CO6180448A2 - Gel conteniendo pirfenidona - Google Patents
Gel conteniendo pirfenidonaInfo
- Publication number
- CO6180448A2 CO6180448A2 CO10015040A CO10015040A CO6180448A2 CO 6180448 A2 CO6180448 A2 CO 6180448A2 CO 10015040 A CO10015040 A CO 10015040A CO 10015040 A CO10015040 A CO 10015040A CO 6180448 A2 CO6180448 A2 CO 6180448A2
- Authority
- CO
- Colombia
- Prior art keywords
- solubilizer
- pirfenidone
- agent
- neutralizing agent
- preservative
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Pyridine Compounds (AREA)
Abstract
La presente invención describe una composición de gel conteniendo Pirfenidona, que ofrece ventajas sobre otras formas farmacéuticas de administración cutánea conocidas en el estado de la técnica, que es útil en el tratamiento para la restauración de los tejidos con lesiones fibróticas y para la prevención de lesiones fibróticas. 1.- Una composición de gel conteniendo Pirfenidone caracterizada porque comprende del 2 al 12% de Pirfenidona, de 0.4 a 1.2% de un agente de viscosidad, de 10 al 30% de un solubizante, del 5 al 15% de un solubilizante no iónico, de 0.2 al 1% de un conservador, del 0.4 al 1.2% de un agente neutralizante y el resto de agua purificada. 2.- La composición de la reivindicación 1, caracterizada porque comprende Pirfenidona 8%; 0.5 de un agente de viscosidad, 20% de un solubizante, 11.5% de un solubilizante no iónico, 0.5% de un conservador, 0.5% de un agente neutralizante y el resto de agua purificada. 3.- La composición de la reivindicación 1, caracterizada porque el agente de viscosidad se selecciona de Carbomero 940 (MR); Ultrex 10(MR), derivados de celulosa; gomas; polioxameros; el solubilizante se selecciona de metil pirrolidona; alcohol etílico y propilenglicol; el conservador se selecciona del grupo que consiste de diazolidinilurea, iodopropinilbutilcarbamato; metilparabeno, propilparabeno y mezclas de los mismos; el agente neutralizante es seleccionado del grupo de aminas alifáticas primaria, secundarias o terciarias del tipo de la mono-, di- y trietanolamina, y de los hidróxidos de metales alcalinos, como el hidróxido de sodio. 4.- La composición de la reivindicación 1, caracterizada porque el agente de viscosidad es Carbomero 940 (MR); el solubilizante es N-metilpirrolidona; el conservador es diazolidinilurea y iodopropinilbutilcarbamato; el agente neutralizante es trietanoalamina.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2007009796A MX2007009796A (es) | 2007-08-14 | 2007-08-14 | Gel conteniendo pirfenidona. |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6180448A2 true CO6180448A2 (es) | 2010-07-19 |
Family
ID=40350871
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO10015040A CO6180448A2 (es) | 2007-08-14 | 2010-02-11 | Gel conteniendo pirfenidona |
Country Status (14)
Country | Link |
---|---|
US (5) | US8492412B2 (es) |
EP (1) | EP2177220B1 (es) |
JP (1) | JP5542053B2 (es) |
KR (1) | KR101235968B1 (es) |
CN (2) | CN104771355A (es) |
BR (1) | BRPI0815203B8 (es) |
CA (1) | CA2696335C (es) |
CO (1) | CO6180448A2 (es) |
EC (1) | ECSP109960A (es) |
HK (1) | HK1211464A1 (es) |
MX (1) | MX2007009796A (es) |
SG (1) | SG183732A1 (es) |
WO (1) | WO2009022899A1 (es) |
ZA (1) | ZA201000918B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2007009796A (es) | 2007-08-14 | 2009-02-25 | Cell Therapy And Technology S | Gel conteniendo pirfenidona. |
CN102099036B (zh) | 2008-06-03 | 2015-05-27 | 英特芒尼公司 | 用于治疗炎性疾患和纤维化疾患的化合物和方法 |
CN101972225A (zh) * | 2010-10-13 | 2011-02-16 | 北京诚创康韵医药科技有限公司 | 一种含吡非尼酮的凝胶组合物 |
AU2012212269B2 (en) | 2011-01-31 | 2016-05-19 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
US10105356B2 (en) | 2011-01-31 | 2018-10-23 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
MX2011007675A (es) | 2011-07-19 | 2012-07-11 | Cell Therapy And Technology S A De C V | Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas. |
MX346763B (es) * | 2012-03-28 | 2017-03-31 | Cell Therapy And Tech S A De C V | Composición tópica semisólida conteniendo pirfenidona y dialil óxido de disulfuro modificado (odd-m) para eliminar o prevenir el acné. |
MX356551B (es) | 2012-08-23 | 2018-06-04 | Grupo Medifarma S A De C V Star | Composición antiséptica, antiseborreica y exfoliante para eliminar o prevenir el acné. |
AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
NZ722927A (en) | 2014-01-10 | 2022-07-29 | Avalyn Pharma Inc | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
CN110452216B (zh) | 2014-04-02 | 2022-08-26 | 英特穆恩公司 | 抗纤维化吡啶酮类 |
MX366086B (es) | 2017-08-15 | 2019-06-27 | Cell Therapy And Tech S A De C V | Composicion topica semisolida conteniendo un agente antimicrobiano y pirfenidona para el tratamiento de daños cronicos de la piel. |
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TWI770157B (zh) | 2017-04-10 | 2022-07-11 | 德商拜耳廠股份有限公司 | 經取代之n-芳基乙基-2-胺基喹啉-4-甲醯胺及其用途 |
MX366086B (es) | 2017-08-15 | 2019-06-27 | Cell Therapy And Tech S A De C V | Composicion topica semisolida conteniendo un agente antimicrobiano y pirfenidona para el tratamiento de daños cronicos de la piel. |
MX368750B (es) | 2018-08-31 | 2019-10-15 | Cell Therapy And Tech S A De C V | Composiciones farmaceuticas semisolidas de base oleosa conteniendo pirfenidona para su aplicacion en la reparacion tisular. |
EP4135671A1 (en) | 2020-04-14 | 2023-02-22 | Excalibur Pharmaceuticals, Inc. | Pirfenidone for coronavirus treatment |
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2007
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2008
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CA2696335A1 (en) | 2009-02-19 |
JP5542053B2 (ja) | 2014-07-09 |
MX2007009796A (es) | 2009-02-25 |
SG183732A1 (en) | 2012-09-27 |
JP2010536747A (ja) | 2010-12-02 |
BRPI0815203B8 (pt) | 2021-05-25 |
US8492412B2 (en) | 2013-07-23 |
US20130245073A1 (en) | 2013-09-19 |
US20200016138A1 (en) | 2020-01-16 |
KR20100040319A (ko) | 2010-04-19 |
BRPI0815203B1 (pt) | 2020-05-05 |
CA2696335C (en) | 2014-03-04 |
WO2009022899A8 (es) | 2009-09-11 |
EP2177220A4 (en) | 2013-09-11 |
US20220016096A1 (en) | 2022-01-20 |
CN104771355A (zh) | 2015-07-15 |
US11779574B2 (en) | 2023-10-10 |
US10376500B2 (en) | 2019-08-13 |
HK1211464A1 (en) | 2016-05-27 |
ECSP109960A (es) | 2010-04-30 |
ZA201000918B (en) | 2011-04-28 |
EP2177220A1 (en) | 2010-04-21 |
US11083719B2 (en) | 2021-08-10 |
EP2177220B1 (en) | 2019-05-29 |
KR101235968B1 (ko) | 2013-02-21 |
CN101808641A (zh) | 2010-08-18 |
US20110224265A1 (en) | 2011-09-15 |
WO2009022899A1 (es) | 2009-02-19 |
US20170216268A1 (en) | 2017-08-03 |
BRPI0815203A2 (pt) | 2017-03-28 |
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