TWI685649B - Multi-sample detection device - Google Patents

Abstract

The invention relates to a multi-sample detection device, which refers to a detection device that uses a fixing member to stabilize the delivery catheter material and the detection test piece without overflowing the detection liquid, and can simultaneously detect a variety of the same or different test items and their test concentrations Device; the present invention includes a delivery tube material, a first detection test piece, a first fixing member and a solution tube; mainly by providing at least one fixing member to fix the delivery tube material and the detection test piece, effectively making the detection test piece It can be firmly attached to the catheter material, and the test liquid flows through the grooves and through holes in the catheter material and is absorbed by the test strip without overflowing. It is indeed achieved that the catheter material and the test strip can be fixed easily And the combination of stable, and the main advantages of simultaneous detection of a variety of the same or different test items and their test concentration.

Description

Multi-sample detection device

The invention relates to a detection device, in particular to a detection device that uses a fixing member to stabilize the delivery catheter material and the detection test piece without overflowing the detection liquid, and can simultaneously detect a variety of the same or different test items and their test concentrations Multiple sample detection device for test piece structure.

According to the test, the detection technology has played a very important role in the field of medical systems or plant cultivation today. It can qualitatively or quantitatively measure the changes of various biological indicators to provide important information for disease diagnosis or medical treatment for the inspection personnel or medical personnel. For reference, the vast majority of test strips currently on the market are based on qualitative design principles to allow testers to know the test results by visual inspection, such as the "Responsive Test Paper for Degenerative Arthritis" of Republic of China Patent No. M474135. The patent is used to detect a urine sample. The rapid test strip includes a substrate, a detection result layer provided on the substrate, a water absorption layer connected to the substrate and covering the detection result layer, and a connection to the A substrate and an antibody release layer covering the detection result layer, and a specimen placement layer connected to the substrate and covering the antibody release layer; the detection result layer includes a result display section and a control section, the antibody release The layer contains a plurality of detection complexes, each of which contains a colloidal gold particle and a plurality of multiple cartilage oligomeric matrix protein antibodies; however, the adhesion between the substrate provided by this patent and each detection layer is insufficient and easy Risk of falling off or peeling off.

In addition, the Republic of China Patent No. I561820 "Upper and lower gastrointestinal cancer screening test kit and its sampling solution and sampling technique" is also described. This patent mainly includes a sample bottle, a test box, and a sampling solution. The test box is provided with an antibody and colloidal gold complex that can bind to occult blood in the feces and H. pylori, and includes a sample tank unit and a test tank unit. The inspection slot unit has a first result area, a second result area, and at least one There is a control region of the control antibody that can bind to the antibody and the colloidal gold complex. The implementation further includes a sample bottle, a test box, and a sample solution contained in the sample bottle. The sample bottle includes a bottle body, a bottle cap that can be opened to cover the bottle body, and a bottle brush extending downward from the bottle cap. The bottle cap has a cap body that allows liquid to flow out, and a cap head that can be opened on the cap body. The bottle brush has a hollow cylindrical shape and is inserted into the sampling liquid to allow the sampling liquid to flow out of the cover through the middle of itself; however, the detection test piece disclosed in the above patent can only detect a single item and cannot achieve simultaneous Detect a variety of different test items; in addition, the sample liquid is dripped from the sample bottle into the first sample tank of the sample tank unit, which has the disadvantage of easily overflowing the sample liquid and reducing the detection accuracy; therefore, how to borrow Innovative hardware design effectively strengthens the bonding strength between the substrate and each detection layer, and can simultaneously detect the content and concentration of multiple same or different sample items through multiple different reaction units, which is still a test piece Developers and related researchers in related industries such as production and sales must continue to work hard to overcome and solve the problems.

Now, in view of the fact that the structure of traditional test strips still has many flaws in actual implementation, the inventor is a tireless spirit, which is improved by the help of his rich professional knowledge and many years of practical experience. , And researched and created the invention accordingly.

The main purpose of the present invention is to provide a multi-sample detection device, in particular to use a fixing member to stabilize the delivery catheter material and the detection test piece without overflowing the detection liquid, and can simultaneously detect a variety of the same or different test items and their test The multi-sample detection device for concentration is mainly designed by providing at least one fixing member to fix the catheter material and the test piece hardware design, which effectively enables the test piece to be firmly attached to the catheter material, and the test liquid is infused The through-groove and through-hole in the catheter material flow inside and are absorbed by the test strip without overflowing. It is indeed achieved that the delivery catheter material and the test strip can be fixed easily and firmly combined, and simultaneously detect multiple same or different test items and their The main advantages such as the tested concentration.

In order to achieve the above-mentioned implementation objective, the inventor proposes a multi-sample detection device, which at least includes a delivery tube material, a first detection test piece, a first fixing member, and a solution tube; the delivery tube material includes a A through slot, a through hole, and a first plane, one end of the through slot is connected to one end of the conduit material, and the other end of the through slot is connected to the through hole, the first plane is the transmission An end face of the catheter material; the first detection test piece is attached to the first plane, the first detection test piece includes a reaction film having a plurality of reaction units, and an adsorption film, the adsorption film is The reaction membranes are arranged adjacently, and each of the reaction units includes a reaction antibody; the first fixing member is corresponding to the slot and sleeved on the other end of the delivery tube; the solution tube is sleeved on the setting The end of the conduit material with the slot.

The multi-sample detection device as described above, wherein the other end surface of the delivery tube material relative to the first plane is a second plane.

The multi-sample detection device as described above, wherein the first fixing member includes a first sleeve, and the first sleeve is sleeved on the catheter material and the first detection test piece.

The multi-sample detection device as described above, wherein a second detection test piece can be further attached on the second plane.

The multi-sample detection device as described above, wherein the solution tube system may further include a sleeve part, and a cover member disposed on the inner side wall of the sleeve part.

The multi-sample detection device as described above, wherein the cover member includes a county portion and a convex portion, the county portion ring is disposed around the convex portion, and the convex portion is correspondingly disposed on the inner side wall of the sleeve portion .

The multi-sample detection device as described above, wherein a second fixing member can be further sleeved between the delivery tube material and the solution tube.

The multi-sample detection device as described above, wherein the second fixing member includes a second set of openings provided on the delivery tube material, and a tube extending outside the solution tube.

The multi-sample detection device as described above, wherein the first detection test piece may be further covered with a filter membrane including a plurality of drip marks, and the position of the drip mark corresponds to the position of the reaction unit.

In the multi-sample detection device as described above, the filter membrane may be further covered with a kit having a plurality of through holes, and the positions of the through holes correspond to the positions of the drip marks.

In this way, the multi-sample detection device of the present invention is mainly designed by providing at least one fixing member to fix the catheter material and the test piece hardware design, so that the test piece can be firmly attached to the catheter material, and the test The liquid flows through the grooves and through holes in the duct material and is absorbed by the test strip without overflowing. It is indeed achieved that the duct material and the test strip can be fixed easily and firmly combined, and simultaneously detect multiple same or different tests The main advantages of the project and its tested concentration.

(10)‧‧‧Conduit material

(11) ‧‧‧ Groove

(12)‧‧‧Through hole

(13)‧‧‧The first plane

(14)‧‧‧Second plane

(20)‧‧‧ First test strip

(21)‧‧‧Reactive membrane

(211)‧‧‧Reaction unit

(2111)‧‧‧Reactive antibody

(22)‧‧‧adsorption membrane

(23)‧‧‧filter

(231)‧‧‧Drip mark

(2311) ‧‧‧ symbol flag

(2312) ‧‧‧ marked line

(24)‧‧‧Suite

(241)‧‧‧Through hole

(30)‧‧‧First fixing piece

(31)‧‧‧First set

(40)‧‧‧Solution tube

(41)‧‧‧fitting department

(42)‧‧‧Cover

(421)‧‧‧ District

(422)‧‧‧Convex

(50)‧‧‧Second testing test piece

(60)‧‧‧Second fixing piece

(61)‧‧‧Second set

(62)‧‧‧Outer tube

(70)‧‧‧Dropper tested

(71)‧‧‧First liquid outlet

(72)‧‧‧Test liquid

Fig. 1 is a schematic diagram of the overall appearance of a preferred embodiment of the multi-sample detection device of the present invention.

Figure 2: An exploded schematic view of the overall device of a preferred embodiment of the multi-sample detection device of the present invention.

Figure 3: A schematic cross-sectional view of the overall device of a preferred embodiment of the multi-sample detection device of the present invention.

Figure 4: A schematic cross-sectional view of the overall device of the second preferred embodiment of the multi-sample detection device of the present invention.

Figure 5: A schematic diagram of the appearance of the solution tube of the second preferred embodiment of the multi-sample detection device of the present invention.

Figure 6: A schematic view of the overall appearance of the third preferred embodiment of the multi-sample detection device of the present invention.

Figure 7: A schematic cross-sectional view of the overall device of the fourth preferred embodiment of the multi-sample detection device of the present invention.

Figure 8: A schematic cross-sectional view of the overall device of the fifth preferred embodiment of the multi-sample detection device of the present invention.

In order to facilitate your examiner to understand the technical features, content and advantages of the present invention and the achievable effects, the present invention is described in detail in conjunction with the drawings and in the form of expressions of the embodiments, and the drawings used therein, which The main purpose is only for illustration and auxiliary description, not necessarily after the implementation of the present invention The true proportion and precise configuration, it should not be interpreted and limited in terms of the relationship between the proportion and configuration of the attached drawings, and the scope of rights of the present invention in actual implementation shall be described first.

First, please refer to FIGS. 1 to 3, which are schematic diagrams of the appearance of the overall device, exploded schematic diagram of the overall device, and schematic cross-sectional diagrams of the overall device. The detection device (1) at least includes a delivery tube material (10), a first detection test piece (20), a first fixing member (30), and a solution tube (40).

The duct material (10) includes a through slot (11), a through hole (12), and a first plane (13), one end of the duct (11) is connected to the duct material (10) One end, and the other end of the through slot (11) is connected to the through hole (12), the first plane (13) is an end face of the delivery tube material (10); In addition, the delivery tube material ( 10) The other end face relative to the first plane (13) is a second plane (14); in a preferred embodiment of the present invention, the delivery tube material (10) in the form of a transparent tube It includes the through slot (11), the through hole (12) and the first plane (13), and the other end relative to the first plane (13) is the second plane (14), wherein The through slot (11) is disposed inside the duct material (10), one end of which is connected to one end of the duct material (10), and the other end is connected to the through hole (12), the through hole (12) The corresponding two ends contact the first plane (13) and the second plane (14) respectively.

The first test strip (20) is attached to the first plane (13), the first test strip (20) includes a reaction film (21) having a plurality of reaction units (211), and An adsorption membrane (22), the adsorption membrane (22) is disposed adjacent to the reaction membrane (21), and each of the reaction units (211) includes a reaction antibody (2111); it is preferred in the present invention In an embodiment, the first detection test piece (20) made of water-absorbing material and attached on the first plane (13) is arranged adjacent to the adsorption film (22) by the reaction film (21) The reaction membrane (21) is provided with three reaction units (211), each reaction unit (211) includes a reaction antibody (2111), three of the reaction units (211) The reactive antibody (2111) series may be the same or different, the main system is to provide simultaneous detection of one or more of the same or different receptors Test items, such as pesticide residues in vegetables, bacteria count in water quality, fecal bacteria content, or urine pregnancy test, etc.

A first fixing member (30) corresponding to one end of the duct material (10) passing through the slot (11) and sleeved on the other end of the duct material (10); in addition, the first fixing member (30) includes a first socket (31), the first socket (31) is provided with the delivery tube material (10) sleeved therein; in a preferred embodiment of the present invention, the first fixed The first sleeve (31) is opened at an end of the member (30) near the delivery tube material (10), and the first sleeve (31) is corresponding to the slot (11) and sleeved on the delivery guide At the other end of the tube (10), the first detection test piece (20) is attached to the first plane (13), and then the first fixing member (30) can be sleeved to the first detection test piece ( 20) It is firmly attached to the catheter material (10) without falling off.

The solution tube (40) is sleeved on the end of the delivery tube material (10) provided with the through slot (11); in a preferred embodiment of the present invention, the solution tube (40) is a kind of A sleeve with a set of joints (41) (see Figure 4), where the solution tube (40) is used to store a certain amount of test liquid (not shown), and The end of the delivery tube material (10) with the through-groove (11) is sheathed in the solution tube (40) via the sheathing portion (41).

In other words, when the relevant test items are to be tested, first, the test liquid stored in the solution tube (40) may be inclined toward the first fixing member (30) due to the delivery tube material (10) And flows into the through hole (12) through the through slot (11) until the through hole (12) is filled with the test liquid and is absorbed by the first test piece (20) with water absorption characteristics; then, The test liquid will continue to flow to the reaction membrane (21) and enter the reaction unit (211) to bind and react with the reaction antibody (2111); finally, the reaction unit (211) is based on the test liquid The amount of binding to the reactive antibody (2111) is different and different chromaticities are displayed. A tester can detect whether the test items are normal or not through the chromaticity test of the reactive antibody (2111) to detect the test solution. The content concentration.

In addition, a second test strip (50) can be further attached to the second plane (14); please refer to FIG. 4 for the entirety of the second preferred embodiment of the multi-sample detection device of the present invention A schematic cross-sectional view of the device and FIG. 5 are schematic diagrams of the appearance of the solution tube of the second preferred embodiment of the multi-sample detection device of the present invention, in which the second detection test piece is the same as the first detection test piece (20) 50) It is attached to the second plane (14) of the catheter material (10), and the test liquid flowing out of the solution tube (40) fills the through hole (12) and can be simultaneously inspected by the first inspection The test piece (20) absorbs with the second detection test piece (50), and finally binds and reacts with the reactive antibody (2111) on the first detection test piece (20) and the second detection test piece (50), In order to detect related test items and content concentration, this double-sided detection method can more easily check the chromaticity change of the test items.

Furthermore, the solution tube (40) may further include a sleeve (41), and a cover (42) disposed on the inner side wall of the sleeve (41), wherein the cover (42) is It includes a county part (421) and a convex part (422), the county part (421) is looped around the convex part (422), and the convex part (422) is correspondingly arranged on the cover part (41) ); please refer to FIG. 5 again, which is a schematic view of the appearance of the solution tube of the second preferred embodiment of the multi-sample detection device of the present invention, wherein the solution tube (40) is composed of the sleeve portion (41) and The cover member (42) is assembled, and the cover member (42) is sleeved on the inner side wall of the sleeve portion (41). The cover member (42) includes the county (421) and the protrusion Part (422), the county part (421) is looped around the convex part (422), and the convex part (422) is correspondingly set on the inner side wall of the sleeve part (41); Before the solution tube (40) of the test liquid is not sleeved on the delivery tube material (10), the lid (42) can be used to cover the sleeve portion (41) to achieve the sealing effect to prevent The test liquid leaked out.

In addition, a second fixing member (60) is further sleeved between the delivery tube material (10) and the solution tube (40), wherein the second fixing member (60) includes a set of the delivery tube material (10) the second set of ports (61), and a tube (62) extending to the solution tube (40); please refer to the multiple sample detection device of the present invention shown in Figure 4 and Figure 6 together A schematic view of the overall appearance of the third preferred embodiment, wherein the second fixing member (60) is disposed between the delivery tube material (10) and the solution tube (40), and the second fixing member (60) The second sleeve (61) is opened near an end of the conduit (10), and the second sleeve (61) is sleeved on the conduit (10) with the through slot (11) End of the second fixed part (60) It has the same function as the first fixing member (30), and is used to firmly attach the first test strip (20) and/or the second test strip (50) to the catheter material (10) ) Without falling off, and the other end of the second fixing member (60) relative to the second sleeve (61) is provided with the outer tube (62) extending to the solution tube (40), wherein The outer tube (62) can be extended to the position of 3/4 of the inside of the solution tube (40) to suck out the test liquid inside the solution tube (40) by the principle of siphon and pass through the trough (11 ) And the through hole (12) to reach the first detection test piece (20) and/or the second detection test piece (50) to detect related test items and content concentration.

Furthermore, please refer to FIG. 7, which is a schematic cross-sectional view of the overall device of the fourth preferred embodiment of the multi-sample detection device of the present invention. The first test strip (20) may be further covered with a plurality of drops The filter membrane (23) marked with a mark (231), and the position of the drip mark (231) corresponds to the position of the reaction unit (211); in addition, the filter membrane (23) may be further covered with a A set (24) of two through holes (241), and the position of the through hole (241) corresponds to the position of the drip mark (231); wherein, in an embodiment of the present invention, the first test strip ( 20) The upper part is covered with the filter membrane (23), the filter membrane (23) can effectively filter the impurities contained in the test liquid (72), and the filter membrane (23) is provided with the drops Note mark (231), the position of the drip mark (231) corresponds to the position of the reaction unit (211); In addition, the drip mark (231) may be a colored flag (2311) or a Marking line (2312), and the symbol flag (2311) can be a round flag, a triangle flag, a square flag, a cross flag or a star flag, which is helpful for a drop tube under test ( 70) One of the first liquid outlets (71) can be directly and accurately aligned, so that the test liquid (72) is dropped to directly correspond to the reaction unit (211) and permeated and absorbed.

In addition, the first test strip (20) can be further covered with a filter membrane (23) including a plurality of drip marks (231); in addition, the filter membrane (23) can be further covered with an opening A plurality of through holes (241) of the kit (24), and the position of the through hole (241) corresponds to the position of the drip mark (231); please refer to FIG. 8 for the multi-sample detection device of the present invention A schematic cross-sectional view of the overall device of the five preferred embodiments, wherein the first detection test piece (20) is covered with the filter membrane (23), and the filter membrane (23) may be Effectively filter the impurities contained in the test liquid, and the filter membrane (23) is provided with the drip marks (231), the positions of the drip marks (231) correspond to the reaction unit (211) In addition, the filter membrane (23) can also cover the kit (24), and the kit (24) is provided with a position corresponding to each drip mark (231) and each reaction unit (211) Each through hole (241), each through hole (241) is useful for detecting the change in chromaticity of the reaction unit (211).

It can be known from the above description of the implementation that the plant trough control structure of the present invention has the following advantages compared with the prior art:

1. The multi-sample detection device of the present invention is mainly designed by providing at least one fixing member to fix the catheter material and the test piece hardware design, so that the test piece can be firmly attached to the catheter material, and the tested liquid The grooves and through holes in the duct material flow inside and are absorbed by the test piece without overflowing. It is indeed achieved that the duct material and the test piece can be fixed easily and firmly combined, and simultaneously detect a variety of different test items and their The main advantages such as the tested concentration.

In summary, the multi-sample detection device of the present invention can indeed achieve the expected use effect by the embodiments disclosed above, and the present invention has not been disclosed before the application, and has fully complied with the provisions of the Patent Law and Claim. I filed an application for a patent for invention in accordance with the law, pleaded for the review, and granted the patent.

However, the illustrations and descriptions disclosed above are only preferred embodiments of the present invention, and are not intended to limit the scope of protection of the present invention; those who are familiar with the art, according to the characteristic scope of the present invention, do other things Equivalent changes or modifications should be regarded as not departing from the design scope of the present invention.

(10)‧‧‧Conduit material

(20)‧‧‧ First test strip

(30)‧‧‧First fixing piece

(40)‧‧‧Solution tube

Claims (10)

A multi-sample detection device at least includes: a delivery tube material (10), including a through slot (11), a through hole (12), and a first plane (13), the through slot (11) One end is connected to one end of the duct material (10), and the other end of the through slot (11) is connected to the through hole (12), and the first plane (13) is the duct material (10) ) One end face; a first test strip (20) attached to the first plane (13), the first test strip (20) includes a reaction having a plurality of reaction units (211) A membrane (21) and an adsorption membrane (22), the adsorption membrane (22) is arranged adjacent to the reaction membrane (21), and each reaction unit (211) includes a reaction antibody (2111); a The first fixing member (30) is sleeved on the delivery tube material (10) and the first detection test piece (20), and the first fixing member (30) corresponds to the one corresponding to the slot (11) One end of the delivery tube material (10) is sleeved on the other end of the delivery tube material (10); and a solution tube (40) is sleeved on the delivery tube material provided with the through slot (11) ( 10) The end portion and the first test piece (20). The multi-sample detection device as described in item 1 of the patent application scope, wherein the other end surface of the delivery tube material (10) relative to the first plane (13) is a second plane (14), and the second A second test piece (50) is further attached on the plane (14). The multi-sample detection device as described in item 1 of the patent application scope, wherein the first fixing member (30) includes a first sleeve (31), and the first sleeve (31) is sleeved on the transmission guide The pipe (10) and the first test piece (20). The multi-sample detection device as described in item 1 of the patent application scope, wherein the solution tube (40) further includes a set of fitting parts (41), and a set of cover members provided on the inner side wall of the set of fitting parts (41) (42). The multi-sample detection device as described in item 4 of the patent application scope, wherein the cover (42) includes a county (421), and a convex portion (422), the county (421) is looped around the convex portion (422) around, and the convex portion (422) is correspondingly covered on the inner side wall of the sleeve portion (41). The multi-sample detection device as described in item 1 of the patent application scope, wherein a second fixing member (60) is further sleeved between the delivery tube material (10) and the solution tube (40). The multi-sample detection device as described in item 6 of the patent application scope, wherein the second fixing member (60) includes a second set of openings (61) provided on the delivery tube material (10), and an extension to The solution tube (40) is the outer tube (62). The multi-sample detection device as described in item 1 of the patent application scope, wherein the first detection test piece (20) is further covered with a filter membrane (23) including a plurality of drip marks (231), and the drop Note that the position of the mark (231) corresponds to the position of the reaction unit (211). The multi-sample detection device as described in item 8 of the patent application scope, wherein the drip mark (231) may be a colored symbol flag (2311) or a marking line (2312). The multi-sample detection device as described in item 8 of the patent application scope, wherein the filter membrane (23) is further covered with a kit (24) having a plurality of through holes (241), and the through holes (241) The position corresponds to the position of the drip mark (231).

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