CN2554171Y - Bio-chip for detecting infections respiratory tract disease index - Google Patents
Bio-chip for detecting infections respiratory tract disease index Download PDFInfo
- Publication number
- CN2554171Y CN2554171Y CN 02261892 CN02261892U CN2554171Y CN 2554171 Y CN2554171 Y CN 2554171Y CN 02261892 CN02261892 CN 02261892 CN 02261892 U CN02261892 U CN 02261892U CN 2554171 Y CN2554171 Y CN 2554171Y
- Authority
- CN
- China
- Prior art keywords
- biochip
- base material
- dot matrix
- shell
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The utility model relates to the field of biomedical technology, in particular to a biological chip which can carry out the detection of the indicators of infectious respiratory diseases. The technical proposal of the utility model is that the utility model includes an outer shell 1, a substrate 7 and a dot-matrix 5 which is arranged on the substrate 7, the outer shell 1 adopts a hollow shell body, the bottom part of the outer shell 1 is provided with a liquid absorbing layer 9, the substrate 7 is arranged on the liquid absorbing layer 9, the upper part of the outer shell 1 is provided with a detection port 2 which is corresponding to the dot-matrix 5, a convex eaves 6 is arranged below the inside of the detection port 2, and one end of the outer shell 1 is provided with a boss 3. The utility model has low manufacturing cost and can ensure the quality during the large-scale production, the utility model can not mis-detect during the detection, the slide glass is easy to take and the safety of the operation is high.
Description
Technical field:
The utility model relates to field of biomedicine technology, is specifically related to a kind of biochip that the infectious respiratory disease index is detected.
Background technology:
Present biochip all is to adopt the detection molecules dot matrix is fixed in structure formation on the slide glass, its slide glass generally adopts sheet glass to make, a large amount of detection molecules are fixed on this sheet glass by in-situ polymerization, by detection molecules density is higher thereon, cause the biochip of this structure to exist the cost of manufacture height, difficult quality guarantee during scale operation, the high defective of false failure rate during detection; Drop to be detected is on slide glass the time, liquid to be detected easily to around outflow, a large amount of liquid to be detected fail to be convened for lack of a quorum outward cause this part detect liquid can't with the detection molecules dot matrix reaction on the slide glass, can not realize testing goal; This slide glass is difficult for taking, and when taking slide glass as the staff and virus to be detected lean on too near, cross infection easily takes place, processing safety is low.
The utility model content:
The technical problem that the utility model is difficult to when having solved the biochip manufacturing cost height in the background technology, scale operation to ensure the quality of products, false failure rate height, liquid to be detected easily outflow when detecting, slide glass is difficult for taking, processing safety is low.
The technical solution of the utility model is: the utility model comprises the dot matrix 5 on shell 1, base material 7 and the base material 7, its special character is: described shell 1 adopts hollow shell, this shell 1 bottom is provided with base material 7, its top be provided with base material 7 on the corresponding detections of dot matrix 5 mouthfuls 2, detect mouthful 2 interior side-lowers and be provided with protruding eaves 6, shell one end is provided with boss 3.
Above-mentioned boss 3 upper and lower surfaces are provided with groove 4.
Above-mentioned boss 3 terminations are arc.
Above-mentioned shell 1 bottom is provided with liquid-adsorption layer 9, and base material 7 is arranged on the liquid-adsorption layer 9.
9 of above-mentioned base material 7 and liquid-adsorption layers are provided with anti-anti-seepage membrane 8.
Above-mentioned base material 7 is nitrocellulose membranes, and liquid-adsorption layer 9 is absorbent wools, thieving paper or macromolecule water uptake synthetic materials.
Above-mentioned dot matrix 5 is square several, and the point of sample number on each dot matrix equates and is square several.
Above-mentioned dot matrix 5 is arranged as square.
Albumen on the above-mentioned dot matrix 5 can be that mycoplasma pneumoniae, Chlamydia pneumoniae, adenovirus, influenza virus A/B, parainfluenza virus, respiratory tract close two or more in bag virus, the viral B of Ke Saqi, mycobacterium tuberculosis, Measles virus, popular B-mode brain viroid B, the vertebra poliovirus associated protein.
Albumen in the above-mentioned dot matrix 5 can be full bacterium or viral protein, wherein in some specific genes or polypeptide fragment albumen, corresponding full bacterium or the antibody protein C of viral protein, corresponding some specific genes or the proteic monoclonal antibody protein D of polypeptide fragment a kind of, two or more.
The utility model is provided with hollow casing, and the base material that will have dot matrix places in this hollow casing, this kind structure low cost of manufacture, and quality can be protected during scale operation, and quick when detecting, accurate; The utility model detects a mouthful interior side-lower and is provided with protruding eaves, and it can prevent liquid to be detected to side leakage all around, guarantees to detect quality; Shell one end of the present utility model also is provided with boss, and it is convenient to taking of operator, can guarantee operator's holding area and the distance between virus to be detected simultaneously, can not produce cross infection, the processing safety height.
Description of drawings:
Fig. 1 is a structural representation of the present utility model;
Fig. 2 is the upward view of Fig. 1;
Fig. 3 is the A-A sectional view of Fig. 1.
Embodiment:
Referring to Fig. 1～3, the utility model comprises the dot matrix 5 on shell 1, base material 7 and the base material 7, this shell 1 is a hollow shell, shell 1 bottom is provided with liquid-adsorption layer 9, base material 7 is arranged on the liquid-adsorption layer 9, and 9 of base material 7 and liquid-adsorption layers are provided with anti-anti-seepage membrane 8, and it can prevent reacted liquid reverse osmosis to be detected, continue reaction with the dot matrix 5 on the base material 7, influence the accuracy of detected result; Shell 1 top is provided with and dot matrix 5 corresponding detections mouths 2; This detection mouthful 2 interior side-lowers are provided with protruding eaves 6, base material 7 can adopt nitrocellulose membrane, and the micropore on the nitrocellulose membrane has stronger diafiltration, concentrated, agglutination, and detection can be carried out fast, improve the accuracy that detects, liquid-adsorption layer is absorbent wool, thieving paper or macromolecule water uptake synthetic materials; Shell 1 one ends are provided with boss 3, and boss 3 upper and lower surfaces are provided with groove 4, and its personnel that are convenient to operation are to the gripping of boss, and boss 3 terminations are arc, can save starting material; Shell 1 is split type hollow casing, and it can make things convenient for picking and placeing of base material 7.
Dot matrix on the described base material can be 16, point of sample number on each dot matrix is 16, be arranged as square, be integrated with mycoplasma pneumoniae respectively on 11 dot matrix therein, Chlamydia pneumoniae, adenovirus, influenza virus A/B, parainfluenza virus, respiratory tract closes bag virus, Ke Saqi virus B, mycobacterium tuberculosis, Measles virus, popular B-mode brain viroid B, the vertebra poliovirus is as point range to be detected, after the adding test solution detects, in order to do contrast with the data refer point range, judge that detected result is positive or negative, used albumen is specific proteins; In remaining five dot matrix, choose wherein two dot matrix as the Quality Control point range, whether effective in order to judge chip, its excess-three dot matrix can be used as the data refer point range, in order to judge the reference of detected result.
Claims (10)
1, a kind of biochip that the infectious respiratory disease index is detected, comprise the dot matrix (5) on shell (1), base material (7) and the base material (7), it is characterized in that: described shell (1) adopts hollow shell, this shell (1) bottom is provided with base material (7), top be provided with base material (7) on corresponding detections of dot matrix (5) mouth (2), described detection mouthful (a 2) interior side-lower is provided with protruding eaves (6), and described shell (1) one end is provided with boss (3).
2, biochip as claimed in claim 1 is characterized in that: the upper and lower surface of described boss (3) is provided with groove (4).
3, biochip as claimed in claim 2 is characterized in that: described boss (3) termination is an arc.
4, biochip as claimed in claim 3 is characterized in that: described shell (1) bottom is provided with liquid-adsorption layer (9), and base material (7) is arranged on the liquid-adsorption layer (9).
5, biochip as claimed in claim 4 is characterized in that: be provided with anti-anti-seepage membrane (8) between described base material (7) and liquid-adsorption layer (9).
6, as the described biochip of the arbitrary claim of claim 1 to 5, it is characterized in that: described base material (7) is a nitrocellulose membrane, and described liquid-adsorption layer (9) is an absorbent wool, thieving paper or macromolecule water uptake synthetic materials.
7, biochip as claimed in claim 6 is characterized in that: described dot matrix (5) is square several, and the point of sample number on each dot matrix equates and is square several.
8, biochip as claimed in claim 7 is characterized in that: described dot matrix (5) is arranged as square.
9, biochip as claimed in claim 8 is characterized in that: the albumen on the described dot matrix (5) is that mycoplasma pneumoniae, Chlamydia pneumoniae, adenovirus, influenza virus A/B, parainfluenza virus, respiratory tract close two or more in bag virus, the viral B of Ke Saqi, mycobacterium tuberculosis, Measles virus, popular B-mode brain viroid B, the vertebra poliovirus associated protein.
10, biochip as claimed in claim 9 is characterized in that: the albumen in the described dot matrix (5) be full bacterium or viral protein, wherein in some specific genes or polypeptide fragment albumen, corresponding full bacterium or the antibody protein of viral protein, corresponding some specific genes or the proteic monoclonal antibody albumen of polypeptide fragment a kind of, two or more.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02261892 CN2554171Y (en) | 2002-07-01 | 2002-07-01 | Bio-chip for detecting infections respiratory tract disease index |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02261892 CN2554171Y (en) | 2002-07-01 | 2002-07-01 | Bio-chip for detecting infections respiratory tract disease index |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2554171Y true CN2554171Y (en) | 2003-06-04 |
Family
ID=33728567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02261892 Expired - Fee Related CN2554171Y (en) | 2002-07-01 | 2002-07-01 | Bio-chip for detecting infections respiratory tract disease index |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2554171Y (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104991062A (en) * | 2015-07-23 | 2015-10-21 | 青岛汉唐生物科技有限公司 | Sample loading method of pneumonia mycoplasma and pneumonia chlamydia antibody detection |
| CN105510596A (en) * | 2015-12-02 | 2016-04-20 | 深圳市赛尔生物技术有限公司 | Protein chip for detecting respiratory virus antigens as well as kit and preparation method thereof |
-
2002
- 2002-07-01 CN CN 02261892 patent/CN2554171Y/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104991062A (en) * | 2015-07-23 | 2015-10-21 | 青岛汉唐生物科技有限公司 | Sample loading method of pneumonia mycoplasma and pneumonia chlamydia antibody detection |
| CN105510596A (en) * | 2015-12-02 | 2016-04-20 | 深圳市赛尔生物技术有限公司 | Protein chip for detecting respiratory virus antigens as well as kit and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105531591B (en) | Digital fluid sample separation equipment and the method for quantifying sample analysis for a step | |
| JPH06509224A (en) | Equipment for growing and processing tissue cultures | |
| CN113447652A (en) | Reagent card box for detecting novel coronavirus (SARS-CoV-2) antigen and preparation method and application thereof | |
| CN2554171Y (en) | Bio-chip for detecting infections respiratory tract disease index | |
| CN107505463A (en) | With the aptamer Sf B09 of sodium formaldehyde sulfoxylate specific bond and its application | |
| CN201828517U (en) | Kit for detecting hand-foot-and-mouth disease by adopting biotin fluorescence method | |
| CN2554170Y (en) | Bio-chip for detecting pylorus spirochete bacillus index | |
| CN111323575A (en) | Structure of test strip for detecting various products | |
| ES2421257T3 (en) | Method and apparatus for simultaneous testing of several analytes with an internal control | |
| CN2554173Y (en) | Bio-chip for detecting infections digestive tract disease index | |
| CN201083736Y (en) | Detachable membrane chip | |
| CN203465269U (en) | Combined detection card for hundestaupe virus antibody, canine parvovirus antibody and canine coronavirus antibody | |
| US6010910A (en) | Devices and kits for testing serum and the like | |
| CN1318850C (en) | Use of ink-jet printing to produce diffraction-based biosensors | |
| CN2554172Y (en) | Bio-chip for detecting sexual propagated disease index | |
| CN111766383A (en) | Method for detecting pathogenic virus and related protein thereof and predicting novel unknown virus | |
| CN205120720U (en) | Kit of anti medicine antibody of short -term test EGFR antibody medicine | |
| CN107505464B (en) | With the aptamer Sf-E07 of sodium formaldehyde sulfoxylate specific bond and its application | |
| CN2554176Y (en) | Bio-chip for detecting rheumatic disease index | |
| CN2554178Y (en) | Bio-chip for detecting acute myocardial infarction index | |
| CN2554181Y (en) | Bio-chip for detecting pre-marital health index | |
| CN2554177Y (en) | Bio-chip for detecting endocrinopathy index | |
| CN2565839Y (en) | Biochip for proceeding detection of immune sterility index | |
| CN2554174Y (en) | Bio-chip for detecting carcinoma of uterine cervix marker | |
| CN202710561U (en) | Biological chip for detecting pathogen indicator |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: SHANGHAI CHUANGYUE BIOLOGY SCIENCE CO., LTD. Free format text: FORMER OWNER: XI AN POTOMAC BIO-TECHNOLOGY CO., LTD. Effective date: 20060908 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20060908 Address after: 200333, building 4, 3, Zhongjiang Road, 879, Shanghai, Putuo District Patentee after: Shanghai creation Biotechnology Co., Ltd. Address before: 710075 No. four, No. 23, hi tech Road, Shaanxi, Xi'an Patentee before: Xi'an Lian'er Biotechnology Co., Ltd. |
|
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |