CO6351710A2 - Composicion topica para el tratamiento de queratosis actinica - Google Patents
Composicion topica para el tratamiento de queratosis actinicaInfo
- Publication number
- CO6351710A2 CO6351710A2 CO11013458A CO11013458A CO6351710A2 CO 6351710 A2 CO6351710 A2 CO 6351710A2 CO 11013458 A CO11013458 A CO 11013458A CO 11013458 A CO11013458 A CO 11013458A CO 6351710 A2 CO6351710 A2 CO 6351710A2
- Authority
- CO
- Colombia
- Prior art keywords
- mixtures
- group
- treatment
- topical composition
- actinic keratosis
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 230000000699 topical effect Effects 0.000 title abstract 2
- 208000009621 actinic keratosis Diseases 0.000 title 1
- 239000013543 active substance Substances 0.000 abstract 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- -1 alcohols esters Chemical class 0.000 abstract 1
- 230000000340 anti-metabolite Effects 0.000 abstract 1
- 239000002256 antimetabolite Substances 0.000 abstract 1
- 229940100197 antimetabolite Drugs 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 229920002678 cellulose Polymers 0.000 abstract 1
- 239000001913 cellulose Substances 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 229920001519 homopolymer Polymers 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000003961 penetration enhancing agent Substances 0.000 abstract 1
- 239000002599 prostaglandin synthase inhibitor Substances 0.000 abstract 1
- 239000000018 receptor agonist Substances 0.000 abstract 1
- 229940044601 receptor agonist Drugs 0.000 abstract 1
- 102000027483 retinoid hormone receptors Human genes 0.000 abstract 1
- 108091008679 retinoid hormone receptors Proteins 0.000 abstract 1
- 229940042129 topical gel Drugs 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a una composición de gel tópica que comprende un agente activo seleccionado del grupo que consiste de inhibidores de ciclooxigenasa, moduladores inmunológicos tópicos, antimetabolitos y mezclas de los mismos; un agente queratolíticamente activo seleccionado del grupo que consiste de agonistas del receptor retinoide, urea, ácidos orgánicos y mezclas de los mismos; un formador de gel que se selecciona del grupo que consiste de homopolímeros y copolímeros de vinilo, derivados de celulosa y mezclas de los mismos; un solvente orgánico que se selecciona del grupo que consiste de alcoholes-C1-C10, ésteres de alcoholes-C1-C10 con ácidos carboxílicos-C1-C10 y mezclas de los mismos y un mejorador de la penetración de la piel.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08012237A EP2143421A1 (en) | 2008-07-07 | 2008-07-07 | Topical composition for the treatment of actinic keratosis |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6351710A2 true CO6351710A2 (es) | 2011-12-20 |
Family
ID=40039993
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO11013458A CO6351710A2 (es) | 2008-07-07 | 2011-02-07 | Composicion topica para el tratamiento de queratosis actinica |
Country Status (32)
Country | Link |
---|---|
US (1) | US8569320B2 (es) |
EP (2) | EP2143421A1 (es) |
JP (2) | JP5654987B2 (es) |
KR (1) | KR101689898B1 (es) |
CN (2) | CN104825384A (es) |
AR (1) | AR072685A1 (es) |
AU (1) | AU2009267471B2 (es) |
BR (1) | BRPI0915439B8 (es) |
CA (1) | CA2729974A1 (es) |
CL (1) | CL2010001642A1 (es) |
CO (1) | CO6351710A2 (es) |
CY (1) | CY1116111T1 (es) |
DK (1) | DK2315581T3 (es) |
EA (1) | EA019533B1 (es) |
EC (1) | ECSP11010762A (es) |
ES (1) | ES2532948T3 (es) |
HK (1) | HK1154793A1 (es) |
HR (1) | HRP20150222T1 (es) |
IL (1) | IL210134A (es) |
ME (1) | ME02147B (es) |
MX (1) | MX2011000054A (es) |
MY (1) | MY158428A (es) |
NZ (1) | NZ590288A (es) |
PE (1) | PE20110330A1 (es) |
PL (1) | PL2315581T3 (es) |
PT (1) | PT2315581E (es) |
RS (1) | RS53887B1 (es) |
SI (1) | SI2315581T1 (es) |
TW (1) | TWI433692B (es) |
UA (1) | UA101044C2 (es) |
WO (1) | WO2010003568A1 (es) |
ZA (1) | ZA201100653B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5798561B2 (ja) * | 2009-10-08 | 2015-10-21 | エムエスディー コンシューマー ケア, インコーポレイテッド | 低エーテル組成物およびデリバリー装置 |
JP5950528B2 (ja) * | 2011-09-30 | 2016-07-13 | 小林製薬株式会社 | 皮膜形成性外用製剤 |
WO2013088375A1 (en) * | 2011-12-12 | 2013-06-20 | Leo Laboratories Limited | A topical composition comprising an ingenol derivative and an oily solvent |
NZ606177A (en) * | 2012-01-30 | 2014-03-28 | Dolorgiet Gmbh & Co Kg | Compositions for the treatment of actinic keratosis |
GB201222405D0 (en) * | 2012-12-12 | 2013-01-23 | Leo Lab Ltd | Gel compositions |
JP2017521470A (ja) * | 2014-07-31 | 2017-08-03 | サン ファーマシューティカル インダストリーズ リミテッドSun Pharmaceutical Industries Ltd. | イソトレチノインの経口医薬組成物 |
MX2017003251A (es) | 2014-09-12 | 2017-12-20 | Antibiotx Aps | Uso antibacteriano de salicilanilidas halogenadas. |
GB201509326D0 (en) | 2015-05-29 | 2015-07-15 | Antibio Tx Aps | Novel use |
JP6659735B2 (ja) * | 2015-07-10 | 2020-03-04 | インフェクトファーム・アルツナイミッテル・ウント・コンシリウム・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 日光角化症の治療における水酸化カリウムの使用 |
GB201604484D0 (en) | 2016-03-16 | 2016-04-27 | Antibiotx Aps And Københavns Uni University Of Copenhagen | Topical antibacterial compositions |
CA3055938A1 (en) | 2017-03-10 | 2018-09-13 | Athenex, Inc. | Methods of treating and/or preventing actinic keratosis |
US11419834B2 (en) | 2019-02-25 | 2022-08-23 | Rhode Island Hospital | Methods for treating diseases or infections caused by or associated with H. pylori using a halogenated salicylanilide |
US20220175769A1 (en) * | 2020-12-08 | 2022-06-09 | Ankh Life Sciences Limited | Method of treatment of actinic keratoses |
DK202370132A1 (en) * | 2023-03-14 | 2024-10-10 | Repoceuticals Aps | Compositions for use in the treatment of actinic keratosis |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2802005A (en) | 1957-08-06 | S-eluorourace | ||
US4234599A (en) * | 1978-10-04 | 1980-11-18 | Scott Eugene J Van | Treatment of skin keratoses with α-hydroxy acids and related compounds |
US5091171B2 (en) * | 1986-12-23 | 1997-07-15 | Tristrata Inc | Amphoteric compositions and polymeric forms of alpha hydroxyacids and their therapeutic use |
US5167649A (en) * | 1988-08-22 | 1992-12-01 | Zook Gerald P | Drug delivery system for the removal of dermal lesions |
US5093360A (en) * | 1989-04-07 | 1992-03-03 | Yu Ruey J | Retinal, derivatives and their therapeutic use |
GB9023701D0 (en) * | 1990-10-31 | 1990-12-12 | Efamol Holdings | Medical treatment |
JP3117502B2 (ja) * | 1991-08-27 | 2000-12-18 | 株式会社資生堂 | 皮膚外用剤 |
US5627187A (en) | 1995-04-12 | 1997-05-06 | Katz; Bruce E. | 5-FU for treating actinic kerotoses |
KR20000022054A (ko) * | 1996-06-20 | 2000-04-25 | 아타나스 라비다스 | 여드름의 국소 치료 제형 및 이의 제조방법 |
US5993787A (en) * | 1996-09-13 | 1999-11-30 | Johnson & Johnson Consumer Products, Inc. | Composition base for topical therapeutic and cosmetic preparations |
US5955097A (en) * | 1996-10-18 | 1999-09-21 | Virotex Corporation | Pharmaceutical preparation applicable to mucosal surfaces and body tissues |
US6462071B1 (en) * | 2000-03-02 | 2002-10-08 | Vitreo-Retinal Technologies, Inc. | Agents for intravitreal administration to treat or prevent disorders of the eye |
ES2223277B1 (es) * | 2003-06-19 | 2006-03-01 | Fernando Bouffard Fita | Composicion anestesica para administracion topica. |
MXPA06002163A (es) * | 2003-08-25 | 2006-05-22 | Foamix Ltd | Espuma farmaceutica de penetracion. |
US20050137164A1 (en) * | 2003-09-22 | 2005-06-23 | Moshe Arkin | Diclofenac compositions for the treatment of skin disorders |
JP5324091B2 (ja) * | 2004-06-24 | 2013-10-23 | アイデックス ラボラトリーズ,インコーポレイティド | 薬物送達のための医薬組成物及びそれを使用する症状の治療又は予防法 |
US20070053984A1 (en) | 2005-03-03 | 2007-03-08 | Monique Spann-Wade | Topical gels compositions |
WO2006134406A1 (en) * | 2005-06-14 | 2006-12-21 | Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. | Stable pharmaceutical gel of diclofenac sodium |
US7851431B2 (en) * | 2005-07-27 | 2010-12-14 | Prescription Dispensing Laboratories | Treatment of actinic keratoses with calcium channel blockers |
US20070264317A1 (en) * | 2006-05-15 | 2007-11-15 | Perrigo Israel Pharmaceuticals Ltd. | Imiquimod cream formulation |
WO2008047857A1 (fr) * | 2006-10-18 | 2008-04-24 | Fujifilm Corporation | Procédé de production d'une composition comprenant un composé difficilement soluble dans l'eau incorporé dans une matrice hydrophile et préparation pour une utilisation externe comprenant un agent ou médicament anticancéreux ayant un coefficient de partage octanol/eau (log p) de -3,0 ou plus mais pas plus de 3,0, incorporé |
-
2008
- 2008-07-07 EP EP08012237A patent/EP2143421A1/en not_active Withdrawn
-
2009
- 2009-06-29 BR BRPI0915439A patent/BRPI0915439B8/pt active IP Right Grant
- 2009-06-29 MY MYPI2011000028A patent/MY158428A/en unknown
- 2009-06-29 MX MX2011000054A patent/MX2011000054A/es active IP Right Grant
- 2009-06-29 WO PCT/EP2009/004682 patent/WO2010003568A1/en active Application Filing
- 2009-06-29 KR KR1020117002825A patent/KR101689898B1/ko active IP Right Grant
- 2009-06-29 PT PT97768766T patent/PT2315581E/pt unknown
- 2009-06-29 NZ NZ590288A patent/NZ590288A/xx unknown
- 2009-06-29 PE PE2010001215A patent/PE20110330A1/es not_active Application Discontinuation
- 2009-06-29 JP JP2011516999A patent/JP5654987B2/ja not_active Expired - Fee Related
- 2009-06-29 DK DK09776876T patent/DK2315581T3/en active
- 2009-06-29 RS RS20150185A patent/RS53887B1/en unknown
- 2009-06-29 UA UAA201101405A patent/UA101044C2/ru unknown
- 2009-06-29 EA EA201100020A patent/EA019533B1/ru unknown
- 2009-06-29 PL PL09776876T patent/PL2315581T3/pl unknown
- 2009-06-29 CA CA2729974A patent/CA2729974A1/en not_active Abandoned
- 2009-06-29 AU AU2009267471A patent/AU2009267471B2/en active Active
- 2009-06-29 US US13/002,971 patent/US8569320B2/en active Active
- 2009-06-29 SI SI200931142T patent/SI2315581T1/sl unknown
- 2009-06-29 ES ES09776876.6T patent/ES2532948T3/es active Active
- 2009-06-29 CN CN201510185320.3A patent/CN104825384A/zh active Pending
- 2009-06-29 ME MEP-2015-38A patent/ME02147B/me unknown
- 2009-06-29 EP EP09776876.6A patent/EP2315581B1/en active Active
- 2009-06-29 CN CN2009801266635A patent/CN102088957A/zh active Pending
- 2009-07-03 AR ARP090102493A patent/AR072685A1/es unknown
- 2009-07-06 TW TW098122756A patent/TWI433692B/zh active
-
2010
- 2010-12-20 IL IL210134A patent/IL210134A/en active IP Right Grant
- 2010-12-30 CL CL2010001642A patent/CL2010001642A1/es unknown
-
2011
- 2011-01-17 EC ECSP11010762 patent/ECSP11010762A/es unknown
- 2011-01-26 ZA ZA2011/00653A patent/ZA201100653B/en unknown
- 2011-02-07 CO CO11013458A patent/CO6351710A2/es not_active Application Discontinuation
- 2011-08-29 HK HK11109094.3A patent/HK1154793A1/xx unknown
-
2014
- 2014-10-16 JP JP2014211989A patent/JP2015038129A/ja not_active Withdrawn
-
2015
- 2015-02-26 HR HRP20150222TT patent/HRP20150222T1/hr unknown
- 2015-03-13 CY CY20151100254T patent/CY1116111T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO6351710A2 (es) | Composicion topica para el tratamiento de queratosis actinica | |
CY1120888T1 (el) | Διαδερμικες φαρμακευτικες συνθεσεις περιλαμβανοντας ενεργους παραγοντες | |
CL2015002710A1 (es) | Composiciones de arni contra el componente c5 del complemento y métodos para su uso. | |
CO7240372A2 (es) | Formulaciones farmacéuticas tópicas no acuosas | |
BR112015019657A2 (pt) | composições tópicas e métodos de uso das mesmas | |
PE20160665A1 (es) | Derivados 11-hidroxilo de acidos biliares y conjugados de aminoacidos de los mismos como moduladores del receptor de farnesoid x | |
CL2012002317A1 (es) | Compuestos derivados de tienopirimidinas, inhibitores de quinasas mnk1/mnk2; composicion farmaceutica; y su uso para elt ratamiento o profilaxis de enfermedades metabolicas, tales como diabetes, daño renal, cancer, enfermedades inflamatorias, entre otras. | |
PE20140489A1 (es) | Produccion de un trasplante a partir de dermis animal con disolucion de sulfuro de sodio | |
PE20131341A1 (es) | Combinaciones de agonistas del receptor beta-3-adrenergico y antagonistas del receptor muscarinico para tratar vejiga hiperactiva | |
CL2013001579A1 (es) | Uso de una composicion farmaceutica que comprende un compuesto agonista ep4 para tratar marcas de la piel tales como heridas superficiales, cicatrices o arrugas. | |
BR112013000613A2 (pt) | composições secas e dispositivos que contêm tais composições secas | |
CY1123805T1 (el) | Διαδερμικο σκευασμα που περιεχει αναστολεις cox | |
GB2525835A (en) | Composition comprising a diindolymethane and a retinoid to treat a skin condition | |
CL2016001130A1 (es) | Composiciones sólidas de triglicéridos y usos de estas | |
UA112418C2 (uk) | Терапевтичний болезаспокійливий засіб | |
PE20151300A1 (es) | Composicion antifungica topica para el tratamiento de onicomicosis | |
PE20140035A1 (es) | Composicion inyectable que comprende un antiinflamatorio no esteroideo y un antibiotico | |
CL2015000197A1 (es) | Formulaciones de opioides | |
AR094035A1 (es) | Estimulantes del colageno y su uso en el tratamiento de la piel | |
AR073512A1 (es) | Procedimiento de preparacion de 1,6:2,3-dianhidro - beta d- manopiranosa | |
CL2010000752A1 (es) | Composicion farmaceutica que comprende un acido carboxilico saturado, un compuesto anti-hongos y un gel penetrante en la piel; y su uso en el tratamiento de onicomicosis. | |
RU2012146168A (ru) | Способ профилактики стресса при иммобилизации в эксперименте | |
RU2012146162A (ru) | Способ профилактики стресса при иммобилизации в эксперименте | |
FR2975595B1 (fr) | Utilisation de la guanosine comme agent anti-irritant. | |
RU2012146166A (ru) | Способ профилактики поражения слизистой оболочки желудка при иммобилизации в эксперименте |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Application refused |