CO6150175A2 - Compuesto triciclico y uso farmaceutico del mismo - Google Patents

Compuesto triciclico y uso farmaceutico del mismo

Info

Publication number
CO6150175A2
CO6150175A2 CO09003953A CO09003953A CO6150175A2 CO 6150175 A2 CO6150175 A2 CO 6150175A2 CO 09003953 A CO09003953 A CO 09003953A CO 09003953 A CO09003953 A CO 09003953A CO 6150175 A2 CO6150175 A2 CO 6150175A2
Authority
CO
Colombia
Prior art keywords
optionally
substituents
possesses
ring
same
Prior art date
Application number
CO09003953A
Other languages
English (en)
Inventor
Osamu Uchikawa
Tatsuki Koike
Yasutaka Hoashi
Takafumi Takai
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of CO6150175A2 publication Critical patent/CO6150175A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1.- Un compuesto caracterizado porque está representado por la fórmula:en la cual R1 es un grupo hidrocarburo que opcionalmente posee uno o más sustituyentes, amino que opcionalmente posee uno o más sustituyentes, hidroxi que opcionalmente posee un sustituyente o un grupo heterocíclico que opcionalmente posee uno o más sustituyentes; R5 es un átomo de hidrógeno, un átomo de halógeno, un grupo hidrocarburo que opcionalmente posee uno o más sustituyentes, amino que opcionalmente posee uno o más sustituyentes, hidroxi que opcionalmente posee un sustituyente o mercapto que opcionalmente posee un sustituyente; R6 es un átomo de hidrógeno o un grupo hidrocarburo que opcionalmente posee uno o más sustituyentes; X es un átomo de oxigeno o un átomo de azufre; m es 0, 1 o 2; el anillo A es un anillo de 5 miembros que opcionalmente posee uno o más sustituyentes; el anillo B es un anillo de 6 miembros que opcionalmente posee uno o más sustituyentes; el anillo C es un anillo de 5 miembros que opcionalmente posee uno o más sustituyentes; en tanto - - - - - - - - - muestra un enlace simple o un enlace doble, o una sal del mismo.
CO09003953A 2006-06-19 2009-01-19 Compuesto triciclico y uso farmaceutico del mismo CO6150175A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2006168518 2006-06-19

Publications (1)

Publication Number Publication Date
CO6150175A2 true CO6150175A2 (es) 2010-04-20

Family

ID=38519675

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09003953A CO6150175A2 (es) 2006-06-19 2009-01-19 Compuesto triciclico y uso farmaceutico del mismo

Country Status (36)

Country Link
US (5) US8030337B2 (es)
EP (1) EP2029561B1 (es)
JP (1) JP5222737B2 (es)
KR (1) KR101442274B1 (es)
CN (1) CN101506181B (es)
AR (1) AR061478A1 (es)
AU (1) AU2007261953B2 (es)
BR (1) BRPI0713743C1 (es)
CA (1) CA2655753C (es)
CL (1) CL2007001779A1 (es)
CO (1) CO6150175A2 (es)
CR (1) CR10524A (es)
CY (1) CY1115729T1 (es)
DK (1) DK2029561T3 (es)
ES (1) ES2523410T3 (es)
GE (1) GEP20125392B (es)
HK (1) HK1130049A1 (es)
HR (1) HRP20141046T1 (es)
IL (1) IL195639A0 (es)
JO (1) JO2999B1 (es)
MA (1) MA30523B1 (es)
ME (2) ME00582A (es)
MX (1) MX2008015842A (es)
MY (1) MY158069A (es)
NO (1) NO341739B1 (es)
NZ (1) NZ574037A (es)
PE (1) PE20080941A1 (es)
PL (1) PL2029561T3 (es)
PT (1) PT2029561E (es)
RS (1) RS53616B1 (es)
RU (1) RU2456278C2 (es)
SI (1) SI2029561T1 (es)
TW (1) TWI402261B (es)
UA (1) UA99104C2 (es)
WO (1) WO2007148808A1 (es)
ZA (1) ZA200900151B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI402261B (zh) * 2006-06-19 2013-07-21 Takeda Pharmaceutical 三環化合物及其醫藥組成物
US8247429B2 (en) * 2006-12-28 2012-08-21 Takeda Pharmaceutical Company Limited Tricyclic compound and pharmaceutical use thereof
CN103450111B (zh) * 2013-09-04 2015-07-08 温州大学 一种苯并噻唑杂环化合物的绿色合成方法
US20160253891A1 (en) * 2015-02-27 2016-09-01 Elwha Llc Device that determines that a subject may contact a sensed object and that warns of the potential contact
AU2017205722B2 (en) * 2016-01-08 2022-02-17 Takeda Pharmaceutical Company Limited Prophylactic or therapeutic agent for autism spectrum disorder
WO2017119456A1 (ja) 2016-01-08 2017-07-13 武田薬品工業株式会社 せん妄の予防または治療剤
BR112019007964A2 (pt) 2016-10-19 2019-07-02 Monsanto Technology Llc composições e métodos para alterar a floração e arquitetura vegetal para aprimorar o potencial de rendimento

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1292226C (en) * 1986-01-16 1991-11-19 Terumi Hachiya Indenothiazole derivative and process for preparing the same
FR2680366B1 (fr) * 1991-08-13 1995-01-20 Adir Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5654325A (en) 1993-11-18 1997-08-05 Eli Lilly And Company Melatonin derivatives for use in treating sleep disorders
US6180657B1 (en) 1993-11-18 2001-01-30 Eli Lilly And Company Melatonin derivatives for use in treating desynchronization disorders
FR2725985B1 (fr) * 1994-10-21 1996-11-15 Adir Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE19502895A1 (de) 1995-01-31 1996-08-01 Merck Patent Gmbh 4-Mercapto-benzoylguanidin-Derivate
US5596019A (en) * 1995-06-07 1997-01-21 Bristol-Myers Squibb Company N-acyl-cycloalkylamine derivatives as melatonergics
US5753709A (en) * 1995-06-07 1998-05-19 Bristol-Myers Squibb Company N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics
CA2176854A1 (en) 1995-06-07 1996-12-08 Daniel J. Keavy N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics
FR2742153B1 (fr) 1995-12-12 1998-02-13 Innothera Lab Sa Utilisation de derives tricycliques du 1,4-dihydro-1,4- dioxo-1h-naphtalene, nouveaux composes obtenus et leur application en therapeutique
HU224220B1 (hu) * 1996-03-08 2005-06-28 Takeda Pharmaceutical Company Limited Triciklusos vegyületek, eljárás előállításukra és alkalmazásuk
US6034239A (en) 1996-03-08 2000-03-07 Takeda Chemical Industries, Ltd. Tricyclic compounds, their production and use
SE9802360D0 (sv) * 1998-07-01 1998-07-01 Wikstroem Hakan Vilhelm New 2-aminothiazol-fused 2-aminoindans and 2-aminotetralins ((basic)-N-substituted and (basic)-N,N-disubstituted derivatives of 2,6-diamino-thiazolo(4,5-f)indan and 2,7-di-amino-thiazolo(4,5-g)tetralin
DE60043017D1 (de) * 1999-08-20 2009-11-05 Takeda Pharmaceutical Zusammensetzung für perkutane Absorption mit einem melantoninrezeptor-agonistisch wirkendem Wirkstoff
CA2428817C (en) * 2000-11-17 2010-06-01 Takeda Chemical Industries, Ltd. Copolyvidone-containing preparation
JP3633895B2 (ja) * 2000-11-17 2005-03-30 武田薬品工業株式会社 コポリビドン含有製剤
US6569894B1 (en) 2001-10-04 2003-05-27 Bristol-Myers Squibb Company Arylalkylbenzofuran derivatives as melatonergic agents
US6737431B2 (en) * 2002-03-12 2004-05-18 Bristol-Myers Squibb Company Benzoxazole derivatives as novel melatonergic agents
US20050197365A1 (en) * 2004-02-27 2005-09-08 Jeffrey Sterling Diamino thiazoloindan derivatives and their use
US20060223877A1 (en) 2005-03-31 2006-10-05 Zemlan Frank P Methods of treatment utilizing certain melatonin derivatives
TWI402261B (zh) * 2006-06-19 2013-07-21 Takeda Pharmaceutical 三環化合物及其醫藥組成物

Also Published As

Publication number Publication date
US8030337B2 (en) 2011-10-04
ES2523410T3 (es) 2014-11-25
NO20090234L (no) 2009-02-12
ME00582A (en) 2011-12-20
CN101506181B (zh) 2011-12-07
RS53616B1 (en) 2015-04-30
BRPI0713743C1 (pt) 2021-05-25
BRPI0713743B1 (pt) 2020-03-17
CY1115729T1 (el) 2017-01-25
AR061478A1 (es) 2008-08-27
HRP20141046T1 (hr) 2014-12-19
EP2029561A1 (en) 2009-03-04
US20110196003A1 (en) 2011-08-11
UA99104C2 (uk) 2012-07-25
GEP20125392B (en) 2012-02-10
RU2009101299A (ru) 2010-07-27
CA2655753C (en) 2015-08-04
TWI402261B (zh) 2013-07-21
PL2029561T3 (pl) 2015-03-31
AU2007261953B2 (en) 2012-11-08
TW200815376A (en) 2008-04-01
DK2029561T3 (da) 2014-11-10
NZ574037A (en) 2011-10-28
US20130079374A1 (en) 2013-03-28
US8895591B2 (en) 2014-11-25
RU2456278C2 (ru) 2012-07-20
KR101442274B1 (ko) 2014-09-22
KR20090023701A (ko) 2009-03-05
US8552037B2 (en) 2013-10-08
ME01998B (me) 2015-05-20
BRPI0713743B8 (pt) 2020-05-19
MY158069A (en) 2016-08-30
MX2008015842A (es) 2009-01-09
CL2007001779A1 (es) 2008-01-04
NO341739B1 (no) 2018-01-15
CA2655753A1 (en) 2007-12-27
CR10524A (es) 2009-01-27
SI2029561T1 (sl) 2014-11-28
JO2999B1 (ar) 2016-09-05
BRPI0713743A2 (pt) 2012-11-06
PT2029561E (pt) 2014-11-12
US8349879B2 (en) 2013-01-08
ZA200900151B (en) 2010-03-31
JP2009541202A (ja) 2009-11-26
MA30523B1 (fr) 2009-06-01
WO2007148808A1 (en) 2007-12-27
JP5222737B2 (ja) 2013-06-26
HK1130049A1 (en) 2009-12-18
PE20080941A1 (es) 2008-09-04
EP2029561B1 (en) 2014-08-13
US20110190361A1 (en) 2011-08-04
IL195639A0 (en) 2009-09-01
AU2007261953A1 (en) 2007-12-27
US20140011849A1 (en) 2014-01-09
US20090182023A1 (en) 2009-07-16
CN101506181A (zh) 2009-08-12
US8236837B2 (en) 2012-08-07

Similar Documents

Publication Publication Date Title
CO6150175A2 (es) Compuesto triciclico y uso farmaceutico del mismo
PE20190711A1 (es) N-(fenils ulfonil) benzamidas y compuestos relacionados como inhibidores de bcl-2
EA201070786A1 (ru) Бензофуропиримидиноны
ES2422299T3 (es) Indoles (4,5-dihidro) indoles tricíclicos
CL2007002167A1 (es) Compuestos derivados de indol, antagonistas iap; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento de cancer.
AR064735A1 (es) Agonistas de gpcr y composicion farmaceutica en base al compuesto
AR074435A1 (es) Derivados de 1,3-benzotiazol, medicamentos que los contienen y uso de los mismos en el tratamiento del cancer.
ECSP099371A (es) INHIBIDORES ESPIRO CETONA DE ACETIL-CoA CARBOXILASA
GT200600125A (es) Nueva sal y polimorfos del inhibidor de la dpp-iv
CO6220878A2 (es) Composicion herbicida que comprende un derivado de isoxazolina o una sal del mismo
ATE479687T1 (de) Kinaseinhibitoren
ECSP10010060A (es) Derivados de pirazol sustituídos
UY32840A (es) Compuestos fungicidas basados en heterociclos que contienen nitrógeno sustituidos con un anillo aromático de seis miembros
PE20130306A1 (es) Morfolinopirimidinas y su uso en terapia
EA200700982A1 (ru) Производные хинолина и изохинолина, замещённые в 5-ом положении, способ их получения и их применение в качестве противовоспалительных средств
AR074902A1 (es) Derivados de 1,2,4-oxadiazoles agonistas de receptores s1p1
ATE553106T1 (de) Heteroarylpyrrolopyridinone als kinaseinhibitoren
TW200740776A (en) N-phenylbenzotriazolyl c-kit inhibitors
CY1114735T1 (el) Θεραπευτικες συνθεσεις οι οποιες περιεχουν εναν ειδικο ανταγωνιστη του υποδοχεα της ενδοθηλινης και εναν αναστολεα της pde5
PH12016502358A1 (en) Novel pyrrolidine compound and application as melanocortin receptor agonist
UY31712A1 (es) Nuevos derivados de diosmetina, su procedimiento de preparacion y las composiciones farmacéuticas que los contienen
DOP2006000234A (es) Inhibidores de cinasa
ATE459620T1 (de) Benzimidazolthiophenverbindungen als plk- modulatoren
UY30009A1 (es) Compuestos benzoilpirazol y herbicidas que los contienen
DE602005010744D1 (de) Piperazinylpyridinderivate als mittel gegen adipositas