CO6251365A2 - Derivados de 4-aminmo-7, 8-dihidro-6-fenil pirmido [5, 4-f] [1, 4] oxazepin-5 (6h)- ona utiles como inhibidores de dgat-1 - Google Patents
Derivados de 4-aminmo-7, 8-dihidro-6-fenil pirmido [5, 4-f] [1, 4] oxazepin-5 (6h)- ona utiles como inhibidores de dgat-1Info
- Publication number
- CO6251365A2 CO6251365A2 CO10010179A CO10010179A CO6251365A2 CO 6251365 A2 CO6251365 A2 CO 6251365A2 CO 10010179 A CO10010179 A CO 10010179A CO 10010179 A CO10010179 A CO 10010179A CO 6251365 A2 CO6251365 A2 CO 6251365A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- aminmo
- dihidro
- oxazepin
- dgat
- Prior art date
Links
- 229940127193 DGAT1 inhibitor Drugs 0.000 title 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 101100240516 Caenorhabditis elegans nhr-10 gene Proteins 0.000 abstract 1
- 229920001774 Perfluoroether Polymers 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- -1 cyano, hydroxyl Chemical group 0.000 abstract 1
- 125000005724 cycloalkenylene group Chemical group 0.000 abstract 1
- 125000002993 cycloalkylene group Chemical group 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
1.- Un compuesto que tiene la fórmulao un tautómero del mismo, o una sal farmacéuticamente aceptable de dicho compuesto o tautómero, en la que: (a) R1 es H -alquilo (C1-C4), -perfluoroalquilo (C1-C4), -perfluoroalcoxi (C1-C4), o -alcoxi (C1-C4); (b) R2 y R3, tomados por separado, son independientemente H, -alquilo (C1-C4), o -perfluoroalquilo (C1-C4); o R2 y R3, tomados junto con el carbono al que están unidos, es - cicloalquilo (C3-C6); (c) R4 es H o -alquilo (C1-C4); (d) cada uno de R5a, R5b, R5c y R5d es independientemente H, F, CI, Br, -alquilo (C1-C4), -OH o -O-alquilo (C1-C4); (e) Q es -O- o un enlace; (f) A es un grupo -cicloalquileno (C3-C6), un grupo -cicloalquenileno (C3-C6) o fenileno; (g) Z es C(R6a)(R6b) o un enlace donde cada R6a y R6b es independientemente -H o -alquilo (C1-C4), o R6a y R6b, tomados junto con el carbono al que están unidos, es un -cicloalquilo (C3-C6); (h) R7 es C(O)R8, ciano, hidroxilo, -alcoxi (C1-C4), -perfluoroalcoxi (C1-C4) o un mimético de ácido carboxílico; (i) R8 es -OR9 o NHR10; (j) R9 es -H, -alquilo (C1-C4), o -perfluoroalquilo (C1-C4); y(k) R10 es -H, -alquilo (C1-C4), tetrazolilo o S(O)2CF3.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95350707P | 2007-08-02 | 2007-08-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6251365A2 true CO6251365A2 (es) | 2011-02-21 |
Family
ID=39926534
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO10010179A CO6251365A2 (es) | 2007-08-02 | 2010-02-01 | Derivados de 4-aminmo-7, 8-dihidro-6-fenil pirmido [5, 4-f] [1, 4] oxazepin-5 (6h)- ona utiles como inhibidores de dgat-1 |
Country Status (34)
Country | Link |
---|---|
US (2) | US20090036425A1 (es) |
EP (1) | EP2185567B1 (es) |
JP (1) | JP4629808B2 (es) |
KR (1) | KR20100032443A (es) |
CN (1) | CN101772504A (es) |
AP (1) | AP2010005163A0 (es) |
AR (1) | AR067780A1 (es) |
AT (1) | ATE502948T1 (es) |
AU (1) | AU2008281545B2 (es) |
BR (1) | BRPI0815067A2 (es) |
CA (1) | CA2695291C (es) |
CL (1) | CL2008002227A1 (es) |
CO (1) | CO6251365A2 (es) |
CR (1) | CR11223A (es) |
CY (1) | CY1111628T1 (es) |
DE (1) | DE602008005757D1 (es) |
DK (1) | DK2185567T3 (es) |
DO (1) | DOP2010000046A (es) |
EA (1) | EA201000050A1 (es) |
EC (1) | ECSP109932A (es) |
ES (1) | ES2361716T3 (es) |
HN (1) | HN2008001191A (es) |
HR (1) | HRP20110335T1 (es) |
MA (1) | MA31580B1 (es) |
PA (1) | PA8791601A1 (es) |
PE (1) | PE20090897A1 (es) |
PL (1) | PL2185567T3 (es) |
PT (1) | PT2185567E (es) |
SI (1) | SI2185567T1 (es) |
TN (1) | TN2010000053A1 (es) |
TW (1) | TWI356059B (es) |
UA (1) | UA94833C2 (es) |
WO (1) | WO2009016462A2 (es) |
ZA (1) | ZA201000255B (es) |
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ATE427310T1 (de) * | 2002-01-18 | 2009-04-15 | Kyorin Seiyaku Kk | Kondensierte bicyclische pyrimidinderivate |
EP1562956A4 (en) * | 2002-11-22 | 2007-10-10 | Japan Tobacco Inc | HETEROCYCLES CONTAINING FUSED BICYCLIC NITROGEN |
CA2554455A1 (en) * | 2004-01-30 | 2005-08-11 | Japan Tobacco Inc. | Anorectic |
JP2006056881A (ja) * | 2004-07-21 | 2006-03-02 | Takeda Chem Ind Ltd | 縮合環化合物 |
JP2009520786A (ja) * | 2005-12-22 | 2009-05-28 | アストラゼネカ アクチボラグ | Dgat阻害剤として使用するためのピリミド−[4,5−b]−オキサジン |
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