuestos intermedios para la síntesis de los derivados. Un proceso para la preparación de derivados del pirimidinilacetonitrilo que se representan por la fórmula general (3) [en donde X es un átomo de halógeno y R es un grupo alcoximetilo], caracterizado por la reacción de un derivado de 2,4-dihalogeno-6- nitrobenceno que se representa por la fórmula general (1) [en donde X y R son cada una como se definieron anteriormente] con 4,6-dimetoxi-2-cianometilpirimidina que se representa por la fórmula general (2) [en donde Me representa un grupo metilo], en la presencia de una base; y compuestos intermedios para la síntesis de los derivados del pirimidinilacetonitrilo.
CO12035697A 2009-08-31 2012-02-29 Proceso para la preparación de derivados de primidinilacetonitrilo e intermediarios para la sintesis de estos CO6511200A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2009200158 2009-08-31

Publications (1)

Publication Number Publication Date
CO6511200A2 true CO6511200A2 (es) 2012-08-31

Family

ID=43627551

Family Applications (1)

Application Number Title Priority Date Filing Date
CO12035697A CO6511200A2 (es) 2009-08-31 2012-02-29 Proceso para la preparación de derivados de primidinilacetonitrilo e intermediarios para la sintesis de estos

Country Status (12)

Country Link
US (1) US20120178931A1 (es)
EP (1) EP2474536B1 (es)
JP (1) JP5663482B2 (es)
KR (1) KR101757873B1 (es)
CN (1) CN102574814B (es)
AU (1) AU2010287976A1 (es)
BR (1) BR112012004513A2 (es)
CO (1) CO6511200A2 (es)
IL (1) IL218384A0 (es)
RU (1) RU2012107429A (es)
TW (1) TWI476183B (es)
WO (1) WO2011024429A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104884424B (zh) 2012-12-25 2016-08-24 日本曹达株式会社 卤代苯胺及其制造方法
CN110981825A (zh) * 2019-12-19 2020-04-10 安徽省化工研究院 2-硝基苯甲酮类化合物、其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1021397A (en) * 1963-05-10 1966-03-02 Nl Combinatie Chem Ind Pyrazineacetonitriles and methods of preparing them
JP3632947B2 (ja) * 1998-07-29 2005-03-30 クミアイ化学工業株式会社 ジフルオロメタンスルホニルアニリド誘導体、その製造方法及びそれを有効成分とする除草剤
BR9912494B1 (pt) * 1998-07-29 2010-07-13 derivado de di ou trifluorometanossulfonil anilida, processo para a sua produção e herbicida contendo o referido derivado como ingrediente ativo.
JP4161290B2 (ja) * 2002-01-22 2008-10-08 イハラケミカル工業株式会社 ピリミジニルアルコール誘導体の製造方法及びその合成中間体
EP2457901A1 (en) * 2005-03-14 2012-05-30 High Point Pharmaceuticals, LLC Benzazole derivatives, compositions, and methods of use as B-secretase inhibitors
GB0710121D0 (en) * 2007-05-25 2007-07-04 F2G Ltd Antifungal agents

Also Published As

Publication number Publication date
CN102574814A (zh) 2012-07-11
BR112012004513A2 (pt) 2015-09-08
EP2474536B1 (en) 2014-06-25
RU2012107429A (ru) 2013-10-10
KR20120056284A (ko) 2012-06-01
KR101757873B1 (ko) 2017-07-14
IL218384A0 (en) 2012-04-30
CN102574814B (zh) 2015-09-16
JP5663482B2 (ja) 2015-02-04
TWI476183B (zh) 2015-03-11
EP2474536A4 (en) 2013-02-13
US20120178931A1 (en) 2012-07-12
AU2010287976A1 (en) 2012-03-29
TW201113257A (en) 2011-04-16
EP2474536A1 (en) 2012-07-11
WO2011024429A1 (ja) 2011-03-03
JPWO2011024429A1 (ja) 2013-01-24

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CO6511200A2 (es) Proceso para la preparación de derivados de primidinilacetonitrilo e intermediarios para la sintesis de estos