CO2019012271A2 - Péptido activador de receptor de gip - Google Patents

Péptido activador de receptor de gip

Info

Publication number
CO2019012271A2
CO2019012271A2 CONC2019/0012271A CO2019012271A CO2019012271A2 CO 2019012271 A2 CO2019012271 A2 CO 2019012271A2 CO 2019012271 A CO2019012271 A CO 2019012271A CO 2019012271 A2 CO2019012271 A2 CO 2019012271A2
Authority
CO
Colombia
Prior art keywords
activating peptide
gip receptor
receptor activating
peptide
peptide compound
Prior art date
Application number
CONC2019/0012271A
Other languages
English (en)
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of CO2019012271A2 publication Critical patent/CO2019012271A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención proporciona un compuesto peptídico novedoso que tiene una acción activadora en los receptores de GIP y el uso del compuesto peptídico como un medicamento. Específicamente, se proporcionan un péptido que contiene una secuencia representada por la fórmula (I) o una sal de este y un medicamento que lo comprende. P1-Tyr-A2-Glu-Gly-Thr-A6-A7-A8-A9-A10-A11-A12-A13-A14-A15-A16-A17-A18-A19-A20-A21-A22-A23-A24-A25-A26-A27-A28-A29-A30-A31-A32-A33-A34-A35-A36-A37-A38-A39-A40-P2 (I) en donde cada símbolo es como se definió en la presente.
CONC2019/0012271A 2017-03-31 2019-10-31 Péptido activador de receptor de gip CO2019012271A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017072556 2017-03-31
PCT/JP2018/013540 WO2018181864A1 (en) 2017-03-31 2018-03-30 Gip receptor activating peptide

Publications (1)

Publication Number Publication Date
CO2019012271A2 true CO2019012271A2 (es) 2020-08-21

Family

ID=62089992

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2019/0012271A CO2019012271A2 (es) 2017-03-31 2019-10-31 Péptido activador de receptor de gip

Country Status (21)

Country Link
US (2) US10435445B2 (es)
EP (1) EP3601329A1 (es)
JP (2) JP7175912B2 (es)
KR (1) KR20190134626A (es)
CN (1) CN110709414A (es)
AR (1) AR111346A1 (es)
AU (2) AU2018246553B2 (es)
BR (1) BR112019020438A2 (es)
CA (1) CA3058361A1 (es)
CL (1) CL2019002790A1 (es)
CO (1) CO2019012271A2 (es)
EA (1) EA201992327A1 (es)
EC (1) ECSP19078239A (es)
IL (1) IL269581B1 (es)
JO (2) JOP20180028A1 (es)
MA (1) MA48998A (es)
PE (1) PE20200675A1 (es)
PH (1) PH12019502252A1 (es)
SG (1) SG11201908542QA (es)
TW (1) TWI801373B (es)
WO (1) WO2018181864A1 (es)

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EP3856768A2 (en) * 2018-09-24 2021-08-04 Takeda Pharmaceutical Company Limited Gip receptor agonist peptide compounds and uses thereof
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AR121649A1 (es) * 2020-03-25 2022-06-22 Takeda Pharmaceuticals Co Dosificación qw de compuestos peptídicos agonistas del receptor de gip y sus usos
WO2021198229A1 (en) 2020-03-31 2021-10-07 Antaros Medical Ab Selective gip receptor agonists comprising a chelating moiety for imaging and therapy purposes
EP4185607A1 (en) 2020-07-22 2023-05-31 Novo Nordisk A/S Co-agonists at glp-1 and gip receptors suitable for oral delivery
WO2022247950A1 (zh) * 2021-05-28 2022-12-01 广东众生睿创生物科技有限公司 多肽的制备及其应用
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WO2023084118A1 (en) 2021-11-15 2023-05-19 Adocia Solid compositions comprising a peptide or a protein and an acylated amino acid
EP4299057A1 (en) 2022-06-30 2024-01-03 Adocia Solid compositions comprising a peptide or a protein and an acylated amino acid
TW202330584A (zh) 2022-01-20 2023-08-01 丹麥商諾佛 儂迪克股份有限公司 前藥及其用途
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EP4299052A1 (en) 2022-06-30 2024-01-03 Adocia Solid compositions comprising a peptide or a protein and a permeation enhancer
EP4299071A1 (en) 2022-07-01 2024-01-03 Adocia Compositions comprising a peptide or a protein and an acylated amino acid

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Also Published As

Publication number Publication date
KR20190134626A (ko) 2019-12-04
TWI801373B (zh) 2023-05-11
CN110709414A (zh) 2020-01-17
PH12019502252A1 (en) 2020-06-29
CL2019002790A1 (es) 2020-05-29
PE20200675A1 (es) 2020-06-11
ECSP19078239A (es) 2019-12-27
JP7175912B2 (ja) 2022-11-21
AR111346A1 (es) 2019-07-03
JOP20190211A1 (ar) 2019-09-15
EP3601329A1 (en) 2020-02-05
TW201841936A (zh) 2018-12-01
AU2022200837A1 (en) 2022-03-03
MA48998A (fr) 2020-02-05
IL269581B1 (en) 2024-02-01
CA3058361A1 (en) 2018-10-04
WO2018181864A1 (en) 2018-10-04
US20180298070A1 (en) 2018-10-18
AU2018246553B2 (en) 2021-11-11
AU2018246553A1 (en) 2019-10-17
US20200140505A1 (en) 2020-05-07
BR112019020438A2 (pt) 2020-06-09
EA201992327A1 (ru) 2020-02-19
JP2023012547A (ja) 2023-01-25
IL269581A (en) 2019-11-28
US11174301B2 (en) 2021-11-16
SG11201908542QA (en) 2019-10-30
JP2020515612A (ja) 2020-05-28
JOP20180028A1 (ar) 2019-01-30
US10435445B2 (en) 2019-10-08

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