CN87100927A - 人类非小细胞肺癌及其它几种癌症的单克隆抗和抗原 - Google Patents

人类非小细胞肺癌及其它几种癌症的单克隆抗和抗原 Download PDF

Info

Publication number
CN87100927A
CN87100927A CN198787100927A CN87100927A CN87100927A CN 87100927 A CN87100927 A CN 87100927A CN 198787100927 A CN198787100927 A CN 198787100927A CN 87100927 A CN87100927 A CN 87100927A CN 87100927 A CN87100927 A CN 87100927A
Authority
CN
China
Prior art keywords
cells
antibody
monoclonal antibody
lung cancer
small cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN198787100927A
Other languages
English (en)
Chinese (zh)
Inventor
卡尔·埃里克·赫尔斯特罗姆
约瑟夫·P·布朗
英吉格·赫尔斯特罗姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ONKJIN CO
Original Assignee
ONKJIN CO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ONKJIN CO filed Critical ONKJIN CO
Publication of CN87100927A publication Critical patent/CN87100927A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3023—Lung
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
    • G01N33/5752—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Metal Extraction Processes (AREA)
  • Wire Processing (AREA)
CN198787100927A 1986-02-26 1987-03-14 人类非小细胞肺癌及其它几种癌症的单克隆抗和抗原 Pending CN87100927A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US834,172 1986-02-26
US06/834,172 US5185432A (en) 1986-02-26 1986-02-26 Monoclonal antibodies and antigen for human non-small cell lung carcinoma and other certain human carcinomas

Publications (1)

Publication Number Publication Date
CN87100927A true CN87100927A (zh) 1988-10-05

Family

ID=25266276

Family Applications (1)

Application Number Title Priority Date Filing Date
CN198787100927A Pending CN87100927A (zh) 1986-02-26 1987-03-14 人类非小细胞肺癌及其它几种癌症的单克隆抗和抗原

Country Status (28)

Country Link
US (1) US5185432A (cg-RX-API-DMAC10.html)
JP (1) JPS62220197A (cg-RX-API-DMAC10.html)
KR (2) KR870008026A (cg-RX-API-DMAC10.html)
CN (1) CN87100927A (cg-RX-API-DMAC10.html)
AT (1) AT400577B (cg-RX-API-DMAC10.html)
AU (1) AU612967B2 (cg-RX-API-DMAC10.html)
BE (1) BE1000611A5 (cg-RX-API-DMAC10.html)
CA (1) CA1312025C (cg-RX-API-DMAC10.html)
CH (1) CH675880A5 (cg-RX-API-DMAC10.html)
DD (2) DD276165A5 (cg-RX-API-DMAC10.html)
DE (1) DE3705276A1 (cg-RX-API-DMAC10.html)
DK (1) DK98187A (cg-RX-API-DMAC10.html)
ES (1) ES2004245A6 (cg-RX-API-DMAC10.html)
FI (1) FI870764A7 (cg-RX-API-DMAC10.html)
FR (1) FR2596062B1 (cg-RX-API-DMAC10.html)
GB (1) GB2186885B (cg-RX-API-DMAC10.html)
GR (1) GR870294B (cg-RX-API-DMAC10.html)
IE (1) IE60286B1 (cg-RX-API-DMAC10.html)
IT (1) IT1203511B (cg-RX-API-DMAC10.html)
LU (1) LU86786A1 (cg-RX-API-DMAC10.html)
NL (1) NL8700415A (cg-RX-API-DMAC10.html)
NO (1) NO174719C (cg-RX-API-DMAC10.html)
NZ (1) NZ219338A (cg-RX-API-DMAC10.html)
OA (1) OA08485A (cg-RX-API-DMAC10.html)
PT (1) PT84370B (cg-RX-API-DMAC10.html)
SE (2) SE467988B (cg-RX-API-DMAC10.html)
YU (1) YU46189B (cg-RX-API-DMAC10.html)
ZA (1) ZA869494B (cg-RX-API-DMAC10.html)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101732333B (zh) * 2000-07-28 2012-08-15 大日本住友制药株式会社 癌症治疗药
CN102791736A (zh) * 2009-09-23 2012-11-21 艾斯可勒皮恩有限公司 用于癌症治疗的dsg2拮抗剂
WO2013063874A1 (zh) * 2011-11-03 2013-05-10 Pan Shiyang 抗人非小细胞肺癌单克隆抗体及其应用
CN103221419A (zh) * 2010-09-17 2013-07-24 独立行政法人产业技术综合研究所 肺癌鉴定标志物

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3531301A1 (de) * 1985-09-02 1987-03-05 Behringwerke Ag Monoklonale antikoerper gegen tumorassoziierte glykoproteine, verfahren zu ihrer herstellung sowie ihre verwendung
JPH0813840B2 (ja) * 1987-03-31 1996-02-14 協和醗酵工業株式会社 抗ヒト肺腺癌単クロ−ン性抗体
US5134075A (en) * 1989-02-17 1992-07-28 Oncogen Limited Partnership Monoclonal antibody to novel antigen associated with human tumors
US5171665A (en) * 1989-04-17 1992-12-15 Oncogen Monoclonal antibody to novel antigen associated with human tumors
US5342774A (en) * 1991-05-23 1994-08-30 Ludwig Institute For Cancer Research Nucleotide sequence encoding the tumor rejection antigen precursor, MAGE-1
US5589579A (en) * 1994-07-19 1996-12-31 Cytoclonal Pharmaceutics, Inc. Gene sequence and probe for a marker of non-small cell lung carinoma
ES2246522T3 (es) 1997-03-03 2006-02-16 Amersham Biosciences Uk Ltd Extraccion celular in-situ y metodo analitico.
DE19725133A1 (de) * 1997-06-13 1998-12-17 Micromet Ges Fuer Biomedizinis Nachweis von seltenen Zellen
US20050089918A1 (en) * 1998-02-23 2005-04-28 Amersham Biosciences Uk Limited In-situ cell extraction and assay method
US6117981A (en) * 1999-06-03 2000-09-12 Cytoclonal Pharmaceutics, Inc. Hybridomas for lung cancer marker and monoclonal antibodies thereof
EP1212344A4 (en) * 1999-09-03 2004-08-04 Human Genome Sciences Inc POLYNUCLEOTIDES, POLYPEPTIDES AND ANTIBODIES OF THE TYPE B7
WO2001094413A2 (en) 2000-06-06 2001-12-13 Bristol-Myers Squibb Company B7-related nucleic acids and polypeptides and their uses for immunomodulation
CN101724072B (zh) * 2008-10-27 2013-10-09 谷为岳 一种抗肿瘤的单克隆抗体的序列及应用
LT2542256T (lt) 2010-03-04 2019-10-25 Macrogenics Inc Su b7-h3 reaguojantys antikūnai, jų imunologiškai aktyvūs fragmentai ir jų naudojimas
PH12012501751A1 (en) 2010-03-04 2012-11-12 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
GEAP202214922A (en) 2016-04-15 2022-02-10 Macrogenics Inc Novel b7-h3 binding molecules, antibody drug conjugates thereof and usage thereof
CN111662371B (zh) * 2020-04-30 2023-07-04 美康生物科技股份有限公司 细胞角蛋白19片段抗原及其制备方法和应用
CN112300284B (zh) * 2020-12-29 2021-04-06 慈达(广州)生物技术有限公司 核酸筛选结合抗体检测用于癌症检测中的用途及其制备的试剂盒

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4569788A (en) * 1983-05-18 1986-02-11 The United States Of America As Represented By The Department Of Health And Human Services Monoclonal antibodies against non small cell lung cancer
IL76877A (en) * 1984-11-02 1991-11-21 Oncogen Diagnostic method for the determination of human non-small cell lung carcinomas employing novel monoclonal antibodies and compositions containing said antibodies
ZA858371B (en) * 1984-11-02 1987-03-25 Oncogen Monoclonal antibodies for human non-small cell lung carcinomas

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101732333B (zh) * 2000-07-28 2012-08-15 大日本住友制药株式会社 癌症治疗药
CN102791736A (zh) * 2009-09-23 2012-11-21 艾斯可勒皮恩有限公司 用于癌症治疗的dsg2拮抗剂
CN103221419A (zh) * 2010-09-17 2013-07-24 独立行政法人产业技术综合研究所 肺癌鉴定标志物
CN103221419B (zh) * 2010-09-17 2015-12-09 独立行政法人产业技术综合研究所 肺癌鉴定标志物
WO2013063874A1 (zh) * 2011-11-03 2013-05-10 Pan Shiyang 抗人非小细胞肺癌单克隆抗体及其应用

Also Published As

Publication number Publication date
DE3705276A1 (de) 1987-08-27
NO174719B (no) 1994-03-14
NZ219338A (en) 1991-11-26
KR880010438A (ko) 1988-10-08
IT8719491A0 (it) 1987-02-25
FI870764A0 (fi) 1987-02-23
DK98187D0 (da) 1987-02-25
FR2596062A1 (fr) 1987-09-25
US5185432A (en) 1993-02-09
SE467988B (sv) 1992-10-12
GB2186885A (en) 1987-08-26
NL8700415A (nl) 1987-09-16
CA1312025C (en) 1992-12-29
KR870008026A (ko) 1987-09-23
PT84370A (en) 1987-03-01
DK98187A (da) 1987-08-27
IE870487L (en) 1987-08-26
DD266028A5 (de) 1989-03-22
SE8700805L (sv) 1987-10-22
DD276165A5 (de) 1990-02-14
YU25787A (en) 1990-12-31
GB8703700D0 (en) 1987-03-25
GB2186885B (en) 1990-10-03
ATA43587A (de) 1995-06-15
JPS62220197A (ja) 1987-09-28
GR870294B (en) 1987-06-30
IE60286B1 (en) 1994-06-29
PT84370B (pt) 1989-11-10
ES2004245A6 (es) 1988-12-16
SE9201529D0 (sv) 1992-05-14
KR900006338B1 (ko) 1990-08-28
IT1203511B (it) 1989-02-15
YU46189B (sh) 1993-05-28
ZA869494B (en) 1987-10-28
AU6927287A (en) 1987-08-27
FI870764A7 (fi) 1987-08-27
OA08485A (fr) 1988-07-29
BE1000611A5 (fr) 1989-02-21
SE9201529A0 (sv) 1992-05-14
AT400577B (de) 1996-01-25
CH675880A5 (cg-RX-API-DMAC10.html) 1990-11-15
NO870770D0 (no) 1987-02-25
FR2596062B1 (fr) 1990-06-08
SE8700805D0 (sv) 1987-02-25
LU86786A1 (fr) 1987-09-15
NO870770L (no) 1987-08-27
NO174719C (no) 1994-06-22
AU612967B2 (en) 1991-07-25

Similar Documents

Publication Publication Date Title
CN87100927A (zh) 人类非小细胞肺癌及其它几种癌症的单克隆抗和抗原
Edwards et al. Monoclonal antibody identification and characterization of a M r 43,000 membrane glycoprotein associated with human breast cancer
KR900003923B1 (ko) 인체 암종양과 관련된 항원에 대한 단일클론성 항체
AU2001292782B2 (en) Novel tumor-associated marker
CA1320459C (en) Anti-human pulmonary carcinoma monoclonal antibody
US5091177A (en) Monoclonal antibodies for treatment of human non-small cell lung carcinomas
JPH066067B2 (ja) モノクロナ−ル抗体およびその製造方法
JPS63294779A (ja) ハイブリドマ
US20020098581A1 (en) Carcinoma associated antigen (SK1) monoclonal antibodies against SK1, methods of producing these antibodies and use therefor
WO1986007089A1 (en) Murine hybridoma lym-2 and diagnostic antibody produced thereby
JP2831852B2 (ja) ヒト胸腺皮質細胞上に発現する細胞表面タンパク質及びその利用
EP0184369B1 (en) Monoclonal antibody specific for a mammary tumor cell surface antigen
JPH0734741B2 (ja) ヒト腎臓がん抗原に対するモノクローナル抗体生産ハイブリドーマ細胞系
JP3212987B2 (ja) ヒト―ヒトハイブリドーマの製造方法並びに該ハイブリドーマからモノクローナル及びポリクローナル抗体を製造する方法
CA1238285A (en) Monoclonal antibody specific for a mammary tumor cytoplasmis antigen
IE59254B1 (en) Monoclonal antibodies for human non-small cell lung carcinomas
JP4493882B2 (ja) 抗原およびこの抗原を識別するモノクローナル抗体
WO1997039774A1 (en) Human monoclonal antibody specific for melanoma-associated antigen and methods of use
EP0339633A2 (en) Anti-human gastric cancer monoclonal antibody
EP0179450A2 (en) Purified antigen isolated from sera of leukemia and lymphoma patients, novel antibodies to said antigen, methods of preparing same and diagnostic and therapeutic methods empolying said antibody
WO2000000591A1 (en) Human monoclonal antibodies against the tumor antigen uk114 and lymphocyte cells and hybridomas for their production
JPS61148199A (ja) 微量抗原に対するモノクロ−ナル抗体
WO1994016726A1 (en) Carcinoma associated antigen (ng1) monoclonal antibodies against ng1, methods of producing these antibodies and use therefor
JPS61289880A (ja) 新規ハイブリド−マ，その製造法および用途
JPH03155799A (ja) ヒト子宮頸部腺癌由来培養細胞株ｏｍｃ―４に対するモノクローナル抗体

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication