WO2009016462A2 - Substituted bicyclolactam compounds - Google Patents
Substituted bicyclolactam compounds Download PDFInfo
- Publication number
- WO2009016462A2 WO2009016462A2 PCT/IB2008/001963 IB2008001963W WO2009016462A2 WO 2009016462 A2 WO2009016462 A2 WO 2009016462A2 IB 2008001963 W IB2008001963 W IB 2008001963W WO 2009016462 A2 WO2009016462 A2 WO 2009016462A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- tautomer
- alkyl
- pharmaceutically acceptable
- crc
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 244
- 150000003839 salts Chemical class 0.000 claims abstract description 82
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- 238000011282 treatment Methods 0.000 claims abstract description 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 78
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- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 30
- 241000124008 Mammalia Species 0.000 claims description 23
- 229910052799 carbon Inorganic materials 0.000 claims description 21
- 229910052739 hydrogen Inorganic materials 0.000 claims description 21
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- 229910052731 fluorine Inorganic materials 0.000 claims description 18
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 17
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims description 16
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- JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 description 1
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Classifications
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- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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Landscapes
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- Pharmacology & Pharmacy (AREA)
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- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Description
Claims
Priority Applications (16)
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PL08788942T PL2185567T3 (en) | 2007-08-02 | 2008-07-22 | Substituted bicyclolactam compounds |
SI200830242T SI2185567T1 (en) | 2007-08-02 | 2008-07-22 | Substituted bicyclolactam compounds |
DK08788942.4T DK2185567T3 (en) | 2007-08-02 | 2008-07-22 | Substituted bicyclolactam compounds |
AP2010005163A AP2010005163A0 (en) | 2007-08-02 | 2008-07-22 | Substituted bicyclolactam compounds |
EA201000050A EA201000050A1 (en) | 2007-08-02 | 2008-07-22 | SUBSTITUTED BICYCLOPLASTIC COMPOUNDS |
CA2695291A CA2695291C (en) | 2007-08-02 | 2008-07-22 | Substituted bicyclolactam compounds |
JP2010518764A JP4629808B2 (en) | 2007-08-02 | 2008-07-22 | Substituted bicyclolactam compounds |
DE602008005757T DE602008005757D1 (en) | 2007-08-02 | 2008-07-22 | SUBSTITUTED BICYCLOLACTAM COMPOUNDS |
EP08788942A EP2185567B1 (en) | 2007-08-02 | 2008-07-22 | Substituted bicyclolactam compounds |
AU2008281545A AU2008281545B2 (en) | 2007-08-02 | 2008-07-22 | Substituted bicyclolactam compounds |
BRPI0815067-2A2A BRPI0815067A2 (en) | 2007-08-02 | 2008-07-22 | REPLACED BICYCLESTATE COMPOUNDS |
AT08788942T ATE502948T1 (en) | 2007-08-02 | 2008-07-22 | SUBSTITUTED BICYCLOLACTAM COMPOUNDS |
CN200880101674A CN101772504A (en) | 2007-08-02 | 2008-07-22 | substituted bicyclolactam compounds |
ZA2010/00255A ZA201000255B (en) | 2007-08-02 | 2010-01-13 | Substituted bicyclolactam compounds |
TNP2010000053A TN2010000053A1 (en) | 2007-08-02 | 2010-01-29 | SUBSTITUTED BI CYCLOLACTAM DERIVATIVES |
HR20110335T HRP20110335T1 (en) | 2007-08-02 | 2011-05-06 | Substituted bicyclolactam compounds |
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US95350707P | 2007-08-02 | 2007-08-02 | |
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WO2009016462A3 WO2009016462A3 (en) | 2009-03-26 |
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US (2) | US20090036425A1 (en) |
EP (1) | EP2185567B1 (en) |
JP (1) | JP4629808B2 (en) |
KR (1) | KR20100032443A (en) |
CN (1) | CN101772504A (en) |
AP (1) | AP2010005163A0 (en) |
AR (1) | AR067780A1 (en) |
AT (1) | ATE502948T1 (en) |
AU (1) | AU2008281545B2 (en) |
BR (1) | BRPI0815067A2 (en) |
CA (1) | CA2695291C (en) |
CL (1) | CL2008002227A1 (en) |
CO (1) | CO6251365A2 (en) |
CR (1) | CR11223A (en) |
CY (1) | CY1111628T1 (en) |
DE (1) | DE602008005757D1 (en) |
DK (1) | DK2185567T3 (en) |
DO (1) | DOP2010000046A (en) |
EA (1) | EA201000050A1 (en) |
EC (1) | ECSP109932A (en) |
ES (1) | ES2361716T3 (en) |
HN (1) | HN2008001191A (en) |
HR (1) | HRP20110335T1 (en) |
MA (1) | MA31580B1 (en) |
PA (1) | PA8791601A1 (en) |
PE (1) | PE20090897A1 (en) |
PL (1) | PL2185567T3 (en) |
PT (1) | PT2185567E (en) |
SI (1) | SI2185567T1 (en) |
TN (1) | TN2010000053A1 (en) |
TW (1) | TWI356059B (en) |
UA (1) | UA94833C2 (en) |
WO (1) | WO2009016462A2 (en) |
ZA (1) | ZA201000255B (en) |
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US7749997B2 (en) | 2005-12-22 | 2010-07-06 | Astrazeneca Ab | Pyrimido [4,5-B] -Oxazines for use as DGAT inhibitors |
WO2010086820A1 (en) * | 2009-02-02 | 2010-08-05 | Pfizer Inc. | 4-amino-5-oxo-7, 8-dihydropyrimido [5,4-f] [1,4] oxazepin-6 (5h) -yl) phenyl derivatives, pharmaceutical compositions and uses thereof |
WO2010089685A1 (en) * | 2009-02-03 | 2010-08-12 | Pfizer Inc. | 4-amino-7,8-dihydropyrido[4,3-d]pyrimidin-5(6h)-one derivatives |
WO2010089686A1 (en) * | 2009-02-04 | 2010-08-12 | Pfizer Inc. | 4-amino-7,8-dihydropyrido[4,3-d]pyrimidin-5(6h)-one derivatives |
US7795283B2 (en) | 2004-12-14 | 2010-09-14 | Astrazeneca Ab | Oxadiazole derivative as DGAT inhibitors |
WO2010108051A2 (en) | 2009-03-20 | 2010-09-23 | Ligand Pharmaceuticals | Inhibitors of diacylglycerol o-acyltransferase 1(dgat-1) and uses thereof |
US7879850B2 (en) | 2007-09-28 | 2011-02-01 | Novartis Ag | Organic compounds |
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US8084478B2 (en) | 2006-05-30 | 2011-12-27 | Asstrazeneca Ab | Substituted 5- phenylamino- 1, 3, 4-oxadiazol-2-ylcarbonylamino-4-phenoxy-cyclohexane carboxylic acid as inhibitors of acetyl coenzyme A diacylglycerol acyltransferase |
WO2012056372A1 (en) | 2010-10-29 | 2012-05-03 | Pfizer Inc. | N1/N2-LACTAM ACETYL-CoA CARBOXYLASE INHIBITORS |
WO2012122075A1 (en) * | 2011-03-08 | 2012-09-13 | Merck Sharp & Dohme Corp. | Lactam derivatives as dgat-1 inhibitors |
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