CO2019008461A2 - Anticuerpos procoagulantes - Google Patents

Anticuerpos procoagulantes

Info

Publication number
CO2019008461A2
CO2019008461A2 CONC2019/0008461A CO2019008461A CO2019008461A2 CO 2019008461 A2 CO2019008461 A2 CO 2019008461A2 CO 2019008461 A CO2019008461 A CO 2019008461A CO 2019008461 A2 CO2019008461 A2 CO 2019008461A2
Authority
CO
Colombia
Prior art keywords
antibodies
fixa
activated form
factor
procoagulant
Prior art date
Application number
CONC2019/0008461A
Other languages
English (en)
Inventor
Karina Thorn
Bjarne Gram Hansen
Laust Bruun Johnsen
Mikkel Nors Harndahl
Zhiru Yang
Henrik Østergaard
Per J Greisen
Eva Johansson
Morten Grønbech Rasch
Jianhe Chen
Anders Svensson
Haisun Zhu
Rong Zhou
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of CO2019008461A2 publication Critical patent/CO2019008461A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001154—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a anticuerpos procoagulantes mejorados que incluyen anticuerpos biespecíficos capaces de unirse al factor de coagulación IX (FIX) o su forma activada IXa (FIXa) y opcionalmente al factor X (FX) y su forma activada Xa (FXa) y que promueven la activación de FX por FIXa, anticuerpos que unen sus epítopos y métodos y composición para tratar sujetos que padecen de una coagulopatía tal como hemofilia A.
CONC2019/0008461A 2017-02-01 2019-08-01 Anticuerpos procoagulantes CO2019008461A2 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2017072796 2017-02-01
CN2017105556 2017-10-10
CN2017115210 2017-12-08
EP18154489 2018-01-31
PCT/EP2018/052550 WO2018141863A1 (en) 2017-02-01 2018-02-01 Procoagulant antibodies

Publications (1)

Publication Number Publication Date
CO2019008461A2 true CO2019008461A2 (es) 2020-01-17

Family

ID=61521468

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2019/0008461A CO2019008461A2 (es) 2017-02-01 2019-08-01 Anticuerpos procoagulantes

Country Status (16)

Country Link
US (1) US12084512B2 (es)
EP (2) EP3848396A1 (es)
JP (3) JP7366747B2 (es)
KR (1) KR20190112747A (es)
CN (1) CN110248964B (es)
AU (1) AU2018216008A1 (es)
BR (1) BR112019015611A2 (es)
CA (1) CA3051639A1 (es)
CL (1) CL2019002136A1 (es)
CO (1) CO2019008461A2 (es)
IL (1) IL268140B2 (es)
MX (1) MX2019009106A (es)
PE (1) PE20191347A1 (es)
PH (1) PH12019501708A1 (es)
TW (1) TWI837084B (es)
WO (1) WO2018141863A1 (es)

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EP3830135A1 (en) 2018-08-01 2021-06-09 Novo Nordisk A/S Improved procoagulant antibodies
WO2020115281A1 (en) * 2018-12-07 2020-06-11 Baxalta GmbH Proteinaceous molecules binding factor ixa and factor x
WO2020114615A1 (en) * 2018-12-07 2020-06-11 Baxalta GmbH Bispecific antibodies binding factor ixa and factor x
WO2020114614A1 (en) * 2018-12-07 2020-06-11 Baxalta GmbH Proteinaceous molecules binding factor ixa and factor x
WO2020115283A1 (en) * 2018-12-07 2020-06-11 Baxalta GmbH Bispecific antibodies binding factor ixa and factor x
US20220064327A1 (en) 2018-12-21 2022-03-03 Kymab Limited Fixaxfx bispecific antibody with common light chain
EP3956359A1 (en) * 2019-04-17 2022-02-23 Novo Nordisk A/S Bispecific antibodies
KR20220044946A (ko) * 2019-07-03 2022-04-12 크리스탈 바이오사이언스 주식회사 항-b7-h3 항체 및 이의 사용 방법
EP4097141A1 (en) 2020-01-30 2022-12-07 Novo Nordisk A/S Bispecific factor viii mimetic antibodies
US20230287142A1 (en) * 2020-07-06 2023-09-14 President And Fellows Of Harvard College Histamine binding polypeptides and uses thereof
WO2023111018A1 (en) * 2021-12-17 2023-06-22 F. Hoffmann-La Roche Ag Antibodies against coagulation factor x and uses thereof
KR20240007881A (ko) 2022-07-08 2024-01-17 노보 노르디스크 에이/에스 FVIII(a)를 치환할 수 있는 매우 강력한 ISVD 화합물
WO2024008904A2 (en) 2022-07-08 2024-01-11 Novo Nordisk A/S Highly potent isvd compounds capable of substituting for fviii(a)

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US11220554B2 (en) 2018-09-07 2022-01-11 Novo Nordisk A/S Procoagulant antibodies

Also Published As

Publication number Publication date
EP3577140A1 (en) 2019-12-11
IL268140B2 (en) 2024-04-01
WO2018141863A9 (en) 2018-11-22
PE20191347A1 (es) 2019-09-30
WO2018141863A1 (en) 2018-08-09
US12084512B2 (en) 2024-09-10
RU2019125970A (ru) 2021-03-02
IL268140A (en) 2019-09-26
AU2018216008A1 (en) 2019-08-01
MX2019009106A (es) 2019-09-10
KR20190112747A (ko) 2019-10-07
PH12019501708A1 (en) 2020-06-01
JP2023179628A (ja) 2023-12-19
TW201835107A (zh) 2018-10-01
JP2020506927A (ja) 2020-03-05
US20210388114A1 (en) 2021-12-16
JP7366747B2 (ja) 2023-10-23
CL2019002136A1 (es) 2019-10-18
RU2019125970A3 (es) 2021-06-18
JP2021176898A (ja) 2021-11-11
TWI837084B (zh) 2024-04-01
CN110248964B (zh) 2024-08-27
BR112019015611A2 (pt) 2020-03-17
EP3848396A1 (en) 2021-07-14
CA3051639A1 (en) 2018-08-09
CN110248964A (zh) 2019-09-17
IL268140B1 (en) 2023-12-01

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