CL2021002316A1 - Síntesis de 4-amino-5-metil-1h-piridin-2(1h)-on (compuesto intermediario para la síntesis del antagonista mr finerenona) a partir de 2-cloro-5-metil-4-nitro-piridina-1-oxido usando el compuesto intermediario 2-cloro-5-metil-4-piridinamina - Google Patents

Síntesis de 4-amino-5-metil-1h-piridin-2(1h)-on (compuesto intermediario para la síntesis del antagonista mr finerenona) a partir de 2-cloro-5-metil-4-nitro-piridina-1-oxido usando el compuesto intermediario 2-cloro-5-metil-4-piridinamina

Info

Publication number
CL2021002316A1
CL2021002316A1 CL2021002316A CL2021002316A CL2021002316A1 CL 2021002316 A1 CL2021002316 A1 CL 2021002316A1 CL 2021002316 A CL2021002316 A CL 2021002316A CL 2021002316 A CL2021002316 A CL 2021002316A CL 2021002316 A1 CL2021002316 A1 CL 2021002316A1
Authority
CL
Chile
Prior art keywords
methyl
chloro
synthesis
intermediate compound
pyridinamine
Prior art date
Application number
CL2021002316A
Other languages
English (en)
Inventor
Johannes Platzek
Kai Lovis
Original Assignee
Bayer Ag
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Bayer Pharma AG filed Critical Bayer Ag
Publication of CL2021002316A1 publication Critical patent/CL2021002316A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La invención se refiere a un método para producir 4-amino-5-metil-2(1H) piridona de la fórmula (I) haciendo reaccionar 2-cloro-5-metil-4-piridinamina de la fórmula 2 con KOH en metanol en un reactor de presión y a un método para producir 2-cloro-5-metil-4-piridinamina de la fórmula 2 hidrogenando 2-cloro-5-metil-4-nitro-piridina-I-óxido de la fórmula 3 utilizando un catalizador de platino. La 4-amino-5-metil-1H-piridina-2(I)-on de la fórmula (I) es un producto intermediario para producir el antagonista MR finerenona de la fórmula (II).
CL2021002316A 2019-03-05 2021-09-03 Síntesis de 4-amino-5-metil-1h-piridin-2(1h)-on (compuesto intermediario para la síntesis del antagonista mr finerenona) a partir de 2-cloro-5-metil-4-nitro-piridina-1-oxido usando el compuesto intermediario 2-cloro-5-metil-4-piridinamina CL2021002316A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP19160904 2019-03-05

Publications (1)

Publication Number Publication Date
CL2021002316A1 true CL2021002316A1 (es) 2022-04-08

Family

ID=65991501

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2021002316A CL2021002316A1 (es) 2019-03-05 2021-09-03 Síntesis de 4-amino-5-metil-1h-piridin-2(1h)-on (compuesto intermediario para la síntesis del antagonista mr finerenona) a partir de 2-cloro-5-metil-4-nitro-piridina-1-oxido usando el compuesto intermediario 2-cloro-5-metil-4-piridinamina

Country Status (16)

Country Link
US (1) US20220153699A1 (es)
EP (1) EP3935045A1 (es)
JP (1) JP2022523986A (es)
KR (1) KR20210135238A (es)
CN (1) CN113474332A (es)
AU (1) AU2020230965A1 (es)
BR (1) BR112021014815A2 (es)
CA (1) CA3132399A1 (es)
CL (1) CL2021002316A1 (es)
CO (1) CO2021011553A2 (es)
IL (1) IL285937A (es)
JO (1) JOP20210242A1 (es)
MX (1) MX2021010612A (es)
PE (1) PE20212199A1 (es)
SG (1) SG11202109546RA (es)
WO (1) WO2020178175A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114656400A (zh) * 2022-04-26 2022-06-24 浙江科聚生物医药有限公司 一种非奈利酮关键中间体的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1311185A (zh) * 2000-03-03 2001-09-05 山东新华制药股份有限公司 4－氨基吡啶及衍生物的制备方法
WO2005100342A1 (en) 2004-03-26 2005-10-27 Vertex Pharmaceuticals, Incorporated Pyridine inhibitors of erk2 and uses thereof
DE102007009494A1 (de) 2007-02-27 2008-08-28 Bayer Healthcare Ag Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung
CN103193704B (zh) * 2013-04-12 2016-03-09 四川铂瑞生物医药有限公司 2-羟基-4-氨基-5-甲基吡啶杂环化合物
RU2729998C9 (ru) 2014-08-01 2020-10-20 Байер Фарма Акциенгезельшафт Способ получения (4s)-4-(4-циано-2-метоксифенил)-5-этокси-2,8-диметил-1,4-дигидро-1,6-нафтиридин-3-карбоксамида и его очистки для применения в качестве фармацевтического активного ингредиента

Also Published As

Publication number Publication date
JOP20210242A1 (ar) 2023-01-30
JP2022523986A (ja) 2022-04-27
AU2020230965A1 (en) 2021-09-23
PE20212199A1 (es) 2021-11-16
SG11202109546RA (en) 2021-09-29
CN113474332A (zh) 2021-10-01
US20220153699A1 (en) 2022-05-19
BR112021014815A2 (pt) 2021-09-28
WO2020178175A1 (de) 2020-09-10
MX2021010612A (es) 2021-09-28
CO2021011553A2 (es) 2021-09-20
KR20210135238A (ko) 2021-11-12
IL285937A (en) 2021-10-31
CA3132399A1 (en) 2020-09-10
EP3935045A1 (de) 2022-01-12

Similar Documents

Publication Publication Date Title
MY153055A (en) Process for the production of alcohol from a carbonaceous feedstock
RU2010126906A (ru) Способ получения производного индолинона
EA201000789A1 (ru) Улучшенный способ получения спирта из углеродсодержащего сырья
MX2012008358A (es) Emulsion acrilica asociativa que contiene un monomero a base de alcohol oxo, su proceso de fabricacion y proceso de espesamiento de una formulacion acuosa a partir de esta emulsion.
MX359432B (es) Método para producir materiales de naftol fusionado a indeno.
CL2021002316A1 (es) Síntesis de 4-amino-5-metil-1h-piridin-2(1h)-on (compuesto intermediario para la síntesis del antagonista mr finerenona) a partir de 2-cloro-5-metil-4-nitro-piridina-1-oxido usando el compuesto intermediario 2-cloro-5-metil-4-piridinamina
NZ606700A (en) Process for manufacturing dihydropteridinones and intermediates thereof
AR116790A1 (es) PROCEDIMIENTO PARA LA PREPARACIÓN DE 3a-HIDROXI-5a-PREGNAN-20-ONA (BREXANOLONA)
MY153935A (en) Method for producing n, n-substituted-3-aminopropan-1-ols
MX363730B (es) Procedimiento para la preparacion de derivados de acido antranilico sustituidos.
MY166775A (en) Process for the production of methanol including one or more membrane separation steps
EA201990237A1 (ru) Новые способы получения стимуляторов растворимой гуанилатциклазы
EA201390650A1 (ru) Способ селективного получения 1-пропанола, изобутанола и других с+ спиртов из синтез-газа и метанола
CA2936279C (en) Process and system for production of dimethyl ether from synthesis gas
TR201007005A2 (tr) İmatinib baz üretim yöntemi
AR095548A1 (es) Preparación de ácido 4-amino-2,4-dioxobutanoico
CR20150387A (es) Proceso para producir compuesto de piridazinona y producción de sus intermediarios
BR112016010239A2 (pt) Utilização de um catalisador, processo de síntese de um éster a partir de um álcool, e, composto
RU2012144244A (ru) Способ энантиоселективного синтеза (s)-прегабалина
RU2008112906A (ru) 5-амино-6-метилурацил, проявляющий антиоксидантную активность, и способ его получения
RU2008142736A (ru) Способ получения производных этилендиамина, имеющих карбаматную группу и ациальную группу, и промежуточных веществ для получения производных
BR112014020820A2 (pt) síntese de fischer - tropsch
PE20120566A1 (es) Emulsiones explosivas espesadas por reaccion de un compuesto de amina y un compuesto carbonilico alfa, beta-insaturado
CN104846129A (zh) 一种绿色环保型皮革糅剂
EA201500754A1 (ru) Замещенная (r)-3-(4-метилкарбамоил-3-фторфениламино)тетрагидрофуран-3-енкарбоновая кислота (варианты) и ее эфир, способ получения и применения