CO5570700A2 - Acilsulfonamidas como inhibidores de sulfatasa esteroide - Google Patents
Acilsulfonamidas como inhibidores de sulfatasa esteroideInfo
- Publication number
- CO5570700A2 CO5570700A2 CO04041364A CO04041364A CO5570700A2 CO 5570700 A2 CO5570700 A2 CO 5570700A2 CO 04041364 A CO04041364 A CO 04041364A CO 04041364 A CO04041364 A CO 04041364A CO 5570700 A2 CO5570700 A2 CO 5570700A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- phenyl
- alkoxy
- substituted
- halo
- Prior art date
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- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
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- A61P17/08—Antiseborrheics
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- A—HUMAN NECESSITIES
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07C311/51—Y being a hydrogen or a carbon atom
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/24—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by sulfur atoms to which a second hetero atom is attached
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
1.- Un compuesto de fórmulaen donde R1 es haloalquilo(C1-6), alquenilo(C2-6) no substituido, alquenilo(C2-6) substituido por fenilo, no substituido o substituido por 1 hasta 5 substituyentes - tienilo, piridina, benztiazolilo, cromanilo (esto es, 1,2-dihidrobenzopiranilo) o arilo(C6-18), en donde los substituyentes son seleccionados del grupo que consiste de - halógeno, nitro, di-alquilamino(C1-4), ciano, alquilo(C1-6), haloalquilo(C1-4), fenilcarbonilamino-alquilo(C1-4) no substituido, alcoxi(C1-4), haloalcoxi(C1-4), aminocarbonilo, di-aIquiIaminocarbonilo (C1-4), aIquiIcarbonilo(C1-4), alcoxicarbonilo(C1-4), fenilo no substituido, carboxilo, y fenilcarbonilamino-alquilo(C1-4) substituido por fenilo o fenilo substituido, en donde los substituyentes fenilo son seleccionados del grupo que consiste de - halógeno, nitro, di-alquilamino(C1-4), ciano, alquilo(C1-6), haloalquilo(C1-4), alcoxi(C1-4), haloalcoxi(C1-4), aminocarbonilo, di-aIquiIaminocarbonilo (C1-4), alquiIcarbonilo (C1-4),alcoxicarbonilo(C1-4) y carboxilo, o R1 es un grupo de la fórmulaR3 y R13 independientemente de cada uno son hidrógeno, hidroxi, halógeno, ciano, alquilo(C1-4), alcoxi(C1-4), fenilo o fenoxi, al menos uno de - R4 y R5 junto con el átomo de carbono al cual están enlazados, - R11 y R12 juntos con el átomo de carbono al cual están enlazados, independientemente de cada uno son un substituido - sistema cicloalquilo de conexión, - cicloalquilo(C4-8),- piperidina, tetrahidropiridina, o ...
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GB0124027A GB0124027D0 (en) | 2001-10-05 | 2001-10-05 | Organic compounds |
GB0124028A GB0124028D0 (en) | 2001-10-05 | 2001-10-05 | Organic compounds |
GB0124839A GB0124839D0 (en) | 2001-10-16 | 2001-10-16 | Organic compounds |
GB0127173A GB0127173D0 (en) | 2001-11-12 | 2001-11-12 | Organic compounds |
GB0127174A GB0127174D0 (en) | 2001-11-12 | 2001-11-12 | Organic compounds |
GB0127343A GB0127343D0 (en) | 2001-11-14 | 2001-11-14 | Organic compounds |
GB0211524A GB0211524D0 (en) | 2002-05-20 | 2002-05-20 | Organic compounds |
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CO5570700A2 true CO5570700A2 (es) | 2005-10-31 |
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US (1) | US7482462B2 (es) |
EP (2) | EP1436253A1 (es) |
JP (1) | JP4390559B2 (es) |
KR (2) | KR20090123988A (es) |
CN (1) | CN100509774C (es) |
AR (1) | AR037097A1 (es) |
AU (1) | AU2002350490B2 (es) |
BR (1) | BR0213131A (es) |
CA (1) | CA2458453A1 (es) |
CO (1) | CO5570700A2 (es) |
HU (1) | HUP0401687A3 (es) |
IL (1) | IL160786A0 (es) |
MX (1) | MXPA04003236A (es) |
NZ (1) | NZ532072A (es) |
PE (1) | PE20030548A1 (es) |
PL (1) | PL367411A1 (es) |
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GB0505539D0 (en) * | 2005-03-17 | 2005-04-27 | Novartis Ag | Organic compounds |
GB0505541D0 (en) * | 2005-03-17 | 2005-04-27 | Novartis Ag | Organic compounds |
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KR20080039405A (ko) * | 2005-07-13 | 2008-05-07 | 아스트라제네카 아베 | 신규한 피리딘 유사체 |
WO2007051255A1 (en) * | 2005-11-04 | 2007-05-10 | The University Of Sydney | Process for the preparation of compounds containing an azacyclic ring system |
DE102006005861A1 (de) | 2006-02-09 | 2007-08-23 | Aicuris Gmbh & Co. Kg | Substituierte Chinolone III |
US20100204146A1 (en) | 2007-09-17 | 2010-08-12 | Preglem S.A. | Treatment of Oestrogen Dependant Conditions in Pre-menopausal Women |
US10538487B2 (en) | 2015-02-16 | 2020-01-21 | The University Of Queensland | Sulfonylureas and related compounds and use of same |
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NZ532072A (en) | 2007-02-23 |
KR20090123988A (ko) | 2009-12-02 |
US7482462B2 (en) | 2009-01-27 |
HUP0401687A3 (en) | 2008-06-30 |
MXPA04003236A (es) | 2004-07-23 |
KR100952770B1 (ko) | 2010-04-14 |
AR037097A1 (es) | 2004-10-20 |
CN100509774C (zh) | 2009-07-08 |
HUP0401687A2 (hu) | 2004-11-29 |
CN1564811A (zh) | 2005-01-12 |
EP1436253A1 (en) | 2004-07-14 |
US20050059712A1 (en) | 2005-03-17 |
BR0213131A (pt) | 2004-09-21 |
WO2003031397A1 (en) | 2003-04-17 |
PL367411A1 (en) | 2005-02-21 |
AU2002350490B2 (en) | 2006-07-27 |
IL160786A0 (en) | 2004-08-31 |
PE20030548A1 (es) | 2003-07-07 |
CA2458453A1 (en) | 2003-04-17 |
JP2005504843A (ja) | 2005-02-17 |
EP2228364A1 (en) | 2010-09-15 |
JP4390559B2 (ja) | 2009-12-24 |
KR20050033509A (ko) | 2005-04-12 |
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