CN111323575A

CN111323575A - Structure of test strip for detecting various products

Info

Publication number: CN111323575A
Application number: CN201911125606.7A
Authority: CN
Inventors: 马萦嬛
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-12-17
Filing date: 2019-11-18
Publication date: 2020-06-23
Also published as: TWM580681U

Abstract

The invention discloses a multi-sample test strip structure, which comprises a supporting pad body, a reaction layer and at least one filter membrane; the present invention effectively uses a reaction unit having a plurality of reaction antibodies, and simultaneously detects the contents of various items, such as: the pesticide content, the water quality bacterial content, the excrement bacterial content or the urine pregnancy test and the like can be really realized after impurities are filtered, various different items and detected concentrations thereof can be simultaneously detected, the impurities in the detected liquid can be filtered through the filter membrane, the detection accuracy is improved, and the supporting cushion body is transparent and can be turned over in a double-sided mode to realize the advantage of being capable of inspecting and observing the colorimetric reaction presented by the reaction antibody.

Description

Structure of test strip for detecting various products

Technical Field

The present invention relates to a multi-sample test strip structure, and more particularly to a test strip structure capable of simultaneously detecting a plurality of different detection items and detected concentrations thereof.

Background

Accordingly, immunochromatography has played an important role in the medical system of today, and can be used to qualitatively or quantitatively measure the changes of various biological indicators, so as to provide reference for the information of disease diagnosis or drug treatment for the examiners or medical staff; at present, most of the test strips on the market are designed qualitatively so that the testers can obtain the test results by visual inspection, for example, the "upper and lower digestive tract cancer sieve test kit and the sampling solution and sampling method thereof" of taiwan patent No. I561820 and the "rapid test paper for degenerative arthritis" of taiwan patent No. M474135 are two examples of the test strips; the "upper and lower digestive tract cancer sieve test kit and its sampling solution and sampling method" of No. I561820 mainly comprises a sample bottle, a test box, and a sample solution. The test kit is provided with an antibody and colloidal gold compound which can be combined with occult blood in excrement and helicobacter pylori, and comprises a sample tank unit and a test tank unit. The test slot unit is provided with a first result area, a second result area and at least one control area which is provided with a control antibody capable of being combined with the antibody and the colloidal gold compound. The sample solution has a pH of 8.0 and includes a component which aids in performing the test, the component assisting in binding of the antibodies contained in the test kit to the colloidal gold complex and to occult blood in the feces and to helicobacter pylori. The component is trihydroxymethyl aminomethane hydrochloride with the concentration of 10 mM; the test paper for rapidly detecting degenerative arthritis of No. M474135 is used for detecting a urine specimen, and comprises a substrate, a detection result layer disposed on the substrate, a water absorption layer connected to the substrate and covering the detection result layer, an antibody release layer connected to the substrate and covering the detection result layer, and a specimen placement layer connected to the substrate and covering the antibody release layer; the detection result layer comprises a result display section and a control section, the antibody release layer comprises a plurality of detection complexes, and the detection complexes respectively comprise a colloidal gold particle and a plurality of cartilage oligomeric matrix protein polyclonal antibodies; the rapid detection test paper provides a non-invasive detection mode, is beneficial to early detection of articular cartilage degradation, namely early treatment, so as to slow down the deterioration speed; however, the test strips disclosed in the above two patents can only detect a single item, and cannot achieve the disadvantages of detecting multiple different detection items simultaneously, detecting the concentration of the object to be detected, and having low detection accuracy; therefore, how to detect the contents and concentrations of various detection items simultaneously by using a plurality of different reaction units and innovative hardware design is still a problem that developers and related researchers in related industries such as manufacturing and selling test strips need to continuously strive to overcome and solve.

Disclosure of Invention

Accordingly, the present invention is directed to a multi-sample test strip structure, which is improved and invented by the aid of abundant professional knowledge and years of practical experience, and aims to provide a test strip structure capable of simultaneously detecting a plurality of different detection items and detected concentrations thereof and improving detection accuracy, wherein the design of arranging at least one reaction unit and dry colloidal gold on a reaction layer is mainly used to effectively filter impurities through a filter membrane above the reaction unit, and the reaction unit with a plurality of reaction antibodies is used to simultaneously detect the contents of the plurality of different detection items, such as: the pesticide content, the water quality bacterial content, the excrement bacterial content or the urine pregnancy test and the like can really achieve the aim of simultaneously detecting various detection items and detected concentrations thereof, and impurities in the detected liquid can be filtered through the filter membrane, so that the detection accuracy is improved.

According to the objective of the present invention, a multi-sample test strip structure is provided, which at least comprises a support pad, a reaction layer, and at least one filter membrane; the support cushion body is transparent, and the reaction layer is attached to one surface of the support cushion body and is provided with at least one reaction unit with a plurality of reaction antibodies; the filter membrane is arranged on the other surface of the reaction layer relative to the support cushion body, at least one instillation mark corresponding to the reaction unit is arranged on the surface of the filter membrane, and the filter membrane is arranged on at least one side of the reaction layer by an adhesion layer so as to be attached to the reaction layer.

In an embodiment of the present invention, a first drop tube is further provided for storing the tested liquid, and the tested liquid contains a plurality of colloidal gold.

In an embodiment of the present invention, a first dropper and a second dropper are further provided, the first dropper stores the liquid to be measured, the second dropper stores a certain amount of solution, the solution includes a plurality of colloidal gold, and the second dropper has a liquid outlet.

In an embodiment of the present invention, a first dropper and a second dropper are further provided, the first dropper stores a measured liquid, the second dropper stores a certain amount of solution, the second dropper has a liquid outlet, the support pad body is provided with a antibody layer, the antibody layer is arranged on one side of the reaction layer, and the antibody layer is provided with a plurality of dry colloidal gold.

In one embodiment of the present invention, the support pad has a liquid absorbing layer, and the liquid absorbing layer is attached to the support pad adjacent to the reaction layer and opposite to the antibody layer.

In one embodiment of the present invention, the reaction layer is attached to a surface of the support pad, and at least one side of the surface of the reaction layer has an exposed area.

In one embodiment of the present invention, the drip mark may be a colored symbol mark or a marking line.

In one embodiment of the present invention, the end of the filter membrane near the reaction layer is provided with a precut line.

In one embodiment of the invention, the end of the filter membrane near the reaction layer is provided with a hand-tearing segment.

Therefore, the structure of the multiple-product detection test piece of the invention mainly uses the design of arranging at least one reaction unit and dry colloidal gold on the reaction layer, and effectively uses the reaction unit with a plurality of reaction antibodies to simultaneously detect the contents of various different detection items, such as: the pesticide content, water quality bacteria content, feces bacteria content or urine pregnancy test and the like can achieve the aim of simultaneously detecting various detection items and detected concentrations thereof, and the supporting cushion body is transparent and can also directly detect and observe the colorimetric reaction presented by the reaction antibody by turning over the supporting cushion body.

Drawings

FIG. 1: the present invention is an exploded view of the whole device of the multi-sample test strip structure.

FIG. 2: the invention discloses an appearance cross-sectional view of an integral device of a multi-sample detection test piece structure.

FIG. 3: the invention relates to an appearance combination diagram of an integral device of a multi-sample detection test piece structure.

FIG. 4: the first embodiment of the multi-sample test strip structure of the present invention is schematically illustrated.

FIG. 5: the second embodiment of the multi-sample test strip structure of the present invention is shown schematically in the drawing (a).

FIG. 6: the second embodiment of the multi-sample test strip structure of the present invention is shown in the schematic diagram (II).

FIG. 7: the third embodiment of the multi-sample test strip structure of the present invention is schematically illustrated.

Description of the figure numbers:

10 support cushion

20 reaction layer

21 reaction unit

211 reactive antibodies

22 exposed area

30 filter membrane

31 drip mark

311 sign flag

312 marking line

32 adhesive layer

33 precutting line

34 hand-tearing segment

40 first drop tube

41 first liquid outlet

42 measured liquid

43 measured object

44 colloidal gold

45 impurities

50 second dropper

51 solution

52 colloidal gold

53 second liquid outlet

60 antibody layer

61 drying the colloidal gold

70 absorbing the liquid layer.

Detailed Description

First, referring to fig. 1 to 4, a multi-sample test strip structure of the present invention is shown, which at least includes a supporting pad 10, a reaction layer 20, and at least one filter membrane 30.

The support pad 10 is a transparent body.

The reaction layer 20 is attached to one surface of the support pad 10, wherein the reaction layer 20 is provided with at least one reaction unit 21 having a plurality of reaction antibodies 211; in addition, the reaction unit 21 is a color reaction zone; in a preferred embodiment of the present invention, the reaction layer 20 is attached to a surface of the support pad 10, and at least one side of the surface of the support pad 10 has an exposed area 22, and the reaction layer 20 is provided with three reaction units 21 having a plurality of reaction antibodies 211, and the three reaction units 21 may be the same or different reaction antibodies 211, and can simultaneously detect a plurality of liquids to be detected, or simultaneously detect a plurality of different detection items, such as: pesticide residue of vegetables, bacteria content of water quality, bacteria content of feces or urine test pregnancy, etc.

The filter membrane 30 is disposed on the other surface of the reaction layer 20 opposite to the support pad 10, the surface of the filter membrane 30 is provided with at least one instillation mark 31 corresponding to the reaction unit 21, wherein the filter membrane 30 is disposed on at least one side of the reaction layer 20 by an adhesive layer 32 to adhere to the reaction layer 20; in a preferred embodiment of the present invention, the filter membrane 30 is disposed on a surface of the reaction layer 20 opposite to the support pad 10, the filter membrane 30 is attached to the surface of the reaction layer 20 by the adhesive layer 32, the filter membrane 30 is provided with drip marks 31 corresponding to the positions of the reaction units 21, at least one first drip tube 40 is used to drip a measured liquid 42 having a plurality of measured objects 43 into the filter membrane 30, the filter membrane 30 can filter impurities 45 (as shown in fig. 4) of the measured objects 43, the reaction layer 20 can be simultaneously provided with multiple layers of the filter membranes 30, and for the measured liquid 42 with more impurities 45, the filtering degree can be increased, which is helpful for achieving more accurate detection results. In addition, the drip mark 31 may be a colored sign mark 311 or a mark line 312, and the sign mark 311 may be a circular mark, a triangular mark, a square mark, a cross mark, or a star mark, which is helpful for the first liquid outlet 41 of the first dropper 40 to be aligned directly and precisely, so that the liquid 42 to be measured is dripped into the reaction unit 21 to permeate and absorb directly.

Referring to fig. 4 together, the first dropper 40 stores the liquid 42 to be measured, and the liquid 42 to be measured is disposed with a plurality of colloidal gold 44. In this embodiment, the reaction layer 20 is provided with three reaction units 21 having a plurality of reaction antibodies 211, when performing detection, three first droppers 40 are taken, the first liquid outlet 41 can directly and precisely align the instillation mark 31, the detected liquid 42 containing the detected object 43 is dripped on the filter membrane 30, so that the impurities 45 of the detected liquid 42 can be filtered in advance on the filter membrane 30, and then the detected liquid 42, the detected object 43 and the colloidal gold 44 permeate through the filter membrane 30 and are directly absorbed by the reaction units 21, the detected object 43 and the reaction antibodies 211 generate combination and reaction, and further the detected object 43 presents chromaticity in the reaction units 21 by the colloidal gold 44, the reaction units 21 presents different chromaticities according to the combination amount of the detected object 43, and a tester can not only detect whether the detected item is normal or not by the chromaticity presented by the reaction antibodies 211, the colloidal gold 44 is quantitatively arranged in the detected liquid 42, the content concentration of the detected object 43 can be measured, the detection is realized by directly dripping the first dropper 40 containing a plurality of colloidal gold 44 on the multi-sample detection test piece structure, the color can be displayed, the quick detection is realized, the operation is easy, and furthermore, the impurities 45 in the detected liquid 42 can be filtered through the filter membrane 30, thereby being beneficial to improving the detection accuracy. Furthermore, a pre-cut line 33 is disposed at an end of the filter 30 close to the reaction layer 20, and when the color of the reaction unit 21 is to be inspected, the filter 30 can be peeled off from the reaction layer 20 by the pre-cut line 33, so that the color of the reaction unit 21 can be inspected by the reaction layer 20. Alternatively, a tearing section 34 is disposed at an end of the filter membrane 30 close to the reaction layer 20, and the filter membrane 30 is torn away from the reaction layer 20 by the tearing section 34, so that the chromaticity of the reaction unit 21 can be observed from the reaction layer 20. In addition, the supporting pad 10 is a transparent body, and the chromaticity represented by the reaction antibody 211 of the reaction layer 20 can be directly inspected by the supporting pad 10 by turning the supporting pad over, so that the convenience of inspecting the chromaticity reaction represented by the reaction unit 21 on both sides can be achieved.

Referring to fig. 5 and 6 together, the first dropper 40 stores the solution 42 to be measured, and a second dropper 50 stores a certain amount of solution 51, wherein the solution 51 includes a plurality of colloidal gold 52. When detecting, three first dripping pipes 40 are taken, the first liquid outlet 41 can directly and accurately align the dripping mark 31, the detected liquid 42 containing the detected object 43 is dripped on the filter membrane 30, the impurities 45 of the detected liquid 42 can be filtered in advance on the filter membrane 30, then the detected liquid 42 and the detected object 43 permeate through the filter membrane 30 and are directly absorbed and stood in the reaction unit 21, the detected object 43 and the reaction antibody 211 are combined and reacted, then the second dripping pipe 50 is taken, the second liquid outlet 53 can directly drip the solution 51 containing a plurality of colloidal gold 52 in the exposed area 22, further the detected object 43 presents chromaticity in the reaction unit 21 by the colloidal gold 52, the reaction unit 21 presents different chromaticities according to the amount of the combined detected object 43, a tester can not only detect whether the detected item is normal or not by the chromaticity presented by the reaction antibody 211, meanwhile, the colloidal gold 52 is quantitatively disposed in the solution 51, and the content concentration of the measured substance 43 can be measured, and the impurities 45 in the measured liquid 42 can be filtered through the filter membrane 30, which is helpful for improving the detection accuracy. Furthermore, a pre-cut line 33 is disposed at an end of the filter 30 close to the reaction layer 20, and when the color of the reaction unit 21 is to be inspected, the filter 30 can be peeled off from the reaction layer 20 by the pre-cut line 33, so that the color of the reaction unit 21 can be inspected by the reaction layer 20. In addition, the supporting pad 10 is a transparent body, and the chromaticity represented by the reaction antibody 211 of the reaction layer 20 can be directly inspected by the supporting pad 10 by turning the supporting pad over, so that the convenience of inspecting the chromaticity reaction represented by the reaction unit 21 on both sides can be achieved.

Referring to fig. 7, in a third embodiment of the present invention, the first dropper 40 stores the liquid to be measured 42, the second dropper 50 stores a certain amount of solution 51, the support pad 10 is provided with a antibody layer 60, the antibody layer 60 is disposed on one side of the reaction layer 20, and the antibody layer 60 is provided with a plurality of dry colloidal gold 61. When detecting, three first dropper 40 are selected, the first liquid outlet 41 can directly and accurately align the symbol mark 311, the detected liquid 42 containing the detected object 43 is dropped on the filter membrane 30, the impurity 45 of the detected liquid 42 is filtered in advance on the filter membrane 30, the detected liquid 42 and the detected object 43 permeate through the filter membrane 30 and are directly absorbed and stand still in the reaction unit 21, the detected object 43 and the reaction antibody 211 are combined and react, then the second dropper 50 is selected, the second liquid outlet 53 can directly drop the solution 51 into the exposed area 22, the plurality of dry colloidal gold 61 can flow to the reaction layer 20 along with the solution 51, the detected object 43 presents chromaticity in the reaction unit 21 by the plurality of dry colloidal gold 61, the reaction unit 21 presents chromaticity with different chromaticities according to the quantity of the combination of the detected object 43, the tester can not only detect the chromaticity presented by the reaction antibody 211 to detect whether the detected item is normal or not, meanwhile, the plural dry colloidal gold 61 is quantitatively disposed on the antibody layer 60, the content concentration of the measured substance 43 can be measured, and the impurities 45 in the measured liquid 42 can be filtered through the filter membrane 30, which is helpful for improving the detection accuracy. Furthermore, a pre-cut line 33 is disposed at an end of the filter 30 close to the reaction layer 20, and when the color of the reaction unit 21 is to be inspected, the filter 30 can be peeled off from the reaction layer 20 by the pre-cut line 33, so that the color of the reaction unit 21 can be inspected by the reaction layer 20. In addition, the supporting pad 10 is a transparent body, and the chromaticity represented by the reaction antibody 211 of the reaction layer 20 can be directly inspected by the supporting pad 10 by turning the supporting pad over, so that the convenience of inspecting the chromaticity reaction represented by the reaction unit 21 on both sides can be achieved.

As can be seen from the above description, the present invention has the following advantages compared with the prior art and the product.

1. The structure of the multiple quality detection test piece of the invention mainly makes the first dropper directly and accurately align on the reaction layer by means of the instillation mark.

2. The multi-sample detection test piece structure can filter impurities in the detected liquid through the filter membrane, and is beneficial to improving the detection accuracy.

3. The supporting pad body in the multi-sample detection test piece structure is a transparent body, so that the convenience of double-sided inspection of the colorimetric reaction presented by the reaction unit can be achieved.

Claims

1. The utility model provides a many samples test strip structure which characterized in that, this various article test strip structure is including at least:

a support cushion body (10) which is a transparent body;

a reaction layer (20) attached to one surface of the support pad (10), wherein the reaction layer (20) is provided with at least one reaction unit (21) having a plurality of reaction antibodies (211);

at least one filter membrane (30) arranged on the other surface of the reaction layer (20) corresponding to the support pad body (10), wherein the surface of the filter membrane (30) is provided with at least one instillation mark (31) corresponding to the reaction unit (21), and the filter membrane (30) is arranged on at least one side of the reaction layer (20) by an adhesion layer (32) to be attached.

2. The multi-sample test strip structure of claim 1, wherein the multi-sample test strip structure comprises a first dropper (40) having a first liquid outlet (41) for storing the liquid (42) to be tested, and the liquid (42) to be tested comprises a plurality of objects (43) to be tested and a plurality of colloidal gold (44).

3. The multi-sample test strip structure of claim 1, wherein the multi-sample test strip structure comprises a first drop tube (40) for storing a liquid (42) to be tested, the liquid (42) to be tested comprising an object (43) to be tested; and a second dropper (50) for storing a certain amount of solution (51), wherein the solution (51) comprises a plurality of colloidal gold (52), and the second dropper (50) has a second liquid outlet (53).

4. The multi-sample test strip structure of claim 1, wherein the multi-sample test strip structure comprises a first drop tube (40) for storing a liquid (42) to be tested, the liquid (42) to be tested comprising an object (43) to be tested; and a second dropper (50) for storing a certain amount of solution (51), the second dropper (50) having a second liquid outlet (53); wherein the support pad body (10) is provided with a antibody layer (60), the antibody layer (60) is arranged on one side of the reaction layer (20), and the antibody layer (60) is provided with a plurality of dry colloidal gold (61).

5. The multi-product test strip structure of claim 3 or 4, wherein the reaction layer (20) is attached to a surface of the support pad (10), and at least one side of the surface of the reaction layer (20) has an exposed area (22).

6. The multi-sample test strip structure according to claim 4, wherein the support pad (10) has a liquid absorbing layer (70), and the liquid absorbing layer (70) is attached to the support pad (10) adjacent to the reaction layer (20) and opposite to the antibody layer (60).

7. A multiple product detection strip structure according to any one of claims 1 to 4, wherein said drip mark (31) is a colored symbol mark (311) or a mark line (312), and said symbol mark (311) is a circular mark, a triangular mark, a square mark, a cross mark or a star mark.

8. The multiple detection strip structure of any one of claims 1 to 4, wherein the end of the filter (30) near the reaction layer (20) is provided with a precut line (33).

9. The multiple product test strip structure of any of claims 1-4, wherein the end of said filter membrane (30) near said reaction layer (20) is provided with a tearing section (34).