CN208109848U - Chemical illumination immunity analysis instrument - Google Patents
Chemical illumination immunity analysis instrument Download PDFInfo
- Publication number
- CN208109848U CN208109848U CN201820626207.3U CN201820626207U CN208109848U CN 208109848 U CN208109848 U CN 208109848U CN 201820626207 U CN201820626207 U CN 201820626207U CN 208109848 U CN208109848 U CN 208109848U
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- fixed plate
- magnetosheath
- reagent
- analysis instrument
- push rod
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Abstract
The utility model provides a kind of chemical illumination immunity analysis instrument, including incubating device, distributor, driving device, separator and optical detection device, driving device includes guide rail and sliding block, sliding block is slidably arranged on guide rail, incubating device includes incubating bottom plate, incubates the reagent trough for being provided with reagent reaction warehouse on bottom plate and being used cooperatively with reagent reaction warehouse；Opening is provided at the top of reagent reaction warehouse, bottom plate is incubated to be fixed on sliding block, distributor, separator and optical detection device are respectively positioned on right above guide rail, the utility model is designed without any fluid path, with matched reagent using lifelong without assembling other disposable consumptive materials, can effectively save cost and time, prevent from source carry pollution, interference pollution risk, and reduce or remit traditional instrument periodic cleaning, maintenance, maintain liquid channel system work.
Description
Technical field
The utility model relates to Medical treatment devices to guard against field, specially a kind of chemical illumination immunity analysis instrument.
Background technique
Chemiluminescence immune assay is to exempt from the innovation of the immuno analytical methods such as analysis, fluoroimmunoassay after radioimmunology analysis, enzyme
The most advanced immuno analytical method to grow up after iteration.It is adopted based on immunology principle combination chemiluminescent agent labelling technique
Detected with chemiluminescence instrument to realize a kind of newest immunoassay method for analyze target substance, with high sensitivity,
The range of linearity is wide, quantitative detection is accurate, testing result is stable, analytical precision is high, flexible operation is easy, the degree of automation height etc.
Advantage.The chemiluminescence immune assay of the developed countries such as America and Europe replaces traditional sensing techniques as the master of immunoassay substantially
Stream, China intensively issues the policy of domestic medical instrument favourable in recent years, wherein classification diagnosis and treatment, range test center and advanced medical
Instrument industrial application and registration are declared, the policies such as the in-depth reform of examination and approval procedures further will effectively push domestic chemiluminescence
Development.Chemiluminescence immune assay it is environmentally friendly, quick, accurate the features such as obtain the generally approval in related application field, have become
For the main means of current clinical immunization diagnosis, and traditional detection technique is just gradually substituted.
Chemical illumination immunity analysis instrument is to combine chemiluminescence with immune response, for detecting trace antigen, antibody
A kind of novel markings immunoassay.Chemical illumination immunity analysis instrument includes two parts, i.e. immune response system and change
Learn luminesceence analysis system.Immune response system is marked directly on luminescent substance on antigen or antibody, through immunological specificity
Immune response forms conjugate and through catalyst action in luminous substrate.Chemiluminescence analysis system is to utilize chemiluminescent substance
The oxidation of catalysis and oxidant through catalyst, the intermediate of one excitation state of stroke are realized steady among this excitation state
When fixed ground state, while launching photon, luminous signal measuring instrument is utilized to measure quantum yield of luminscence.Chemiluminescence immune assay
Core sensitive detection parts are photomultiplier tube in instrument, it is the vacuum electron device that faint optical signal can be converted into electric signal, by
Singl e photon detection is simultaneously transmitted to amplifier, and analog current is converted digital current by the Current amplifier that adds high pressure, amplifier, number
Luminous signal is transferred to computer by data line and is calculated by electric current, obtains testing result.Existing chemiluminescence immunoassay point
There is the problems such as detection trouble and low accuracy in analyzer.
Therefore, it is necessary to improve to the prior art.
Utility model content
The technical problem to be solved by the present invention is to provide a kind of efficient chemical illumination immunity analysis instrument and methods.
In order to solve the above technical problems, the utility model provides a kind of chemical illumination immunity analysis instrument：Including incubate device,
Distributor, driving device, separator and optical detection device；
The driving device includes guide rail and sliding block, and sliding block is slidably arranged on guide rail；
The incubation device includes incubating bottom plate, incubates and is provided with reagent reaction warehouse on bottom plate and cooperates with reagent reaction warehouse
The reagent trough used；Opening is provided at the top of reagent reaction warehouse；
The incubation bottom plate is fixed on sliding block, and distributor, separator and optical detection device are respectively positioned on guide rail
Surface；
The distributor includes push rod pulling plate and note plug fixed plate, and note plug fixed plate bottom is fixedly installed hollow suction
Liquid pipette tips, push rod pulling plate bottom are provided with the push rod being used cooperatively with imbibition pipette tips；The push rod pulling plate is located at note plug fixed plate
Surface, push rod pass through note plug fixed plate and extend into imbibition pipette tips inner cavity, and push rod bottom is slided close with imbibition pipette tips inner cavity
Envelope connection；
The separator includes magnetosheath fixed plate and bar magnet fixed plate, and magnetosheath fixed plate bottom is provided with matches with reagent trough
The magnetosheath used is closed, bar magnet fixed plate bottom is provided with the bar magnet being used cooperatively with magnetosheath；The bar magnet fixed plate is located at magnetosheath
Right above fixed plate, bar magnet passes through magnetosheath fixed plate and protrudes into magnetosheath.
As the improvement to the utility model chemical illumination immunity analysis instrument：The push rod bottom is provided with piston head, living
The sealed connection of chock plug and the sliding of imbibition pipette tips intracavity sidewall.
As the further improvement to the utility model chemical illumination immunity analysis instrument：The imbibition pipette tips intracavity sidewall is set
It is equipped with annular notch.
As the further improvement to the utility model chemical illumination immunity analysis instrument：The distributor, separator
It is successively set on right above guide rail with optical detection device, distributor, separator and optical detection device are located at same horizontal line
On.
As the further improvement to the utility model chemical illumination immunity analysis instrument：The opening is provided with rotatable
Cover board.
As the further improvement to the utility model chemical illumination immunity analysis instrument：The magnetosheath side wall setting is flexible
Fastener, reagent trough surrounding are provided with the fastener slot with flexible clamp piece cooperation.
As the further improvement to the utility model chemical illumination immunity analysis instrument：The optical detection device includes light inspection
Bracket is surveyed, light detection bracket is equipped with PMT detection device.
The technical advantage of the utility model chemical illumination immunity analysis instrument and method is：
The utility model chemical illumination immunity analysis instrument as a kind of supermatic analysis instrument, the utility model without
The design of any fluid path, with matched reagent using lifelong without assembling other disposable consumptive materials, can effectively save cost and time,
Prevent the risk for carrying pollution, interference is polluted from source, and reduces or remits traditional instrument periodic cleaning, maintenance, maintenance liquid channel system
Work.Push rod and imbibition pipette tips, which are used cooperatively, can easily draw a certain amount of reagent.
Detailed description of the invention
Specific embodiment of the present utility model is described in further detail with reference to the accompanying drawing.
Fig. 1 is the overlooking structure figure of the utility model chemical illumination immunity analysis instrument；
Fig. 2 is the structural schematic diagram of driving device 1 in Fig. 1；
Fig. 3 is the structural schematic diagram that device 2 is incubated in Fig. 1；
Fig. 4 is the structural schematic diagram of distributor 3 in Fig. 1；
Fig. 5 is the structural schematic diagram of separator 4 in Fig. 1；
Fig. 6 is the structural schematic diagram that separator 4 and incubation device 2 are used cooperatively in Fig. 1；
Fig. 7 is the structural schematic diagram that push rod 32 and imbibition pipette tips 34 are used cooperatively in Fig. 4.
Specific embodiment
The utility model is described further combined with specific embodiments below, but the protection scope of the utility model is simultaneously
It is not limited only to this.
Embodiment, chemical illumination immunity analysis instrument as shown in figs. 1-7, including incubate device 2, distributor 3, driving dress
Set 1, separator 4 and optical detection device 5.Incubate device 2, distributor 3, driving device 1, separator 4 and light detection dress
5 are set to be arranged on bottom plate.
Driving device 1：Including guide rail 11 and sliding block 12, sliding block 12 is slidably arranged on guide rail 11, distributor 3, separation
Device 4 and optical detection device 5 are respectively positioned on right above guide rail 11.It incubates device 2 to be arranged on guide rail 11 by sliding block 12, incubates dress
Setting 2 can slide along guide rail 11 driven by the motor.
Distributor 3, separator 4 and 5 three of optical detection device are to set gradually in the same horizontal line.
Incubate device 2：Suitable temperature environment is provided for liquid reagent, including incubates bottom plate 21 and heating plate, heating plate
Setting incubates bottom plate 21 and is fixed on sliding block 12 on incubating bottom plate 21.It is anti-that eight reagents are provided on incubation bottom plate 21
Eight reagent troughs 23 answering storehouse 22 and being used cooperatively with reagent reaction warehouse 22.Reagent reaction warehouse 22 and reagent trough 23 correspond,
Each reagent reaction warehouse 22 is parallel with guide rail 11 with the line for the reagent trough 23 being used cooperatively.Heating plate is reacted with all reagents
Storehouse 22 is bonded.Heating plate can heat reagent reaction warehouse 22, make reagent reaction warehouse 22 that certain temperature (37 DEG C) be kept to be incubated.
Magnetic bead is housed in reagent trough 23.Opening 24 is provided at the top of reagent reaction warehouse 22, opening 24 is provided with rotatable cover board, cover board
It can laterally rotate.When not in use, cover board energy sealed opening 24；When in use, opening other devices of cover board can be passed through and be opened
Mouth 24.
Distributor 3：Push rod pulling plate 31 for pipetting each liquid reagent of distribution, including imbibition pipette tips 34, with motor
Fixed plate 33 is filled in note.
Note plug fixed plate 33 vertical direction can move driven by the motor, and note plug 33 bottom of fixed plate is fixedly installed eight
A hollow imbibition pipette tips 34 being used cooperatively with reagent reaction warehouse 22, imbibition pipette tips 34 are downwards；Imbibition pipette tips 34 use
Transparent plastic.
Push rod pulling plate 31 is located at right above note plug fixed plate 33, and push rod pulling plate 31 can be transported vertical direction driven by the motor
It is dynamic.31 bottom of push rod pulling plate is fixedly installed eight push rods being used cooperatively with imbibition pipette tips 34 32, and it is solid that push rod 32 passes through note plug
Fixed board 33 is extend into 34 inner cavity of imbibition pipette tips, and 32 bottom of push rod is fixedly installed piston head 321, piston head 321 and imbibition rifle
The sealed connection of first 34 inner cavity sliding.34 intracavity sidewall of imbibition pipette tips is provided with a ring v notch v 341, and piston head 321 will not
It is sealed with annular notch 341.When drawing liquid and push rod 32 (piston head 321) is by annular notch 341, imbibition pipette tips 34 are not
Corresponding suction can be generated, user can be reminded to have drawn enough liquid.
The level height of distributor 3, which is greater than, incubates device 2.
Distributor 3 when in use, incubates device 2 along guide rail 11 and is moved to (eight imbibition rifles immediately below distributor 3
Eight reagent reaction warehouses 22 of first 34 alignment), the cover board at the opening of reagent reaction warehouse 22 24 is opened, control is infused plug fixed plate 33 and pushed away
Bar pulling plate 31 moves down (synchronized) jointly, so that imbibition pipette tips 34 pass through opening 24 and extend into reagent reaction warehouse 22, then
Control push rod pulling plate 31 drives push rod 32 (piston head 321) to move up, and imbibition pipette tips 34 generate suction and draw reagent reaction warehouse
Liquid in 22.When push rod 32 (piston head 321) is by annular notch 341, can obviously observe in imbibition pipette tips 34
Liquid temporarily ceases growth, at this moment terminates imbibition.Then device 2 is incubated further along the mobile a small distance of guide rail 11, so that inhaling
Liquid pipette tips 34 are directed at reagent trough 23, and imbibition pipette tips 34 are by the liquid injection being drawn into reagent trough 23.
Separator 4：To the mixing, cleaning of reagent, Magneto separate function in experiment, the magnetosheath including having motor is fixed
Plate 41 and bar magnet fixed plate 43；Bar magnet fixed plate 43 is located at right above magnetosheath fixed plate 41, and magnetosheath fixed plate 41 and bar magnet are fixed
Plate 43 can move straight down under the drive of respective motor.
41 bottom of magnetosheath fixed plate is provided with eight magnetosheaths 42 being used cooperatively with reagent trough 23,43 bottom of bar magnet fixed plate
It is provided with eight bar magnets 44 being used cooperatively with eight magnetosheaths 42.Magnetosheath 42 can protrude into reagent trough 23, and bar magnet 44 can pass through magnetic
Set fixed plate 41 protrudes into magnetosheath 42.Magnetosheath 42 can prevent the direct contact liq of bar magnet 44, and the up and down motion of bar magnet 44 can be completed to inhale
Attached and release magnetic bead.
Bar magnet 44 and magnetosheath 42 are all arranged straight down.
42 side wall of magnetosheath is provided with flexible clamp piece 45, and 23 surrounding of reagent trough is both provided with the fastener cooperated with flexible clamp piece 45
Slot 25.Flexible clamp piece 45 is inserted into corresponding fastener slot 25, can play positioning action, it is ensured that magnetosheath 42 can protrude into reagent trough
23。
Separator 4 when in use, incubates device 2 along guide rail 11 and is moved to (eight magnetosheaths 42 immediately below separator 4
It is directed at eight reagent troughs 23), magnetosheath fixed plate 41 moves down, until flexible clamp piece 45 is inserted into corresponding fastener slot 25 and is
Only, magnetosheath 42 is extend into reagent trough 23 at this time；Then about 43 bar magnet fixed plate of control moves back and forth, so that magnetosheath 42 is abundant
Magnetic bead in adsorptive agent.
Optical detection device 5 includes：Light detection bracket, light detection bracket are equipped with：For luminous value in detection reagent slot 23
PMT detection device, the luminous value of reagent in reagent trough 23 is detected, according to the processing of light signal strength convert, most
The testing result of substance to be checked is obtained eventually.
Optical detection device 5 when in use, incubates device 2 along guide rail 11 and is moved to immediately below optical detection device 5 (PMT inspection
Survey the alignment probe reagent trough 23 of device), it is converted according to the processing of light signal strength, the performance of reagent in detection reagent slot 23.
The use process of the utility model is：
Reagent is added in the reagent reaction warehouse 22 for incubating device 2 to be incubated；
Then device 2 will be incubated to be moved to immediately below distributor 3, distributor 3 is by the part in reagent reaction warehouse 22
Agent transfer is into reagent trough 23；
Then device 2 will be incubated to be moved to immediately below separator 4, separator 4 carries out the reagent in reagent trough 23
Magnetic bead cleaning separation；
Device 2 will finally be incubated to be moved to immediately below optical detection device 5, the performance of reagent in detection reagent slot 23.
Finally, it should also be noted that it is listed above be only the utility model several specific embodiments.Obviously,
The utility model is not limited to above embodiments, and acceptable there are many deformations.Those skilled in the art can be practical new from this
All deformations that type disclosure is directly exported or associated, are considered as the protection scope of the utility model.
Claims (7)
1. chemical illumination immunity analysis instrument, it is characterised in that：Including incubate device (2), distributor (3), driving device (1),
Separator (4) and optical detection device (5)；
The driving device (1) includes guide rail (11) and sliding block (12), and sliding block (12) is slidably arranged on guide rail (11)；
The incubation device (2) include incubate bottom plate (21), incubate bottom plate (21) on be provided with reagent reaction warehouse (22) and with examination
The reagent trough (23) that agent reaction warehouse (22) is used cooperatively；Opening (24) are provided at the top of reagent reaction warehouse (22)；
The incubation bottom plate (21) is fixed on sliding block (12), distributor (3), separator (4) and optical detection device
(5) it is respectively positioned on right above guide rail (11)；
The distributor (3) includes push rod pulling plate (31) and note plug fixed plate (33), and fixed plate (33) the bottom fixation of note plug is set
Hollow imbibition pipette tips (34) are equipped with, push rod pulling plate (31) bottom is provided with the push rod being used cooperatively with imbibition pipette tips (34)
(32)；The push rod pulling plate (31) is located at right above note plug fixed plate (33), and push rod (32) passes through note plug fixed plate (33) and protrudes into
Into imbibition pipette tips (34) inner cavity, the sealed connection of push rod (32) bottom and the sliding of imbibition pipette tips (34) inner cavity；
The separator (4) includes magnetosheath fixed plate (41) and bar magnet fixed plate (43), the setting of magnetosheath fixed plate (41) bottom
There is a magnetosheath (42) being used cooperatively with reagent trough (23), bar magnet fixed plate (43) bottom is provided with to be used cooperatively with magnetosheath (42)
Bar magnet (44)；The bar magnet fixed plate (43) is located at right above magnetosheath fixed plate (41), and bar magnet (44) passes through magnetosheath fixed plate
(41) it protrudes into magnetosheath (42).
2. chemical illumination immunity analysis instrument according to claim 1, it is characterised in that：Push rod (32) bottom is provided with
Piston head (321), the sealed connection of piston head (321) and the sliding of imbibition pipette tips (34) intracavity sidewall.
3. chemical illumination immunity analysis instrument according to claim 2, it is characterised in that：Imbibition pipette tips (34) lumen side
Wall is provided with annular notch (341).
4. chemical illumination immunity analysis instrument according to claim 3, it is characterised in that：
The distributor (3), separator (4) and optical detection device (5) are successively set on right above guide rail (11), distribution dress
(3), separator (4) and optical detection device (5) is set to be located in same horizontal line.
5. chemical illumination immunity analysis instrument according to claim 4, it is characterised in that：The opening (24) is provided with and can turn
Dynamic cover board.
6. chemical illumination immunity analysis instrument according to claim 5, it is characterised in that：Magnetosheath (42) side wall is provided with
Flexible clamp piece (45), reagent trough (23) surrounding are provided with the fastener slot (25) with flexible clamp piece (45) cooperation.
7. chemical illumination immunity analysis instrument according to claim 6, it is characterised in that：The optical detection device (5) includes
Light detection bracket, light detection bracket are equipped with PMT detection device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820626207.3U CN208109848U (en) | 2018-04-28 | 2018-04-28 | Chemical illumination immunity analysis instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820626207.3U CN208109848U (en) | 2018-04-28 | 2018-04-28 | Chemical illumination immunity analysis instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208109848U true CN208109848U (en) | 2018-11-16 |
Family
ID=64113870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201820626207.3U Expired - Fee Related CN208109848U (en) | 2018-04-28 | 2018-04-28 | Chemical illumination immunity analysis instrument |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN208109848U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110806491A (en) * | 2019-11-15 | 2020-02-18 | 成都宜乐芯生物科技有限公司 | Full-automatic POCT multiple detection liquid phase chip system |
| CN113820195A (en) * | 2021-11-25 | 2021-12-21 | 成都宜乐芯生物科技有限公司 | Multichannel parallel pretreatment device |
| CN114441510A (en) * | 2022-01-18 | 2022-05-06 | 成都宜乐芯生物科技有限公司 | POCT full-automatic chemiluminescence device based on multi-channel parallel pretreatment technology |
-
2018
- 2018-04-28 CN CN201820626207.3U patent/CN208109848U/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110806491A (en) * | 2019-11-15 | 2020-02-18 | 成都宜乐芯生物科技有限公司 | Full-automatic POCT multiple detection liquid phase chip system |
| CN110806491B (en) * | 2019-11-15 | 2024-03-29 | 成都宜乐芯生物科技有限公司 | Full-automatic POCT multiple detection liquid phase chip system |
| CN113820195A (en) * | 2021-11-25 | 2021-12-21 | 成都宜乐芯生物科技有限公司 | Multichannel parallel pretreatment device |
| CN113820195B (en) * | 2021-11-25 | 2022-03-08 | 成都宜乐芯生物科技有限公司 | Multichannel parallel pretreatment device |
| EP4187250A1 (en) * | 2021-11-25 | 2023-05-31 | Chengdu Illumaxbio Technology Co., Ltd. | Multi-channel parallel pretreatment device |
| CN114441510A (en) * | 2022-01-18 | 2022-05-06 | 成都宜乐芯生物科技有限公司 | POCT full-automatic chemiluminescence device based on multi-channel parallel pretreatment technology |
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20181116 Termination date: 20210428 |