CO2017000687A2 - Derivados de cromeno sustituidos como inhibidores duales selectivos de proteínas cinasas pi3 delta y gamma - Google Patents

Derivados de cromeno sustituidos como inhibidores duales selectivos de proteínas cinasas pi3 delta y gamma

Info

Publication number
CO2017000687A2
CO2017000687A2 CONC2017/0000687A CO2017000687A CO2017000687A2 CO 2017000687 A2 CO2017000687 A2 CO 2017000687A2 CO 2017000687 A CO2017000687 A CO 2017000687A CO 2017000687 A2 CO2017000687 A2 CO 2017000687A2
Authority
CO
Colombia
Prior art keywords
delta
protein kinases
selective inhibitors
gamma protein
chromene derivatives
Prior art date
Application number
CONC2017/0000687A
Other languages
English (en)
Inventor
Swaroop Kumar Venkata Satya Vakkalanka
Prashant Kashinath Bhavar
Original Assignee
Rhizen Pharmaceuticals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhizen Pharmaceuticals Sa filed Critical Rhizen Pharmaceuticals Sa
Publication of CO2017000687A2 publication Critical patent/CO2017000687A2/es

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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/06Antipsoriatics
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
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    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/025Boronic and borinic acid compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
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  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invención se refiere a un modulador de la proteína cinasa PI3K delta (δ) y gamma (γ) dual (S)-N-(5-(4- amino-1-(1-(5-fluoro-3-(3-fluorofenil)-4-oxo-4H-cromen-2- il)etil)-1H-pirazolo[3,4-d]pirimidin-3-il)-2- metoxifenil)metansulfonamida, métodos para prepararlos, composiciones farmacéuticas que los contienen y métodos de tratamiento, prevención y/o mejora de enfermedades o trastornos mediados por la cinasa PI3K o trastornos que los usan.
CONC2017/0000687A 2014-06-27 2017-01-26 Derivados de cromeno sustituidos como inhibidores duales selectivos de proteínas cinasas pi3 delta y gamma CO2017000687A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3144CH2014 2014-06-27
PCT/IB2015/054844 WO2015198289A1 (en) 2014-06-27 2015-06-26 Substituted chromene derivatives as selective dual inhibitors of pi3 delta and gamma protein kinases

Publications (1)

Publication Number Publication Date
CO2017000687A2 true CO2017000687A2 (es) 2017-06-09

Family

ID=53761447

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2017/0000687A CO2017000687A2 (es) 2014-06-27 2017-01-26 Derivados de cromeno sustituidos como inhibidores duales selectivos de proteínas cinasas pi3 delta y gamma

Country Status (18)

Country Link
US (4) US9708329B2 (es)
EP (1) EP3160968B1 (es)
JP (1) JP6557266B2 (es)
KR (1) KR20170016489A (es)
CN (1) CN106661029B (es)
AP (1) AP2017009670A0 (es)
AU (1) AU2015278699B2 (es)
CA (1) CA2951370A1 (es)
CL (1) CL2016003328A1 (es)
CO (1) CO2017000687A2 (es)
DK (1) DK3160968T3 (es)
EA (1) EA031135B1 (es)
ES (1) ES2708748T3 (es)
IL (1) IL249740A0 (es)
MX (1) MX2016016892A (es)
PH (1) PH12016502572A1 (es)
SG (1) SG11201610745XA (es)
WO (1) WO2015198289A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20190052A1 (ar) 2016-09-22 2019-03-21 Astrazeneca Ab 5-[2-(بيريدين-2-يلامينو )-3،1 ثيازول-5-يال]-3،2 – ثنائي هيدرو- 1h- إيزوإندول 1--مشتق واحد واستخدامها كمثبطات مزدوجة للدلتا وغاما فوسفاتيديلينوسيتول 3-كيناز
US20230201202A1 (en) * 2020-05-27 2023-06-29 Duke University Compositions and methods for sensitizing acute myeloid leukemias to chemotherapy
CN114258393A (zh) * 2020-07-21 2022-03-29 中国医药研究开发中心有限公司 具有磷脂酰肌醇3-激酶δ和γ的双重抑制剂活性的杂环化合物及其医药用途
CN114891005B (zh) * 2022-03-30 2024-01-19 武汉九州钰民医药科技有限公司 一种乌帕利斯对甲苯磺酸盐的制备工艺

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4779897A (en) * 1996-10-02 1998-04-24 Novartis Ag Fused pyrazole derivatives and processes for their preparation
KR101821768B1 (ko) 2009-11-05 2018-01-24 리젠 파마슈티컬스 소시에떼 아노님 신규한 벤조피란 키나제 조절제
JP5099570B2 (ja) 2010-07-12 2012-12-19 国立大学法人鳥取大学 siRNA導入による新規hiPSC作製法
WO2012121953A1 (en) 2011-03-08 2012-09-13 The Trustees Of Columbia University In The City Of New York Methods and pharmaceutical compositions for treating lymphoid malignancy
JP5590221B2 (ja) 2011-03-30 2014-09-17 トヨタ自動車株式会社 インホイールモータ車
US9775841B2 (en) * 2011-05-04 2017-10-03 Rhizen Pharmaceuticals Sa Compounds as modulators of protein kinases
JP6290186B2 (ja) 2012-05-04 2018-03-07 ライゼン・ファーマシューティカルズ・エスアー 光学的に純粋で置換基を有していてもよい2−(1−ヒドロキシ−アルキル)クロメン−4−オン誘導体の調製方法および医薬品調製におけるそれらの使用
SI2870157T1 (en) * 2012-07-04 2018-02-28 Rhizen Pharmaceuticals S.A. SELECTIVE PI3K-DELTA INHIBITORS
CN111153905A (zh) * 2013-07-02 2020-05-15 理森制药股份公司 PI3K蛋白激酶抑制剂,特别是δ抑制剂和/或γ抑制剂

Also Published As

Publication number Publication date
DK3160968T3 (en) 2019-02-18
NZ727214A (en) 2021-08-27
SG11201610745XA (en) 2017-01-27
CN106661029B (zh) 2019-04-05
PH12016502572A1 (en) 2017-04-17
CL2016003328A1 (es) 2017-12-01
EP3160968A1 (en) 2017-05-03
US20170204106A1 (en) 2017-07-20
US9708329B2 (en) 2017-07-18
EA201692297A1 (ru) 2017-06-30
JP6557266B2 (ja) 2019-08-07
AU2015278699A1 (en) 2017-01-05
MX2016016892A (es) 2017-07-28
US10179786B2 (en) 2019-01-15
EA031135B1 (ru) 2018-11-30
WO2015198289A1 (en) 2015-12-30
IL249740A0 (en) 2017-02-28
JP2017526631A (ja) 2017-09-14
KR20170016489A (ko) 2017-02-13
CN106661029A (zh) 2017-05-10
EP3160968B1 (en) 2018-10-31
AP2017009670A0 (en) 2017-01-31
US20200199133A1 (en) 2020-06-25
AU2015278699B2 (en) 2019-10-31
US20150376188A1 (en) 2015-12-31
CA2951370A1 (en) 2015-12-30
US20190202836A1 (en) 2019-07-04
ES2708748T3 (es) 2019-04-11

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