CO6321152A2 - Matriz de comprimidos de compresion directa y rapida desintegracion - Google Patents
Matriz de comprimidos de compresion directa y rapida desintegracionInfo
- Publication number
- CO6321152A2 CO6321152A2 CO10159492A CO10159492A CO6321152A2 CO 6321152 A2 CO6321152 A2 CO 6321152A2 CO 10159492 A CO10159492 A CO 10159492A CO 10159492 A CO10159492 A CO 10159492A CO 6321152 A2 CO6321152 A2 CO 6321152A2
- Authority
- CO
- Colombia
- Prior art keywords
- parts
- range
- bet surface
- mix
- matrix
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Communicable Diseases (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1.- Comezcla para preparar comprimidos de rápida desintegración en un proceso de formación directa de comprimidos, compuesta por 90 - 98 partes de un manitol pulveriza- y 10 - 2 partes de una carboximetilcelulosa sódica, y caracterizada porque la comezcla presenta una superficie BET mayor que 1,5 mi/g.2.- Comezcla para preparar comprimidos de rápida desintegración en un proceso de formación directa de comprimidos de acuerdo con la reivindicación 1, compuesta por 95 partes de un manitol pulverizado y 5 partes de una carboximetilcelulosa sódica, y caracterizada porque la comezcla presenta una superficie BET mayor que 1,5 m2/g.3.- Comezcla de acuerdo con la reivindicación 1 ó 2, caracterizada porque presenta una superficie BET en el rango de 1,9 a 4,0 m2/g.4.- Comezcla de acuerdo con la reivindicación 1 ó 2, caracterizada porque presenta una superficie BET en el rango de 1,9 a 2,6 m2/g.5.- Comezcla de acuerdo con una o varias de las reivindicaciones 1 - 4, caracterizada por una densidad aparente de 0,45 a 0,60 g/ml, una densidad de masa apisonada de 0,60 a 0,75 g/ml, un ángulo de inclinación de flujo de 30 a 38°.6.- Comezcla de acuerdo con una o varias de las reivindicaciones 1 - 5, caracterizada por un diámetro medio de partícula (láser) en el rango de entre 60 y 200 pm.7.- Comezcla de acuerdo con una o varias de las reivindicaciones 1 - 5, caracterizada por un diámetro medio de partícula (láser) en el rango de entre 64 y 114 pm.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08011238 | 2008-06-20 | ||
EP08014287 | 2008-08-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6321152A2 true CO6321152A2 (es) | 2011-09-20 |
Family
ID=41134695
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO10159492A CO6321152A2 (es) | 2008-06-20 | 2010-12-20 | Matriz de comprimidos de compresion directa y rapida desintegracion |
Country Status (15)
Country | Link |
---|---|
US (1) | US11166917B2 (es) |
EP (1) | EP2299982B1 (es) |
JP (1) | JP5756749B2 (es) |
KR (1) | KR101647855B1 (es) |
CN (1) | CN102088959B (es) |
AR (1) | AR072259A1 (es) |
BR (1) | BRPI0914164B1 (es) |
CA (1) | CA2728436C (es) |
CL (1) | CL2009001450A1 (es) |
CO (1) | CO6321152A2 (es) |
ES (1) | ES2676288T3 (es) |
MX (1) | MX2010014209A (es) |
RU (1) | RU2519768C2 (es) |
TR (1) | TR201808694T4 (es) |
WO (1) | WO2009152922A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20130403A1 (es) * | 2010-04-27 | 2013-04-13 | Bayer Ip Gmbh | Comprimido de desintegracion via oral que contiene acarbosa |
EP2455069A1 (de) * | 2010-11-11 | 2012-05-23 | Laburnum GMBH | Wirkstofffreie Darreichungsform, Verfahren zu deren Herstellung sowie deren Verwendung |
JP6363993B2 (ja) * | 2012-04-27 | 2018-07-25 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | コーティングを有する錠剤および該錠剤の製造 |
WO2015005241A1 (ja) * | 2013-07-06 | 2015-01-15 | 株式会社ダイセル | 超速崩壊錠剤及びその製造方法 |
FR3132522A1 (fr) * | 2022-02-08 | 2023-08-11 | Roquette Freres | Granules de mannitol directement comprimable |
WO2023151868A1 (fr) * | 2022-02-08 | 2023-08-17 | Roquette Freres | Granules de mannitol directement comprimables |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US100419A (en) * | 1870-03-01 | Improved rudder-collar | ||
DE4439858A1 (de) | 1994-11-08 | 1996-05-09 | Merck Patent Gmbh | Durch Co-Sprühtrocknung erhältliche Polyol-Zusammensetzung |
JPH08208523A (ja) * | 1995-02-03 | 1996-08-13 | Gun Ei Chem Ind Co Ltd | 製剤素材 |
JP2001114712A (ja) * | 1996-04-16 | 2001-04-24 | Takeda Chem Ind Ltd | D−マンニトールおよびその製造法 |
DE19615418A1 (de) | 1996-04-22 | 1997-10-23 | Merck Patent Gmbh | Polyol-Zusammensetzung |
DE19617487A1 (de) | 1996-05-02 | 1997-11-06 | Merck Patent Gmbh | Geschmacksverbesserung von Arzneimittelwirkstoffen |
JP3195290B2 (ja) | 1997-03-31 | 2001-08-06 | キヤノン株式会社 | 画像形成装置 |
US20020071864A1 (en) * | 1999-03-25 | 2002-06-13 | Yuhan Corporation | Rapidly disintegrable tablet for oral administration |
DE19927537A1 (de) * | 1999-06-16 | 2000-12-21 | Merck Patent Gmbh | Sprühtrocknungsanlage und Verfahren zu ihrer Verwendung |
JP3435664B2 (ja) * | 1999-12-08 | 2003-08-11 | ヤンセンファーマ株式会社 | 口腔内速崩壊型錠剤及びその製造方法 |
US6316029B1 (en) * | 2000-05-18 | 2001-11-13 | Flak Pharma International, Ltd. | Rapidly disintegrating solid oral dosage form |
WO2002030400A1 (fr) * | 2000-10-06 | 2002-04-18 | Takeda Chemical Industries, Ltd. | Preparations solides |
JPWO2002069934A1 (ja) * | 2001-03-06 | 2004-07-02 | 協和醗酵工業株式会社 | 口腔内速崩壊性製剤 |
DE10161402A1 (de) | 2001-12-13 | 2003-06-18 | Merck Patent Gmbh | Verfahren zur Herstellung von direkt tablettierbarem beta-Mannit |
US7118765B2 (en) * | 2001-12-17 | 2006-10-10 | Spi Pharma, Inc. | Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms |
ES2199061B1 (es) | 2002-06-10 | 2005-02-16 | Laboratorios Vita, S.A. | Comprimidos bucodispersables y procedimiento para su obtencion. |
AU2004212976A1 (en) * | 2003-02-19 | 2004-09-02 | Biovail Laboratories Inc. | Rapid absorption selective 5-HT agonist formulations |
EP2316431B1 (en) * | 2003-04-08 | 2015-09-30 | Novartis AG | Solid oral composition comprising a S1P receptor agonist and a sugar alcohol |
US7282217B1 (en) * | 2003-08-29 | 2007-10-16 | Kv Pharmaceutical Company | Rapidly disintegrable tablets |
JP2005306770A (ja) | 2004-04-21 | 2005-11-04 | Toa Eiyo Ltd | 口腔内速崩壊型製剤及びその製造方法 |
JP5208348B2 (ja) | 2004-05-13 | 2013-06-12 | 旭化成ファーマ株式会社 | ナフトピジルを含有する医薬 |
GB0423800D0 (en) * | 2004-10-27 | 2004-12-01 | Orexo Ab | New pharmaceutical formulations |
IS7748A (is) * | 2005-03-17 | 2006-09-18 | Actavis Group | Samsetning fyrir töflur sem innihalda topiramate |
US20090232898A1 (en) * | 2005-03-28 | 2009-09-17 | Anders Pettersson | Pharmaceutical Compositions Useful in the Treatment of Migraine |
WO2007029376A1 (ja) * | 2005-09-02 | 2007-03-15 | Fuji Chemical Industry Co., Ltd. | 口腔内速崩壊性錠剤 |
WO2007043538A1 (ja) * | 2005-10-05 | 2007-04-19 | Kyoto Pharmaceutical Industries, Ltd. | 経口用組成物 |
GB0523810D0 (en) * | 2005-11-23 | 2006-01-04 | Astrazeneca Ab | Pharmaceutical compositions |
JP5498020B2 (ja) * | 2006-01-05 | 2014-05-21 | ベロクシス ファーマシューティカルズ エー/エス | 崩壊性の充填可能な錠剤 |
TWI428151B (zh) * | 2006-12-07 | 2014-03-01 | Daiichi Sankyo Co Ltd | 含有甘露醇或乳糖之固形製劑 |
EP2168601B1 (en) * | 2007-05-28 | 2013-08-21 | Mitsubishi Shoji Foodtech Co., Ltd | Spherical mannitol crystal particle |
-
2009
- 2009-05-25 CN CN200980127245.8A patent/CN102088959B/zh active Active
- 2009-05-25 MX MX2010014209A patent/MX2010014209A/es active IP Right Grant
- 2009-05-25 BR BRPI0914164-2A patent/BRPI0914164B1/pt active IP Right Grant
- 2009-05-25 ES ES09765502.1T patent/ES2676288T3/es active Active
- 2009-05-25 JP JP2011513898A patent/JP5756749B2/ja active Active
- 2009-05-25 KR KR1020117001381A patent/KR101647855B1/ko active IP Right Grant
- 2009-05-25 WO PCT/EP2009/003677 patent/WO2009152922A1/de active Application Filing
- 2009-05-25 EP EP09765502.1A patent/EP2299982B1/de active Active
- 2009-05-25 CA CA2728436A patent/CA2728436C/en active Active
- 2009-05-25 US US13/000,241 patent/US11166917B2/en active Active
- 2009-05-25 RU RU2011130597/15A patent/RU2519768C2/ru active
- 2009-05-25 TR TR2018/08694T patent/TR201808694T4/tr unknown
- 2009-06-19 CL CL2009001450A patent/CL2009001450A1/es unknown
- 2009-06-19 AR ARP090102228A patent/AR072259A1/es not_active Application Discontinuation
-
2010
- 2010-12-20 CO CO10159492A patent/CO6321152A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TR201808694T4 (tr) | 2018-07-23 |
EP2299982A1 (de) | 2011-03-30 |
CN102088959A (zh) | 2011-06-08 |
BRPI0914164B1 (pt) | 2019-04-30 |
US20110091545A1 (en) | 2011-04-21 |
JP5756749B2 (ja) | 2015-07-29 |
KR101647855B1 (ko) | 2016-08-11 |
BRPI0914164A2 (pt) | 2015-10-20 |
KR20110022061A (ko) | 2011-03-04 |
ES2676288T3 (es) | 2018-07-18 |
CA2728436A1 (en) | 2009-12-23 |
WO2009152922A1 (de) | 2009-12-23 |
EP2299982B1 (de) | 2018-04-04 |
CL2009001450A1 (es) | 2010-06-11 |
RU2011130597A (ru) | 2013-01-27 |
RU2519768C2 (ru) | 2014-06-20 |
JP2011524386A (ja) | 2011-09-01 |
CN102088959B (zh) | 2016-05-25 |
CA2728436C (en) | 2016-07-26 |
MX2010014209A (es) | 2011-02-21 |
US11166917B2 (en) | 2021-11-09 |
AR072259A1 (es) | 2010-08-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Application refused |