CO6160223A2 - Un proceso novedoso para preparar ester de acido 3-amino-5-fluoro-4-dialcoxipentanoico - Google Patents

Un proceso novedoso para preparar ester de acido 3-amino-5-fluoro-4-dialcoxipentanoico

Info

Publication number
CO6160223A2
CO6160223A2 CO09015064A CO09015064A CO6160223A2 CO 6160223 A2 CO6160223 A2 CO 6160223A2 CO 09015064 A CO09015064 A CO 09015064A CO 09015064 A CO09015064 A CO 09015064A CO 6160223 A2 CO6160223 A2 CO 6160223A2
Authority
CO
Colombia
Prior art keywords
compound
formula
group
dialcoxipentanoico
fluoro
Prior art date
Application number
CO09015064A
Other languages
English (en)
Inventor
Hyun Ik Shin
Hyeong Wook Choi
Jae-Hoon Lee
Kyu-Woong Lee
Original Assignee
Lg Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Life Sciences Ltd filed Critical Lg Life Sciences Ltd
Publication of CO6160223A2 publication Critical patent/CO6160223A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/10—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/20—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C07C41/50—Preparation of compounds having groups by reactions producing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

1.- Un proceso para producir un compuesto de la fórmula 6, caracterizado porque comprende las siguientes etapas: (a) preparar un compuesto de la fórmula 4 al desproteger un compuesto de la fórmula 3; (b) preparar un compuesto de la fórmula 9 al hacer reaccionar el compuesto de la fórmula 4 con R1OC(=O)OR3; y (c) hacer reaccionar el compuesto de la fórmula 9 con NH(R4)(R5);en donde, R1 y R3 independientemente representan un grupo alquilo;R2 independientemente representa un grupo alquilo, o junto con el átomo de oxígeno al cual están unidos puede formar dioxolano o dioxano;R4 y R5 independientemente representan hidrógeno, un grupo trialquilsililo, un grupo arilmetilo o un grupo 1-ariletilo, y P representa un grupo protector.2.- El proceso de conformidad con la reivindicación 1, caracterizado porque la etapa (a) se lleva a cabo en la presencia de una o más bases seleccionadas del grupo que consiste de M1OH, M2(OH)2, (M1)2CO3, (M1)HCO3 y M2CO3, en donde M1 representa un metal alcalino, y M2 representa un metal alcalinotérreo.
CO09015064A 2006-08-16 2009-02-16 Un proceso novedoso para preparar ester de acido 3-amino-5-fluoro-4-dialcoxipentanoico CO6160223A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020060077360A KR101299720B1 (ko) 2006-08-16 2006-08-16 3-아미노-5-플루오로-4-디알콕시펜탄산 에스테르의 새로운제조방법

Publications (1)

Publication Number Publication Date
CO6160223A2 true CO6160223A2 (es) 2010-05-20

Family

ID=39082197

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09015064A CO6160223A2 (es) 2006-08-16 2009-02-16 Un proceso novedoso para preparar ester de acido 3-amino-5-fluoro-4-dialcoxipentanoico

Country Status (13)

Country Link
US (1) US7906676B2 (es)
EP (1) EP2051959A4 (es)
JP (1) JP4956614B2 (es)
KR (1) KR101299720B1 (es)
CN (1) CN101506146B (es)
AU (1) AU2007285155B2 (es)
BR (1) BRPI0716662A2 (es)
CA (1) CA2660348C (es)
CO (1) CO6160223A2 (es)
EA (1) EA016854B1 (es)
MX (1) MX2009001508A (es)
NZ (1) NZ574792A (es)
WO (1) WO2008020691A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106008245A (zh) * 2016-05-31 2016-10-12 北京华清科创科技开发有限公司 基于触媒法的氨基酮戊酸的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5770847A (en) * 1980-10-21 1982-05-01 Microbial Chem Res Found Preparation of 3-aminoglutaric acid dialkyl ester
DE3343531A1 (de) * 1983-12-01 1985-06-13 Bayer Ag, 5090 Leverkusen Substituierte acetylenketone
JPS6191160A (ja) * 1984-10-09 1986-05-09 Nisshin Flour Milling Co Ltd Ｌ−カルニチンの製造法
JP2620533B2 (ja) * 1985-12-28 1997-06-18 住友製薬株式会社 新規なアミノ酸誘導体
JPH0742258B2 (ja) * 1989-04-14 1995-05-10 宇部興産株式会社 ３―置換アミノアクリル酸エステル類の製造法
JP2891740B2 (ja) * 1990-03-30 1999-05-17 塩野義製薬株式会社 光学活性ノルボルナン系アミン誘導体の製造方法
US6200969B1 (en) 1996-09-12 2001-03-13 Idun Pharmaceuticals, Inc. Inhibition of apoptosis using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors
ATE221517T1 (de) * 1997-11-07 2002-08-15 Solvay Fluor & Derivate Herstellung von aminohalogencrotonaten
ATE295177T1 (de) 1998-03-16 2005-05-15 Cytovia Inc Dipeptid kaspase inhibitoren und deren verwendung
JP3632069B2 (ja) * 1999-09-03 2005-03-23 国立大学法人東北大学 含フッ素モノマーおよびその合成方法
US6566338B1 (en) 1999-10-12 2003-05-20 Cytovia, Inc. Caspase inhibitors for the treatment and prevention of chemotherapy and radiation therapy induced cell death
EP1463699A2 (en) * 2001-07-03 2004-10-06 ALTANA Pharma AG Process for the production of 3-phenylisoserine
US7553841B2 (en) * 2003-03-18 2009-06-30 Merck & Co., Inc. Amino cyclobutylamide modulators of chemokine receptor activity
KR100594544B1 (ko) * 2003-08-27 2006-06-30 주식회사 엘지생명과학 이소옥사졸린 구조를 갖는 캐스파제 저해제
AU2005264036A1 (en) * 2004-07-09 2006-01-26 Warner-Lambert Company Llc Preparation of beta-amino acids having affinity for the alpha-2-delta protein
KR100774999B1 (ko) * 2005-02-26 2007-11-09 주식회사 엘지생명과학 이소옥사졸린 유도체 및 그의 제조 방법

Also Published As

Publication number Publication date
KR20080015692A (ko) 2008-02-20
KR101299720B1 (ko) 2013-08-28
MX2009001508A (es) 2009-02-18
CN101506146A (zh) 2009-08-12
WO2008020691A1 (en) 2008-02-21
BRPI0716662A2 (pt) 2013-09-17
NZ574792A (en) 2011-12-22
EP2051959A4 (en) 2011-04-13
AU2007285155B2 (en) 2012-05-31
JP4956614B2 (ja) 2012-06-20
CA2660348A1 (en) 2008-02-21
EP2051959A1 (en) 2009-04-29
US7906676B2 (en) 2011-03-15
JP2010500403A (ja) 2010-01-07
CN101506146B (zh) 2013-06-12
CA2660348C (en) 2013-03-12
EA200970203A1 (ru) 2009-08-28
AU2007285155A1 (en) 2008-02-21
EA016854B1 (ru) 2012-08-30
US20100036158A1 (en) 2010-02-11

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