CO6321152A2 - Matriz de comprimidos de compresion directa y rapida desintegracion - Google Patents

Matriz de comprimidos de compresion directa y rapida desintegracion

Info

Publication number
CO6321152A2
CO6321152A2 CO10159492A CO10159492A CO6321152A2 CO 6321152 A2 CO6321152 A2 CO 6321152A2 CO 10159492 A CO10159492 A CO 10159492A CO 10159492 A CO10159492 A CO 10159492A CO 6321152 A2 CO6321152 A2 CO 6321152A2
Authority
CO
Colombia
Prior art keywords
parts
range
bet surface
mix
matrix
Prior art date
Application number
CO10159492A
Other languages
English (en)
Inventor
Daniela Kleinwaechter
Guenter Moddelmog
Roberto Ognibene
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41134695&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6321152(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of CO6321152A2 publication Critical patent/CO6321152A2/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1.- Comezcla para preparar comprimidos de rápida desintegración en un proceso de formación directa de comprimidos, compuesta por 90 - 98 partes de un manitol pulveriza- y 10 - 2 partes de una carboximetilcelulosa sódica, y caracterizada porque la comezcla presenta una superficie BET mayor que 1,5 mi/g.2.- Comezcla para preparar comprimidos de rápida desintegración en un proceso de formación directa de comprimidos de acuerdo con la reivindicación 1, compuesta por 95 partes de un manitol pulverizado y 5 partes de una carboximetilcelulosa sódica, y caracterizada porque la comezcla presenta una superficie BET mayor que 1,5 m2/g.3.- Comezcla de acuerdo con la reivindicación 1 ó 2, caracterizada porque presenta una superficie BET en el rango de 1,9 a 4,0 m2/g.4.- Comezcla de acuerdo con la reivindicación 1 ó 2, caracterizada porque presenta una superficie BET en el rango de 1,9 a 2,6 m2/g.5.- Comezcla de acuerdo con una o varias de las reivindicaciones 1 - 4, caracterizada por una densidad aparente de 0,45 a 0,60 g/ml, una densidad de masa apisonada de 0,60 a 0,75 g/ml, un ángulo de inclinación de flujo de 30 a 38°.6.- Comezcla de acuerdo con una o varias de las reivindicaciones 1 - 5, caracterizada por un diámetro medio de partícula (láser) en el rango de entre 60 y 200 pm.7.- Comezcla de acuerdo con una o varias de las reivindicaciones 1 - 5, caracterizada por un diámetro medio de partícula (láser) en el rango de entre 64 y 114 pm.
CO10159492A 2008-06-20 2010-12-20 Matriz de comprimidos de compresion directa y rapida desintegracion CO6321152A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08011238 2008-06-20
EP08014287 2008-08-11

Publications (1)

Publication Number Publication Date
CO6321152A2 true CO6321152A2 (es) 2011-09-20

Family

ID=41134695

Family Applications (1)

Application Number Title Priority Date Filing Date
CO10159492A CO6321152A2 (es) 2008-06-20 2010-12-20 Matriz de comprimidos de compresion directa y rapida desintegracion

Country Status (15)

Country Link
US (1) US11166917B2 (es)
EP (1) EP2299982B1 (es)
JP (1) JP5756749B2 (es)
KR (1) KR101647855B1 (es)
CN (1) CN102088959B (es)
AR (1) AR072259A1 (es)
BR (1) BRPI0914164B1 (es)
CA (1) CA2728436C (es)
CL (1) CL2009001450A1 (es)
CO (1) CO6321152A2 (es)
ES (1) ES2676288T3 (es)
MX (1) MX2010014209A (es)
RU (1) RU2519768C2 (es)
TR (1) TR201808694T4 (es)
WO (1) WO2009152922A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20130403A1 (es) * 2010-04-27 2013-04-13 Bayer Ip Gmbh Comprimido de desintegracion via oral que contiene acarbosa
EP2455069A1 (de) * 2010-11-11 2012-05-23 Laburnum GMBH Wirkstofffreie Darreichungsform, Verfahren zu deren Herstellung sowie deren Verwendung
JP6363993B2 (ja) * 2012-04-27 2018-07-25 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung コーティングを有する錠剤および該錠剤の製造
WO2015005241A1 (ja) * 2013-07-06 2015-01-15 株式会社ダイセル 超速崩壊錠剤及びその製造方法
FR3132522A1 (fr) * 2022-02-08 2023-08-11 Roquette Freres Granules de mannitol directement comprimable
WO2023151868A1 (fr) * 2022-02-08 2023-08-17 Roquette Freres Granules de mannitol directement comprimables

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US100419A (en) * 1870-03-01 Improved rudder-collar
DE4439858A1 (de) 1994-11-08 1996-05-09 Merck Patent Gmbh Durch Co-Sprühtrocknung erhältliche Polyol-Zusammensetzung
JPH08208523A (ja) * 1995-02-03 1996-08-13 Gun Ei Chem Ind Co Ltd 製剤素材
JP2001114712A (ja) * 1996-04-16 2001-04-24 Takeda Chem Ind Ltd D−マンニトールおよびその製造法
DE19615418A1 (de) 1996-04-22 1997-10-23 Merck Patent Gmbh Polyol-Zusammensetzung
DE19617487A1 (de) 1996-05-02 1997-11-06 Merck Patent Gmbh Geschmacksverbesserung von Arzneimittelwirkstoffen
JP3195290B2 (ja) 1997-03-31 2001-08-06 キヤノン株式会社 画像形成装置
US20020071864A1 (en) * 1999-03-25 2002-06-13 Yuhan Corporation Rapidly disintegrable tablet for oral administration
DE19927537A1 (de) * 1999-06-16 2000-12-21 Merck Patent Gmbh Sprühtrocknungsanlage und Verfahren zu ihrer Verwendung
JP3435664B2 (ja) * 1999-12-08 2003-08-11 ヤンセンファーマ株式会社 口腔内速崩壊型錠剤及びその製造方法
US6316029B1 (en) * 2000-05-18 2001-11-13 Flak Pharma International, Ltd. Rapidly disintegrating solid oral dosage form
WO2002030400A1 (fr) * 2000-10-06 2002-04-18 Takeda Chemical Industries, Ltd. Preparations solides
JPWO2002069934A1 (ja) * 2001-03-06 2004-07-02 協和醗酵工業株式会社 口腔内速崩壊性製剤
DE10161402A1 (de) 2001-12-13 2003-06-18 Merck Patent Gmbh Verfahren zur Herstellung von direkt tablettierbarem beta-Mannit
US7118765B2 (en) * 2001-12-17 2006-10-10 Spi Pharma, Inc. Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms
ES2199061B1 (es) 2002-06-10 2005-02-16 Laboratorios Vita, S.A. Comprimidos bucodispersables y procedimiento para su obtencion.
AU2004212976A1 (en) * 2003-02-19 2004-09-02 Biovail Laboratories Inc. Rapid absorption selective 5-HT agonist formulations
EP2316431B1 (en) * 2003-04-08 2015-09-30 Novartis AG Solid oral composition comprising a S1P receptor agonist and a sugar alcohol
US7282217B1 (en) * 2003-08-29 2007-10-16 Kv Pharmaceutical Company Rapidly disintegrable tablets
JP2005306770A (ja) 2004-04-21 2005-11-04 Toa Eiyo Ltd 口腔内速崩壊型製剤及びその製造方法
JP5208348B2 (ja) 2004-05-13 2013-06-12 旭化成ファーマ株式会社 ナフトピジルを含有する医薬
GB0423800D0 (en) * 2004-10-27 2004-12-01 Orexo Ab New pharmaceutical formulations
IS7748A (is) * 2005-03-17 2006-09-18 Actavis Group Samsetning fyrir töflur sem innihalda topiramate
US20090232898A1 (en) * 2005-03-28 2009-09-17 Anders Pettersson Pharmaceutical Compositions Useful in the Treatment of Migraine
WO2007029376A1 (ja) * 2005-09-02 2007-03-15 Fuji Chemical Industry Co., Ltd. 口腔内速崩壊性錠剤
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GB0523810D0 (en) * 2005-11-23 2006-01-04 Astrazeneca Ab Pharmaceutical compositions
JP5498020B2 (ja) * 2006-01-05 2014-05-21 ベロクシス ファーマシューティカルズ エー/エス 崩壊性の充填可能な錠剤
TWI428151B (zh) * 2006-12-07 2014-03-01 Daiichi Sankyo Co Ltd 含有甘露醇或乳糖之固形製劑
EP2168601B1 (en) * 2007-05-28 2013-08-21 Mitsubishi Shoji Foodtech Co., Ltd Spherical mannitol crystal particle

Also Published As

Publication number Publication date
TR201808694T4 (tr) 2018-07-23
EP2299982A1 (de) 2011-03-30
CN102088959A (zh) 2011-06-08
BRPI0914164B1 (pt) 2019-04-30
US20110091545A1 (en) 2011-04-21
JP5756749B2 (ja) 2015-07-29
KR101647855B1 (ko) 2016-08-11
BRPI0914164A2 (pt) 2015-10-20
KR20110022061A (ko) 2011-03-04
ES2676288T3 (es) 2018-07-18
CA2728436A1 (en) 2009-12-23
WO2009152922A1 (de) 2009-12-23
EP2299982B1 (de) 2018-04-04
CL2009001450A1 (es) 2010-06-11
RU2011130597A (ru) 2013-01-27
RU2519768C2 (ru) 2014-06-20
JP2011524386A (ja) 2011-09-01
CN102088959B (zh) 2016-05-25
CA2728436C (en) 2016-07-26
MX2010014209A (es) 2011-02-21
US11166917B2 (en) 2021-11-09
AR072259A1 (es) 2010-08-18

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