WO2003062259A3 - Non-aromatic 17.alpha.-esters of androstane-17.beta.-carboxylate esters as anti-inflammatory agents - Google Patents
Non-aromatic 17.alpha.-esters of androstane-17.beta.-carboxylate esters as anti-inflammatory agents Download PDFInfo
- Publication number
- WO2003062259A3 WO2003062259A3 PCT/GB2003/000234 GB0300234W WO03062259A3 WO 2003062259 A3 WO2003062259 A3 WO 2003062259A3 GB 0300234 W GB0300234 W GB 0300234W WO 03062259 A3 WO03062259 A3 WO 03062259A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- esters
- aromatic
- androstane
- beta
- alpha
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003201693A AU2003201693A1 (en) | 2002-01-21 | 2003-01-20 | Non-aromatic 17.alpha.-esters of androstane-17.beta.-carboxylate esters as anti-inflammatory agents |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0201357.1 | 2002-01-21 | ||
GB0201357A GB0201357D0 (en) | 2002-01-21 | 2002-01-21 | Novel compounds |
GB0224608A GB0224608D0 (en) | 2002-10-23 | 2002-10-23 | Novel compounds |
GB0224608.0 | 2002-10-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003062259A2 WO2003062259A2 (en) | 2003-07-31 |
WO2003062259A3 true WO2003062259A3 (en) | 2003-08-28 |
Family
ID=27614790
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2003/000234 WO2003062259A2 (en) | 2002-01-21 | 2003-01-20 | Non-aromatic 17.alpha.-esters of androstane-17.beta.-carboxylate esters as anti-inflammatory agents |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2003201693A1 (en) |
WO (1) | WO2003062259A2 (en) |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3828080A (en) * | 1972-01-20 | 1974-08-06 | Glaxo Lab Ltd | Androstane-17beta-carboxylic acids and processes for the preparation thereof |
US3856828A (en) * | 1972-07-19 | 1974-12-24 | Glaxo Lab Ltd | Anti-inflammatory steroids of the androstane series having a halo-substituted c{11 {14 c{11 {11 alkoxy carbonyl group at the 17{62 {0 position |
GB1514476A (en) * | 1974-08-30 | 1978-06-14 | Glaxo Lab Ltd | Alkyl and haloalkyl androst-4-ene and androsta-1,4-diene-17beta-carboxylates |
WO2002000679A2 (en) * | 2000-06-28 | 2002-01-03 | Novartis Ag | 9.alpha.-chloro-6.alpha.-fluoro-17.alpha.-hydroxy-16-methyl-17-beta-methoxycarbonyl-androst-1,4-dienes esterified in position 17.alpha. by a cyclic acyl group |
-
2003
- 2003-01-20 AU AU2003201693A patent/AU2003201693A1/en not_active Abandoned
- 2003-01-20 WO PCT/GB2003/000234 patent/WO2003062259A2/en not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3828080A (en) * | 1972-01-20 | 1974-08-06 | Glaxo Lab Ltd | Androstane-17beta-carboxylic acids and processes for the preparation thereof |
US3856828A (en) * | 1972-07-19 | 1974-12-24 | Glaxo Lab Ltd | Anti-inflammatory steroids of the androstane series having a halo-substituted c{11 {14 c{11 {11 alkoxy carbonyl group at the 17{62 {0 position |
GB1514476A (en) * | 1974-08-30 | 1978-06-14 | Glaxo Lab Ltd | Alkyl and haloalkyl androst-4-ene and androsta-1,4-diene-17beta-carboxylates |
WO2002000679A2 (en) * | 2000-06-28 | 2002-01-03 | Novartis Ag | 9.alpha.-chloro-6.alpha.-fluoro-17.alpha.-hydroxy-16-methyl-17-beta-methoxycarbonyl-androst-1,4-dienes esterified in position 17.alpha. by a cyclic acyl group |
Non-Patent Citations (2)
Title |
---|
ISOGAI M ET AL: "BINDING AFFINITIES OF MOMETASONE FUROATE AND RELATED COMPOUNDS INCLUDING ITS METABOLITES FOR THE GLUCOCORTICOID RECEPTOR OF RAT SKIN TISSUE", JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, ELSEVIER SCIENCE LTD., OXFORD, GB, vol. 44, no. 2, 1993, pages 141 - 145, XP001040943, ISSN: 0960-0760 * |
KNOBIL K ET AL: "ADDING SALMETEROL IS MORE EFFECTIVE THAN INCREASING THE DOSE OF FLUTICASONE FOR PATIENTS WITH ASTHMA WHO ARE SYMPTOMATIC ON LOW DOSE FLUTICASONE", EUROPEAN RESPIRATORY REVIEW, COPENHAGEN, DK, vol. 12, no. SUPPL 29, December 1998 (1998-12-01), pages 19S - 20S, XP000992769 * |
Also Published As
Publication number | Publication date |
---|---|
AU2003201693A1 (en) | 2003-09-02 |
WO2003062259A2 (en) | 2003-07-31 |
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