ES2422299T3 - Indoles (4,5-dihidro) indoles tricíclicos - Google Patents

Indoles (4,5-dihidro) indoles tricíclicos

Info

Publication number
ES2422299T3
ES2422299T3 ES07847308T ES07847308T ES2422299T3 ES 2422299 T3 ES2422299 T3 ES 2422299T3 ES 07847308 T ES07847308 T ES 07847308T ES 07847308 T ES07847308 T ES 07847308T ES 2422299 T3 ES2422299 T3 ES 2422299T3
Authority
ES
Spain
Prior art keywords
formula
group
hydrogen atom
aryl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES07847308T
Other languages
English (en)
Inventor
Ermes Vanotti
Marina Caldarelli
Francesco Casuscelli
Barbara Forte
Maria Menichincheri
Alessandra Scolaro
Gabriella Traquandi
Paola Vianello
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nerviano Medical Sciences SRL
Original Assignee
Nerviano Medical Sciences SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nerviano Medical Sciences SRL filed Critical Nerviano Medical Sciences SRL
Application granted granted Critical
Publication of ES2422299T3 publication Critical patent/ES2422299T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un compuesto de la fórmula (I): **Fórmula** en la que el anillo A representa un heterociclo condensado de la fórmula IIa, IIb, III o IV: **Fórmula** R1 representa un átomo de hidrógeno o un grupo opcionalmente sustituido seleccionado de grupo alquilo,cicloalquilo, alquenilo, alquinilo, heterociclilo, arilo, heterocicliloxi-alquilo y alcoxicarbonilo; R2 es átomo de hidrógeno o de halógeno o un grupo de fórmula -COOR5 o -CONHR5, donde R5 representa uno delos significados definidos antes para R1, o un grupo arilo o heterociclilo opcionalmente sustituido; R3 es átomo de hidrógeno o un grupo de fórmula - CHO, -COOR5 o-CONHR5, donde R5 es como se ha definidoantes; R4 es átomo de hidrógeno o NHR6, donde R6 es átomo de hidrógeno o un grupo alquilo, arilo o heterocicliloopcionalmente sustituido.
ES07847308T 2006-11-28 2007-11-23 Indoles (4,5-dihidro) indoles tricíclicos Active ES2422299T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06124947 2006-11-28
PCT/EP2007/062762 WO2008065054A1 (en) 2006-11-28 2007-11-23 Tricyclic indoles and (4,5-dihydro) indoles

Publications (1)

Publication Number Publication Date
ES2422299T3 true ES2422299T3 (es) 2013-09-10

Family

ID=38921744

Family Applications (1)

Application Number Title Priority Date Filing Date
ES07847308T Active ES2422299T3 (es) 2006-11-28 2007-11-23 Indoles (4,5-dihidro) indoles tricíclicos

Country Status (5)

Country Link
US (1) US8207180B2 (es)
EP (1) EP2118102B1 (es)
JP (1) JP5284973B2 (es)
ES (1) ES2422299T3 (es)
WO (1) WO2008065054A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7974235B2 (en) * 2006-11-13 2011-07-05 Telecommunication Systems, Inc. Secure location session manager
US8084621B2 (en) * 2006-12-04 2011-12-27 Jiangsu Simcere Pharmaceutical R&D Co. Ltd. 3-Pyrrolo[b]cyclohexylene-2-dihydroindolinone derivatives and uses thereof
JP5337717B2 (ja) * 2007-02-27 2013-11-06 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ キナーゼ阻害剤として活性なイソキノリノピロロピリジノン
DE102008027331A1 (de) * 2008-06-07 2009-12-10 Friedrich-Alexander-Universität Erlangen-Nürnberg Verwendung von Indol-3-carbonsäureestern zur Hemmung der mikrosomalen Prostaglandin E2 Synthase
EP2417125B1 (en) * 2009-03-27 2015-09-09 Nerviano Medical Sciences S.r.l. N-aryl-2-(2-arylaminopyrimidin-4-yl)pyrrol-4-carboxamide derivatives as mps1 kinase inhibitors
ES2527363T3 (es) * 2009-12-04 2015-01-22 Nerviano Medical Sciences S.R.L. Derivados de triciclopirazol
WO2011130654A1 (en) * 2010-04-16 2011-10-20 Genentech, Inc. Fox03a as predictive biomarker for pi3k/akt kinase pathway inhibitor efficacy
RU2591191C2 (ru) * 2011-01-26 2016-07-10 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. Трициклические пирроло производные, способ их получения и их применение в качестве ингибиторов киназы
US8916577B2 (en) * 2011-01-26 2014-12-23 Nerviano Medical Sciences S.R.L. Tricyclic derivatives, process for their preparation and their use as kinase inhibitors
CA2850551A1 (en) 2011-09-30 2013-04-04 Endo Pharmaceuticals Inc. Pyridine derivatives
US8809372B2 (en) 2011-09-30 2014-08-19 Asana Biosciences, Llc Pyridine derivatives
EP2825889A4 (en) 2012-03-14 2015-10-28 Salk Inst For Biological Studi ADENOVIRAL TUMOR DIAGNOSIS
AU2014236207B2 (en) 2013-03-14 2019-05-23 Salk Institute For Biological Studies Oncolytic adenovirus compositions
WO2015115355A1 (ja) 2014-01-31 2015-08-06 カルナバイオサイエンス株式会社 抗がん剤組成物
PL3129374T3 (pl) 2014-04-07 2019-07-31 Netherlands Translational Research Center B.V. (5,6-Dihydro)pirymido[4,5-e]indolizyny
CN108026110B (zh) 2015-08-26 2022-02-08 国家公共部门基金会卡洛斯三世国家癌症研究中心(F.S.P.Cnio) 作为蛋白激酶抑制剂的稠合三环化合物
ES2933174T3 (es) 2016-02-23 2023-02-02 Salk Inst For Biological Studi Expresión génica exógena en adenovirus terapéutico para mínimo impacto sobre la cinética viral
EP3390428B1 (en) 2016-02-23 2019-09-25 Salk Institute for Biological Studies High throughput assay for measuring adenovirus replication kinetics
US10654868B2 (en) * 2016-06-16 2020-05-19 Harbin Zhenbao Pharmaceutical Co., Ltd. Dihydropyrazole azepine compound serving as Akt inhibitor
CN110062630A (zh) 2016-12-12 2019-07-26 萨克生物研究学院 肿瘤靶向合成腺病毒及其用途
CN107383019B (zh) * 2017-07-28 2019-10-15 江苏艾凡生物医药有限公司 吡唑并[4,3-h]喹唑啉类化合物及其用途
KR102394934B1 (ko) * 2017-12-13 2022-05-04 하얼빈 젠바오 파마슈티컬 컴퍼니, 리미티드 Akt 억제제로서의 염 형태 및 이의 결정 형태

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070054916A1 (en) * 2004-10-01 2007-03-08 Amgen Inc. Aryl nitrogen-containing bicyclic compounds and methods of use

Also Published As

Publication number Publication date
US8207180B2 (en) 2012-06-26
EP2118102A1 (en) 2009-11-18
JP2010527324A (ja) 2010-08-12
JP5284973B2 (ja) 2013-09-11
WO2008065054A1 (en) 2008-06-05
EP2118102B1 (en) 2013-06-12
US20100075998A1 (en) 2010-03-25

Similar Documents

Publication Publication Date Title
ES2422299T3 (es) Indoles (4,5-dihidro) indoles tricíclicos
PE20130155A1 (es) Derivados de ariletinilo
PE20200388A1 (es) Amidas heterociclicas de 5 miembros y biciclicas como inhibidores de rock
SV2010003459A (es) Derivados de pirimidina 934
NI200700242A (es) Derivados de cumarina sustituidos con tiadiazol y sus usos como inhibidores de la biosíntesis de leucotrienos.
CO6180506A2 (es) Inhibidores de la proteasa ns3 del hcv
AR058562A1 (es) Derivados de pirimido [4,5 b] (1,4) oxazinas , procedimientos de obtencion y su uso como inhibidores de acetil coa y dgat 1
CO6231035A2 (es) Novedoso compuesto heteromonociclico que tiene propiedades superiores como agente farmaceutico
PE20130375A1 (es) Compuestos de triazolopiridinas y triazolopirazinas inhibidores de c-met y composiciones de los mismos
CR20110049A (es) Derivados de benzazepina y su uso como antagonistas de histamina h3
AR079334A1 (es) Derivados de oxazin amino
CO6321130A2 (es) Piridinas carboxamidas como inhibidores de la 11 beta-hsd1
GT200500286A (es) Analogos de anilino-pirimidina
PE20121506A1 (es) Compuestos triazolopiridinas como inhibidores de c-met
PE20121312A1 (es) Metodo para preparar compuestos macrociclicos inhibidores de serina proteasas de hepatitis c
ECSP088559A (es) Derivados de pirimidina
SV2009003373A (es) COMPUESTOS AMINO-5-[-4-(DIFLUOROMETOXI)FENIL SUSTITUIDO]-5- FENILIMIDAZOLONA COMO INHIBIDORES DE ß-SECRETASA REF. AM102759
CO6321282A2 (es) Derivados de piperidinilindol como inhibidores de aldosterona sintasa
AR074435A1 (es) Derivados de 1,3-benzotiazol, medicamentos que los contienen y uso de los mismos en el tratamiento del cancer.
EA200971101A1 (ru) Соединения на основе лантибиотиков, обладающие противомикробной активностью
CO6220949A2 (es) Derivados pirazolicos como inhibidores de la 11 beta -hsd1
ECSP11010770A (es) Compuesto heterocíclico y su uso
CO6362009A2 (es) Derivados de morfolinopurina
PE20090601A1 (es) Derivados de piridin-il-oxi-piridinas como inhibidores de alk5
CY1110010T1 (el) Πυριδιναμινοσουλφονυλ υποκατεστημενα βενζαμιδια ως αναστολεις κυτοχρωματος ρ450 3α4 (cyp3a4)