CO6290632A2 - Composición oral que contiene péptidos y proteasas - Google Patents
Composición oral que contiene péptidos y proteasasInfo
- Publication number
- CO6290632A2 CO6290632A2 CO10109364A CO10109364A CO6290632A2 CO 6290632 A2 CO6290632 A2 CO 6290632A2 CO 10109364 A CO10109364 A CO 10109364A CO 10109364 A CO10109364 A CO 10109364A CO 6290632 A2 CO6290632 A2 CO 6290632A2
- Authority
- CO
- Colombia
- Prior art keywords
- composition
- amino acids
- peptide
- source
- basic amino
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 9
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 108091005804 Peptidases Proteins 0.000 title abstract 2
- 239000004365 Protease Substances 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 102000035195 Peptidases Human genes 0.000 title 1
- 235000001014 amino acid Nutrition 0.000 abstract 6
- 150000001413 amino acids Chemical class 0.000 abstract 6
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 abstract 2
- 210000000214 mouth Anatomy 0.000 abstract 2
- BLCJBICVQSYOIF-UHFFFAOYSA-N 2,2-diaminobutanoic acid Chemical compound CCC(N)(N)C(O)=O BLCJBICVQSYOIF-UHFFFAOYSA-N 0.000 abstract 1
- PECYZEOJVXMISF-UHFFFAOYSA-N 3-aminoalanine Chemical compound [NH3+]CC(N)C([O-])=O PECYZEOJVXMISF-UHFFFAOYSA-N 0.000 abstract 1
- 239000004475 Arginine Substances 0.000 abstract 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 abstract 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 abstract 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 abstract 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 abstract 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 abstract 1
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 abstract 1
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 229960003121 arginine Drugs 0.000 abstract 1
- 229910001424 calcium ion Inorganic materials 0.000 abstract 1
- 229960002173 citrulline Drugs 0.000 abstract 1
- 235000013477 citrulline Nutrition 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 229960003624 creatine Drugs 0.000 abstract 1
- 239000006046 creatine Substances 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 229960002885 histidine Drugs 0.000 abstract 1
- 239000003906 humectant Substances 0.000 abstract 1
- 229960003646 lysine Drugs 0.000 abstract 1
- 229960003104 ornithine Drugs 0.000 abstract 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 229940085991 phosphate ion Drugs 0.000 abstract 1
- 229920005862 polyol Polymers 0.000 abstract 1
- 150000003077 polyols Chemical class 0.000 abstract 1
- 229910001414 potassium ion Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1.- Una composición para cuidado oral que comprende (i) una cantidad efectiva de un péptido o mezcla de péptidos enriquecida con aminoácidos básicos y (ii) una proteasa que produce la escisión de dicho péptido y suministra un aminoácido básico en una cavidad oral cuando dicha composición es utilizada en la cavidad oral de un usuario.2.- La composición de la reivindicación 1, donde el péptido presenta una longitud de aproximadamente 5 a aproximadamente 500 aminoácidos.3.- La composición de la reivindicación 1 o 2, donde la composición además comprende uno o más de a. una fuente de ión calcio, b. una fuente de ión fosfato c. una fuente de ión potasio, d. una fuente de fluoruro, e. un humectante poliol, f. un inhibidor de proteasa, y combinaciones de los mismos.4.- La composición de cualquiera de las reivindicaciones anteriores, donde los aminoácidos básicos se seleccionaron de arginina, lisina, citrulina, ornitina, creatina, histidina, ácido diaminobutanoico, ácido diaminopropiónico, sales de los mismos y/o combinaciones de los mismos.5.- La composición de cualquiera de las reivindicaciones anteriores, donde más que alrededor del 50% de los aminoácidos en el péptido son aminoácidos básicos.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2743108P | 2008-02-08 | 2008-02-08 | |
| US2743508P | 2008-02-08 | 2008-02-08 | |
| US2743208P | 2008-02-08 | 2008-02-08 | |
| US2742008P | 2008-02-08 | 2008-02-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6290632A2 true CO6290632A2 (es) | 2011-06-20 |
Family
ID=40114426
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO10108677A CO6531500A2 (es) | 2008-02-08 | 2010-09-02 | Composiciones y metodos para el tratamiento de la xerostomia |
| CO10108722A CO6300929A2 (es) | 2008-02-08 | 2010-09-02 | Composicion oral que contiene amino acidos y sal soluble de calcio |
| CO10109376A CO6290630A2 (es) | 2008-02-08 | 2010-09-03 | Composición oral que contiene amino ácidos y particulas pequeñas |
| CO10109364A CO6290632A2 (es) | 2008-02-08 | 2010-09-03 | Composición oral que contiene péptidos y proteasas |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO10108677A CO6531500A2 (es) | 2008-02-08 | 2010-09-02 | Composiciones y metodos para el tratamiento de la xerostomia |
| CO10108722A CO6300929A2 (es) | 2008-02-08 | 2010-09-02 | Composicion oral que contiene amino acidos y sal soluble de calcio |
| CO10109376A CO6290630A2 (es) | 2008-02-08 | 2010-09-03 | Composición oral que contiene amino ácidos y particulas pequeñas |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9682027B2 (es) |
| EP (1) | EP2249784B1 (es) |
| JP (2) | JP6034549B2 (es) |
| CN (2) | CN101938977A (es) |
| AR (1) | AR065887A1 (es) |
| AU (1) | AU2008349847C1 (es) |
| BR (1) | BRPI0821860B1 (es) |
| CA (1) | CA2706486C (es) |
| CL (1) | CL2008000895A1 (es) |
| CO (4) | CO6531500A2 (es) |
| ES (1) | ES2594428T3 (es) |
| MX (2) | MX2010005542A (es) |
| PA (1) | PA8774801A1 (es) |
| PE (2) | PE20091312A1 (es) |
| PL (1) | PL2249784T3 (es) |
| RU (2) | RU2475231C2 (es) |
| TW (1) | TWI355280B (es) |
| WO (1) | WO2009099452A1 (es) |
| ZA (1) | ZA201003693B (es) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101938977A (zh) * | 2008-02-08 | 2011-01-05 | 高露洁-棕榄公司 | 口腔护理产品及其使用和生产方法 |
| MX357344B (es) | 2008-02-08 | 2018-07-05 | Colgate Palmolive Co | Producto para el cuidado oral y métodos de uso y fabricación del mismo. |
| MX2010005211A (es) | 2008-02-08 | 2010-09-30 | Colgate Palmolive Co | Metodos y sistemas para el cuidado oral. |
| TW201138843A (en) | 2009-12-18 | 2011-11-16 | Colgate Palmolive Co | Biguanide preservation of precipitated calcium carbonate |
| MY179976A (en) * | 2010-01-29 | 2020-11-19 | Colgate Palmolive Co | Oral care product for sensitive enamel care |
| WO2011123121A1 (en) | 2010-03-31 | 2011-10-06 | Colgate-Palmolive Company | Oral care composition |
| JP5694506B2 (ja) | 2010-03-31 | 2015-04-01 | コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ | 口腔ケア組成物 |
| WO2012057739A1 (en) * | 2010-10-27 | 2012-05-03 | Colgate-Palmolive Company | Oral care composition comprising arginine and calcium carbonate |
| US9717929B2 (en) * | 2010-12-07 | 2017-08-01 | Colgate-Palmolive Company | Dentifrice compositions containing calcium silicate and a basic amino acid |
| MX341155B (es) * | 2010-12-07 | 2016-08-09 | Colgate Palmolive Co | Composiciones de dentifricos que contienen silicato de calcio. |
| RU2467739C1 (ru) * | 2011-10-31 | 2012-11-27 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" | Состав стоматологический для лечения гиперестезии зубов |
| CN104684618B (zh) * | 2012-08-09 | 2017-02-22 | 荷兰联合利华有限公司 | 用于治疗牙齿敏感症的方法和组合物 |
| WO2014023465A1 (en) * | 2012-08-09 | 2014-02-13 | Unilever Plc | Methods and compositions for treating tooth hypersensitivity |
| CN104717955B (zh) * | 2012-10-01 | 2018-04-27 | 狮王株式会社 | 洁齿剂组合物以及牙齿再矿化促进剂 |
| US9795554B2 (en) * | 2012-12-03 | 2017-10-24 | Colgate-Palmolive Company | Oral care compositions comprising calcium carbonate and a preservative system based on benzyl alcohol or benzoic acid, and an alkylene glycol |
| AU2012396257B2 (en) * | 2012-12-03 | 2015-10-08 | Colgate-Palmolive Company | Compositions and methods for treating dental caries |
| US20150313813A1 (en) * | 2012-12-05 | 2015-11-05 | Colgate-Palmolive Company | Fluoride-Stable Zinc Containing Oral Care Compositions |
| IN2015DN03993A (es) * | 2012-12-06 | 2015-10-02 | Colgate Palmolive Co | |
| US20150351634A1 (en) * | 2013-01-18 | 2015-12-10 | Colgate-Palmolive Company | Method for Evaluating the Potential of a Test Composition to Inhibit Demineralization or Promote Remineralization of Enamel |
| EP2968084B1 (en) * | 2013-03-14 | 2022-04-13 | 3 in 1 Dental Pllc | Compositions for treatment of xerostomia and for tooth treatment |
| SG11201600137UA (en) | 2013-07-23 | 2016-02-26 | Univ Melbourne | Compositions and methods for dental mineralization |
| EP3076920B1 (en) * | 2013-12-03 | 2019-04-17 | Colgate-Palmolive Company | Oral care compositions |
| EP2883573B2 (en) * | 2013-12-13 | 2020-10-28 | Omya International AG | Abrasive cleaning composition |
| CN105813618B (zh) * | 2013-12-16 | 2019-03-29 | 高露洁-棕榄公司 | 包含碳酸钙和二氧化硅的口腔护理组合物 |
| EP2921173A1 (en) * | 2014-03-21 | 2015-09-23 | Omya International AG | Surface-reacted calcium carbonate for desensitizing teeth |
| WO2015172348A1 (en) * | 2014-05-15 | 2015-11-19 | The Procter & Gamble Company | Dentifrice compositions having dental plaque mitigation or improved fluoride uptake |
| RU2017104238A (ru) * | 2014-07-11 | 2018-08-13 | Конинклейке Филипс Н.В. | Система для состава по уходу за полостью рта, обеспечивающая аморфный фосфат кальция |
| RU2580636C1 (ru) * | 2014-12-23 | 2016-04-10 | Аркадий Анатольевич Козлов | Порошковая композиция для профессиональной гигиены полости рта и способ её использования |
| CA2971574C (en) * | 2014-12-23 | 2022-03-08 | Colgate-Palmolive Company | Oral care compositions |
| RU2705377C2 (ru) * | 2015-04-29 | 2019-11-07 | Колгейт-Палмолив Компани | Композиции для ухода за полостью рта |
| BR112018009609B1 (pt) * | 2015-11-13 | 2021-03-16 | The Procter & Gamble Company | composições dentifrícias com absorção melhorada de fluoreto |
| AU2016381976B2 (en) * | 2015-12-31 | 2019-12-19 | Colgate-Palmolive Company | Cleansing compositions |
| US10058493B2 (en) | 2016-12-21 | 2018-08-28 | Colgate-Palmolive Company | Oral care compositions and methods of use |
| AU2017382600B2 (en) | 2016-12-21 | 2020-08-13 | Colgate-Palmolive Company | Oral care compositions |
| SG10202110136XA (en) | 2017-03-14 | 2021-10-28 | Univ Melbourne | Treatment for gingivitis |
| CN110325172A (zh) | 2017-03-16 | 2019-10-11 | 江崎格力高株式会社 | 能够促进牙齿的再矿化的口腔用组合物 |
| WO2019108558A1 (en) * | 2017-11-28 | 2019-06-06 | Corning Incorporated | High liquidus viscosity bioactive glass |
| JP7058343B2 (ja) | 2018-03-29 | 2022-04-21 | ザ プロクター アンド ギャンブル カンパニー | 歯肉健康を促進するための口腔ケア組成物 |
| CN111989083B (zh) * | 2018-03-29 | 2024-02-13 | 宝洁公司 | 用于促进牙龈健康的口腔护理组合物 |
| AU2018415261B2 (en) | 2018-03-29 | 2021-11-04 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
| US10736830B2 (en) | 2018-11-02 | 2020-08-11 | Colgate-Palmolive Company | Oral care compositions and methods for the same |
| JP7210264B2 (ja) * | 2018-12-21 | 2023-01-23 | 株式会社パイロットコーポレーション | 筆記具用水性インキ組成物 |
| US10918584B2 (en) | 2018-12-26 | 2021-02-16 | Colgate-Palmolive Company | Oral care compositions and methods for the same |
| BR112021011686A2 (pt) * | 2018-12-26 | 2021-09-08 | Colgate-Palmolive Company | Papel prebiótico da arginina em bactérias orais benéficas |
| BR112021012342A2 (pt) * | 2018-12-26 | 2021-08-31 | Colgate-Palmolive Company | Inibição de co-agregação específica pela arginina |
| CN113543765A (zh) * | 2019-03-29 | 2021-10-22 | 高露洁-棕榄公司 | 口腔护理产品及其使用和制造方法 |
| WO2020205342A1 (en) | 2019-03-29 | 2020-10-08 | Colgate-Palmolive Company | Oral care product |
| WO2020212361A1 (en) * | 2019-04-17 | 2020-10-22 | Unilever Plc | Oral care compositions |
| JP7414973B2 (ja) | 2019-09-30 | 2024-01-16 | ザ プロクター アンド ギャンブル カンパニー | 歯科バイオフィルムの処置のための歯磨剤組成物 |
| AU2019468797A1 (en) | 2019-09-30 | 2022-03-17 | The Procter & Gamble Company | Dentifrice compositions for treatment of dental biofilm |
| CN114466651A (zh) | 2019-09-30 | 2022-05-10 | 宝洁公司 | 使用包含啤酒花的口腔护理组合物的方法 |
| WO2021062607A1 (en) | 2019-09-30 | 2021-04-08 | The Procter & Gamble Company | Oral care compositions comprising hops beta acid and amino acid |
| EP4014948A1 (de) * | 2020-12-18 | 2022-06-22 | Ivoclar Vivadent AG | Zusammensetzung zur remineralisation von zähnen |
| CN113908067B (zh) * | 2021-10-19 | 2024-03-19 | 四川涑爽医疗用品有限公司 | 一种抗牙齿敏感的组合物及其制备方法与应用、包含该组合物的口腔护理产品 |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3932608A (en) * | 1971-08-30 | 1976-01-13 | General Mills, Inc. | Food composition |
| US3943241A (en) * | 1971-08-30 | 1976-03-09 | General Mills, Inc. | Cariostatic composition |
| US3932605A (en) * | 1972-06-12 | 1976-01-13 | Jaroslav Vit | Dental treatment |
| US4089979A (en) * | 1972-06-30 | 1978-05-16 | Imperial Chemical Industries Limited | Formulation of feed additives, mineral supplements and liquid feeds for animals and preservatives for silage, hay and grain |
| US3988434A (en) * | 1972-08-07 | 1976-10-26 | Schole Murray L | Dental preparation |
| US4025616A (en) * | 1973-03-06 | 1977-05-24 | The Procter & Gamble Company | Oral compositions for plaque, caries and calculus retardation with reduced staining tendencies |
| US4100269A (en) * | 1973-06-28 | 1978-07-11 | Lever Brothers Company | Anticalculus dentifrice |
| US4022880A (en) * | 1973-09-26 | 1977-05-10 | Lever Brothers Company | Anticalculus composition |
| US3925543A (en) * | 1973-11-01 | 1975-12-09 | Colgate Palmolive Co | Antibacterial oral compositions containing preservative-antioxidants |
| CA1063357A (en) * | 1974-05-21 | 1979-10-02 | James J. Benedict | Abrasive composition |
| US4011309A (en) * | 1975-01-20 | 1977-03-08 | Marion Laboratories, Inc. | Dentifrice composition and method for desensitizing sensitive teeth |
| US4064138A (en) * | 1975-11-12 | 1977-12-20 | General Mills, Inc. | Amino acid derivatives |
| USRE31181E (en) * | 1976-06-18 | 1983-03-15 | Means and method for improving natural defenses against caries | |
| ZA773318B (en) * | 1976-06-18 | 1978-04-26 | I Kleinberg | Means and method for improving natural defenses against caries |
| US4108979A (en) | 1976-08-02 | 1978-08-22 | Indiana University Foundation | Dentifrice preparations comprising aluminum and a compatible abrasive |
| US4042680A (en) * | 1976-08-02 | 1977-08-16 | Indiana University Foundation | Anticariogenic maloaluminate complexes |
| US4108981A (en) * | 1976-08-02 | 1978-08-22 | Indiana University Foundation | Alkaline oral compositions comprising aluminum and a carboxylic acid |
| US4146607A (en) * | 1977-11-07 | 1979-03-27 | Lever Brothers Company | Synergistic anti-plaque mixture with tetradecylamine plus aluminum and/or zinc |
| US4160821A (en) * | 1978-02-27 | 1979-07-10 | Johnson & Johnson | Treatment for gingivitis |
| US4213961A (en) | 1978-03-23 | 1980-07-22 | Beecham, Inc. | Oral compositions |
| GB1573727A (en) * | 1978-05-19 | 1980-08-28 | Colgate Palmolive Co | Dentifrices |
| US4216961A (en) * | 1978-08-04 | 1980-08-12 | Mcquillan Mary J | Table baseball apparatus |
| US4225579A (en) * | 1979-02-27 | 1980-09-30 | Israel Kleinberg | Means and method for improving defenses against caries |
| US4339432A (en) * | 1979-06-20 | 1982-07-13 | Lever Brothers Company | Oral mouthwash containing zinc and glycine |
| US4269822A (en) * | 1979-07-20 | 1981-05-26 | Laclede Professional Products, Inc. | Antiseptic dentifrice |
| JPS5835965B2 (ja) * | 1979-07-31 | 1983-08-05 | ライオン株式会社 | 口腔用組成物 |
| JPS5846483B2 (ja) * | 1979-09-20 | 1983-10-17 | ライオン株式会社 | 口腔用組成物 |
| US4532124A (en) * | 1981-08-19 | 1985-07-30 | Development Finance Corporation Of New Zealand | Dental rinse |
| JPS58118509A (ja) * | 1981-12-29 | 1983-07-14 | Lion Corp | 口腔用組成物 |
| US4725576A (en) * | 1983-12-29 | 1988-02-16 | Research Foundation Of State University Of New York | Fungicidal polypeptide compositions containing L-histidine and methods for use therefore |
| US4528181A (en) * | 1984-02-01 | 1985-07-09 | Colgate-Palmolive Company | Dentifrice containing dual sources of fluoride |
| US5334617A (en) * | 1984-03-19 | 1994-08-02 | The Rockefeller University | Amino acids useful as inhibitors of the advanced glycosylation of proteins |
| GB8411731D0 (en) * | 1984-05-09 | 1984-06-13 | Unilever Plc | Oral compositions |
| JPH0742219B2 (ja) * | 1984-07-26 | 1995-05-10 | ライオン株式会社 | 口腔用組成物 |
| US4538990A (en) * | 1984-09-24 | 1985-09-03 | Medical College Of Ga. Research Institute, Inc. | Method of decreasing the permeability of a dental cavity |
| US5032386A (en) * | 1988-12-29 | 1991-07-16 | Colgate-Palmolive Company | Antiplaque antibacterial oral composition |
| GB8729564D0 (en) * | 1987-12-18 | 1988-02-03 | Unilever Plc | Oral compositions |
| US5438076A (en) * | 1988-05-03 | 1995-08-01 | Perio Products, Ltd. | Liquid polymer composition, and method of use |
| US4992258A (en) * | 1989-10-23 | 1991-02-12 | Colgate-Palmolive Company | Dentrifice composition |
| US5096700A (en) * | 1990-09-28 | 1992-03-17 | The Procter & Gamble Company | Halogenated aminohexanoates and aminobutyrates antimicrobial agents |
| US5270031A (en) | 1991-12-20 | 1993-12-14 | Block Drug Company Inc. | Dentinal desensitizing compositions |
| JP2627709B2 (ja) * | 1992-05-15 | 1997-07-09 | 花王株式会社 | 口腔用組成物 |
| US5370865A (en) * | 1992-05-15 | 1994-12-06 | Kao Corporation | Composition for use in oral cavity |
| GB9212706D0 (en) | 1992-06-16 | 1992-07-29 | Smithkline Beecham Plc | Novel composition |
| US5286480A (en) * | 1992-06-29 | 1994-02-15 | The Procter & Gamble Company | Use of N-acetylated amino acid complexes in oral care compositions |
| JPH0692860A (ja) | 1992-09-14 | 1994-04-05 | Kao Corp | 知覚過敏症治療剤 |
| CA2165013C (en) * | 1994-12-13 | 2004-01-06 | Nobuo Nakabayashi | Dental composition for relieving dentin hypersensitivity |
| JP3389719B2 (ja) * | 1994-12-22 | 2003-03-24 | ライオン株式会社 | 口腔用組成物 |
| US5589159A (en) * | 1995-04-11 | 1996-12-31 | Block Drug Company Inc. | Dispersible particulate system for desensitizing teeth |
| DE69618786T2 (de) * | 1995-07-10 | 2002-11-07 | Unilever N.V., Rotterdam | Wärmeerzeugende zahnpasta |
| DE19707785A1 (de) * | 1996-03-05 | 1997-10-30 | Luk Lamellen & Kupplungsbau | Reibungskupplung |
| US5762911A (en) * | 1996-03-05 | 1998-06-09 | The Research Foundation Of State University Of New York | Anti-caries oral compositions |
| JPH09295924A (ja) | 1996-04-30 | 1997-11-18 | Lion Corp | 歯垢の酸中和剤及び口腔用組成物 |
| JPH1017449A (ja) | 1996-07-05 | 1998-01-20 | Sangi Co Ltd | 知覚過敏症用組成物 |
| US6488961B1 (en) * | 1996-09-20 | 2002-12-03 | Ethypharm, Inc. | Effervescent granules and methods for their preparation |
| US5906811A (en) * | 1997-06-27 | 1999-05-25 | Thione International, Inc. | Intra-oral antioxidant preparations |
| US5922346A (en) * | 1997-12-01 | 1999-07-13 | Thione International, Inc. | Antioxidant preparation |
| US6805883B2 (en) | 1998-03-12 | 2004-10-19 | Mars, Incorporated | Food products containing polyphenol(s) and L-arginine to stimulate nitric oxide |
| US5997301A (en) * | 1998-10-20 | 1999-12-07 | Linden; Lars Ake | Treatment of tooth surfaces and substances therefor |
| US20020037258A1 (en) * | 1999-08-05 | 2002-03-28 | Gregory P. Dodd | Dental composition for the mineral occlusion of dentinal tubules in sensitive teeth |
| US6436370B1 (en) * | 1999-06-23 | 2002-08-20 | The Research Foundation Of State University Of New York | Dental anti-hypersensitivity composition and method |
| US6558654B2 (en) * | 2000-04-11 | 2003-05-06 | Mclaughlin Gerald | Composition and method for whitening teeth |
| US20020081360A1 (en) | 2000-12-27 | 2002-06-27 | Andreas Burgard | Salts of L-amino acid having improved taste and their preparation |
| CA2443747A1 (en) | 2001-04-24 | 2002-10-31 | Specialty Minerals (Michigan) Inc. | Fluoride compatible calcium carbonate |
| US7731110B2 (en) | 2005-06-29 | 2010-06-08 | J.M. Huber Corporation | Method for making precipitated silica compositions and products thereof |
| US20070014740A1 (en) * | 2005-07-15 | 2007-01-18 | Colgate-Palmolive Company | Oral compositions having cationic active ingredients |
| GB0525369D0 (en) * | 2005-12-14 | 2006-01-18 | Ineos Silicas Ltd | Silicas |
| US20070258916A1 (en) * | 2006-04-14 | 2007-11-08 | Oregon Health & Science University | Oral compositions for treating tooth hypersensitivity |
| CN101938977A (zh) * | 2008-02-08 | 2011-01-05 | 高露洁-棕榄公司 | 口腔护理产品及其使用和生产方法 |
-
2008
- 2008-03-28 CN CN2008801264391A patent/CN101938977A/zh active Pending
- 2008-03-28 PL PL08732990.0T patent/PL2249784T3/pl unknown
- 2008-03-28 MX MX2010005542A patent/MX2010005542A/es unknown
- 2008-03-28 MX MX2015016556A patent/MX364537B/es unknown
- 2008-03-28 PE PE2008000567A patent/PE20091312A1/es not_active Application Discontinuation
- 2008-03-28 EP EP08732990.0A patent/EP2249784B1/en active Active
- 2008-03-28 CN CN201510400698.0A patent/CN104921966A/zh active Pending
- 2008-03-28 PE PE2012001558A patent/PE20130148A1/es not_active Application Discontinuation
- 2008-03-28 RU RU2010137333/15A patent/RU2475231C2/ru active
- 2008-03-28 RU RU2012150444/15A patent/RU2543656C2/ru active
- 2008-03-28 CA CA2706486A patent/CA2706486C/en active Active
- 2008-03-28 AU AU2008349847A patent/AU2008349847C1/en active Active
- 2008-03-28 ES ES08732990.0T patent/ES2594428T3/es active Active
- 2008-03-28 CL CL2008000895A patent/CL2008000895A1/es unknown
- 2008-03-28 WO PCT/US2008/058679 patent/WO2009099452A1/en active Application Filing
- 2008-03-28 JP JP2010545848A patent/JP6034549B2/ja not_active Expired - Fee Related
- 2008-03-28 US US12/058,424 patent/US9682027B2/en active Active
- 2008-03-28 BR BRPI0821860A patent/BRPI0821860B1/pt active IP Right Grant
- 2008-03-31 AR ARP080101323A patent/AR065887A1/es not_active Application Discontinuation
- 2008-03-31 PA PA20088774801A patent/PA8774801A1/es unknown
- 2008-04-07 TW TW097112583A patent/TWI355280B/zh not_active IP Right Cessation
-
2010
- 2010-05-24 ZA ZA2010/03693A patent/ZA201003693B/en unknown
- 2010-09-02 CO CO10108677A patent/CO6531500A2/es not_active Application Discontinuation
- 2010-09-02 CO CO10108722A patent/CO6300929A2/es not_active Application Discontinuation
- 2010-09-03 CO CO10109376A patent/CO6290630A2/es not_active Application Discontinuation
- 2010-09-03 CO CO10109364A patent/CO6290632A2/es not_active Application Discontinuation
-
2014
- 2014-07-07 JP JP2014139414A patent/JP2014224124A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO6290632A2 (es) | Composición oral que contiene péptidos y proteasas | |
| AR070588A1 (es) | Composiciones que contienen aminoacido basico y sal carbonato soluble | |
| AR070590A1 (es) | Limpiador dental | |
| CO6290629A2 (es) | Composiciones de limpieza de amino ácido básico y métodos | |
| PE20191136A1 (es) | Composiciones de aminoacidos y metodos de tratamiento de enfermedades hepaticas | |
| CO6290631A2 (es) | Composición oral que contiene amino ácidos y un agente blanqueador | |
| AR070355A1 (es) | Composiciones, metodos para el tratamiento de la xerostomia y uso | |
| ES2637380T3 (es) | Remineralización de tejido calcificado | |
| CO6290627A2 (es) | Composicion oral que contiene amino acidos, tensoactivo anionico y agentes antibacterianos | |
| CO6290623A2 (es) | Composicion efervescente que comprende una sal fisiologicamente aceptable de un amino acido basico, una fuente de acido y una sal de carbonato soluble | |
| UY36036A (es) | “una composición para el cuidado oral que comprende un carbonato de calcio tratado mediante reacción superficial”. | |
| MX339060B (es) | Formulaciones del factor viii. | |
| PE20090605A1 (es) | Composiciones de fenilalanina amoniaco-liasa procariotica y metodos del tratamiento del cancer usando composiciones de la misma | |
| EP1786931A4 (en) | METHODS AND COMPOSITIONS FOR MEASURING NATRIURETIC PEPTIDES AND USES THEREOF | |
| CL2012000063A1 (es) | Polipéptido factor ix (fix) o un fragmento del mismo porque comprende la modificación de un aminoácido; vector; célula; método para expresar el polipéptido fix; composición farmacéutica; uso de la composición para tratar enfermedades trombóticas, hemorrágicas y coagulación intravascular diseminada (cid) (div. sol. 1796-07). | |
| PE20141672A1 (es) | FORMULACION PARA ANTICUERPO ANTI-alfa4�7 | |
| CY1126067T1 (el) | Συντηγμενες πυρρολινες που δρουν σαν ειδικοι για ουβικιτινη αναστολεις πρωτεασης 30 (usp30) | |
| AR083862A1 (es) | Producto de cuidado oral y metodo para su uso y fabricacion | |
| AR070491A1 (es) | Variante de enzima lipolitica con estabilidad aumentada y polinucleotidos que la codifican | |
| AR077384A1 (es) | Una formulacion farmaceutica inyectable de melfalano. | |
| CO2022005904A2 (es) | Composiciones sólidas que comprenden un inhibidor de pcsk9 y una sal de ácido n-(8-(2-hidroxibenzoil)amino)caprílico | |
| CO2022000575A2 (es) | Composiciones sólidas que comprenden un derivado de egf(a) y una sal de ácido n-(8-(2-hidroxibenzoil)amino)caprílico | |
| CL2019001746A1 (es) | Amidas aromáticas de ácido carboxílico | |
| BRPI0417366A (pt) | composição detergente lìquida, método de limpeza de um substrato de tecido, e, uso de um antioxidante | |
| CL2009001156A1 (es) | Acetato de un peptido de 12 aminoacidos; metodo de preparacion; composicion farmaceutica y agente que lo contiene, solo o conjuntamente con un principio activo que dana el acido nucleico; util para el tratamiento o profilaxis de trastornos proliferativos celulares. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |