AR074902A1 - Derivados de 1,2,4-oxadiazoles agonistas de receptores s1p1 - Google Patents

Derivados de 1,2,4-oxadiazoles agonistas de receptores s1p1

Info

Publication number
AR074902A1
AR074902A1 ARP090105087A ARP090105087A AR074902A1 AR 074902 A1 AR074902 A1 AR 074902A1 AR P090105087 A ARP090105087 A AR P090105087A AR P090105087 A ARP090105087 A AR P090105087A AR 074902 A1 AR074902 A1 AR 074902A1
Authority
AR
Argentina
Prior art keywords
group
groups
alkyl
hydrogen atom
optionally substituted
Prior art date
Application number
ARP090105087A
Other languages
English (en)
Inventor
Riera Marta Carrascal
Figueras Aranzazu Cardus
Izquierdo Nuria Aguilar
Pou Silvia Fonquerna
Palomino Laria Julio Cesar Castro
Sola Montserrat Erra
Cepeda Marta Mir
Matassa Victor Giulio
Original Assignee
Almirall Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Sa filed Critical Almirall Sa
Publication of AR074902A1 publication Critical patent/AR074902A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Reivindicación 1: Un compuesto de fórmula general (1), o una sal farmacéuticamente aceptable o N-óxido del mismo: Fórmula (1). Donde: (i) A se selecciona del grupo que consiste en -N-, -O- y -S-; B y C se seleccionan independientemente del grupo que consiste en -N- y -O-, con la condición de que dos de A, B y C sean átomos de nitrógeno; o (ii) dos de A, B y C son -N- y uno de A, B, y C es -NH-; G1 se selecciona del grupo que consiste en -CH2-, -NH- y -O-; G2 se selecciona del grupo que consiste en -NR4- y -O-; R1 representa: - un grupo heteroarilo que contiene N, bicílico, de 8 a 10 miembros, opcionalmente sustituido con un grupo carboxialquiIo C1-4 o un grupo aminoalquilo C1-4, - un grupo piridilo opcionalmente sustituido con uno o más sustituyentes seleccionados de grupos hidroxi, grupos alquilo C1-4, grupos carboxialquilo C1-4, grupos haloalquilo C1-4, grupos alcoxi C1-4, grupos amino, grupos aminoalquilo C1-4 y grupos aminoalcoxi C1-4, - un grupo piridona sustituido con uno o más grupos alquilo C1-4; grupos haloalquilo C1-4 o grupos aminoalquilo C1-4, o un grupo de fórmula (2) donde: - Ra representa un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo C1-4 , un grupo cicloalquilo C3-4 o un grupo -CF3; - Rb representa un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo C1-4, un grupo -CF3 o un grupo alcoxi C1-4; - Rd representa un átomo de hidrógeno, un grupo alquilo C1-4 o un grupo alcoxi C1-4; - Rc representa: -Un átomo de hidrógeno, un grupo hidroxialquilo C1-4, un grupo aminoalquilo C1-4 que está opcionalmente sustituido con uno o más sustituyentes seleccionados de átomos de halógeno, grupos hidroxi y grupos -CF3; -un anillo heterocíclico que contiene N, saturado, de 4 a 6 miembros, opcionalmente sustituido con un grupo carboxialquilo C1-2; - -(CH2)(0-4)-C(O)OR', -(CH2)(0-4)-C(O)NR'R”, -(CH2)(0-4)-NHC(O)R”, -S(O)2NR'R”, -O-(CH2)(2-4)NR'R”, -O-(CH2)(1-4)C(O)OR'', -O-(CH2)(1-4)-C(O)NR'R”, -(CH2)(0-4)NR'R”, -(CH2)(0-4)-CONHS(O)2R', -(CH2)(0-4)-NHS(O)2R' o -(CH2)(0-3)-NH-(CH2)((1-3)(NH)(0-1)S(O)2R' donde, * R' representa un átomo de hidrógeno o un grupo alquilo C1-4, * R” representa un átomo de hidrógeno, un grupo alquilo C1-4, un grupo cicloalquilo C3-4, un grupo carboxialquilo C1-4 un grupo haloaquilo C1-4, un grupo hidroxialquilo C1-4 o un anillo heterocíclico que contiene N, saturado, de 6 miembros, o * R' y R” junio con el átomo de nitrógeno al que están unidos forman un grupo heterocíclico de 4 a 6 miembros que contiene, como heteroátomos, un átomo de N y, opcionalmente, un átomo adicional seleccionado de N y O, y que está opcionalmente sustituido con un grupo carboxi o carboxialquilo C1-4, o Rc junto con Rd forman un grupo cicloalquilo C5-6 opcionalmente sustituido con un grupo -NHRf, donde Rf se selecciona del grupo que consiste en un átomo de hidrógeno y un grupo carboximetilo; R2 y R3 se seleccionan independientemente del grupo que consiste en átomos de hidrógeno, átomos de halógeno y grupos alquilo C1-4 ; y R4 se selecciona del grupo que consiste en un átomo de hidrógeno, un grupo fenilo, un grupo cicloalquil C3-4-alquilo C1-4, un grupo aminoalquilo C1-4, un grupo haloalquilo C1-4 y un grupo alquilo C1-4 lineal o ramificado que está opcionalmente sustituido con un grupo fenilo o piridilo.
ARP090105087A 2008-12-26 2009-12-23 Derivados de 1,2,4-oxadiazoles agonistas de receptores s1p1 AR074902A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08382090A EP2202232A1 (en) 2008-12-26 2008-12-26 1,2,4-oxadiazole derivatives and their therapeutic use

Publications (1)

Publication Number Publication Date
AR074902A1 true AR074902A1 (es) 2011-02-23

Family

ID=40671021

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090105087A AR074902A1 (es) 2008-12-26 2009-12-23 Derivados de 1,2,4-oxadiazoles agonistas de receptores s1p1

Country Status (18)

Country Link
US (1) US20110311485A1 (es)
EP (2) EP2202232A1 (es)
JP (1) JP2012513958A (es)
KR (1) KR20110104075A (es)
CN (1) CN102264731A (es)
AR (1) AR074902A1 (es)
AU (1) AU2009331959A1 (es)
BR (1) BRPI0918194A2 (es)
CA (1) CA2748397A1 (es)
CO (1) CO6341631A2 (es)
EA (1) EA201100975A1 (es)
EC (1) ECSP11011083A (es)
IL (1) IL213168A0 (es)
MX (1) MX2011006505A (es)
SG (1) SG172152A1 (es)
TW (1) TW201024287A (es)
UY (1) UY32296A (es)
WO (1) WO2010072352A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8399451B2 (en) 2009-08-07 2013-03-19 Bristol-Myers Squibb Company Heterocyclic compounds
EP2366702A1 (en) * 2010-03-18 2011-09-21 Almirall, S.A. New oxadiazole derivatives
US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
MX2012012905A (es) 2010-05-08 2012-12-17 Bayer Ip Gmbh Hidroxialquilbencilpirazoles y su uso para tratamiento de enfermedades hiperproliferativas y angiogenicas.
BR112012028651A2 (pt) 2010-05-08 2016-08-09 Bayer Ip Gmbh heterociclilbenzilpirazóis substituídos e uso do mesmo
CN103124727B (zh) * 2010-07-20 2015-03-25 百时美施贵宝公司 取代的3-苯基-1,2,4-噁二唑化合物
WO2012061459A1 (en) * 2010-11-03 2012-05-10 Bristol-Myers Squibb Company Heterocyclic compounds as s1p1 agonists for the treatment of autoimmune and vascular diseases
EP2455080A1 (en) * 2010-11-23 2012-05-23 Almirall, S.A. S1P1 receptor agonists for use in the treatment of multiple sclerosis
EP2455081A1 (en) * 2010-11-23 2012-05-23 Almirall, S.A. S1P1 receptor agonists for use in the treatment of crohn's disease
KR101299512B1 (ko) * 2011-04-19 2013-08-22 전북대학교산학협력단 스핑고신 1-포스페이트를 유효성분으로 함유하는 관절염 질환 치료 조성물
US9855225B2 (en) * 2011-08-18 2018-01-02 Temple University Office Of Technology Transfer Cannabinoid receptor treatments
ES2575604T3 (es) * 2012-01-13 2016-06-29 Bristol-Myers Squibb Company Compuestos de piridilo sustituidos con tiazolilo o tiadiazolilo útiles como inhibidores cinasa
CA2876215A1 (en) 2012-07-02 2014-01-09 Monsanto Technology Llc Processes for the preparation of 3,5-disubstituted-1,2,4-oxadiazoles
SI2958913T1 (sl) 2013-02-20 2018-12-31 Lg Chem, Ltd. Sfingozin-1-fosfat receptor agonisti, postopki za njegovo pripravo in farmacevtski sestavki, ki ga vsebujejo kot aktivno sredstvo
US9115054B2 (en) 2013-02-21 2015-08-25 Bristol-Myers Squibb Company Tetrahydronaphthalenyl compounds useful as sipi agonists
TW201534586A (zh) 2013-06-11 2015-09-16 Orion Corp 新穎ｃｙｐ１７抑制劑／抗雄激素劑
AR101591A1 (es) 2014-08-20 2016-12-28 Bristol Myers Squibb Co Compuestos bicíclicos sustituidos
DK3256125T3 (da) 2014-12-11 2022-03-21 Actelion Pharmaceuticals Ltd Doseringsregimen for ponesimod, en selektiv s1p1-receptoragonist
MA41139B1 (fr) 2014-12-11 2026-02-27 Laboratoires Juvise Pharmaceuticals Combinaison pharmaceutique comprenant du ponesimod et son utilisation dans le traitement de la sclérose en plaque
JP7178357B2 (ja) * 2017-03-07 2022-11-25 エフ．ホフマン－ラ ロシュ アーゲー オキサジアゾール一過性受容器電位チャネル阻害剤
US11439623B2 (en) 2017-04-04 2022-09-13 Case Western Reserve University Method of modulating ribonucleotide reductase
CN108546266B (zh) * 2018-07-25 2020-09-22 上海毕得医药科技有限公司 一种1,4,6,7-四氢吡喃[4,3-c]吡唑-3-羧酸的合成方法
KR20220044721A (ko) * 2019-08-06 2022-04-11 도메인 테라퓨틱스 신경펩타이드 ff 수용체 길항제로서의 5-헤테로아릴-피리딘-2-아민 화합물
KR20220118525A (ko) 2019-12-20 2022-08-25 화이자 인코포레이티드 벤즈이미다졸 유도체
WO2023077046A1 (en) 2021-10-29 2023-05-04 Arcus Biosciences, Inc. Inhibitors of hif-2alpha and methods of use thereof
EP4402129A1 (en) 2022-08-01 2024-07-24 Valo Health, Inc. <smallcaps/>? ? ?h? ? ? ? ?process for preparing 6-substituted-1-(2)-isoquinolinones and intermediate compound

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2303792A (en) 1992-06-23 1994-01-24 Motorola, Inc. Multi-modulation scheme compatible radio
JP3299971B2 (ja) 1995-06-21 2002-07-08 アスタ メディカ アクチエンゲゼルシャフト 一体的に形成された調量装置を備えた薬用粉末カートリッジおよび粉末薬剤吸入器
DE50204780D1 (de) * 2001-04-19 2005-12-08 Bayer Healthcare Ag Arylsulfonamide als antivirale mittel
DE10129703A1 (de) 2001-06-22 2003-01-02 Sofotec Gmbh & Co Kg Zerstäubungssystem für eine Pulvermischung und Verfahren für Trockenpulverinhalatoren
DE10202940A1 (de) 2002-01-24 2003-07-31 Sofotec Gmbh & Co Kg Patrone für einen Pulverinhalator
CA2483594C (en) 2002-05-16 2011-02-15 Novartis Ag Use of edg receptor binding agents in cancer
GB0217152D0 (en) 2002-07-24 2002-09-04 Novartis Ag Organic compounds
EP1484057A1 (en) 2003-06-06 2004-12-08 Aventis Pharma Deutschland GmbH Use of 2-amino-1-3-propanediol derivatives for the manufacture of a medicament for the treatment of various types of pain
US20050090520A1 (en) 2003-09-12 2005-04-28 Per Lindquist Treatment of disease or injury of the nervous system with FTY720
GB0329498D0 (en) 2003-12-19 2004-01-28 Novartis Ag Organic compounds
MX2008009579A (es) 2006-01-27 2008-09-25 Univ Virginia Metodo para el tratamiento de dolor neuropatico.
TWI389683B (zh) 2006-02-06 2013-03-21 Kyorin Seiyaku Kk A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
MX2008012738A (es) * 2006-04-03 2009-02-06 Astellas Pharma Inc Heterocompuesto.
WO2007143081A2 (en) 2006-06-02 2007-12-13 The Ohio State University Research Foundation Therapeutic agents for the treatment of lymphoid malignancies
GB0612721D0 (en) 2006-06-27 2006-08-09 Novartis Ag Organic compounds
WO2008021532A2 (en) 2006-08-17 2008-02-21 University Of Chicago Treatment of inflammatory diseases
JO2701B1 (en) * 2006-12-21 2013-03-03 جلاكسو جروب ليميتد Vehicles

Also Published As

Publication number Publication date
EA201100975A1 (ru) 2012-02-28
EP2202232A1 (en) 2010-06-30
WO2010072352A1 (en) 2010-07-01
CO6341631A2 (es) 2011-11-21
EP2370431A1 (en) 2011-10-05
ECSP11011083A (es) 2011-06-30
CA2748397A1 (en) 2010-07-01
SG172152A1 (en) 2011-07-28
CN102264731A (zh) 2011-11-30
UY32296A (es) 2010-05-31
TW201024287A (en) 2010-07-01
MX2011006505A (es) 2011-07-12
JP2012513958A (ja) 2012-06-21
KR20110104075A (ko) 2011-09-21
AU2009331959A1 (en) 2011-06-30
BRPI0918194A2 (pt) 2015-12-01
US20110311485A1 (en) 2011-12-22
IL213168A0 (en) 2011-07-31

Similar Documents

Publication Publication Date Title
ECSP11011083A (es) Nuevos compuestos
EA200800478A1 (ru) Макроциклические ингибиторы вируса гепатита с
AR063458A1 (es) Derivados de piridina inhibidores de 11beta hsd1
CA2616580A1 (en) Macrocyclic inhibitors of hepatitis c virus
CO6220878A2 (es) Composicion herbicida que comprende un derivado de isoxazolina o una sal del mismo
AR067757A1 (es) Derivados de imidazo[4,5-c]piridin-2-ona, composiciones farmaceuticas que los contienen, procedimiento para su preparacion y uso de los mismos como agentes antivirales.
DE602005023343D1 (de) Pyrimidinderivate als gpcr-agonisten
EA200800477A1 (ru) Макроциклические ингибиторы вируса гепатита с
AR046244A1 (es) Activadores de glucoquinasa heteroaromaticos de seis miembros 5- sustituidos
ECSP056016A (es) Nuevos derivados de 2-piridinacarboxamida
AR079541A1 (es) Compuestos sustituidos de n-(1h-indazol-4-il) imidazo (1,2-a) piridin-3-carboxamida como inhibidores de cfms
AR074596A1 (es) Derivados de (3-oxo) piridazin-4-ilurea
AR038888A1 (es) Amidas heterociclicas
EA201001368A1 (ru) Гетероциклические производные мочевины и способы их применения-211
CO6160231A2 (es) Compuestos de isoindolina 5-substituidos
EP2308877A4 (en) Imidazopyridine-2-ON DERIVATIVE
ES2572148T3 (es) Un método para el tratamiento de la enfermedad de Pompe usando 1-desoxinojirimicina y derivados
ECSP099638A (es) Nuevo compuesto de adenina
TW200745118A (en) Macrocylic inhibitors of hepatitis C virus
AR072900A1 (es) Agentes terapeuticos derivados de pirazolo[3,4-d]pirimidina
TW200738655A (en) Novel bicyclic sulfonamide derivatives
ES2606197T3 (es) Moduladores pirrolidina de GPR40
EA201070839A1 (ru) Новые производные ацилцианопирролидинов
ECSP11010842A (es) Nuevos derivados de 2-amidotiadiazol
AR062258A1 (es) Compuestos heterociclicos condensados de tieno-pirrol, composiciones farmaceuticas que los contienen y usos para el tratamiento de infecciones por hcv

Legal Events

Date Code Title Description
FB Suspension of granting procedure