SG11202109546RA - Synthesis of 4-amino-5-methyl-1h-pyridin-2(1h)-on (intermediate compound for the synthesis of the mr antagonist finerenone) from 2-chloro-5-methyl-4-nitro-pyridine-1-oxide using the intermediate compound 2-chloro-5-methyl-4-pyridinamine - Google Patents
Synthesis of 4-amino-5-methyl-1h-pyridin-2(1h)-on (intermediate compound for the synthesis of the mr antagonist finerenone) from 2-chloro-5-methyl-4-nitro-pyridine-1-oxide using the intermediate compound 2-chloro-5-methyl-4-pyridinamineInfo
- Publication number
- SG11202109546RA SG11202109546RA SG11202109546RA SG11202109546RA SG11202109546RA SG 11202109546R A SG11202109546R A SG 11202109546RA SG 11202109546R A SG11202109546R A SG 11202109546RA SG 11202109546R A SG11202109546R A SG 11202109546RA SG 11202109546R A SG11202109546R A SG 11202109546RA
- Authority
- SG
- Singapore
- Prior art keywords
- methyl
- chloro
- synthesis
- intermediate compound
- pyridinamine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19160904 | 2019-03-05 | ||
| PCT/EP2020/055292 WO2020178175A1 (de) | 2019-03-05 | 2020-02-28 | Synthese von 4-amino-5-methyl-1h-pyridin-2(1h)-on (zwischenverbindung der synthese des mr antagonisten finerenone) aus 2-chloro-5-methyl-4-nitro-pyridine-1-oxid über die zwischenverbindung 2-chloro-5-methyl-4-pyridinamin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202109546RA true SG11202109546RA (en) | 2021-09-29 |
Family
ID=65991501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202109546RA SG11202109546RA (en) | 2019-03-05 | 2020-02-28 | Synthesis of 4-amino-5-methyl-1h-pyridin-2(1h)-on (intermediate compound for the synthesis of the mr antagonist finerenone) from 2-chloro-5-methyl-4-nitro-pyridine-1-oxide using the intermediate compound 2-chloro-5-methyl-4-pyridinamine |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20220153699A1 (es) |
| EP (1) | EP3935045A1 (es) |
| JP (1) | JP2022523986A (es) |
| KR (1) | KR20210135238A (es) |
| CN (1) | CN113474332A (es) |
| AU (1) | AU2020230965A1 (es) |
| BR (1) | BR112021014815A2 (es) |
| CA (1) | CA3132399A1 (es) |
| CL (1) | CL2021002316A1 (es) |
| CO (1) | CO2021011553A2 (es) |
| IL (1) | IL285937A (es) |
| JO (1) | JOP20210242A1 (es) |
| MX (1) | MX2021010612A (es) |
| PE (1) | PE20212199A1 (es) |
| SG (1) | SG11202109546RA (es) |
| WO (1) | WO2020178175A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210135509A (ko) * | 2019-03-05 | 2021-11-15 | 바이엘 악티엔게젤샤프트 | 4-아미노-5-메틸피리돈을 제조하는 방법 |
| CN114656400A (zh) * | 2022-04-26 | 2022-06-24 | 浙江科聚生物医药有限公司 | 一种非奈利酮关键中间体的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1311185A (zh) * | 2000-03-03 | 2001-09-05 | 山东新华制药股份有限公司 | 4－氨基吡啶及衍生物的制备方法 |
| JP2007530595A (ja) | 2004-03-26 | 2007-11-01 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｅｒｋ２のピリジンインヒビターおよびそれらの使用 |
| DE102007009494A1 (de) | 2007-02-27 | 2008-08-28 | Bayer Healthcare Ag | Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung |
| CN103193704B (zh) * | 2013-04-12 | 2016-03-09 | 四川铂瑞生物医药有限公司 | 2-羟基-4-氨基-5-甲基吡啶杂环化合物 |
| MY198066A (en) | 2014-08-01 | 2023-07-31 | Bayer Pharma AG | Method for the preparation of (4s)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carbox-amide and the purification thereof for use as an active pharmaceutical ingredient |
-
2020
- 2020-02-28 JO JOP/2021/0242A patent/JOP20210242A1/ar unknown
- 2020-02-28 CA CA3132399A patent/CA3132399A1/en active Pending
- 2020-02-28 CN CN202080013586.9A patent/CN113474332A/zh active Pending
- 2020-02-28 EP EP20706521.0A patent/EP3935045A1/de active Pending
- 2020-02-28 KR KR1020217027997A patent/KR20210135238A/ko unknown
- 2020-02-28 SG SG11202109546RA patent/SG11202109546RA/en unknown
- 2020-02-28 PE PE2021001422A patent/PE20212199A1/es unknown
- 2020-02-28 MX MX2021010612A patent/MX2021010612A/es unknown
- 2020-02-28 JP JP2021552653A patent/JP2022523986A/ja active Pending
- 2020-02-28 WO PCT/EP2020/055292 patent/WO2020178175A1/de active Application Filing
- 2020-02-28 US US17/435,606 patent/US20220153699A1/en active Pending
- 2020-02-28 BR BR112021014815-9A patent/BR112021014815A2/pt not_active Application Discontinuation
- 2020-02-28 AU AU2020230965A patent/AU2020230965A1/en not_active Abandoned
-
2021
- 2021-08-29 IL IL285937A patent/IL285937A/en unknown
- 2021-08-31 CO CONC2021/0011553A patent/CO2021011553A2/es unknown
- 2021-09-03 CL CL2021002316A patent/CL2021002316A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CL2021002316A1 (es) | 2022-04-08 |
| EP3935045A1 (de) | 2022-01-12 |
| IL285937A (en) | 2021-10-31 |
| KR20210135238A (ko) | 2021-11-12 |
| JOP20210242A1 (ar) | 2023-01-30 |
| CO2021011553A2 (es) | 2021-09-20 |
| PE20212199A1 (es) | 2021-11-16 |
| WO2020178175A1 (de) | 2020-09-10 |
| MX2021010612A (es) | 2021-09-28 |
| CN113474332A (zh) | 2021-10-01 |
| JP2022523986A (ja) | 2022-04-27 |
| BR112021014815A2 (pt) | 2021-09-28 |
| US20220153699A1 (en) | 2022-05-19 |
| CA3132399A1 (en) | 2020-09-10 |
| AU2020230965A1 (en) | 2021-09-23 |
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