CN2554184Y - Bio-chip for detecting woman health index - Google Patents
Bio-chip for detecting woman health index Download PDFInfo
- Publication number
- CN2554184Y CN2554184Y CN 02261906 CN02261906U CN2554184Y CN 2554184 Y CN2554184 Y CN 2554184Y CN 02261906 CN02261906 CN 02261906 CN 02261906 U CN02261906 U CN 02261906U CN 2554184 Y CN2554184 Y CN 2554184Y
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- China
- Prior art keywords
- index
- womanhealth
- biochip
- detected
- shell
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- Expired - Fee Related
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
The utility model relates to the field of biomedical technology, in particular to a biological chip which can carry out the detection of the indicators of women health. The utility model aims at providing the biological chip to overcome the shortcomings that the manufacturing cost of the prior art is high, the quality is difficult to be ensured during large-scale production and the accuracy of the detection is poor. The technical proposal of the utility model is that the utility model includes an outer shell, a substrate and a dot-matrix which is arranged on the substrate; the utility model is characterized in that the outer shell is a hollow shell body, a liquid absorbing layer and the substrate are arranged in the outer shell, the liquid absorbing layer is arranged at the bottom part of the outer shell, a detection port which is corresponding to the dot-matrix on the substrate is arranged at the upper part of the outer shell, a liquid application port which is corresponding to the dot-matrix on the substrate is arranged at the upper part of the outer shell, a convex eaves is arranged below the inside of the liquid application port, and a vent hole is arranged at the bottom part of the outer shell which is corresponding to the liquid application port.
Description
Affiliated technical field:
The utility model relates to field of biomedicine technology, is specifically related to a kind of biochip that the WomanHealth index is detected.
Background technology:
The structure of biochip generally all comprises base material and the detection molecules dot matrix that is fixed on the base material, its base material adopts sheet glass to make, a large amount of detection molecules are fixed on this glass baseplate by in-situ polymerization, exist following shortcoming: 1, be difficult to ensure the quality of products when cost height, scale operation; 2, test solution side leakage can't complete reaction, and the test solution infiltration is inhomogeneous, so detection accuracy is poor.
The utility model content:
The purpose of this utility model provides a kind of biochip that the WomanHealth index is detected, and is difficult to when overcoming prior art manufacturing cost height, scale operation to ensure the quality of products and the shortcoming of detection accuracy difference.
For achieving the above object, technical solution of the present utility model is: a kind of biochip that the WomanHealth index is detected, comprise the dot matrix 11 on shell 1, base material 5 and the base material 5, its special character is, described shell 1 is a hollow shell, be folded with liquid-adsorption layer 7 and base material 5 in this shell 1, liquid-adsorption layer 7 is arranged at shell 1 bottom, shell 1 top be provided with base material 5 on 11 corresponding somes liquid mouths 2 of dot matrix, side-lower is provided with protruding eaves 8 in this liquid mouth 2, and described shell 1 bottom is provided with breather hole 4 corresponding to a liquid mouth 2.
Above-mentioned some liquid mouth 2 can be one or more.When being provided with a plurality of somes liquid mouths 2, each some liquid mouth 2 corresponding one or more dot matrix 11 can be avoided disease indicators cross infection each other like this.
Be provided with anti-anti-seepage membrane 6 between above-mentioned liquid-adsorption layer 7 and the base material 5, be used to stop infiltrated liquid-adsorption layer 7 test solution again reverse osmosis go on the base material 5 and reaction again take place, influence detected result.
Above-mentioned shell 1 upper surface is provided with tag slot 3 near a side of putting liquid mouth 2, and this tag slot 3 is used for chip is carried out mark.
Above-mentioned base material 5 is nitrocellulose membranes, and described liquid-adsorption layer 7 can be an absorbent wool, thieving paper or macromolecule water uptake synthetic materials.Millipore filtration has stronger diafiltration, concentrates, agglutination, when detecting the test solution infiltration more even, it is more complete that reaction is carried out, and improves the accuracy that detects.
Above-mentioned shell 1 is made of two portions clamping, comprises the drain pan 10 that a loam cake of liquid mouth 29 is arranged and be provided with liquid-adsorption layer 7 and base material 5 is set, and is convenient to dismounting.
Dot matrix 11 on the above-mentioned base material 51 is square several, and the point of sample number on each dot matrix 11 equates and is square several.
Above-mentioned square of several dot matrix 11 is arranged as square.
Albumen on the above-mentioned dot matrix 11 can be two or more in human papillomavirus's 6 types in the WomanHealth index, human papillomavirus's 11 types, human papillomavirus's 16 types, human papillomavirus's 18 types, human papillomavirus's 58 types, chlamydia trachomatis, the Ureaplasma urealyticum associated protein.
Albumen in the above-mentioned dot matrix 11 can be full bacterium or viral protein, wherein in some specific genes or polypeptide fragment albumen, corresponding full bacterium or the whole antibody albumen of viral protein, corresponding some specific genes or the proteic monoclonal antibody albumen of polypeptide fragment a kind of, two or more.
Compared with prior art, the utility model has the advantages that: the utility model is simple in structure, low cost of manufacture, and quality can be protected during scale operation; Because of side-lower in the liquid mouth is provided with protruding eaves, not side leakage of test solution, can with the check point complete reaction on the dot matrix, and because of being provided with breather hole, the test solution infiltration evenly, therefore can reliably guarantee detected result accurately.
Description of drawings:
Fig. 1 is a structural representation of the present utility model;
Fig. 2 is the rear view of Fig. 1;
Fig. 3 is the A-A sectional view of Fig. 1;
Fig. 4 is that the B of Fig. 1 is to view.
Description of reference numerals is as follows:
The 1-shell, 2-point liquid mouth, the 3-tag slot, the 4-breather hole, the 5-base material, 6-prevents anti-seepage membrane, 7-liquid-adsorption layer, the protruding eaves of 8-, 9-loam cake, 10-drain pan, 11-dot matrix.
Embodiment:
Below in conjunction with accompanying drawing the utility model is done and to be described in further detail.
Referring to Fig. 1～3, a kind of biochip that the WomanHealth index is detected, comprise shell 1, dot matrix 11 on base material 5 and the base material 5, described shell 1 adopts hollow shell, this shell 1 is made of two portions, comprise loam cake 9 and drain pan 10, clamping between two portions, be disposed with the base material 5 of cellulose nitrate film production in the said shell 1, the liquid-adsorption layer 7 that anti-anti-seepage membrane 6 and absorbent wool are made, shell 1 top be provided with base material 5 on 11 corresponding somes liquid mouths 2 of dot matrix, shell 1 bottom is provided with breather hole 4 corresponding to a liquid mouth 2, above said some liquid mouth 2 be one, side-lower is provided with protruding eaves 8 in this liquid mouth 2, and said shell 1 upper surface is provided with tag slot 3 near a side of some liquid mouth 2.
Dot matrix 11 on the said base material 5 is 64, is arranged as square, and the point of sample number on each dot matrix is 4, is arranged as square.Therein in 63 dot matrix, with 9 dot matrix is that a class is integrated with human papillomavirus's 6 types, human papillomavirus's 11 types, human papillomavirus's 16 types, human papillomavirus's 18 types, human papillomavirus's 58 types, chlamydia trachomatis, 7 kinds of associated protein of Ureaplasma urealyticum respectively, used albumen is specific proteins, on said in the above each dot matrix, get 1 dot matrix in each class associated protein 9 dot matrix as the data refer point range, in order to judge the reference of detected result; Remaining 8 dot matrix after the adding test solution detects, in order to do contrast with the data refer point range, judge that detected result is positive or negative as point range to be detected; Remaining 1 dot matrix is as the Quality Control point range.
Claims (10)
1, a kind of biochip that the WomanHealth index is detected, comprise the dot matrix (11) on shell (1), base material (5) and the base material (5), it is characterized in that: described shell (1) is a hollow shell, be folded with liquid-adsorption layer (7) and base material (5) in this shell (1), liquid-adsorption layer (7) is arranged at shell (1) bottom, shell (1) top be provided with base material (5) on corresponding some liquid mouth of dot matrix (11) (2), the interior side-lower of this liquid mouth (2) is provided with protruding eaves (8), and described shell (1) bottom is provided with breather hole (4) corresponding to a liquid mouth (2).
2, a kind of biochip that the WomanHealth index is detected as claimed in claim 1, it is characterized in that: described some liquid mouth (2) is one or more.
3, a kind of biochip that the WomanHealth index is detected as claimed in claim 1 is characterized in that: be provided with anti-anti-seepage membrane (6) between described liquid-adsorption layer (7) and the base material (5).
4, a kind of biochip that the WomanHealth index is detected as claimed in claim 3 is characterized in that: described shell (1) upper surface is provided with tag slot (3) near a side of putting liquid mouth (2).
5, as any described a kind of biochip that the WomanHealth index is detected among the claim 1-4, it is characterized in that: described base material (5) is a nitrocellulose membrane, and described liquid-adsorption layer (7) is an absorbent wool, thieving paper or macromolecule water uptake synthetic materials.
6, a kind of biochip that the WomanHealth index is detected as claimed in claim 5, it is characterized in that: described shell (1) is made of two portions clamping, and comprising being provided with has the loam cake (9) of a liquid mouth (2) and be provided with liquid-adsorption layer (7) and the drain pan (10) of base material (5).
7, a kind of biochip that the WomanHealth index is detected as claimed in claim 6 is characterized in that: described dot matrix (11) is square several, and the point of sample number on each dot matrix (11) equates and is square several.
8, a kind of biochip that the WomanHealth index is detected as claimed in claim 7, it is characterized in that: described square of several dot matrix (11) are arranged as square.
9, a kind of biochip that the WomanHealth index is detected as claimed in claim 8 is characterized in that: the albumen on the described dot matrix (11) is two or more of associated protein in human papillomavirus's 6 types in the WomanHealth index, human papillomavirus's 11 types, human papillomavirus's 16 types, human papillomavirus's 18 types, human papillomavirus's 58 types, chlamydia trachomatis, the Ureaplasma urealyticum.
10, a kind of biochip that the WomanHealth index is detected as claimed in claim 9 is characterized in that: the albumen in the described dot matrix (11) be full bacterium or viral protein, wherein in some specific genes or polypeptide fragment albumen, corresponding full bacterium or the whole antibody albumen of viral protein, corresponding some specific genes or the proteic monoclonal antibody albumen of polypeptide fragment a kind of, two or more.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02261906 CN2554184Y (en) | 2002-07-01 | 2002-07-01 | Bio-chip for detecting woman health index |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02261906 CN2554184Y (en) | 2002-07-01 | 2002-07-01 | Bio-chip for detecting woman health index |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2554184Y true CN2554184Y (en) | 2003-06-04 |
Family
ID=33728581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02261906 Expired - Fee Related CN2554184Y (en) | 2002-07-01 | 2002-07-01 | Bio-chip for detecting woman health index |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2554184Y (en) |
-
2002
- 2002-07-01 CN CN 02261906 patent/CN2554184Y/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: SHANGHAI CHUANGYUE BIOLOGY SCIENCE CO., LTD. Free format text: FORMER OWNER: XI AN POTOMAC BIO-TECHNOLOGY CO., LTD. Effective date: 20060901 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20060901 Address after: 200333, building 4, 3, Zhongjiang Road, 879, Shanghai, Putuo District Patentee after: Shanghai creation Biotechnology Co., Ltd. Address before: 710075 No. four, No. 23, hi tech Road, Shaanxi, Xi'an Patentee before: Xi'an Lian'er Biotechnology Co., Ltd. |
|
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |