CO6280528A2 - Compuesto de acido carboxilico - Google Patents
Compuesto de acido carboxilicoInfo
- Publication number
- CO6280528A2 CO6280528A2 CO10162533A CO10162533A CO6280528A2 CO 6280528 A2 CO6280528 A2 CO 6280528A2 CO 10162533 A CO10162533 A CO 10162533A CO 10162533 A CO10162533 A CO 10162533A CO 6280528 A2 CO6280528 A2 CO 6280528A2
- Authority
- CO
- Colombia
- Prior art keywords
- carbon atoms
- group
- atoms
- optionally substituted
- alkyl group
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
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- A61K31/425—Thiazoles
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- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
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- C07C205/34—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups bound to carbon atoms of six-membered aromatic rings and etherified hydroxy groups bound to acyclic carbon atoms of the carbon skeleton
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- C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
- C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
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- C07C217/76—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and etherified hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
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- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
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- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
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- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C59/40—Unsaturated compounds
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Child & Adolescent Psychology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se da a conocer un agente altamente seguro para el tratamiento y/o la prevención de diabetes o similares, que tiene una excelente actividad. Se da a conocer específicamente un compuesto representado por la fórmula general (I):o una sal farmacológicamente aceptable del mismo. (En la fórmula, X representa =C(R5)- o =N-; Y representa -O- o -NH-; L representa un enlace individual o un grupo alquileno de 1 a 3 átomos de carbono opcionalmente sustituido; M representa un grupo cicloalquilo de 3 a 10 átomos de carbono opcionalmente sustituido, un grupo arilo de 6 a 10 átomos de carbono opcionalmente sustituido, o un grupo heterocíclico opcionalmente sustituido; R1 representa un grupo alquilo de 1 a 6 átomos de carbono, un grupo cicloalquilo de 3 a 10 átomos de carbono, un grupo halo-alquilo de 1 a 6 átomos de carbono, un grupo alquenilo de 2 a 6 átomos de carbono, un grupo alquinilo de 2 a 6 átomos de carbono, un grupo acilo alifático de 1 a 6 átomos de carbono, un grupo alcoxilo de 1 a 6 átomos de carbono-alquilo de 1 a 6 átomos de carbono, o un grupo arilo de 6 a 10 átomos de carbono; y R2, R3, R4, y R5 pueden ser iguales o diferentes, y cada uno representa un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo de 1 a 3 átomos de carbono, un grupo halo-alquilo de 1 a 3 átomos de carbono, un grupo alcoxilo de 1 a 3 átomos de carbono, o un grupo nitro. En relación con esto, las fracciones de grupo alquilo de R1 y R2 se pueden enlazar una a la otra para formar un anillo heterocíclico de 5 ó 6 miembros que contiene un átomo de oxígeno).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008165756 | 2008-06-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6280528A2 true CO6280528A2 (es) | 2011-05-20 |
Family
ID=41444484
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO10162533A CO6280528A2 (es) | 2008-06-25 | 2010-12-27 | Compuesto de acido carboxilico |
Country Status (18)
Country | Link |
---|---|
US (1) | US8222281B2 (es) |
EP (1) | EP2289868B1 (es) |
JP (1) | JP5425772B2 (es) |
KR (1) | KR20110027657A (es) |
CN (1) | CN102076650A (es) |
AU (1) | AU2009263384A1 (es) |
BR (1) | BRPI0913368A2 (es) |
CA (1) | CA2727340A1 (es) |
CO (1) | CO6280528A2 (es) |
ES (1) | ES2516716T3 (es) |
HK (1) | HK1153453A1 (es) |
IL (1) | IL210246A0 (es) |
MX (1) | MX2010014571A (es) |
NZ (1) | NZ588983A (es) |
RU (1) | RU2011102560A (es) |
TW (1) | TW201004917A (es) |
WO (1) | WO2009157418A1 (es) |
ZA (1) | ZA201008096B (es) |
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BRPI0818687A2 (pt) | 2007-10-26 | 2017-05-02 | Japan Tobacco Inc | composto espiro, o sal deste farmaceuticamente aceitavél ou o solvato deste, composição farmacêutica, medicamento agonista de gpr40, agente promotor da secreção de insulina ou um agente hipoglicêmico, uso do composto espíro, o sal deste farmaceuticamente aceitavél ou o solvato deste, e, métodos para a ativação de gpr40, para promover secreção de insulina ou diminuir o nível de glicose sanguínea, e para tratar ou prevenir uma doença. |
EP2518060A4 (en) | 2009-12-25 | 2014-01-08 | Mochida Pharm Co Ltd | NEW 3-HYDROXY-5-ARYLISOTHIAZOL DERIVATIVE |
JP5809157B2 (ja) | 2010-10-08 | 2015-11-10 | 持田製薬株式会社 | 環状アミド誘導体 |
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WO2012086406A1 (ja) * | 2010-12-22 | 2012-06-28 | 花王株式会社 | Glp-1分泌促進剤 |
AR085990A1 (es) | 2011-04-27 | 2013-11-13 | Mochida Pharm Co Ltd | Derivados de 1-oxido de 3-hidroxiisotiazol utiles en el tratamiento de la diabetes y composiciones farmaceuticas que los contienen |
AU2012248627A1 (en) | 2011-04-28 | 2013-11-14 | Mochida Pharmaceutical Co., Ltd. | Cyclic amide derivative |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013139341A1 (en) * | 2012-03-20 | 2013-09-26 | Syddansk Universitet | Gpr120 receptor modulators |
US8642585B2 (en) | 2012-03-26 | 2014-02-04 | Boehringer Ingelheim International Gmbh | Indanyloxydihydrobenzofuranylacetic acids |
US8809376B2 (en) | 2012-04-30 | 2014-08-19 | Boehringer Ingelheim International Gmbh | Indanyloxydihydrobenzofuranylacetic acids |
UA112897C2 (uk) | 2012-05-09 | 2016-11-10 | Байєр Фарма Акцієнгезелльшафт | Біциклічно заміщені урацили та їх застосування для лікування і/або профілактики захворювань |
US8633182B2 (en) | 2012-05-30 | 2014-01-21 | Boehringer Ingelheim International Gmbh | Indanyloxyphenylcyclopropanecarboxylic acids |
WO2013185766A1 (en) * | 2012-06-15 | 2013-12-19 | Syddansk Universitet | Gpr120 receptor modulators |
CN104507917B (zh) | 2012-08-07 | 2017-10-17 | 巴斯利尔药物股份公司 | 用于制造艾沙康唑或雷夫康唑的方法 |
CN104884452A (zh) | 2012-11-20 | 2015-09-02 | 沃泰克斯药物股份有限公司 | 用作吲哚胺2,3-二氧化酶的抑制剂的化合物 |
EA201500574A1 (ru) | 2012-11-28 | 2015-11-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Новые инданилоксидигидробензофуранилуксусные кислоты |
US20140163025A1 (en) | 2012-12-07 | 2014-06-12 | Boehringer Ingelheim International Gmbh | Indanyloxydihydrobenzofuranylacetic acids |
WO2014122067A1 (en) | 2013-02-06 | 2014-08-14 | Boehringer Ingelheim International Gmbh | New indanyloxydihydrobenzofuranylacetic acids |
TWI594975B (zh) * | 2013-04-24 | 2017-08-11 | 第一三共股份有限公司 | 二羧酸化合物 |
WO2015078802A1 (en) * | 2013-11-28 | 2015-06-04 | Boehringer Ingelheim International Gmbh | New indanyloxyphenylcyclopropanecarboxylic acids |
EP3191453B1 (en) | 2014-09-09 | 2019-10-23 | Bristol-Myers Squibb Company | Phenyl-(aza)cycloalkyl carboxylic acid gpr120 modulators |
ES2864277T3 (es) | 2014-09-26 | 2021-10-13 | Daiichi Sankyo Co Ltd | Sal de compuestos de ácido dicarboxílico |
WO2016074696A1 (en) * | 2014-11-10 | 2016-05-19 | Givaudan Ag | Perfume ingredients and perfume preparations containing same |
AU2017268006B2 (en) | 2016-05-20 | 2021-03-11 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
CN110088089B (zh) | 2016-10-25 | 2023-08-29 | 勃林格殷格翰国际有限公司 | 苄基氨基吡啶基环丙烷甲酸、药物组合物及其用途 |
US10125101B2 (en) | 2016-11-28 | 2018-11-13 | Boehringer Ingelheim International Gmbh | Indanylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
RU2760303C2 (ru) | 2016-12-09 | 2021-11-23 | Ксенон Фармасьютикалз Инк. | Соединения бензолсульфонамидов и их использование в качестве терапевтических средств |
CN110214135B (zh) | 2017-01-26 | 2023-02-21 | 勃林格殷格翰国际有限公司 | 茚满基氨基吡嗪基环丙烷羧酸、药物组合物及其用途 |
CN110248929B (zh) | 2017-01-26 | 2023-05-12 | 勃林格殷格翰国际有限公司 | 苄基氨基吡嗪基环丙烷甲酸、其药物组合物和用途 |
JP7050792B2 (ja) | 2017-01-26 | 2022-04-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ベンジルオキシピラジニルシクロプロパンカルボン酸、その医薬組成物及び使用 |
CN110198928B (zh) | 2017-01-26 | 2023-08-29 | 勃林格殷格翰国际有限公司 | 苄氧基吡啶基环丙烷甲酸、其药物组合物和用途 |
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US10550127B1 (en) | 2017-02-08 | 2020-02-04 | Boehringer Ingelheim International Gmbh | Indanylaminoazadihydrobenzofuranylacetic acids, pharmaceutical compositions for the treatment of diabetes |
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CN112262142B (zh) | 2018-06-13 | 2023-11-14 | 泽农医药公司 | 苯磺酰胺化合物及其作为治疗剂的用途 |
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CN112638898B (zh) | 2018-08-31 | 2024-04-09 | 泽农医药公司 | 杂芳基取代的磺酰胺化合物及其作为钠通道抑制剂的用途 |
CN114163408B (zh) * | 2020-09-10 | 2024-03-19 | 上海爱博医药科技有限公司 | 苯并含氧杂环类化合物及其医药应用 |
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EP1431280A1 (en) | 2001-08-29 | 2004-06-23 | Kyowa Hakko Kogyo Co., Ltd | Aryl sulfamate derivatives |
EP2385032A1 (en) | 2002-11-08 | 2011-11-09 | Takeda Pharmaceutical Company Limited | GPR40 Receptor function regulator |
NZ540515A (en) | 2002-12-02 | 2008-01-31 | Astellas Pharma Inc | Pyrazole derivatives useful as COX-I inhibitors |
WO2005051890A1 (en) | 2003-11-19 | 2005-06-09 | Smithkline Beecham Corporation | Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to gpr40 |
AU2005220728B2 (en) * | 2004-02-27 | 2009-08-06 | Amgen Inc. | Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders |
JP2007284350A (ja) | 2004-07-27 | 2007-11-01 | Takeda Chem Ind Ltd | 糖尿病治療剤 |
BRPI0818687A2 (pt) * | 2007-10-26 | 2017-05-02 | Japan Tobacco Inc | composto espiro, o sal deste farmaceuticamente aceitavél ou o solvato deste, composição farmacêutica, medicamento agonista de gpr40, agente promotor da secreção de insulina ou um agente hipoglicêmico, uso do composto espíro, o sal deste farmaceuticamente aceitavél ou o solvato deste, e, métodos para a ativação de gpr40, para promover secreção de insulina ou diminuir o nível de glicose sanguínea, e para tratar ou prevenir uma doença. |
-
2009
- 2009-06-23 KR KR1020107025765A patent/KR20110027657A/ko not_active Application Discontinuation
- 2009-06-23 AU AU2009263384A patent/AU2009263384A1/en not_active Abandoned
- 2009-06-23 JP JP2010518013A patent/JP5425772B2/ja not_active Expired - Fee Related
- 2009-06-23 CA CA2727340A patent/CA2727340A1/en not_active Abandoned
- 2009-06-23 WO PCT/JP2009/061350 patent/WO2009157418A1/ja active Application Filing
- 2009-06-23 BR BRPI0913368A patent/BRPI0913368A2/pt not_active Application Discontinuation
- 2009-06-23 EP EP09770128.8A patent/EP2289868B1/en not_active Not-in-force
- 2009-06-23 NZ NZ588983A patent/NZ588983A/en not_active IP Right Cessation
- 2009-06-23 MX MX2010014571A patent/MX2010014571A/es not_active Application Discontinuation
- 2009-06-23 ES ES09770128.8T patent/ES2516716T3/es active Active
- 2009-06-23 CN CN2009801251860A patent/CN102076650A/zh active Pending
- 2009-06-23 RU RU2011102560/04A patent/RU2011102560A/ru not_active Application Discontinuation
- 2009-06-24 TW TW098121093A patent/TW201004917A/zh unknown
-
2010
- 2010-09-29 US US12/893,592 patent/US8222281B2/en not_active Expired - Fee Related
- 2010-11-11 ZA ZA2010/08096A patent/ZA201008096B/en unknown
- 2010-12-23 IL IL210246A patent/IL210246A0/en unknown
- 2010-12-27 CO CO10162533A patent/CO6280528A2/es not_active Application Discontinuation
-
2011
- 2011-07-22 HK HK11107658.5A patent/HK1153453A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
TW201004917A (en) | 2010-02-01 |
RU2011102560A (ru) | 2012-07-27 |
HK1153453A1 (en) | 2012-03-30 |
EP2289868B1 (en) | 2014-08-13 |
AU2009263384A1 (en) | 2009-12-30 |
JP5425772B2 (ja) | 2014-02-26 |
CN102076650A (zh) | 2011-05-25 |
BRPI0913368A2 (pt) | 2015-11-24 |
KR20110027657A (ko) | 2011-03-16 |
ZA201008096B (en) | 2011-08-31 |
JPWO2009157418A1 (ja) | 2011-12-15 |
WO2009157418A1 (ja) | 2009-12-30 |
MX2010014571A (es) | 2011-03-25 |
EP2289868A4 (en) | 2011-12-07 |
US8222281B2 (en) | 2012-07-17 |
IL210246A0 (en) | 2011-03-31 |
NZ588983A (en) | 2011-11-25 |
US20110053974A1 (en) | 2011-03-03 |
ES2516716T3 (es) | 2014-10-31 |
CA2727340A1 (en) | 2009-12-30 |
EP2289868A1 (en) | 2011-03-02 |
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