CO5700734A2 - Derivados de p-diamonobenceno substituidos - Google Patents

Derivados de p-diamonobenceno substituidos

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Publication number
CO5700734A2
CO5700734A2 CO05106417A CO05106417A CO5700734A2 CO 5700734 A2 CO5700734 A2 CO 5700734A2 CO 05106417 A CO05106417 A CO 05106417A CO 05106417 A CO05106417 A CO 05106417A CO 5700734 A2 CO5700734 A2 CO 5700734A2
Authority
CO
Colombia
Prior art keywords
alk
cycloalk
cyano
hydroxy
hydrogen
Prior art date
Application number
CO05106417A
Other languages
English (en)
Inventor
Nikolay Khanzhin
Mario Rottlander
Andreas Ritzen
William Patrick Watson
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of CO5700734A2 publication Critical patent/CO5700734A2/es

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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
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    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
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    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C07C217/86—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical containing six-membered aromatic rings
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    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
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Abstract

1.- Derivados p-diaminobenceno substituidos de la fórmula general 1) en la cual s es 0 o 1;U es 0, S, S02, S02NR11, CO-O o CO-NR11; donde R11 está seleccionado del grupo que consiste en hidrógeno, alq(en/in)iloC1-6, cicloalq( en )iloC3-8, cicloalqu( en )iloC3-8-alqu( en/in )ilo C1-6, R2 y R11 conjuntamente con el átomo de nitrógeno forma un anillo de 5-8 miembros saturado o insaturado que opcionalmente contiene 1, 2 o 3 heteroátomos adicionales, q es 0 o 1;X es CO o S02; con la condición de que q es 0 cuando X es S02;Z es O o S;R1 está seleccionado del grupo que consiste en hidrógeno, alqu(en)iloC1-6, cicloalqu( en )iloC3-8, cicloalqu( en )iloC3-8-alq( en/in )iloC1-6, acilo, hidroxi alqu(en)iloC1-6,hidroxi-cicloalqu( en )iloC3-8, hidroxi-cicloalqu( en)iloC3-8 alqu( en/in )iloC1-6, halo- alqu(en/in)iloC1-6, halo-cicloalqu(en)iloC3-8, halocicloalquC3-8(en)ilo-alqu(en/in)iloC1-6, ciano-alqu(en/in)iloC1-6, cianocicloalqu(en)iloC3-8, y ciano-cicloalqu(en)iloC3-8-alqu(en/in)iloC1-6;R2 está seleccionado del grupo que consiste en hidrógeno, alqu(en/in)iloC1-6, cicloalqu(en)iloC3-8, cicloalqu(en)iloC3-8-alqu(en/in)iloC1-6, Ar, Ar-alqu(en/in)iloC1-6, Ar-cicloalquil(en) iloC3-8, Ar-cicloalqu(en)iloC3-8-alqu(en/in)iloC1-6, acilo, hidroxialqu(en/in)iloC1-6, hidroxi-cicloalqu(en)iloC3-8, hidroxi-cicloalqu(en)iloC3-8 alqu(en/in)iloC1-6, halógeno, halo-alqu(en/in)iloC1-6, halocicloalqu(en)iloC3-8, halocicloalqu(en)iloC3-8-alqu(en/in)iloC1-6, ciano, ciano-alqu(en/in)iloC1-6, ciano cicloalqu(en)iloC3-8, ciano, cicloalq(en)iloC3-8-alqu(en/in)iloC1-6, NR10R10&#39 alqu( en/in)iloC1-6, NR10R10&#39-cicloalqu(en)iloC3-8 y NR10R10&#39-cicloalqu(en)iloC3-8 alqu(en/in)ilo; donde R10 y R10&#39 están independientemente seleccionados del grupo que consiste en hidrógeno, alqu(en(in)iloC1-6, cicloalqu(en)iloC3-8, cicloalqu(en)iloC3-8-alqu(en/in)iloC1-6, hidroxi-alqu(en/in)iloC1-6, ...
CO05106417A 2003-03-21 2005-10-19 Derivados de p-diamonobenceno substituidos CO5700734A2 (es)

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