CN2554170Y - Bio-chip for detecting pylorus spirochete bacillus index - Google Patents
Bio-chip for detecting pylorus spirochete bacillus index Download PDFInfo
- Publication number
- CN2554170Y CN2554170Y CN 02261891 CN02261891U CN2554170Y CN 2554170 Y CN2554170 Y CN 2554170Y CN 02261891 CN02261891 CN 02261891 CN 02261891 U CN02261891 U CN 02261891U CN 2554170 Y CN2554170 Y CN 2554170Y
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- biochip
- dot matrix
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- liquid
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Abstract
The utility model relates to the field of biomedical technology, in particular to a biological chip which can carry out the detection of the indicators of helicobacter pylori. The technical proposal of the utility model is that the utility model includes an outer shell 1, a substrate 6 and a dot-matrix 5 which is arranged on the substrate 6, the outer shell 1 adopts a hollow shell body, the bottom part of the outer shell 1 is provided with a liquid absorbing layer 8, the substrate 6 is arranged on the liquid absorbing layer 8, the upper part of the outer shell 1 is provided with a detection port 2 which is corresponding to the dot-matrix 5, and one end of the outer shell 1 is provided with a boss 3. The utility model has low manufacturing cost and can ensure the quality during the large-scale production, the utility model can not mis-detect during the detection, the slide glass is easy to take and the safety of the operation is high.
Description
Technical field:
The utility model relates to field of biomedicine technology, is specifically related to a kind of biochip that the Hp index is detected.
Background technology:
Present biochip all is to adopt the detection molecules dot matrix is fixed in structure formation on the slide glass, its slide glass generally adopts sheet glass to make, a large amount of detection molecules are fixed on this sheet glass by in-situ polymerization, by detection molecules density is higher thereon, cause the biochip of this structure to exist the cost of manufacture height, difficult quality guarantee during scale operation, the high defective of false failure rate during detection; When drop to be detected detected on this slide glass simultaneously, because the slide glass material, liquid to be detected permeated inhomogeneous thereon, also can cause detected result inaccurate; This slide glass is difficult for taking, and when taking slide glass as the staff and virus to be detected lean on too near, cross infection easily takes place, processing safety is low.
The utility model content:
The technical problem that the utility model is difficult to when having solved the biochip manufacturing cost height in the background technology, scale operation to ensure the quality of products, false failure rate height, slide glass are difficult for taking when detecting, processing safety is low.
The technical solution of the utility model is: the utility model comprises the dot matrix 5 on shell 1, base material 6 and the base material 6, its special character is: described shell 1 adopts hollow shell, this shell 1 bottom is provided with liquid-adsorption layer 8, base material 6 is arranged on the liquid-adsorption layer 8, its top is provided with and dot matrix 5 corresponding detections mouths 2, and shell 1 one ends are provided with boss 3.
Above-mentioned boss 3 upper and lower surfaces are provided with groove 4.
Above-mentioned boss 3 terminations are arc.
Above-mentioned shell 1 is split type hollow casing.
Above-mentioned base material 6 is nitrocellulose membranes, and liquid-adsorption layer 8 is absorbent wools, thieving paper or macromolecule water uptake synthetic materials.
Be provided with anti-anti-seepage membrane 7 between above-mentioned base material 6 and the liquid-adsorption layer 8.
Above-mentioned dot matrix 5 is square several, and the point of sample number on each dot matrix equates and is square several.
Above-mentioned dot matrix 5 is arranged as square.
Albumen on the above-mentioned dot matrix 5 can be two or three in vacuolating cytotoxin associated protein, cytotoxin-associated protein and the urease associated protein.
Albumen in the above-mentioned dot matrix 5 can be full bacterium specific proteins, wherein in antibody protein C, corresponding some specific genes or the proteic monoclonal antibody protein D of polypeptide fragment of some specific genes or polypeptide fragment albumen, corresponding full bacterium a kind of, two or more.
The utility model is provided with hollow casing, and the base material that will have dot matrix places in this hollow casing, this kind structure low cost of manufacture, and quality can be protected during scale operation, and quick when detecting, accurate; The utility model outer casing bottom is provided with liquid-adsorption layer, and base material is arranged on the liquid-adsorption layer, and it can guarantee that liquid to be detected permeates evenly on base material, improves the accuracy of detected result; Shell one end of the present utility model also is provided with boss, and it is convenient to taking of operator, can guarantee operator's holding area and the distance between virus to be detected simultaneously, can not produce cross infection, the processing safety height; The anti-anti-seepage membrane that between base material and liquid-adsorption layer, is provided with in the utility model, can effectively stop infiltrate liquid-adsorption layer test solution again reverse osmosis go on the base material and reaction again take place, so detected result is accurate.
Description of drawings:
Fig. 1 is a structural representation of the present utility model;
Fig. 2 is the upward view of Fig. 1;
Fig. 3 is the A-A sectional view of Fig. 1.
Embodiment:
Referring to Fig. 1～3, the utility model comprises the dot matrix 5 on shell 1, base material 6 and the base material, this shell 1 is a hollow shell, and shell 1 bottom is provided with liquid-adsorption layer 8, and base material 6 is arranged on the liquid-adsorption layer 8, be provided with anti-anti-seepage membrane 7 between base material 6 and the liquid-adsorption layer 8, base material 6 can adopt nitrocellulose membrane, and the micropore on the nitrocellulose membrane has stronger diafiltration, concentrated, agglutination, and detection can be carried out fast, improve the accuracy that detects, liquid-adsorption layer 8 is absorbent wool, thieving paper or macromolecule water uptake synthetic materials; Shell 1 top is provided with and the corresponding detection of dot matrix mouthfuls 2, and shell 1 one ends are provided with boss 3, and boss 3 upper and lower surfaces are provided with groove 4, and its personnel that are convenient to operation are to the gripping of boss 3, and boss 3 terminations are arc, can save starting material; Above-mentioned shell 1 is split type hollow casing, and it can make things convenient for taking of base material;
Claims (10)
1, a kind of biochip that the Hp index is detected, comprise the dot matrix (5) on shell (1), base material (6) and the base material (6), it is characterized in that: described shell (1) adopts hollow shell, this shell (1) bottom is provided with liquid-adsorption layer (8), described base material (6) is arranged on the liquid-adsorption layer (8), described shell (1) top be provided with base material (6) on corresponding detections of dot matrix (5) mouth (2), an end is provided with boss (3).
2, biochip as claimed in claim 1 is characterized in that: the upper and lower surface of described boss (3) is provided with groove (4).
3, biochip as claimed in claim 2 is characterized in that: described boss (3) termination is an arc.
4, biochip as claimed in claim 3 is characterized in that: described shell (1) is split type hollow casing.
5, as the described biochip of the arbitrary claim of claim 1 to 4, it is characterized in that: described base material (6) is a nitrocellulose membrane, and described liquid-adsorption layer (8) is an absorbent wool, thieving paper or macromolecule water uptake synthetic materials.
6, biochip as claimed in claim 5 is characterized in that: be provided with anti-anti-seepage membrane (7) between described base material (6) and the liquid-adsorption layer (8).
7, biochip as claimed in claim 6 is characterized in that: described dot matrix (5) is square several, and the point of sample number on each dot matrix equates and is square several.
8, biochip as claimed in claim 7 is characterized in that: described dot matrix (5) is arranged as square.
9, biochip as claimed in claim 8 is characterized in that: the albumen on the described dot matrix (5) is two or three in vacuolating cytotoxin associated protein, cytotoxin-associated protein and the urease associated protein.
10, biochip as claimed in claim 9 is characterized in that: the albumen in the described dot matrix (5) be full bacterium specific proteins, wherein in antibody protein, corresponding some specific genes or the proteic monoclonal antibody albumen of polypeptide fragment of some specific genes or polypeptide fragment albumen, corresponding full bacterium a kind of, two or more.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02261891 CN2554170Y (en) | 2002-07-01 | 2002-07-01 | Bio-chip for detecting pylorus spirochete bacillus index |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02261891 CN2554170Y (en) | 2002-07-01 | 2002-07-01 | Bio-chip for detecting pylorus spirochete bacillus index |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2554170Y true CN2554170Y (en) | 2003-06-04 |
Family
ID=33728566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02261891 Expired - Fee Related CN2554170Y (en) | 2002-07-01 | 2002-07-01 | Bio-chip for detecting pylorus spirochete bacillus index |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2554170Y (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102721815A (en) * | 2012-04-18 | 2012-10-10 | 天津天佛罗生物技术有限公司 | Detection kit for helicobacter pylori virulence protein antibody and detection method by using the same |
| CN105277722A (en) * | 2015-10-28 | 2016-01-27 | 泰州欣康基因数码科技有限公司 | Protein chip for typing detection on helicobacter pylori infection |
| CN107952149A (en) * | 2017-12-20 | 2018-04-24 | 陈顺超 | One kind operation suction type anaesthetic machine |
| CN108279302A (en) * | 2017-07-11 | 2018-07-13 | 深圳市伯劳特生物制品有限公司 | A kind of composition and pylori spiral bacilli antibody for enzyme linked immunological kit composes detection kit and preparation method thereof |
-
2002
- 2002-07-01 CN CN 02261891 patent/CN2554170Y/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102721815A (en) * | 2012-04-18 | 2012-10-10 | 天津天佛罗生物技术有限公司 | Detection kit for helicobacter pylori virulence protein antibody and detection method by using the same |
| CN105277722A (en) * | 2015-10-28 | 2016-01-27 | 泰州欣康基因数码科技有限公司 | Protein chip for typing detection on helicobacter pylori infection |
| CN108279302A (en) * | 2017-07-11 | 2018-07-13 | 深圳市伯劳特生物制品有限公司 | A kind of composition and pylori spiral bacilli antibody for enzyme linked immunological kit composes detection kit and preparation method thereof |
| CN108279302B (en) * | 2017-07-11 | 2020-05-26 | 深圳市伯劳特生物制品有限公司 | Composition for enzyme-linked immunosorbent assay kit, helicobacter pylori antibody spectrum detection kit and preparation method thereof |
| CN107952149A (en) * | 2017-12-20 | 2018-04-24 | 陈顺超 | One kind operation suction type anaesthetic machine |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: SHANGHAI CHUANGYUE BIOLOGY SCIENCE CO., LTD. Free format text: FORMER OWNER: XI AN POTOMAC BIO-TECHNOLOGY CO., LTD. Effective date: 20060901 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20060901 Address after: 200333, building 4, 3, Zhongjiang Road, 879, Shanghai, Putuo District Patentee after: Shanghai creation Biotechnology Co., Ltd. Address before: 710075 No. four, No. 23, hi tech Road, Shaanxi, Xi'an Patentee before: Xi'an Lian'er Biotechnology Co., Ltd. |
|
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |