CO6382117A2 - Metodo para clasificar compuestos que interactuan selectivamente con rad9 - Google Patents
Metodo para clasificar compuestos que interactuan selectivamente con rad9Info
- Publication number
- CO6382117A2 CO6382117A2 CO11064192A CO11064192A CO6382117A2 CO 6382117 A2 CO6382117 A2 CO 6382117A2 CO 11064192 A CO11064192 A CO 11064192A CO 11064192 A CO11064192 A CO 11064192A CO 6382117 A2 CO6382117 A2 CO 6382117A2
- Authority
- CO
- Colombia
- Prior art keywords
- cancer
- securolide
- rad9
- hrad9
- compounds
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4739—Cyclin; Prad 1
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2510/00—Detection of programmed cell death, i.e. apoptosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Compuestos naturales y sintéticos de las fórmulas la-le que tienen una estructura de lactona, en particular Securolide, se han determinado que son compuestos anti-tumorales efectivos que se dirigen al gen hrad9 y/o proteína codificada por el mismo o complejo que contiene la proteína y/o el gen p53 y/o proteína. El Securolide es citoselectivo para mutantes de hRad9 con base en estudios conducidos en cepas de levadura de mutante rad9. El Securolide parece que interactúa con el mutante hRad9 en células cancerosas para producir lesiones de DNA las cuales dan por resultado la apoptosis. Los estudios han demostrado que el Securolide es útil para tratar desórdenes de proliferación tal como melanoma, leucemia, cáncer de seno, cáncer de pulmón, cáncer de ovarios, cáncer de colon, cáncer de esófago, cáncer de hígado, y cáncer linfático, y para mitigar el dolor asociado con el cáncer. Otros compuestos efectivos para el tratamiento de cáncer y opcionalmente dolor asociado con el mismo también se pueden identificar usando los mismos ensayos, por ejemplo, mediante la clasificación de eficacia en ensayos que usan levaduras de mutante defectuosas de Rad9 y/o p53.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10822408P | 2008-10-24 | 2008-10-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6382117A2 true CO6382117A2 (es) | 2012-02-15 |
Family
ID=41491699
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO11064192A CO6382117A2 (es) | 2008-10-24 | 2011-05-24 | Metodo para clasificar compuestos que interactuan selectivamente con rad9 |
Country Status (15)
Country | Link |
---|---|
US (2) | US8501431B2 (es) |
EP (1) | EP2350645A2 (es) |
JP (1) | JP2012507010A (es) |
KR (1) | KR20110128785A (es) |
CN (1) | CN102265154A (es) |
AU (1) | AU2009308423B2 (es) |
BR (1) | BRPI0920297A2 (es) |
CA (1) | CA2741526A1 (es) |
CL (1) | CL2011000912A1 (es) |
CO (1) | CO6382117A2 (es) |
DO (1) | DOP2011000111A (es) |
IL (1) | IL212475A0 (es) |
MX (1) | MX2011004331A (es) |
WO (1) | WO2010048616A2 (es) |
ZA (1) | ZA201103769B (es) |
Family Cites Families (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2624723A (en) | 1947-03-03 | 1953-01-06 | Allied Chem & Dye Corp | Lactone derivatives and method of making |
US3203953A (en) | 1963-01-18 | 1965-08-31 | Ciba Geigy Corp | Lactone obtained from helenium sp. and derivatives thereof |
US3210377A (en) | 1963-06-05 | 1965-10-05 | Olin Mathieson | Gamma lactones |
US3933771A (en) * | 1973-07-16 | 1976-01-20 | Hooker Chemicals & Plastics Corporation | Composition of and method of obtaining small particle size polymers and copolymers of vinyl chloride having a fused surface |
US4001425A (en) | 1974-04-17 | 1977-01-04 | E. I. Du Pont De Nemours And Company | Methods of treating hypertension and pharmaceutical compositions comprising 1-tertiary-alkyl-3-(substituted furyl)ureas as antihypertensive agents |
JPS5111173B2 (es) | 1974-04-25 | 1976-04-09 | ||
JPS51125722A (en) | 1975-01-13 | 1976-11-02 | Sumitomo Chem Co Ltd | Germicides for industry and their preparation |
JPS597713B2 (ja) | 1977-12-19 | 1984-02-20 | 三井東圧化学株式会社 | 新規γ↓−ブチロラクトン誘導体とその製造法 |
JPS56128776A (en) | 1980-03-14 | 1981-10-08 | Otsuka Pharmaceut Factory Inc | Alpha-methylene gamma-butyrolactone derivative |
JPS5899413A (ja) | 1981-12-08 | 1983-06-13 | Kanegafuchi Chem Ind Co Ltd | 抗炎症剤 |
JPS6058973A (ja) | 1983-09-13 | 1985-04-05 | Mitsubishi Yuka Yakuhin Kk | γ−プチロラクトン誘導体及びそれを有効成分とする免疫調節剤 |
JPS6226221A (ja) | 1985-07-29 | 1987-02-04 | Japan Tobacco Inc | 抗変異原性剤 |
JP2524760B2 (ja) | 1987-07-10 | 1996-08-14 | テイカ株式会社 | 新規抗生物質 |
JPH01163175A (ja) | 1987-12-21 | 1989-06-27 | Ss Pharmaceut Co Ltd | フラン−2−オン誘導体 |
US5242945A (en) | 1991-04-12 | 1993-09-07 | American Home Products Corporation | Tetronic and thiotetronic acid derivatives as phospholipase a2 inhibitors |
EP0534907B1 (en) * | 1991-09-26 | 1998-08-05 | Nippon Zoki Pharmaceutical Co., Ltd. | The use of furanone derivatives for the prevention or treatment of autoimmune diseases |
US5250735A (en) | 1992-04-03 | 1993-10-05 | University Of Pittsburgh | 2-(N-substituted-aminoalkyl)-5-(E)-alkylidene cyclopentanones, 2-(N-substituted-aminoalkyl)-5-(E)-arylalkylidene cyclopentanones, and derivatives thereof |
CA2168757A1 (en) | 1993-09-17 | 1995-03-23 | Robert A. Chrusciel | Substituted tetronic acids useful for treating hiv and other retroviruses |
US5595756A (en) | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
ATE201397T1 (de) | 1994-06-07 | 2001-06-15 | Teijin Ltd | Vitamin d3 derivate und ein verfahren zu ihrer herstellung |
AUPN191295A0 (en) | 1995-03-23 | 1995-04-27 | Unisearch Limited | Microbiocide or microbial regulator |
US5962460A (en) | 1995-06-27 | 1999-10-05 | National Science Council (Taiwan) | Antineoplastic α-methylene-γ-butyrolactones |
US5646164A (en) | 1995-11-14 | 1997-07-08 | National Science Council | α-methylene-γ-butyrolactones: new inhibitors of platelet aggregation |
ES2251002T3 (es) | 1995-11-17 | 2006-04-16 | The Johns Hopkins University | Inhibicion de sintasa de acido graso, como medio para reducir la masa adipocita. |
US6222048B1 (en) | 1995-12-18 | 2001-04-24 | Merck Frosst Canada & Co. | Diaryl-2-(5H)-furanones as Cox-2 inhibitors |
US5618835A (en) | 1996-02-01 | 1997-04-08 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
US6180651B1 (en) | 1996-04-04 | 2001-01-30 | Bristol-Myers Squibb | Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics |
US5981575A (en) | 1996-11-15 | 1999-11-09 | Johns Hopkins University, The | Inhibition of fatty acid synthase as a means to reduce adipocyte mass |
AU6818298A (en) | 1997-04-02 | 1998-10-22 | Merck Frosst Canada & Co. | Alpha-methylene gamma lactones as selective cyclooxygenase-2 inhibitors |
US5905089A (en) | 1997-04-14 | 1999-05-18 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Use of sesquiterpene lactones for treatment of severe inflammatory disorders |
AUPP303498A0 (en) | 1998-04-17 | 1998-05-14 | Unisearch Limited | Inhibition of gram positive bacteria |
AU4428899A (en) | 1998-06-08 | 1999-12-30 | Advanced Medicine, Inc. | Multibinding inhibitors of cyclooxygenase-2 |
WO2000058297A2 (en) | 1999-03-30 | 2000-10-05 | E.I. Du Pont De Nemours And Company | PROCESS FOR THE PREPARATION OF α-METHYLENE LACTONES |
US6660511B1 (en) * | 2000-03-03 | 2003-12-09 | Rigel Pharmaceuticals, Inc. | Methods of screening for modulation of cell cycle |
US6686390B2 (en) | 2000-05-22 | 2004-02-03 | Dr. Reddy's Laboratories Limited | Compounds having antiinflamatory activity: process for their preparation and pharmaceutical compositions containing them |
JP2002037797A (ja) | 2000-07-25 | 2002-02-06 | Kanegafuchi Chem Ind Co Ltd | マクロファージ選択的細胞死誘導物質 |
EP1334358A1 (en) * | 2000-10-03 | 2003-08-13 | Regents of the University of California | Targeting cells having mad2 mutation for treatment and/or prevention of disease |
IL159296A0 (en) * | 2001-06-13 | 2004-06-01 | Magnachem Int Lab Inc | Lactone formulations and method of use |
US20040208944A1 (en) | 2002-06-26 | 2004-10-21 | Armand Malnoe | Compositions and methods against inflammatory processes |
MXPA05001690A (es) * | 2002-08-13 | 2005-10-19 | Univ Illinois | Estrategia de deteccion para farmacos anticancer. |
EP1562930A4 (en) * | 2002-11-05 | 2008-12-10 | Magnachem Int Lab Inc | SYNTHETIC LACTONE FORMULATIONS AND METHOD OF USE |
GB0317466D0 (en) * | 2003-07-25 | 2003-08-27 | Univ Sheffield | Use |
JP4590629B2 (ja) * | 2004-08-23 | 2010-12-01 | 国立大学法人金沢大学 | Psf1遺伝子欠損動物およびその利用方法 |
JP4560430B2 (ja) * | 2005-03-17 | 2010-10-13 | 株式会社リコー | 画像形成装置、画像印刷システム、プログラムおよび画像合成出力方法 |
JP2008105963A (ja) * | 2006-10-23 | 2008-05-08 | Iwate Univ | Dna損傷チェックポイント活性化剤 |
-
2009
- 2009-10-26 MX MX2011004331A patent/MX2011004331A/es active IP Right Grant
- 2009-10-26 WO PCT/US2009/062082 patent/WO2010048616A2/en active Application Filing
- 2009-10-26 KR KR1020117011828A patent/KR20110128785A/ko not_active Application Discontinuation
- 2009-10-26 AU AU2009308423A patent/AU2009308423B2/en not_active Ceased
- 2009-10-26 EP EP09752576A patent/EP2350645A2/en not_active Withdrawn
- 2009-10-26 CA CA2741526A patent/CA2741526A1/en not_active Abandoned
- 2009-10-26 BR BRPI0920297A patent/BRPI0920297A2/pt not_active IP Right Cessation
- 2009-10-26 JP JP2011533409A patent/JP2012507010A/ja not_active Ceased
- 2009-10-26 CN CN2009801526204A patent/CN102265154A/zh active Pending
- 2009-10-26 US US12/605,896 patent/US8501431B2/en active Active
-
2011
- 2011-04-21 DO DO2011000111A patent/DOP2011000111A/es unknown
- 2011-04-21 CL CL2011000912A patent/CL2011000912A1/es unknown
- 2011-04-26 IL IL212475A patent/IL212475A0/en unknown
- 2011-05-23 ZA ZA2011/03769A patent/ZA201103769B/en unknown
- 2011-05-24 CO CO11064192A patent/CO6382117A2/es not_active Application Discontinuation
-
2013
- 2013-08-05 US US13/959,324 patent/US20140194632A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CL2011000912A1 (es) | 2011-10-07 |
ZA201103769B (en) | 2012-01-25 |
US8501431B2 (en) | 2013-08-06 |
US20100137618A1 (en) | 2010-06-03 |
US20140194632A1 (en) | 2014-07-10 |
JP2012507010A (ja) | 2012-03-22 |
AU2009308423A1 (en) | 2010-04-29 |
EP2350645A2 (en) | 2011-08-03 |
WO2010048616A3 (en) | 2010-06-10 |
CA2741526A1 (en) | 2010-04-29 |
DOP2011000111A (es) | 2012-01-15 |
MX2011004331A (es) | 2011-09-21 |
CN102265154A (zh) | 2011-11-30 |
IL212475A0 (en) | 2011-06-30 |
BRPI0920297A2 (pt) | 2016-08-02 |
AU2009308423B2 (en) | 2013-08-29 |
WO2010048616A2 (en) | 2010-04-29 |
KR20110128785A (ko) | 2011-11-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Application refused |