CN2554183Y - Bio-chip for detecting various routine examination items index - Google Patents
Bio-chip for detecting various routine examination items index Download PDFInfo
- Publication number
- CN2554183Y CN2554183Y CN 02261905 CN02261905U CN2554183Y CN 2554183 Y CN2554183 Y CN 2554183Y CN 02261905 CN02261905 CN 02261905 CN 02261905 U CN02261905 U CN 02261905U CN 2554183 Y CN2554183 Y CN 2554183Y
- Authority
- CN
- China
- Prior art keywords
- kinds
- detected
- biochip
- dot matrix
- inspection project
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Landscapes
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The utility model relates to the field of biomedical technology, in particular to a biological chip which can carry out the detection of the indicators of various routine examination items. The utility model aims at providing the biological chip to overcome the shortcomings that the detection results of the prior art are not accurate and the rate of the misdetection is high. The technical proposal of the utility model to achieve the above purpose is that the utility model includes a hollow outer shell, a substrate which is arranged in the outer shell and a dot-matrix which is arranged on the substrate; the utility model is characterized in that the interior of the outer shell is further provided with a reverse osmosis membrane, the reverse osmosis membrane is arranged at the lower part of the substrate, a detection port which is corresponding to the dot-matrix on the substrate is arranged at the upper part of the outer shell, and a convex eaves is arranged below the inside of the detection port.
Description
Affiliated technical field:
The utility model relates to field of biomedicine technology, is specifically related to a kind of biochip that all kinds of routine inspection project indicators are detected.
Background technology:
Biochip comprises base material and the detection molecules dot matrix that is fixed on the base material, and a large amount of detection molecules are fixed on the material base by in-situ polymerization.There is the shortcoming that detected result is inaccurate, false failure rate is high in existing chip, this be because: 1, test solution not with dot matrix on some when fully reaction takes place by around side leakage; 2, seen through after the reaction base material test solution generation reverse osmosis phenomenon and once more with base material on the dot matrix reaction.
The utility model content:
The purpose of this utility model provides a kind of biochip that all kinds of routine inspection project indicators are detected, to overcome the shortcoming that the prior art detected result is inaccurate, false failure rate is high.
For achieving the above object, the technical solution of the utility model is: a kind of biochip that all kinds of routine inspection project indicators are detected, comprise base material 8 in the hollow shell 1, shell 1 and the dot matrix 5 on the base material 8, its special character is, also be provided with anti-anti-seepage membrane 9 in the described shell 1, anti-anti-seepage membrane 9 is arranged at base material 8 bottoms, described shell 1 top be provided with base material 8 on dot matrix 5 corresponding detection mouthfuls 2, above-mentioned detection mouth 2 interior side-lowers are provided with protruding eaves 7.
Also be provided with liquid-adsorption layer 10 in the above-mentioned shell 1, this liquid-adsorption layer 10 is arranged at anti-anti-seepage membrane 9 bottoms, and the micropore on it has stronger diafiltration, agglutination, can guarantee the test solution infiltration evenly, and detection is carried out fast, improves the accuracy that detects.
Above-mentioned base material 8 is nitrocellulose membranes, and described liquid-adsorption layer 10 is absorbent wools, thieving paper or macromolecule water uptake synthetic materials.
Above-mentioned shell 1 bottom is provided with breather hole 6 corresponding to detecting mouth 2, and the test solution infiltration is more even, thereby improves the accuracy of detected result.
Above-mentioned shell 1 one ends are provided with boss 3, and described boss 3 upper and lower surfaces are provided with groove 4, boss 3 is set can makes operator that the take position of chip of one fixed is arranged, and described groove 4 can guarantee operational safety, reduces mistake and surveys.
Above-mentioned boss 3 terminations are arc, save material.
Above-mentioned dot matrix 5 is square several, and the point of sample number on each dot matrix 5 equates and is square several.
Above-mentioned dot matrix 5 is arranged as square.
Albumen on the above-mentioned dot matrix 5 can be the IgG during immunoglobulin (Ig) detects in all kinds of routine inspection project indicators, IgM, IgA, IgE, alpha-fetoprotein during M albumen and tumor marker detect, carcinomebryonic antigen, cancer antigen 1 5-3, cancer antigen 125, sugar refining antigen 1 9-9, sugar refining antigen 72-4, squamous cell carcinoma antigen, tissue polypeptide antigen, prostate specific antigen, prostate acid phosphatase, neuronspecific enolase, gamma-glutamyltranspeptidase, in the human chorionic gonadotrophin index of correlation two or more.
Albumen in the above-mentioned dot matrix 5 can be specific proteins, wherein in antibody protein, corresponding some specific genes or the proteic monoclonal antibody albumen of polypeptide fragment of some specific genes or polypeptide fragment albumen, corresponding each index a kind of, two or more.
Compared with prior art, the utility model has the advantages that: simple in structure, low cost of manufacture; Owing to be provided with anti-anti-seepage membrane, and below detecting mouth, be provided with protruding eaves, therefore the reacting phenomenon again of having avoided reverse osmosis to cause, stop that simultaneously test solution side leakage current goes in the housing, guaranteed that the point range on test solution and the dot matrix reacts completely, so the detected result accuracy improves greatly, reduced mistake and surveyed; The utility model is rational in infrastructure, and the test solution requirement is few, can reduce patient's misery.
Description of drawings:
Fig. 1 is a structural representation of the present utility model;
Fig. 2 is the rear view of Fig. 1;
Fig. 3 is the A-A sectional view of Fig. 1.
The accompanying drawing drawing is described as follows:
1-shell, 2-detect mouth, the 3-boss, and the 4-groove, the 5-dot matrix, the 6-breather hole, the protruding eaves of 7-, the 8-base material, 9-prevents anti-seepage membrane, the 10-liquid-adsorption layer.
Embodiment: below in conjunction with accompanying drawing the utility model is done to describe in further detail.
Referring to Fig. 1～3, a kind of biochip that all kinds of routine inspection project indicators are detected includes hollow shell 1, and said shell 1 one ends are provided with boss 3, and described boss 3 upper and lower surfaces are provided with groove 4.Be provided with the base material 8 of liquid-adsorption layer 10 that absorbent wool makes, cellulose nitrate film production in the said shell 1 and be arranged at their anti-anti-seepage membranes 9 between the two, base material 8 is provided with dot matrix 5, shell 1 top be provided with base material 8 on corresponding one of dot matrix 5 detect mouthfuls 2, this detection mouthful 2 interior side-lowers are provided with protruding eaves 7, and said shell 1 bottom is provided with breather hole 6 corresponding to detecting mouth 2.
Claims (10)
1, a kind of biochip that all kinds of routine inspection project indicators are detected, comprise base material (8) in the hollow shell (1), shell (1) and the dot matrix (5) on the base material (8), it is characterized in that: also be provided with anti-anti-seepage membrane (9) in the described shell (1), anti-anti-seepage membrane (9) is arranged at base material (8) bottom, described shell (1) top be provided with base material (8) on corresponding detections of dot matrix (5) mouth (2), the interior side-lower of above-mentioned detection mouth (2) is provided with protruding eaves (7).
2, a kind of biochip that all kinds of routine inspection project indicators are detected as claimed in claim 1 is characterized in that: be provided with liquid-adsorption layer (10) in the described shell (1), this liquid-adsorption layer (10) is arranged at anti-anti-seepage membrane (9) bottom.
3, a kind of biochip that all kinds of routine inspection project indicators are detected as claimed in claim 2, it is characterized in that: described base material (8) is a nitrocellulose membrane, described liquid-adsorption layer (10) is absorbent wool, thieving paper or macromolecule water uptake synthetic materials.
4, as claim 1 or 2 or 3 described a kind of biochips that all kinds of routine inspection project indicators are detected, it is characterized in that: described shell (1) bottom is provided with breather hole (6) corresponding to detecting mouthful (2).
5, a kind of biochip that all kinds of routine inspection project indicators are detected as claimed in claim 4 is characterized in that: described shell (1) one end is provided with boss (3).
6, a kind of biochip that all kinds of routine inspection project indicators are detected as claimed in claim 5, it is characterized in that: described boss (3) termination is an arc.
7, a kind of biochip that all kinds of routine inspection project indicators are detected as claimed in claim 6 is characterized in that: described dot matrix (5) is square several, and the point of sample number on each dot matrix (5) equates and is square several.
8, a kind of biochip that all kinds of routine inspection project indicators are detected as claimed in claim 7, it is characterized in that: described dot matrix (5) is arranged as square.
9, a kind of biochip that all kinds of routine inspection project indicators are detected as claimed in claim 8 is characterized in that: the albumen on the described dot matrix (5) is the IgG during immunoglobulin (Ig) detects, IgM, IgA, IgE, alpha-fetoprotein during M albumen and tumor marker detect, carcinomebryonic antigen, cancer antigen 1 5-3, cancer antigen 125, sugar refining antigen 1 9-9, sugar refining antigen 72-4, squamous cell carcinoma antigen, tissue polypeptide antigen, prostate specific antigen, prostate acid phosphatase, neuronspecific enolase, gamma-glutamyltranspeptidase, in the human chorionic gonadotrophin associated protein two or more.
10, a kind of biochip that all kinds of routine inspection project indicators are detected as claimed in claim 9 is characterized in that: the albumen in the described dot matrix (5) be each index specific proteins, wherein in antibody protein, corresponding some specific genes or the proteic monoclonal antibody albumen of polypeptide fragment of some specific genes or polypeptide fragment albumen, corresponding each index a kind of, two or more.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02261905 CN2554183Y (en) | 2002-07-01 | 2002-07-01 | Bio-chip for detecting various routine examination items index |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02261905 CN2554183Y (en) | 2002-07-01 | 2002-07-01 | Bio-chip for detecting various routine examination items index |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2554183Y true CN2554183Y (en) | 2003-06-04 |
Family
ID=33728580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02261905 Expired - Fee Related CN2554183Y (en) | 2002-07-01 | 2002-07-01 | Bio-chip for detecting various routine examination items index |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2554183Y (en) |
-
2002
- 2002-07-01 CN CN 02261905 patent/CN2554183Y/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Valcárcel et al. | Flow–Through (Bio) Chemical Sensors | |
| US9551661B2 (en) | Assay chip | |
| CN101526520B (en) | Method and device for biological sample detection | |
| CN101120253B (en) | Immunochromatographic test instrument and semiquantitative method using the same | |
| JP2002509605A (en) | Electronic verification device and method | |
| EP0981750A1 (en) | Method and device for producing a predetermined distribution of detectable change in assays | |
| CN110133255A (en) | A kind of quickly SERS- immunochromatography detection method with highly sensitive detection mycoplasma pneumoniae infection | |
| CN1117284C (en) | Microfluid biochip detection-analysis board and its detection method | |
| MX2011010586A (en) | Device and method for the verification and quantitative analysis of analytes, particularly mycotoxins. | |
| NO314206B1 (en) | Quantitative chemical analysis method, device / device, and application of said method and analysis set | |
| KR101190190B1 (en) | Device for measuring reflective absorbance and combined device for reflective absorbance and lateral flow analysis | |
| CN109669037B (en) | Separated multi-channel chromatographic device | |
| CN206920451U (en) | A kind of test strips for detecting glycosylated hemoglobin | |
| CN2554183Y (en) | Bio-chip for detecting various routine examination items index | |
| CN105891519B (en) | A kind of kit and assay method for being used to determine glycosylated hemoglobin ratio | |
| US20040053419A1 (en) | Test device | |
| CN212568472U (en) | Spectrum biological sensing device | |
| CN2554176Y (en) | Bio-chip for detecting rheumatic disease index | |
| CN2554182Y (en) | Bio-chip for detecting child health examination index | |
| CN209542626U (en) | A kind of Seperated multiple channel chromatographic apparatus | |
| JPWO2004081568A1 (en) | Specimen inspection method and specimen storage container used in the inspection method | |
| CN209656714U (en) | A kind of push type multichannel chromatographic apparatus | |
| CN2849725Y (en) | Kit for testing occult blood | |
| CN109212183B (en) | One-step fecal hemoglobin rapid detection kit | |
| CN2554178Y (en) | Bio-chip for detecting acute myocardial infarction index |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: SHANGHAI CHUANGYUE BIOLOGY SCIENCE CO., LTD. Free format text: FORMER OWNER: XI AN POTOMAC BIO-TECHNOLOGY CO., LTD. Effective date: 20060901 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20060901 Address after: 200333, building 4, 3, Zhongjiang Road, 879, Shanghai, Putuo District Patentee after: Shanghai creation Biotechnology Co., Ltd. Address before: 710075 No. four, No. 23, hi tech Road, Shaanxi, Xi'an Patentee before: Xi'an Lian'er Biotechnology Co., Ltd. |
|
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |