CN212255364U

CN212255364U - Full-automatic chemiluminescence immunoassay analyzer

Info

Publication number: CN212255364U
Application number: CN201922302215.XU
Authority: CN
Inventors: 靳明; 高燕; 刘振世; 王俊杰
Original assignee: Jiangsu Zecen Biotech Co ltd
Current assignee: Jiangsu Zecen Biotech Co ltd
Priority date: 2019-12-19
Filing date: 2019-12-19
Publication date: 2020-12-29
Anticipated expiration: 2029-12-19

Abstract

The utility model discloses a full-automatic chemiluminescence immunoassay analyzer, which relates to the field of luminescence analysis equipment, and comprises a reaction tube module, a sample tube module, a reagent box module, a three-dimensional mechanical arm module, a test tube taking gripper device, a mixing structure, an incubation bin, a cleaning device, an electric control part and a PC control end; the three-dimensional mechanical arm module comprises an X-axis mechanical arm, a Y-axis mechanical arm and a Z-axis mechanical arm, and a sampling needle is arranged at the bottom of the Z-axis mechanical arm; a test tube taking gripper is arranged beside the reaction tube module; the mixing structure comprises a mixing motor, a first mixing wheel is installed at the power output end of the mixing motor, a second mixing wheel is installed on the first mixing wheel, an inverted U-shaped mixing retaining sheet is arranged on one side of the second mixing wheel, and a mixing retaining rod is fixed on the outer wall of the second mixing wheel. The utility model discloses a get test tube tongs device and replace original getting and put a tub device, the cost is reduced has improved the stability of removing the reaction tube.

Description

Full-automatic chemiluminescence immunoassay analyzer

Technical Field

The utility model relates to a luminescence analysis equipment field, in particular to full-automatic chemiluminescence immunoassay appearance.

Background

Chemiluminescence immunoassay is a clinical medical testing technique for the detection of antigens or antibodies in human body fluids. The method is widely applied due to the advantages of high sensitivity, good selectivity and the like, and the theoretical research in a laboratory is a common means in clinical immunological detection at present. Accordingly, the development of various chemiluminescent immunoassay instruments is becoming more and more mature. The chemiluminescence amplification technology is characterized in that an antigen or an antibody is labeled with enzyme or other non-radioactive markers by utilizing an antigen-antibody reaction principle, then the antigen or the antibody reacts with the known antigen or antibody, the labeled enzyme enables a reaction substrate to emit light, the light-emitting counts per second of a detected sample can be obtained after the measurement of a photon counter, and the light-emitting counts are converted into concentration values of the sample according to a built-in standard curve. Due to the application of the technology, the reaction time of the antigen-antibody is shortened, the specificity degree and the sensitivity are improved, and the full automation of the whole reaction is possible.

Before my department, a full-automatic chemiluminescence immunoassay analyzer is developed, the specific content of the full-automatic chemiluminescence immunoassay analyzer is disclosed as CN103743916A, and the name of the invention is as follows: the invention discloses a full-automatic chemiluminescence immunoassay analyzer, which is further optimized on the basis of the above, so that the full-automatic chemiluminescence immunoassay analyzer is more stable, has higher test flux, is low in cost, is simple to install, has good stability, and can enable a sample, a reagent and magnetic particles to react more fully.

SUMMERY OF THE UTILITY MODEL

The utility model provides a full-automatic chemiluminescence immunoassay appearance solves the problem that current analysis appearance still remains further optimization.

In order to solve the technical problem, the utility model discloses a technical scheme does:

a full-automatic chemiluminescence immunoassay analyzer comprises a reaction tube module, a sample tube module, a reagent box module, a three-dimensional mechanical arm module, a test tube taking gripper device, a mixing structure, an incubation bin, a cleaning device, an electric control part and a PC control end; the three-dimensional mechanical arm module comprises an X-axis mechanical arm, a Y-axis mechanical arm and a Z-axis mechanical arm, and a sampling needle is arranged at the bottom of the Z-axis mechanical arm; a test tube taking gripper is arranged beside the reaction tube module; the mixing structure includes the mixing motor, first mixing wheel is installed to the power take off end of mixing motor, install the second mixing wheel on the first mixing wheel, connect through the bearing between first mixing wheel and the second mixing wheel, the second mixing wheel is hollow structure, second mixing wheel one side is equipped with "type of falling U" mixing separation blade, second mixing wheel outer wall is fixed with mixing shelves pole, mixing shelves pole stretches into in the mixing separation blade.

Preferably, the three-dimensional arm module includes X axle arm, Y axle arm and Z axle arm, X axle arm includes mounting platform, the last wide type linear guide that is equipped with of mounting platform, Y axle arm passes through X axle bottom plate slidable mounting in on the wide type linear guide, Z axle arm passes through the movably installation on Y axle arm of Y axle drive belt, install X axle action wheel and X axle from the driving wheel along the X axle on the mounting platform, the X axle action wheel links to each other with the power take off end of X axle motor, the cover is equipped with the X axle belt on X axle action wheel and the X axle driven wheel, X axle bottom plate is fixed mutually with the X axle belt.

Preferably, the hollow structure inner wall of the second mixing wheel is provided with an anti-skid layer.

Preferably, dust covers are arranged on outer covers of the Y-axis mechanical arm and the Z-axis mechanical arm of the three-dimensional mechanical arm module.

Preferably, the test tube taking gripper is installed in the installation shell.

Preferably, reaction tube module, sample tube module, reagent box module, three-dimensional arm module get test tube tongs device, mixing structure, incubation storehouse and belt cleaning device install in transparent frame.

By adopting the technical scheme, the utility model discloses a get test tube tongs device replaces original get and put a tub device, and the cost is reduced has improved the stability of removing the reaction tube, and the injection pump formula that used before moves the tubular construction, and the mode similar to the liquid-transfering gun is got and is put the reaction tube, but the condition that can't hit the reaction tube appears occasionally, and the get test tube tongs device after the improvement has two tongs pieces to hold the reaction tube, puts down the reaction tube when tongs piece opens, and the cost is reduced, and the installation is simple, and stability is good; the utility model discloses increased the mixing structure on original model, can make sample, reagent and magnetic particle reaction more abundant, reduced the rate of portable pollution.

Drawings

Fig. 1 is a schematic structural view of the present invention;

fig. 2 is a schematic structural view of the three-dimensional robot arm module according to the present invention in one direction;

fig. 3 is a schematic structural view of the three-dimensional robot arm module according to another direction of the present invention;

fig. 4 is a schematic structural diagram of the blending structure of the present invention;

fig. 5 is a main sectional view of the blending structure of the present invention.

In the figure, 1-three-dimensional mechanical arm module, 1-1-mounting platform, 1-2-wide linear guide rail, 1-3-X axis base plate, 1-4-Z axis mechanical arm, 1-5-Y axis transmission belt, 1-6-X axis driving wheel, 1-7-X axis driven wheel, 1-8-X axis motor, 1-9-X axis belt, 1-10-dust cover, 2-test tube taking gripping device, 3-blending structure, 3-1-blending motor, 3-2-first blending wheel, 3-3-second blending wheel, 3-4-bearing, 3-5-blending block sheet, 3-6-blending rod and 4-sample tube module, 5-reagent box module, 6-reaction tube module, 7-incubation bin, 8-sampling needle, 9-cleaning device, 10-PC control end and 11-transparent frame.

Detailed Description

The following describes the present invention with reference to the accompanying drawings. It should be noted that the description of the embodiments is provided to help understanding of the present invention, but the present invention is not limited thereto. In addition, the technical features related to the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.

In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", and the like, indicate the orientation or positional relationship indicated based on the drawings, and are only for convenience of description and simplicity of description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be construed as limiting the present invention.

As shown in fig. 1-5, a full-automatic chemiluminescence immunoassay analyzer comprises a reaction tube module 6, a sample tube module 4, a kit module 5, a three-dimensional mechanical arm module 1, a test tube taking gripper 2, a mixing structure 3, an incubation bin 7, a cleaning device 9, an electric control part and a PC control end 10; three-dimensional arm module 1 includes X axle arm, Y axle arm and Z axle arm 1-4, Z axle arm 1-4 bottom is equipped with sampling needle 8, can add the sample in sample cell module 4 and the kit module 5 respectively, reagent and magnetic particle sample to the reaction tube of reaction tube module 6 under three-dimensional arm module 1's drive in, the other test tube gripper 2 of getting of installing of reaction tube module 6, the structure of specifically getting test tube gripper 2 can be seen the publication number that this department applied is CN207373198U, the patent name is: a utility model of a test tube taking gripper device; the blending structure 3 comprises a blending motor 3-1, a first blending wheel 3-2 is installed at the power output end of the blending motor 3-1, a second blending wheel 3-3 is installed on the first blending wheel 3-2, the first blending wheel 3-2 is connected with the second blending wheel 3-3 through a bearing 3-4, the second blending wheel 3-3 is of a hollow structure and is convenient for placing a reaction tube into the second blending wheel 3-3 for blending, an inverted U-shaped blending baffle 3-5 is arranged on one side of the second blending wheel 3-3, a blending baffle rod 3-6 is fixed on the outer wall of the second blending wheel 3-3, and the blending baffle rod 3-6 extends into the blending baffle 3-5.

When the device is used, the sample tube module 4, the reagent box module 5 and the reaction tube module 6 are respectively used for storing samples, reagents and reaction tubes, after an experiment is started, the three-dimensional mechanical arm module 1 drives the sampling needle 8 to respectively sample the samples, the reagents and the magnetic particles in the sample tube module 4 and the reagent box module 5 into the reaction tubes of the reaction tube module 6, the test tube taking gripper 2 can take the reaction tubes added with liquid into the mixing structure 3 for mixing, the mixing motor 3-1 rotates to drive the first mixing wheel 3-2 fixed at the shaft end of the motor to rotate together, the first mixing wheel 3-2 further drives the second mixing wheel 3-3 to rotate together with the reaction tubes in the second mixing wheel 3-3, because the connection between the second mixing wheel 3-3 and the first mixing wheel 3-2 is a connection mode depending on a bearing, when the second mixing wheel 3-3 rotates, the blending baffle rods 3-6 on the second blending wheel 3-3 are blocked by the blending baffles 3-5, and then the second blending wheel 3-3 oscillates among the blending baffles 3-5, so that the sample, the reagent and the magnetic particles in the reaction tube are fully blended; after the mixing, the test tube gripper device 2 is taken to place the reaction tube into the incubation bin 7 for reaction and incubation, after the reaction is finished, the test tube gripper device 2 is taken to grip the reaction tube into the cleaning device 9 for cleaning and detection, and the detection result can be displayed at the PC control end 10.

The utility model adopts the test tube taking gripper device 2 to replace the original tube taking and placing device, thereby reducing the cost and improving the stability of moving the reaction tube, the injection pump type tube moving structure used before is similar to a liquid-moving gun for taking and placing the reaction tube, but the condition that the reaction tube can not be taken down occasionally occurs, the improved test tube taking gripper device 2 has two gripper sheets to hold the reaction tube, and the reaction tube is put down when the gripper sheets are opened, thereby reducing the cost, simplifying the installation and having good stability; the utility model discloses increased mixing structure 3 on original model, can make sample, reagent and magnetic particle reaction more abundant, reduced the rate of portable pollution.

Specifically, the three-dimensional mechanical arm module 1 comprises an X-axis mechanical arm, a Y-axis mechanical arm and a Z-axis mechanical arm 1-4, the X-axis mechanical arm comprises a mounting platform 1-1, a wide linear guide rail 1-2 is arranged on the mounting platform 1-1, the Y-axis mechanical arm is slidably mounted on the wide linear guide rail 1-2 through an X-axis base plate 1-3, the Z-axis mechanical arm 1-4 is movably mounted on the Y-axis mechanical arm through a Y-axis transmission belt 1-5, an X-axis driving wheel 1-6 and an X-axis driven wheel 1-7 are mounted on the mounting platform 1-1 along the X axis, the X-axis driving wheel 1-6 is connected with the power output end of an X-axis motor 1-8, an X-axis belt 1-9 is sleeved on the X-axis driving wheel 1-6 and the X-axis driven wheel 1-7, and the X, the X-axis belt 1-9 can be driven to move along the X-axis driving wheel 1-6 and the X-axis driven wheel 1-7 under the driving of the X-axis motor 1-8, and further the Y-axis mechanical arm on the X-axis bottom plate 1-3 is driven to move along the X-axis direction; the two cylindrical guide rails of the original X-axis mechanical arm are optimized into a single wide linear guide rail 1-2, so that the installation requirement is low, the installation requirement of the two cylindrical guide rails of the original X-axis mechanical arm is strict, the two cylindrical guide rails are required to be relatively parallel, otherwise the smooth motion of the mechanical arm is influenced, the blocking phenomenon is easy to occur, the stability of the optimized X-axis mechanical arm is improved, the noise is relatively reduced, and the X-axis mechanical arm can operate more stably and efficiently; the utility model discloses an optimize two cylinder guide rails of former X axle arm for single wide type linear guide 1-2, the installation requirement is low, and the installation requirement of two cylinder guide rails of former X axle arm is stricter, need to guarantee that two cylinder guide rails will be parallel relatively, otherwise can influence the smooth and easy motion of arm, the card pause phenomenon appears easily, and the X axle arm stability after optimizing improves, and the noise also reduces relatively, can more stabilize the efficient operation.

In order to ensure the stability of the reaction tube in the second mixing wheel 3-3, the inner wall of the hollow structure of the second mixing wheel 3-3 is provided with an anti-slip layer, so that the reaction tube can be prevented from being thrown out in the vibrating process.

In order to prolong the service life and improve the aesthetic property of the utility model, the Y-axis mechanical arm and the Z-axis mechanical arm 1-4 of the three-dimensional mechanical arm module 1 are covered with dust covers 1-10.

In order to prevent getting test tube tongs 2 and taking place the circumstances such as the card pause or pollution in the use, get test tube tongs 2 and install in the installation shell, not only can prolong the life who gets test tube tongs 2 and can strengthen the aesthetic property.

In order to promote the utility model discloses a monitorable nature and stability of use, reaction tube module 6, sample cell module 4, kit module 5, three-dimensional arm module 1 gets test tube tongs device 2, mixing structure 3, and incubation storehouse 7 and belt cleaning device 9 are installed in transparent frame 11, can be convenient for the staff at the in-process of reaction and monitor internal behavior, and can promote the utility model discloses a life.

The above description is only a preferred embodiment of the present invention, and the present invention is not limited to the above embodiments, and although the present invention has been disclosed with the preferred embodiments, it is not limited to the present invention, and any skilled person in the art can make some modifications or equivalent embodiments without departing from the scope of the present invention, but all the technical matters of the present invention are within the scope of the present invention.

Claims

1. A full-automatic chemiluminescence immunoassay analyzer is characterized in that: the device comprises a reaction tube module (6), a sample tube module (4), a reagent box module (5), a three-dimensional mechanical arm module (1), a test tube taking gripper device (2), a uniformly mixing structure (3), an incubation bin (7), a cleaning device (9), an electric control part and a PC control end (10); the three-dimensional mechanical arm module (1) comprises an X-axis mechanical arm, a Y-axis mechanical arm and a Z-axis mechanical arm (1-4), and a sampling needle (8) is arranged at the bottom of the Z-axis mechanical arm (1-4); a test tube taking gripper device (2) is arranged beside the reaction tube module (6); mixing structure (3) include mixing motor (3-1), first mixing wheel (3-2) is installed to the power take off end of mixing motor (3-1), install second mixing wheel (3-3) on first mixing wheel (3-2), connect through bearing (3-4) between first mixing wheel (3-2) and the second mixing wheel (3-3), second mixing wheel (3-3) are hollow structure, second mixing wheel (3-3) one side is equipped with "type of falling U" mixing separation blade (3-5), second mixing wheel (3-3) outer wall is fixed with mixing shelves pole (3-6), mixing shelves pole (3-6) stretch into in mixing separation blade (3-5).

2. The full-automatic chemiluminescence immunoassay analyzer of claim 1, wherein: the X-axis mechanical arm comprises a mounting platform (1-1), a wide linear guide rail (1-2) is arranged on the mounting platform (1-1), the Y-axis mechanical arm is slidably mounted on the wide linear guide rail (1-2) through an X-axis bottom plate (1-3), the Z-axis mechanical arm (1-4) is movably mounted on the Y-axis mechanical arm through a Y-axis transmission belt (1-5), an X-axis driving wheel (1-6) and an X-axis driven wheel (1-7) are mounted on the mounting platform (1-1) along the X axis, the X-axis driving wheel (1-6) is connected with the power output end of an X-axis motor (1-8), and X-axis belts (1-9) are sleeved on the X-axis driving wheel (1-6) and the X-axis driven wheel (1-7), the X-axis bottom plate (1-3) is fixed with the X-axis belt (1-9).

3. The full-automatic chemiluminescence immunoassay analyzer of claim 1, wherein: the inner wall of the hollow structure of the second mixing wheel (3-3) is provided with an anti-skid layer.

4. The full-automatic chemiluminescence immunoassay analyzer of claim 1, wherein: and dust covers (1-10) are arranged outside Y-axis mechanical arms and Z-axis mechanical arms (1-4) of the three-dimensional mechanical arm module (1).

5. The full-automatic chemiluminescence immunoassay analyzer of claim 1, wherein: the test tube taking gripper device (2) is installed in the installation shell.

6. The full-automatic chemiluminescence immunoassay analyzer of claim 1, wherein: reaction tube module (6), sample tube module (4), reagent box module (5), three-dimensional arm module (1), get test tube tongs device (2), mixing structure (3), incubation storehouse (7) and belt cleaning device (9) are installed in transparent frame (11).