CO6280528A2 - Compuesto de acido carboxilico - Google Patents
Compuesto de acido carboxilicoInfo
- Publication number
- CO6280528A2 CO6280528A2 CO10162533A CO10162533A CO6280528A2 CO 6280528 A2 CO6280528 A2 CO 6280528A2 CO 10162533 A CO10162533 A CO 10162533A CO 10162533 A CO10162533 A CO 10162533A CO 6280528 A2 CO6280528 A2 CO 6280528A2
- Authority
- CO
- Colombia
- Prior art keywords
- carbon atoms
- group
- atoms
- optionally substituted
- alkyl group
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
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- A61K31/425—Thiazoles
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- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
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- C07C205/34—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups bound to carbon atoms of six-membered aromatic rings and etherified hydroxy groups bound to acyclic carbon atoms of the carbon skeleton
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- C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
- C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
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- C07C217/76—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and etherified hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
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- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
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- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
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- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C59/40—Unsaturated compounds
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Child & Adolescent Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Nutrition Science (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se da a conocer un agente altamente seguro para el tratamiento y/o la prevención de diabetes o similares, que tiene una excelente actividad. Se da a conocer específicamente un compuesto representado por la fórmula general (I):o una sal farmacológicamente aceptable del mismo. (En la fórmula, X representa =C(R5)- o =N-; Y representa -O- o -NH-; L representa un enlace individual o un grupo alquileno de 1 a 3 átomos de carbono opcionalmente sustituido; M representa un grupo cicloalquilo de 3 a 10 átomos de carbono opcionalmente sustituido, un grupo arilo de 6 a 10 átomos de carbono opcionalmente sustituido, o un grupo heterocíclico opcionalmente sustituido; R1 representa un grupo alquilo de 1 a 6 átomos de carbono, un grupo cicloalquilo de 3 a 10 átomos de carbono, un grupo halo-alquilo de 1 a 6 átomos de carbono, un grupo alquenilo de 2 a 6 átomos de carbono, un grupo alquinilo de 2 a 6 átomos de carbono, un grupo acilo alifático de 1 a 6 átomos de carbono, un grupo alcoxilo de 1 a 6 átomos de carbono-alquilo de 1 a 6 átomos de carbono, o un grupo arilo de 6 a 10 átomos de carbono; y R2, R3, R4, y R5 pueden ser iguales o diferentes, y cada uno representa un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo de 1 a 3 átomos de carbono, un grupo halo-alquilo de 1 a 3 átomos de carbono, un grupo alcoxilo de 1 a 3 átomos de carbono, o un grupo nitro. En relación con esto, las fracciones de grupo alquilo de R1 y R2 se pueden enlazar una a la otra para formar un anillo heterocíclico de 5 ó 6 miembros que contiene un átomo de oxígeno).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008165756 | 2008-06-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6280528A2 true CO6280528A2 (es) | 2011-05-20 |
Family
ID=41444484
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO10162533A CO6280528A2 (es) | 2008-06-25 | 2010-12-27 | Compuesto de acido carboxilico |
Country Status (18)
Country | Link |
---|---|
US (1) | US8222281B2 (es) |
EP (1) | EP2289868B1 (es) |
JP (1) | JP5425772B2 (es) |
KR (1) | KR20110027657A (es) |
CN (1) | CN102076650A (es) |
AU (1) | AU2009263384A1 (es) |
BR (1) | BRPI0913368A2 (es) |
CA (1) | CA2727340A1 (es) |
CO (1) | CO6280528A2 (es) |
ES (1) | ES2516716T3 (es) |
HK (1) | HK1153453A1 (es) |
IL (1) | IL210246A0 (es) |
MX (1) | MX2010014571A (es) |
NZ (1) | NZ588983A (es) |
RU (1) | RU2011102560A (es) |
TW (1) | TW201004917A (es) |
WO (1) | WO2009157418A1 (es) |
ZA (1) | ZA201008096B (es) |
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WO2012046869A1 (ja) | 2010-10-08 | 2012-04-12 | 持田製薬株式会社 | 環状アミド誘導体 |
PL2646425T3 (pl) * | 2010-12-01 | 2015-12-31 | Boehringer Ingelheim Int | Kwasy indanyloksydihydrobenzofuranylooctowe użyteczne do leczenia zespołu metabolicznego |
WO2012086406A1 (ja) * | 2010-12-22 | 2012-06-28 | 花王株式会社 | Glp-1分泌促進剤 |
JP5420796B2 (ja) | 2011-04-27 | 2014-02-19 | 持田製薬株式会社 | 新規3−ヒドロキシイソチアゾール1−オキシド誘導体 |
JPWO2012147516A1 (ja) | 2011-04-28 | 2014-07-28 | 持田製薬株式会社 | 環状アミド誘導体 |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013139341A1 (en) * | 2012-03-20 | 2013-09-26 | Syddansk Universitet | Gpr120 receptor modulators |
US8642585B2 (en) | 2012-03-26 | 2014-02-04 | Boehringer Ingelheim International Gmbh | Indanyloxydihydrobenzofuranylacetic acids |
US8809376B2 (en) | 2012-04-30 | 2014-08-19 | Boehringer Ingelheim International Gmbh | Indanyloxydihydrobenzofuranylacetic acids |
UA112897C2 (uk) | 2012-05-09 | 2016-11-10 | Байєр Фарма Акцієнгезелльшафт | Біциклічно заміщені урацили та їх застосування для лікування і/або профілактики захворювань |
US8633182B2 (en) | 2012-05-30 | 2014-01-21 | Boehringer Ingelheim International Gmbh | Indanyloxyphenylcyclopropanecarboxylic acids |
WO2013185766A1 (en) * | 2012-06-15 | 2013-12-19 | Syddansk Universitet | Gpr120 receptor modulators |
PL2882723T3 (pl) | 2012-08-07 | 2017-05-31 | Basilea Pharmaceutica Ag | Sposób wytwarzania izawukonazolu lub rawukonazolu |
CA2891412A1 (en) | 2012-11-20 | 2014-05-30 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase |
AP2015008364A0 (en) | 2012-11-28 | 2015-04-30 | Boehringer Ingelheim Int | New idanyloxydihydrobenzof uranylacetic acids |
JP6283862B2 (ja) * | 2012-12-07 | 2018-02-28 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規インダニルオキシジヒドロベンゾフラニル酢酸 |
EP2953681B1 (en) | 2013-02-06 | 2017-03-15 | Boehringer Ingelheim International GmbH | New indanyloxydihydrobenzofuranylacetic acids |
TWI594975B (zh) | 2013-04-24 | 2017-08-11 | 第一三共股份有限公司 | 二羧酸化合物 |
EP3074375B1 (en) * | 2013-11-28 | 2018-04-04 | Boehringer Ingelheim International GmbH | New indanyloxyphenylcyclopropanecarboxylic acids |
ES2760266T3 (es) | 2014-09-09 | 2020-05-13 | Bristol Myers Squibb Co | Moduladores de GPR120 de ácido fenil-(aza)cicloalquil carboxílico |
BR112017005694A2 (pt) | 2014-09-26 | 2017-12-12 | Daiichi Sankyo Co Ltd | cristais de um sal, ou hidrato do mesmo, cristais de um trihidrato de sal dissódico, composição farmacêutica, uso dos cristais, e, método para prevenção ou tratamento de hiperfosfatemia. |
WO2016074696A1 (en) * | 2014-11-10 | 2016-05-19 | Givaudan Ag | Perfume ingredients and perfume preparations containing same |
CN109526219B (zh) | 2016-05-20 | 2021-03-12 | 泽农医药公司 | 苯磺酰胺及其作为治疗剂的用途 |
US10538490B2 (en) | 2016-10-25 | 2020-01-21 | Boehringer Ingelheim International Gmbh | Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
EP3544958B1 (en) | 2016-11-28 | 2021-03-24 | Boehringer Ingelheim International GmbH | Indanylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
BR112019011121A2 (pt) | 2016-12-09 | 2019-10-01 | Xenon Pharmaceuticals Inc | compostos de benzenossulfonamida e seu uso como agentes terapêuticos |
JP6968181B2 (ja) | 2017-01-26 | 2021-11-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | インダニルアミノピラジニルシクロプロパンカルボン酸、その医薬組成物及び使用 |
US10919859B2 (en) | 2017-01-26 | 2021-02-16 | Boehringer Ingelheim International Gmbh | Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
JP7050792B2 (ja) | 2017-01-26 | 2022-04-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ベンジルオキシピラジニルシクロプロパンカルボン酸、その医薬組成物及び使用 |
JP7049349B2 (ja) | 2017-01-26 | 2022-04-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ベンジルアミノピラジニルシクロプロパンカルボン酸、その医薬組成物及び使用 |
US10913720B2 (en) | 2017-01-26 | 2021-02-09 | Boehringer Ingelheim International Gmbh | Benzyloxypyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
WO2018146008A1 (en) | 2017-02-08 | 2018-08-16 | Boehringer Ingelheim International Gmbh | Indanylaminoazadihydrobenzofuranylacetic acids, pharmaceutical compositions for the treatment of diabetes |
CN110719903A (zh) * | 2017-03-31 | 2020-01-21 | 武田药品工业株式会社 | 芳族环化合物 |
CN112262142B (zh) | 2018-06-13 | 2023-11-14 | 泽农医药公司 | 苯磺酰胺化合物及其作为治疗剂的用途 |
US10752623B2 (en) | 2018-08-31 | 2020-08-25 | Xenon Pharmaceuticals Inc. | Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors |
CR20210099A (es) | 2018-08-31 | 2021-06-24 | Xenon Pharmaceuticals Inc | Compuestos de sulfonamida sustituidos con heteroarilo y su uso como agentes terapèuticos |
CN114163408B (zh) * | 2020-09-10 | 2024-03-19 | 上海爱博医药科技有限公司 | 苯并含氧杂环类化合物及其医药应用 |
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WO2003020690A1 (en) | 2001-08-29 | 2003-03-13 | Kyowa Hakko Kogyo Co., Ltd. | Aryl sulfamate derivatives |
WO2004041266A1 (ja) | 2002-11-08 | 2004-05-21 | Takeda Pharmaceutical Company Limited | 受容体機能調節剤 |
PL377778A1 (pl) | 2002-12-02 | 2006-02-20 | Astellas Pharma Inc. | Pochodne pirazolu |
WO2005051890A1 (en) * | 2003-11-19 | 2005-06-09 | Smithkline Beecham Corporation | Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to gpr40 |
KR20070004769A (ko) | 2004-02-27 | 2007-01-09 | 암젠 인코포레이션 | 대사 장애의 치료에 사용되는 화합물, 약제학적 조성물 및그 사용방법 |
JP2007284350A (ja) | 2004-07-27 | 2007-11-01 | Takeda Chem Ind Ltd | 糖尿病治療剤 |
NZ584161A (en) * | 2007-10-26 | 2011-12-22 | Japan Tobacco Inc | Spiro-ring compound and use thereof for medical purposes |
-
2009
- 2009-06-23 EP EP09770128.8A patent/EP2289868B1/en not_active Not-in-force
- 2009-06-23 AU AU2009263384A patent/AU2009263384A1/en not_active Abandoned
- 2009-06-23 JP JP2010518013A patent/JP5425772B2/ja not_active Expired - Fee Related
- 2009-06-23 RU RU2011102560/04A patent/RU2011102560A/ru not_active Application Discontinuation
- 2009-06-23 KR KR1020107025765A patent/KR20110027657A/ko not_active Application Discontinuation
- 2009-06-23 CA CA2727340A patent/CA2727340A1/en not_active Abandoned
- 2009-06-23 CN CN2009801251860A patent/CN102076650A/zh active Pending
- 2009-06-23 ES ES09770128.8T patent/ES2516716T3/es active Active
- 2009-06-23 MX MX2010014571A patent/MX2010014571A/es not_active Application Discontinuation
- 2009-06-23 BR BRPI0913368A patent/BRPI0913368A2/pt not_active Application Discontinuation
- 2009-06-23 NZ NZ588983A patent/NZ588983A/en not_active IP Right Cessation
- 2009-06-23 WO PCT/JP2009/061350 patent/WO2009157418A1/ja active Application Filing
- 2009-06-24 TW TW098121093A patent/TW201004917A/zh unknown
-
2010
- 2010-09-29 US US12/893,592 patent/US8222281B2/en not_active Expired - Fee Related
- 2010-11-11 ZA ZA2010/08096A patent/ZA201008096B/en unknown
- 2010-12-23 IL IL210246A patent/IL210246A0/en unknown
- 2010-12-27 CO CO10162533A patent/CO6280528A2/es not_active Application Discontinuation
-
2011
- 2011-07-22 HK HK11107658.5A patent/HK1153453A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP5425772B2 (ja) | 2014-02-26 |
KR20110027657A (ko) | 2011-03-16 |
US20110053974A1 (en) | 2011-03-03 |
RU2011102560A (ru) | 2012-07-27 |
ES2516716T3 (es) | 2014-10-31 |
BRPI0913368A2 (pt) | 2015-11-24 |
AU2009263384A1 (en) | 2009-12-30 |
TW201004917A (en) | 2010-02-01 |
CN102076650A (zh) | 2011-05-25 |
HK1153453A1 (en) | 2012-03-30 |
EP2289868A1 (en) | 2011-03-02 |
CA2727340A1 (en) | 2009-12-30 |
IL210246A0 (en) | 2011-03-31 |
NZ588983A (en) | 2011-11-25 |
JPWO2009157418A1 (ja) | 2011-12-15 |
MX2010014571A (es) | 2011-03-25 |
US8222281B2 (en) | 2012-07-17 |
ZA201008096B (en) | 2011-08-31 |
WO2009157418A1 (ja) | 2009-12-30 |
EP2289868B1 (en) | 2014-08-13 |
EP2289868A4 (en) | 2011-12-07 |
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