CO2021011553A2 - Síntesis de 4-amino-5-metil-1h-piridin-2 (1h) -on (compuesto intermedio para la síntesis del antagonista finerenona de mr) a partir de 2-cloro-5-metil-4-nitro-piridina-1-óxido usando el compuesto intermedio 2-cloro-5-metil-4-piridinamina - Google Patents

Síntesis de 4-amino-5-metil-1h-piridin-2 (1h) -on (compuesto intermedio para la síntesis del antagonista finerenona de mr) a partir de 2-cloro-5-metil-4-nitro-piridina-1-óxido usando el compuesto intermedio 2-cloro-5-metil-4-piridinamina

Info

Publication number
CO2021011553A2
CO2021011553A2 CONC2021/0011553A CO2021011553A CO2021011553A2 CO 2021011553 A2 CO2021011553 A2 CO 2021011553A2 CO 2021011553 A CO2021011553 A CO 2021011553A CO 2021011553 A2 CO2021011553 A2 CO 2021011553A2
Authority
CO
Colombia
Prior art keywords
methyl
chloro
synthesis
amino
finerenone
Prior art date
Application number
CONC2021/0011553A
Other languages
English (en)
Inventor
Johannes Platzek
Kai Lovis
Original Assignee
Bayer Pharma AG
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG, Bayer Ag filed Critical Bayer Pharma AG
Publication of CO2021011553A2 publication Critical patent/CO2021011553A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invención se refiere a un nuevo y mejorado procedimiento para la preparación de 4–amino–5–metilpiridona de la fórmula (I) (I) que representa un producto intermedio para la preparación del antagonista MR finerenona.
CONC2021/0011553A 2019-03-05 2021-08-31 Síntesis de 4-amino-5-metil-1h-piridin-2 (1h) -on (compuesto intermedio para la síntesis del antagonista finerenona de mr) a partir de 2-cloro-5-metil-4-nitro-piridina-1-óxido usando el compuesto intermedio 2-cloro-5-metil-4-piridinamina CO2021011553A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19160904 2019-03-05
PCT/EP2020/055292 WO2020178175A1 (de) 2019-03-05 2020-02-28 Synthese von 4-amino-5-methyl-1h-pyridin-2(1h)-on (zwischenverbindung der synthese des mr antagonisten finerenone) aus 2-chloro-5-methyl-4-nitro-pyridine-1-oxid über die zwischenverbindung 2-chloro-5-methyl-4-pyridinamin

Publications (1)

Publication Number Publication Date
CO2021011553A2 true CO2021011553A2 (es) 2021-09-20

Family

ID=65991501

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2021/0011553A CO2021011553A2 (es) 2019-03-05 2021-08-31 Síntesis de 4-amino-5-metil-1h-piridin-2 (1h) -on (compuesto intermedio para la síntesis del antagonista finerenona de mr) a partir de 2-cloro-5-metil-4-nitro-piridina-1-óxido usando el compuesto intermedio 2-cloro-5-metil-4-piridinamina

Country Status (16)

Country Link
US (1) US20220153699A1 (es)
EP (1) EP3935045A1 (es)
JP (1) JP2022523986A (es)
KR (1) KR20210135238A (es)
CN (1) CN113474332A (es)
AU (1) AU2020230965A1 (es)
BR (1) BR112021014815A2 (es)
CA (1) CA3132399A1 (es)
CL (1) CL2021002316A1 (es)
CO (1) CO2021011553A2 (es)
IL (1) IL285937A (es)
JO (1) JOP20210242A1 (es)
MX (1) MX2021010612A (es)
PE (1) PE20212199A1 (es)
SG (1) SG11202109546RA (es)
WO (1) WO2020178175A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3935044B1 (de) * 2019-03-05 2023-04-12 Bayer Aktiengesellschaft Verfahren zur herstellung von 4-amino-5-methylpyridon
CN114656400A (zh) * 2022-04-26 2022-06-24 浙江科聚生物医药有限公司 一种非奈利酮关键中间体的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1311185A (zh) * 2000-03-03 2001-09-05 山东新华制药股份有限公司 4－氨基吡啶及衍生物的制备方法
WO2005100342A1 (en) 2004-03-26 2005-10-27 Vertex Pharmaceuticals, Incorporated Pyridine inhibitors of erk2 and uses thereof
DE102007009494A1 (de) 2007-02-27 2008-08-28 Bayer Healthcare Ag Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung
CN103193704B (zh) * 2013-04-12 2016-03-09 四川铂瑞生物医药有限公司 2-羟基-4-氨基-5-甲基吡啶杂环化合物
AU2015295376C1 (en) 2014-08-01 2020-07-16 Bayer Pharma Aktiengesellschaft Method for the preparation of (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1-6-naphthyridine-3-carbox-amide and the purification thereof for use as an active pharmaceutical ingredient

Also Published As

Publication number Publication date
EP3935045A1 (de) 2022-01-12
KR20210135238A (ko) 2021-11-12
SG11202109546RA (en) 2021-09-29
BR112021014815A2 (pt) 2021-09-28
US20220153699A1 (en) 2022-05-19
CL2021002316A1 (es) 2022-04-08
JP2022523986A (ja) 2022-04-27
WO2020178175A1 (de) 2020-09-10
CN113474332A (zh) 2021-10-01
MX2021010612A (es) 2021-09-28
IL285937A (en) 2021-10-31
AU2020230965A1 (en) 2021-09-23
CA3132399A1 (en) 2020-09-10
JOP20210242A1 (ar) 2023-01-30
PE20212199A1 (es) 2021-11-16

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