CN2554178Y - Bio-chip for detecting acute myocardial infarction index - Google Patents
Bio-chip for detecting acute myocardial infarction index Download PDFInfo
- Publication number
- CN2554178Y CN2554178Y CN 02261900 CN02261900U CN2554178Y CN 2554178 Y CN2554178 Y CN 2554178Y CN 02261900 CN02261900 CN 02261900 CN 02261900 U CN02261900 U CN 02261900U CN 2554178 Y CN2554178 Y CN 2554178Y
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- CN
- China
- Prior art keywords
- myocardial infarction
- acute myocardial
- biochip
- detected
- shell
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The utility model relates to the field of biomedical technology, in particular to a biological chip which can carry out the detection of the indicators of acute myocardial infarction. The utility model aims at providing the biological chip to overcome the shortcomings that the manufacturing cost of the prior art is high and the quality is difficult to be ensured during the large-scale production. The technical proposal of the utility model to achieve the above purpose is that the utility model includes an outer shell, a substrate and a dot-matrix which is arranged on the substrate; the utility model is characterized in that the outer shell is a hollow shell body, a liquid absorbing layer and the substrate are arranged in the outer shell, the liquid absorbing layer is arranged at the bottom part of the outer shell, a detection port which is corresponding to the dot-matrix on the substrate is arranged at the upper part of the outer shell, and a convex eaves is arranged below the inside of the detection port.
Description
Affiliated technical field:
The utility model relates to field of biomedicine technology, is specifically related to a kind of biochip that the acute myocardial infarction index is detected.
Background technology:
General biochip all comprises sheet base and the detection molecules dot matrix that is fixed on the base material, a large amount of detection molecules are fixed on the base material by in-situ polymerization, in use, exist and react shortcoming incomplete, the detected result poor accuracy, this is caused by two reasons, the one, test solution adds the back side leakage takes place, and the 2nd, it is inhomogeneous that test solution adds the back infiltration.
Summary of the invention:
The purpose of this utility model provides a kind of biochip that the acute myocardial infarction index is detected, with overcome reaction that prior art exists not exclusively, the shortcoming of detected result poor accuracy.
For achieving the above object, the technical solution of the utility model is: a kind of biochip that the acute myocardial infarction index is detected, comprise the dot matrix 4 on shell 1, base material 6 and the base material 6, its special character is, described shell 1 is a hollow shell, is provided with liquid-adsorption layer 8 and base material 6 in the shell 1, and liquid-adsorption layer 8 is arranged at shell 1 bottom, shell 1 top be provided with base material 6 on the corresponding detections of dot matrix 4 mouthfuls 2, described detections mouthful 2 interior side-lowers are provided with protruding eaves 5.
Can be provided with anti-anti-seepage membrane 7 between above-mentioned liquid-adsorption layer 8 and the base material 6, its sepage direction be by base material 6 to liquid-adsorption layer 8 infiltrations, this anti-anti-seepage membrane 7 can avoid test solution after infiltrating liquid-adsorption layer 8 again reverse osmosis go into dot matrix 4 on the base material 6, influence detected result.
Above-mentioned detection mouth 2 can be one or more, and each detects mouthful 2 corresponding one or more dot matrix 4, can avoid disease indicators cross infection each other like this.
Above-mentioned shell 1 upper surface is provided with tag slot 3 near a side that detects mouth 2, and this tag slot 3 is used for chip is carried out mark.
Above-mentioned base material 6 is nitrocellulose membranes, and described liquid-adsorption layer 8 is absorbent wool, thieving paper or macromolecule water uptake synthetic materials.Millipore filtration has stronger diafiltration, concentrated, agglutination, and detection can be carried out fast, improves the accuracy that detects.
Above-mentioned shell 1 is made of two portions clamping, comprises being provided with loam cake 9 that detects mouth 2 and the drain pan 10 that is provided with liquid-adsorption layer 8 and base material 6, is convenient to dismounting.
Above-mentioned dot matrix 4 is square several, and the point of sample number on each dot matrix 4 equates and is square several.
Above-mentioned dot matrix 4 is arranged as square.
Albumen on the above-mentioned dot matrix 4 can be to detect two or more in E.C. 3.5.3.3, E.C. 3.5.3.3 isozyme, myohaemoglobin, serum cardiac troponin T, cardiac muscle troponin I, cardiac troponin C and the fatty acid binding protein associated protein in the acute myocardial infarction index.
Albumen in the above-mentioned dot matrix 4 can be in the specific antibody protein of corresponding each index, corresponding some specific genes or the proteic monoclonal antibody albumen of polypeptide fragment a kind of, two or more.
Compared with prior art, the utility model has the advantages that: because of a detection mouthful interior side-lower is provided with protruding eaves, side leakage can not take place after adding the detection mouth in test solution, and because of the utility model is provided with liquid-adsorption layer, test solution adds the back infiltration evenly, so detection speed is fast, and detected result is accurate.
Description of drawings:
Fig. 1 is a structural representation of the present utility model;
Fig. 2 is the A-A sectional view of Fig. 1;
Fig. 3 is that the B of Fig. 1 is to view.
Description of reference numerals is as follows:
1-shell, 2-detect mouth, 3-tag slot, 4-dot matrix, the protruding eaves of 5-, 6-base material, 7 anti-anti-seepage membranes, 8-liquid-adsorption layer, 9-loam cake, 10-drain pan.
Embodiment:
Below in conjunction with accompanying drawing the utility model is done and to be described in further detail.
Referring to Fig. 1～3, a kind of biochip that the acute myocardial infarction index is detected comprises the dot matrix 4 on shell 1, base material 6 and the base material 6, described shell 1 adopts hollow shell, this shell 1 is made of two portions, comprises loam cake 9 and drain pan 10, clamping between two portions.Be provided with the base material 6 of the liquid-adsorption layer 8 of absorbent wool making, anti-anti-seepage membrane 7 and cellulose nitrate film production in the said drain pan 10 successively, liquid-adsorption layer 8 is arranged at drain pan 10 bottoms; Said loam cake 9 be provided with base material 6 on the corresponding detections of dot matrix 4 mouthfuls 2, said detection mouth 2 is one, this detection mouthful 2 interior side-lowers are provided with protruding eaves 5, said loam cake 9 upper surfaces are provided with tag slot 3 near a side that detects mouthfuls 2, and the sign bar that this tag slot 3 is used to stick content such as examinee's name carries out mark to chip.
Dot matrix 4 on the said base material 6 is 9, is arranged as square, and the point of sample number on each dot matrix 4 is 36, is arranged as square.Be integrated with E.C. 3.5.3.3, E.C. 3.5.3.3 isozyme, myohaemoglobin, serum cardiac troponin T, cardiac muscle troponin I, cardiac troponin C and fatty acid binding protein in the detection acute myocardial infarction index respectively on 7 dot matrix 4 therein, used albumen is each index specific proteins, as point range to be detected; A remaining dot matrix 4 is as the Quality Control point range, and a dot matrix 4 in addition is as the data refer point range.
Claims (10)
1, a kind of biochip that the acute myocardial infarction index is detected, comprise the dot matrix (4) on shell (1), base material (6) and the base material (6), it is characterized in that: described shell (1) is a hollow shell, be provided with liquid-adsorption layer (8) and base material (6) in the shell (1), liquid-adsorption layer (8) is arranged at shell (1) bottom, shell (1) top be provided with base material (6) on corresponding detections of dot matrix (4) mouthful (2), described detection mouth (a 2) interior side-lower is provided with protruding eaves (5).
2, a kind of biochip that the acute myocardial infarction index is detected as claimed in claim 1 is characterized in that: be provided with anti-anti-seepage membrane (7) between described liquid-adsorption layer (8) and the base material (6).
3, a kind of biochip that the acute myocardial infarction index is detected as claimed in claim 1 or 2 is characterized in that: described detection mouthful (2) is one or more.
4, a kind of biochip that the acute myocardial infarction index is detected as claimed in claim 3 is characterized in that: described shell (1) upper surface is provided with tag slot (3) near a side that detects mouthful (2).
5, a kind of biochip that the acute myocardial infarction index is detected as claimed in claim 4, it is characterized in that: described base material (6) is a nitrocellulose membrane, described liquid-adsorption layer (8) is absorbent wool, thieving paper or macromolecule water uptake synthetic materials.
6, a kind of biochip that the acute myocardial infarction index is detected as claimed in claim 5, it is characterized in that: described shell (1) is made of two portions clamping, comprises being provided with the loam cake (9) that detects mouthful (2) and being provided with liquid-adsorption layer (8) and the drain pan (10) of base material (6).
7, a kind of biochip that the acute myocardial infarction index is detected as claimed in claim 6 is characterized in that: described dot matrix (4) is square several, and the point of sample number on each dot matrix (4) equates and is square several.
8, a kind of biochip that the acute myocardial infarction index is detected as claimed in claim 7, it is characterized in that: described dot matrix (4) is arranged as square.
9, a kind of biochip that the acute myocardial infarction index is detected as claimed in claim 8 is characterized in that: the albumen on the described dot matrix (4) is to detect two or more in E.C. 3.5.3.3, E.C. 3.5.3.3 isozyme, myohaemoglobin, serum cardiac troponin T, cardiac muscle troponin I, cardiac troponin C and the fatty acid binding protein associated protein in the acute myocardial infarction index.
10, a kind of biochip that the acute myocardial infarction index is detected as claimed in claim 9 is characterized in that: the albumen in the described dot matrix (4) be in the specific antibody protein of each index, corresponding some specific genes or the proteic monoclonal antibody albumen of polypeptide fragment a kind of, two or more.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02261900 CN2554178Y (en) | 2002-07-01 | 2002-07-01 | Bio-chip for detecting acute myocardial infarction index |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02261900 CN2554178Y (en) | 2002-07-01 | 2002-07-01 | Bio-chip for detecting acute myocardial infarction index |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2554178Y true CN2554178Y (en) | 2003-06-04 |
Family
ID=33728575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02261900 Expired - Fee Related CN2554178Y (en) | 2002-07-01 | 2002-07-01 | Bio-chip for detecting acute myocardial infarction index |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2554178Y (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104714031A (en) * | 2015-03-25 | 2015-06-17 | 王义明 | Rapid detection kit for myocardial infarction |
-
2002
- 2002-07-01 CN CN 02261900 patent/CN2554178Y/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104714031A (en) * | 2015-03-25 | 2015-06-17 | 王义明 | Rapid detection kit for myocardial infarction |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: SHANGHAI CHUANGYUE BIOLOGY SCIENCE CO., LTD. Free format text: FORMER OWNER: XI AN POTOMAC BIO-TECHNOLOGY CO., LTD. Effective date: 20060908 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20060908 Address after: Upper 200333 Sea city, Zhongjiang Road, No. 4, unit 879, building 3, Putuo District Patentee after: Shanghai creation Biotechnology Co., Ltd. Address before: 710075 No. four, No. 23, hi tech Road, Shaanxi, Xi'an Patentee before: Xi'an Lian'er Biotechnology Co., Ltd. |
|
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |