AR072259A1 - Matriz de comprimidos de compresion directa y rapida desintegracion - Google Patents

Matriz de comprimidos de compresion directa y rapida desintegracion

Info

Publication number
AR072259A1
AR072259A1 ARP090102228A ARP090102228A AR072259A1 AR 072259 A1 AR072259 A1 AR 072259A1 AR P090102228 A ARP090102228 A AR P090102228A AR P090102228 A ARP090102228 A AR P090102228A AR 072259 A1 AR072259 A1 AR 072259A1
Authority
AR
Argentina
Prior art keywords
material according
support material
preparing
matrix
tablet formulations
Prior art date
Application number
ARP090102228A
Other languages
English (en)
Inventor
Daniela Kleinwaechter
Guenter Moddelmog
Roberto Ognibene
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41134695&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR072259(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of AR072259A1 publication Critical patent/AR072259A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Nutrition Science (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Es objeto de la presente una matriz que se puede comprimir directamente para preparar comprimidos de rápida desintegracion en presencia de humedad, en especial en la boca. Reivindicacion 1: Comezcla para preparar comprimidos de rápida desintegracion en un proceso de formacion directa de comprimidos, compuesta por 90 - 98 partes en peso de un manitol pulverizado y 10 - 2 partes en peso de una carboximetilcelulosa sodica reticulada, caracterizada porque la comezcla presenta una superficie BET mayor que 1,5 m2/g. Reivindicacion 11: Uso de un material de soporte de acuerdo con una o varias de las reivindicaciones 1 - 9 para preparar formulaciones en comprimidos, que contienen vitaminas, minerales, oligoelementos, componentes funcionales de comestibles. Reivindicacion 12: Uso de un material de soporte de acuerdo con una o varias de las reivindicaciones 1 - 9 para preparar formulaciones en comprimidos, que contienen componentes vegetales y extractos vegetales. Reivindicacion 14: Uso de un material de soporte de acuerdo con una o varias de las reivindicaciones 1 - 9 para preparar formulaciones en comprimidos, que contienen sustancias con accion farmacologica tales como, por ejemplo, antiácidos, antiinfectivos, también para la accion local en el área de la boca y la garganta, analgésicos incluyendo opioides, antialérgicos, antieméticos, antidiarreicos.
ARP090102228A 2008-06-20 2009-06-19 Matriz de comprimidos de compresion directa y rapida desintegracion AR072259A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08011238 2008-06-20
EP08014287 2008-08-11

Publications (1)

Publication Number Publication Date
AR072259A1 true AR072259A1 (es) 2010-08-18

Family

ID=41134695

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090102228A AR072259A1 (es) 2008-06-20 2009-06-19 Matriz de comprimidos de compresion directa y rapida desintegracion

Country Status (15)

Country Link
US (1) US11166917B2 (es)
EP (1) EP2299982B1 (es)
JP (1) JP5756749B2 (es)
KR (1) KR101647855B1 (es)
CN (1) CN102088959B (es)
AR (1) AR072259A1 (es)
BR (1) BRPI0914164B1 (es)
CA (1) CA2728436C (es)
CL (1) CL2009001450A1 (es)
CO (1) CO6321152A2 (es)
ES (1) ES2676288T3 (es)
MX (1) MX2010014209A (es)
RU (1) RU2519768C2 (es)
TR (1) TR201808694T4 (es)
WO (1) WO2009152922A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG184851A1 (en) * 2010-04-27 2012-11-29 Bayer Ip Gmbh Orally disintegrating tablet containing acarbose
EP2455069A1 (de) * 2010-11-11 2012-05-23 Laburnum GMBH Wirkstofffreie Darreichungsform, Verfahren zu deren Herstellung sowie deren Verwendung
WO2013159861A1 (de) 2012-04-27 2013-10-31 Merck Patent Gmbh Tabletten mit überzug und deren herstellung
TWI673069B (zh) * 2013-07-06 2019-10-01 日商大賽璐股份有限公司 超高速崩解錠劑及其製造方法
KR20240138086A (ko) * 2022-02-08 2024-09-20 호케트프레르 직접 압축용 만니톨 과립
FR3132522A1 (fr) * 2022-02-08 2023-08-11 Roquette Freres Granules de mannitol directement comprimable

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US100419A (en) * 1870-03-01 Improved rudder-collar
DE4439858A1 (de) 1994-11-08 1996-05-09 Merck Patent Gmbh Durch Co-Sprühtrocknung erhältliche Polyol-Zusammensetzung
JPH08208523A (ja) * 1995-02-03 1996-08-13 Gun Ei Chem Ind Co Ltd 製剤素材
JP2001114712A (ja) * 1996-04-16 2001-04-24 Takeda Chem Ind Ltd Ｄ−マンニトールおよびその製造法
DE19615418A1 (de) 1996-04-22 1997-10-23 Merck Patent Gmbh Polyol-Zusammensetzung
DE19617487A1 (de) * 1996-05-02 1997-11-06 Merck Patent Gmbh Geschmacksverbesserung von Arzneimittelwirkstoffen
JP3195290B2 (ja) 1997-03-31 2001-08-06 キヤノン株式会社 画像形成装置
US20020071864A1 (en) * 1999-03-25 2002-06-13 Yuhan Corporation Rapidly disintegrable tablet for oral administration
DE19927537A1 (de) 1999-06-16 2000-12-21 Merck Patent Gmbh Sprühtrocknungsanlage und Verfahren zu ihrer Verwendung
JP3435664B2 (ja) * 1999-12-08 2003-08-11 ヤンセンファーマ株式会社 口腔内速崩壊型錠剤及びその製造方法
US6316029B1 (en) * 2000-05-18 2001-11-13 Flak Pharma International, Ltd. Rapidly disintegrating solid oral dosage form
WO2002030400A1 (fr) * 2000-10-06 2002-04-18 Takeda Chemical Industries, Ltd. Preparations solides
CA2440361A1 (en) * 2001-03-06 2002-09-12 Kyowa Hakko Kogyo Co. Ltd. Intraorally rapidly disintegrable preparation
DE10161402A1 (de) 2001-12-13 2003-06-18 Merck Patent Gmbh Verfahren zur Herstellung von direkt tablettierbarem beta-Mannit
US7118765B2 (en) * 2001-12-17 2006-10-10 Spi Pharma, Inc. Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms
ES2199061B1 (es) * 2002-06-10 2005-02-16 Laboratorios Vita, S.A. Comprimidos bucodispersables y procedimiento para su obtencion.
US20040162333A1 (en) * 2003-02-19 2004-08-19 Naima Mezaache Rapid absorption selective 5-HT agonist formulations
PE20131352A1 (es) * 2003-04-08 2013-11-14 Novartis Ag Composicion farmaceutica que contiene un agonista del receptor s1p y un alcohol de azucar
US7282217B1 (en) * 2003-08-29 2007-10-16 Kv Pharmaceutical Company Rapidly disintegrable tablets
JP2005306770A (ja) * 2004-04-21 2005-11-04 Toa Eiyo Ltd 口腔内速崩壊型製剤及びその製造方法
JP5208348B2 (ja) * 2004-05-13 2013-06-12 旭化成ファーマ株式会社 ナフトピジルを含有する医薬
GB0423800D0 (en) * 2004-10-27 2004-12-01 Orexo Ab New pharmaceutical formulations
IS7748A (is) * 2005-03-17 2006-09-18 Actavis Group Samsetning fyrir töflur sem innihalda topiramate
WO2006103407A2 (en) * 2005-03-28 2006-10-05 Orexo Ab New pharmaceutical compositions useful in the treatment of migraine
JP5074190B2 (ja) 2005-09-02 2012-11-14 富士化学工業株式会社 口腔内速崩壊性錠剤
JP5100391B2 (ja) * 2005-10-05 2012-12-19 京都薬品工業株式会社 経口用組成物
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JP5289975B2 (ja) * 2006-12-07 2013-09-11 第一三共株式会社 マンニトール又は乳糖を含有する固形製剤
US8883307B2 (en) * 2007-05-28 2014-11-11 Mitsubishi Shoji Foodtech Co., Ltd. Spherical particle of crystalline mannitol

Also Published As

Publication number Publication date
BRPI0914164B1 (pt) 2019-04-30
CA2728436A1 (en) 2009-12-23
CL2009001450A1 (es) 2010-06-11
KR20110022061A (ko) 2011-03-04
BRPI0914164A2 (pt) 2015-10-20
WO2009152922A1 (de) 2009-12-23
EP2299982A1 (de) 2011-03-30
JP2011524386A (ja) 2011-09-01
CN102088959A (zh) 2011-06-08
EP2299982B1 (de) 2018-04-04
CA2728436C (en) 2016-07-26
TR201808694T4 (tr) 2018-07-23
KR101647855B1 (ko) 2016-08-11
RU2011130597A (ru) 2013-01-27
MX2010014209A (es) 2011-02-21
US20110091545A1 (en) 2011-04-21
ES2676288T3 (es) 2018-07-18
US11166917B2 (en) 2021-11-09
RU2519768C2 (ru) 2014-06-20
CO6321152A2 (es) 2011-09-20
JP5756749B2 (ja) 2015-07-29
CN102088959B (zh) 2016-05-25

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