CO6140032A2 - Dihidrotienopirimidinas para el tratamiento de enfermedades inflamatorias - Google Patents

Dihidrotienopirimidinas para el tratamiento de enfermedades inflamatorias

Info

Publication number
CO6140032A2
CO6140032A2 CO08111120A CO08111120A CO6140032A2 CO 6140032 A2 CO6140032 A2 CO 6140032A2 CO 08111120 A CO08111120 A CO 08111120A CO 08111120 A CO08111120 A CO 08111120A CO 6140032 A2 CO6140032 A2 CO 6140032A2
Authority
CO
Colombia
Prior art keywords
bicyclic
mono
aryl
alkyl
alkylene
Prior art date
Application number
CO08111120A
Other languages
English (en)
Inventor
Pascale Pouzet
Dennis Fiegen
Thomas Fox
Rolf Goeggel
Christoph Hoenke
Birgit Jung
Peter Nickolaus
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CO6140032A2 publication Critical patent/CO6140032A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1.- Compuestos de la fórmula 1, 1en donde X es SO o SO2;R1 es H, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo C6-10, aril C6-10-alquileno C1-6 o heteroaril C5-10-alquileno C1-6 R2 es H o un radical seleccionado del grupo compuesto por alquilo C1-10, alquenilo C2-6 y alquinilo C2-6, que eventualmente puede estar sustituido con halógeno y que eventualmente puede estar sustituido con uno o varios radicales seleccionados del grupo compuesto por OR2.1, COOR2.1, CONR2.2R2.3, SR2.1, arilo C6-10, un heterociclo C3-10 mono- o bicíclico, un heteroarilo C5-10 mono- o bicíclico, un cicloalquilo C3-10 mono- o bicíclico, CH2-NR2.2R2.3 y NR2.2R2.3 que, a su vez, puede estar eventualmente sustituido con uno o varios radicales del grupo compuesto por OH, halógeno, OR2.1, oxo, alquilo C1-6, arilo C6-10, COOR2.1, CH2-NR2.2R2.3 y NR2.2R2.3, en donde R2.1 es H o un radical seleccionado del grupo compuesto por alquilo C1-6, alcanol C1-6, haloalquilo C1-3, cicloalquilo C3-10 mono- o bicíclico, aril C6-10-alquileno C1-6, heteroaril C5-10-alquileno C1-6mono- o bicíclico, heterociclo C3-10-alquileno C1-6, cicloalquil C3-10-alquileno C1-6, un arilo C6-10 mono- o bicíclico, un heteroarilo C5-10 mono- o bicíclico y un heterociclo mono- o bicíclico, saturado o insaturado que eventualmente puede estar sustituido con uno o varios radicales seleccionados del grupo compuesto por OH, halógeno, alquilo C1-6 y arilo C6-10, en donde R2.2 y R2.3 son, de modo independiente entre sí, H o un radical seleccionado del grupo compuesto por halógeno, alquilo C1-6, cicloalquilo C3-10 mono- o bicíclico, aril C6-10-alquileno C1-6, heteroaril C5-10-alquileno C1-6, arilo C6-10 mono- o bicíclico, heterociclo C3-10 mono- o bicíclico, heteroarilo C5-10 mono- o bicíclico, CO-NH2, CO-NHCH3, CO-N(CH3)2, SO2(alquilo C1-C2), CO-R2.1 y COOR2.1, que eventualmente puede estar sustituido con uno o varios radicales seleccionados del grupo compuesto por OH, halógeno, alquilo C1-6, arilo C6-10 y COOR2.1, ...
CO08111120A 2006-04-19 2008-10-17 Dihidrotienopirimidinas para el tratamiento de enfermedades inflamatorias CO6140032A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06112779A EP1847543A1 (de) 2006-04-19 2006-04-19 Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen

Publications (1)

Publication Number Publication Date
CO6140032A2 true CO6140032A2 (es) 2010-03-19

Family

ID=36847643

Family Applications (1)

Application Number Title Priority Date Filing Date
CO08111120A CO6140032A2 (es) 2006-04-19 2008-10-17 Dihidrotienopirimidinas para el tratamiento de enfermedades inflamatorias

Country Status (20)

Country Link
US (3) US8114878B2 (es)
EP (2) EP1847543A1 (es)
JP (1) JP5214588B2 (es)
KR (1) KR20090009885A (es)
CN (1) CN101426505A (es)
AR (1) AR060516A1 (es)
AU (1) AU2007239573A1 (es)
BR (1) BRPI0710459A2 (es)
CA (1) CA2647243A1 (es)
CO (1) CO6140032A2 (es)
EA (1) EA200802051A1 (es)
EC (1) ECSP088738A (es)
IL (1) IL194739A0 (es)
MX (1) MX2008012915A (es)
NO (1) NO20083710L (es)
PE (1) PE20080319A1 (es)
TW (1) TW200808811A (es)
UY (1) UY30287A1 (es)
WO (1) WO2007118793A1 (es)
ZA (1) ZA200807015B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1847543A1 (de) 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
EP2205608B1 (en) * 2007-10-18 2013-05-08 Boehringer Ingelheim International GmbH Preparation of dihydrothieno[3, 2-d]pyrimidines and intermediates used therein
BRPI0817781A2 (pt) 2007-10-19 2019-09-24 Boehringer Ingelheim Int piperazino-diidroteinopirimidinas substituídas com heterociclo
CA2702518A1 (en) 2007-10-19 2009-04-23 Boehringer Ingelheim International Gmbh New piperazino-dihydrothienopyrimidine derivatives
JP2011500621A (ja) * 2007-10-19 2011-01-06 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規フェニル置換ピペラジノ−ジヒドロチエノピリミジン
NZ585346A (en) 2007-10-19 2011-09-30 Boehringer Ingelheim Int Substituted piperidino-dihydrothienopyrimidines
US8592400B2 (en) 2009-02-27 2013-11-26 Boehringer Ingelheim International Gmbh Drug combinations containing PDE4 inhibitors and NSAIDs
US9802954B2 (en) 2011-08-24 2017-10-31 Boehringer Ingelheim International Gmbh Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma
US20130059866A1 (en) * 2011-08-24 2013-03-07 Boehringer Ingelheim International Gmbh Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
WO2014124860A1 (en) 2013-02-14 2014-08-21 Boehringer Ingelheim International Gmbh Specific pde4b-inhibitors for the treatment of diabetes mellitus
CN105037369B (zh) * 2015-06-23 2017-07-07 河南师范大学 一种吡唑并[5,1‑a]异吲哚‑3‑甲酰胺类化合物的合成方法
CN111108109A (zh) 2017-09-20 2020-05-05 利奥制药有限公司 取代的二氢噻吩并嘧啶及其作为磷酸二酯酶抑制剂的用途
AU2018357775B2 (en) 2017-10-23 2024-02-15 Boehringer Ingelheim International Gmbh New combination of active agents for the treatment of progressive fibrosing interstitial lung diseases (PF-ILD)
JP7201688B2 (ja) 2017-12-15 2023-01-10 ユニオン・セラピューティクス・アクティエセルスカブ 置換テトラヒドロピランジヒドロチエノピリミジンおよびホスホジエステラーゼ阻害剤としてのそれらの使用
JP7203846B2 (ja) 2017-12-15 2023-01-13 ユニオン・セラピューティクス・アクティエセルスカブ 置換アゼチジンジヒドロチエノピリジンおよびホスホジエステラーゼ阻害剤としてのそれらの使用
CN111712502B (zh) 2017-12-15 2023-10-27 联合疗法公司 取代的氮杂环丁烷二氢噻吩并嘧啶类化合物及其作为磷酸二酯酶抑制剂的用途
WO2023104958A1 (en) 2021-12-09 2023-06-15 Boehringer Ingelheim International Gmbh New oral pharmaceutical composition and dose regimen for the therapy of progressive fibrosing interstitial lung diseases
WO2023104961A1 (en) 2021-12-09 2023-06-15 Boehringer Ingelheim International Gmbh New therapeutic combinations for the treatment of progressive fibrosing interstitial lung diseases
WO2024032673A1 (zh) * 2022-08-09 2024-02-15 西藏海思科制药有限公司 Pde4b抑制剂及其用途
WO2024068386A1 (en) 2022-09-28 2024-04-04 Boehringer Ingelheim International Gmbh Use of biomarkers in the treatment of fibrotic conditions with a pde4b-inhibitor
WO2024067660A1 (zh) * 2022-09-29 2024-04-04 苏州爱科百发生物医药技术有限公司 氮杂稠环类化合物、其制备方法及其在医药上的应用

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1470336A1 (de) * 1962-07-04 1969-03-20 Thomae Gmbh Dr K Neue Dihydrothieno-[3,4-d]-pyrimidine und Verfahren zu ihrer Herstellung
NL122810C (es) 1963-06-17
DE1470356A1 (de) 1964-01-15 1970-04-30 Thomae Gmbh Dr K Neue Thieno[3,2-d]pyrimidine und Verfahren zu ihrer Herstellung
BE663693A (es) 1965-03-31
BE754606A (fr) 1969-08-08 1971-02-08 Thomae Gmbh Dr K Nouvelles 2-aminoalcoylamino-thieno(3,2-d)pyrimidines et leurs procedesde fabrication
DE2032687A1 (en) 1970-07-02 1972-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach Cardiovascular 2-aminoalkylamino-thienopyrimidines - and 4-morpholino derivatives from 4-diethanolamino-compounds by intramolecular cyclisa
DE1940572A1 (de) 1969-08-08 1971-02-11 Thomae Gmbh Dr K Neue 2-Aminoalkylamino-thieno[3,2-d]pyrimidine und Verfahren zu ihrer Herstellung
US3763156A (en) 1970-01-28 1973-10-02 Boehringer Sohn Ingelheim 2-heterocyclic amino-4-morpholinothieno(3,2-d)pyrimidines
FR2082496A5 (es) 1970-03-18 1971-12-10 Westinghouse Freins & Signaux
DE2121950A1 (en) 1971-05-04 1972-11-23 Dr. Karl Thomae Gmbh, 7950 Biberach Thieno(3,2-d)pyrimidine derivs - with thrombocyte aggregation inhibiting activity
DE2750288A1 (de) 1977-11-10 1979-05-17 Thomae Gmbh Dr K Neue 9-(omega-heteroarylamino- alkylamino)-erythromycine, ihre salze, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4256737A (en) 1979-06-11 1981-03-17 Syntex (U.S.A.) Inc. Long acting depot injectable formulations for LH-RH analogues
US5187168A (en) 1991-10-24 1993-02-16 American Home Products Corporation Substituted quinazolines as angiotensin II antagonists
JPH07330777A (ja) 1994-06-08 1995-12-19 Taisho Pharmaceut Co Ltd チエノ［３，２−ｄ］ピリミジン−４−オン誘導体
JPH09301958A (ja) 1996-05-09 1997-11-25 Nippon Shoji Kk 新規ピリミジン化合物及び抗ロタウイルス剤
US6339089B2 (en) 1997-08-13 2002-01-15 Fujirebio Inc. Pyrimidine nucleus-containing compound and a medicament containing the same for a blood oxygen partial pressure amelioration, and a method for preparing the same
DK1326862T3 (da) 2000-10-12 2004-11-22 Boehringer Ingelheim Pharma Krystallinsk monohydrat af tiotropiumbromid, fremgangsmåde til fremstilling deraf og anvendelse deraf til fremstilling af et lægemiddel
DE10064994A1 (de) 2000-12-23 2002-07-04 Merck Patent Gmbh Sulfamidothienopyrimidine
KR100971616B1 (ko) 2001-06-22 2010-07-22 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 결정질 항콜린제, 이의 제조방법 및 이를 포함하는 약제학적 조성물
US6587548B2 (en) 2001-07-17 2003-07-01 Hewlett-Packard Development Co., L.P. Method and system of using a single telephone number for multiple services
AU2002364211A1 (en) 2001-12-21 2003-07-15 Bayer Pharmaceuticals Corporation Thienopyrimidine derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents
ES2305435T3 (es) 2002-01-10 2008-11-01 Bayer Healthcare Ag Inhibidores de la rho-quinasa.
CN1867336B (zh) 2002-06-12 2010-05-12 凯莫森特里克斯股份有限公司 1-芳基-4-取代的哌嗪衍生物及其制药用途
GEP20084329B (en) 2003-04-29 2008-03-25 Pfizer Ltd 5,7-diaminopyrazolo [4,3-d] pyrimidines useful in the treatment of hypertension
MX351381B (es) 2003-10-02 2017-10-12 Dsm Ip Assets Bv Produccion de altos niveles de dha en microalgas usando cantidades modificadas de cloruro y de potasio.
MY141220A (en) 2003-11-17 2010-03-31 Astrazeneca Ab Pyrazole derivatives as inhibitors of receptor tyrosine kinases
WO2005082865A1 (ja) 2004-02-27 2005-09-09 Astellas Pharma Inc. 縮合二環性ピリミジン誘導体
WO2006111549A1 (de) 2005-04-21 2006-10-26 Boehringer Ingelheim International Gmbh Dihydrothienopyrimidine zur behandlung von entzündlichen erkrankungen
EP1847543A1 (de) 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
SI2137196T1 (sl) 2007-04-20 2011-01-31 Glaxo Group Ltd Glaxo Welcome House Tricikliäśne spojine, ki vsebujejo duĺ ik, uporabne kot antibakterijska sredstva
EP2205608B1 (en) 2007-10-18 2013-05-08 Boehringer Ingelheim International GmbH Preparation of dihydrothieno[3, 2-d]pyrimidines and intermediates used therein
TW200934771A (en) 2007-10-19 2009-08-16 Astrazeneca Ab New compounds
FR2922550B1 (fr) 2007-10-19 2009-11-27 Sanofi Aventis Nouveaux derives de 6-aryl/heteroalkyloxy benzothiazole et benzimidazole, application comme medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de cmet
BRPI0817781A2 (pt) 2007-10-19 2019-09-24 Boehringer Ingelheim Int piperazino-diidroteinopirimidinas substituídas com heterociclo
JP2011500621A (ja) 2007-10-19 2011-01-06 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規フェニル置換ピペラジノ−ジヒドロチエノピリミジン
EP2220061B1 (en) 2007-10-19 2016-02-17 Merck Sharp & Dohme Corp. Spiro-condensed 1, 3, 4-thiadiazole derivatives for inhibiting ksp kinesin activity
CA2702518A1 (en) 2007-10-19 2009-04-23 Boehringer Ingelheim International Gmbh New piperazino-dihydrothienopyrimidine derivatives
NZ585346A (en) 2007-10-19 2011-09-30 Boehringer Ingelheim Int Substituted piperidino-dihydrothienopyrimidines
CA2753604A1 (en) 2009-02-27 2010-09-02 Boehringer Ingelheim International Gmbh Drug combinations containing pde4-inhibitors and nsaids
US8592400B2 (en) 2009-02-27 2013-11-26 Boehringer Ingelheim International Gmbh Drug combinations containing PDE4 inhibitors and NSAIDs

Also Published As

Publication number Publication date
US20080096882A1 (en) 2008-04-24
BRPI0710459A2 (pt) 2011-08-16
IL194739A0 (en) 2009-08-03
AR060516A1 (es) 2008-06-25
US8822474B2 (en) 2014-09-02
KR20090009885A (ko) 2009-01-23
US8114878B2 (en) 2012-02-14
US8604039B2 (en) 2013-12-10
NO20083710L (no) 2008-11-18
ECSP088738A (es) 2008-10-31
EP1847543A1 (de) 2007-10-24
TW200808811A (en) 2008-02-16
UY30287A1 (es) 2007-11-30
ZA200807015B (en) 2010-01-27
MX2008012915A (es) 2008-10-15
PE20080319A1 (es) 2008-05-13
EP2010185B1 (de) 2012-06-13
CN101426505A (zh) 2009-05-06
CA2647243A1 (en) 2007-10-25
AU2007239573A1 (en) 2007-10-25
EP2010185A1 (de) 2009-01-07
US20140005154A1 (en) 2014-01-02
JP2010523467A (ja) 2010-07-15
US20120108534A1 (en) 2012-05-03
EA200802051A1 (ru) 2009-04-28
JP5214588B2 (ja) 2013-06-19
WO2007118793A1 (de) 2007-10-25

Similar Documents

Publication Publication Date Title
CO6140032A2 (es) Dihidrotienopirimidinas para el tratamiento de enfermedades inflamatorias
AR086828A1 (es) Compuestos heterociclicos fusionados como moduladores del canal ionico
AR076235A1 (es) Compuestos organicos y sus usos
PE20160501A1 (es) Derivados de quinolizina sustituidos utiles como inhibidores de integrasa del vih
AR076685A1 (es) Compuesto de pirimidina y su uso en el control de plagas
ES2524910T3 (es) Piperidino-dihidrotienopirimidinas sustituidas
AR069334A1 (es) Inhibidores de la replicacion del virus de inmunodeficiencia humana
AR078622A1 (es) Piperidinas sustituidas que aumentan la actividad de p53 y sus usos
CO5700770A2 (es) 1,4-diazepinas sustituidas y usos de las mismas
AR061548A1 (es) 3-aminopirrolidino-4-lactamas sustituidas como inhibidoras de dipeptidilpeptidasa iv (dpp-iv), composiciones farmaceuticas que las comprenden y el uso de las mismas en el tratamiento de la diabetes ii.
AR085324A1 (es) Composiciones de moleculas pesticidas y proceso de aplicacion de dichas composiciones para controlar acaros, insectos y otras plagas
AR107616A1 (es) Compuestos de 6,7-dihidro-5h-benzo[7]anuleno sustituidos, procesos para su preparación y usos terapéuticos de los mismos
AR077417A1 (es) Compuesto triazolopiridina y su accion como inhibidor de prolil hidroxilasa o agente inductor de la produccion de eritropoyetina
CO5611167A2 (es) Composiciones farmaceuticas para inhibidores de proteasa viral de la hepatitis c
AR063318A1 (es) Pirazoliltienopiridinas terapeuticas
CO2017001178A2 (es) Derivado de piridona que tiene un grupo tetrahidropiranil metilo
PE20170144A1 (es) 1h-pirrolo[2,3-c] piridin-7(6h)-onas y pirazolo[3,4-c]piridin-7(6h)-onas como inhibidores de proteinas bet
UY32325A (es) Inhibidores de ns3 proteasa del vhc
AR069076A1 (es) Piperazino- dihidrotienopirimidinas sustituidas en heterociclo
AR071055A1 (es) Compuestos espiro, composiciones farmaceuticas y medicamentos que los comprenden, agente promotor de la secrecion de insulina y usos para la preparacion de medicamentos y composiciones farmaceuticas
CO6420344A2 (es) Derivados de triazolopiridina como inhibidores de proteínas cinasas activadas por mitogeno p38 (map)
AR049319A1 (es) Derivados de 6-heteroarilfenantridinas
AR069596A1 (es) Regulador del crecimiento de plantas
AR086144A1 (es) Derivados de pirrolotriazinona como inhibidores de pi3k
PE20160689A1 (es) Derivados del isocromeno como inhibidores de las fosfoinositido-3 quinasas