CN201765226U - Dial type direct-reading fully-automatic immune luminescence analysis system - Google Patents
Dial type direct-reading fully-automatic immune luminescence analysis system Download PDFInfo
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- CN201765226U CN201765226U CN2010201535472U CN201020153547U CN201765226U CN 201765226 U CN201765226 U CN 201765226U CN 2010201535472 U CN2010201535472 U CN 2010201535472U CN 201020153547 U CN201020153547 U CN 201020153547U CN 201765226 U CN201765226 U CN 201765226U
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Abstract
The utility model discloses a dial type direct-reading fully-automatic immune luminescence analysis system, which adopts a dial type structure and a shading black reaction cup. Incubation, magnetic separation, cleaning and final measurement are all carried out in a dial, the system only adopts simple XYZ movement and a transfer mechanism, and due to the black reaction cup and a bayonet type measurement head, the system needs no closed dark chamber for measurement; and during measurement, a reagent in a reagent kit and samples in a sample test tube are fed into the reaction cup through XYZ movement of a left arm and a right arm and a feeding pump, incubation is carried out in a constant-temperature incubation slot of the reaction cup, the reaction dial is rotated a certain period after incubation for magnetic separation through a magnetic separation body, a cleaning pump cleans the reaction cup through a cleaning needle on a cleaning bracket, waste solution is pumped by a waste solution pump, the reaction cup is rotated into the measurement mode after cleaning, and the measurement head is lowered so that external light can not enter the reaction cup. A stimulation reagent is then added through a stimulation reagent pump according to specified procedures, the produced light is measured through a photon measurement unit, and measurement results are sent into a computer for processing.
Description
Technical field
The utility model relates to the medical instruments and equipment field, the full-automatic immunoluminescence analytic system of particularly a kind of rotating disk direct-reading.
Background technology
Along with science and technology development, chemiluminescence and biochemical luminous measurement had become very common in recent years, they often are used to determine in the sample certain not content of principal component, and in the past ten years, important effect has also been brought into play in luminous measurement in the research of gene expression and adjusting, chemiluminescence is the light that utilizes in the chemical reaction process to be excited, biochemical luminous is to utilize in chemical reaction process, to add the light that enzymaticization is sent.Chemical and biochemical luminous measuring technique is compared with other measuring technique, and following advantage is arranged: high sensitivity, wide dynamic range, the luminous measurement reagent that continues to bring out.Luminous measurement has high sensitivity, and it is higher by 10 than the sensitivity of spectral absorption measuring technique
5Doubly, exceed 1000 times at least than fluorescence measurement techniques.The luminous surveying instrument of an excellent in design can detect the luciferase of (ATP) the formula 0.1fg that is lower than 0.6pg.The luminous quantity of measurement in chemical reaction process is very useful because in the sample not the content of principal component can from this luminous quantity, calculate.Measuring equipment for luminescent system has semi-automatic and full-automatic two big classes at present.The semi-automatic measuring complicated operation needs operating personnel that higher experimental technique is arranged, and introduce personal error easily, and testing process is slower.And the luminous measuring system of full-automatic chemical mainly is divided into two major types, one is based on the measuring system of ELISA Plate technology, one is based on the cup type measuring system of reaction, because the latter's sensitivity is higher, more can give full play to chemiluminescent advantage, therefore, adopt the mark of the cup type chemiluminescence measurement system incorporates nanometer magnetic bead of reaction and isolation technics to become the main flow that chemiluminescence is measured.The full-automatic chemical electrochemiluminescent immunoassay measuring system that more external well-known manufacturers are released all adopts this pattern.But all automatic measurement systemic-function in the market is powerful, complex structure (failure rate height), and the cost height is fit to some large hospitals and uses, and is difficult to select present all automatic measurement system for a large amount of middle and small hospitals.For the ease of popularizing of luminous measuring method, be badly in need of the simple and easy full-automatic chemical luminous diagnostic system of development based on the nanometer magnetic bead technology, can satisfy the request for utilization of middle and small hospital, can reduce cost again, reduce failure rate, be convenient to reviewer's operation and maintenance.
Tubular type full-automatic chemical luminescence immunoassay system in the market is by following linear model operation substantially: sample and reagent are added reaction cup, make reaction cup be recycled to incubation respectively again, magnetic separates and purging system, making reaction cup enter airtight darkroom at last measures, in order to make reaction cup can arrive above-mentioned appointed area, need a cover complicated mechanical transport system, thereby make general tubular type full-automatic chemical luminescence immunoassay system become very huge and complicated.
The utility model content
In order to overcome the deficiencies in the prior art, the utility model provides a kind of rotating disk direct-reading full-automatic immunoluminescence analytic system, the black reaction cup, the incubation that adopt rotary-disk type structure and have the shading performance, magnetic separation and purging system and last measurement are all carried out in rotating disk, system has only simple XYZ motion and transshipment acitivity, and owing to adopt black reaction cup and bayonet type measuring head, the system that makes need not measure in airtight darkroom.
The full-automatic immunoluminescence analytic system of a kind of rotating disk direct-reading comprises: can carry out XYZ motion left arm and right arm, fluid filling pump, sample needle, reagent storehouse, kit, sample disk, sample tube, reaction rotating disk, reaction cup, incubation groove, magnetic chorista, clean support, scavenging pump, waste drains pump, excite reagent pump, measuring head, photon survey unit, catoptron, sampling probe and computing machine; Left arm and right arm can side-to-side movements on X-axis, and X-axis is mounted on the left and right sides support on the system backplane, and Y-axis motion and Z shaft movement mechanism are installed on left arm and right arm.
During measurement, XYZ motion and fluid filling pump by left and right arms are added to reagent in the kit and the sample in the sample tube in the reaction cup, reaction cup is carried out incubation in keeping the incubation groove of constant temperature, behind the incubation certain hour, the rotational response rotating disk, make it pass through the magnetic chorista and realize that magnetic separates, reaction cup is cleaned by the cleaning needle that cleans on the support by scavenging pump, waste liquid is taken away by waste drains pump, after cleaning finishes, forward reaction cup to measured place again, fall measuring head, make extraneous light can not enter reaction cup.Program according to the rules excites reagent by exciting reagent pump to add then, and the light of institute's output is measured by the photon survey unit, and the result of measurement sends into computing machine and handles.
Left arm and right arm can side-to-side movements on X-axis, X-axis is mounted on the left and right sides support on the system backplane, Y-axis motion and Z shaft movement mechanism are installed on left arm and right arm, thereby realize the motion of the XYZ axle of left and right arms, on the Z axle, sample needle is installed, sample needle links to each other with fluid filling pump by plastic tube, thereby reagent in the kit and the sample in the sample tube can be added in the reaction cup.The reagent storehouse is installed on the base plate in system left side, kit is placed in the reagent storehouse, sample disk, reaction rotating disk, incubation groove, magnetic chorista as an integral installation on the base plate on system right side, sample tube puts into sample disk, reaction cup is put into the incubation groove of locating behind the reaction rotating disk, and can arrive magnetic separation, cleaning and measuring position along with the reaction dial rotation.The magnetic separation is to realize by the magnet that is installed on the incubation groove, at cleaning positions, by being installed in the scavenging pump on the machine bed plate and cleaning support, the content in the reaction cup is cleaned, and waste liquid is taken away by the waste drains pump that is installed on the machine.After cleaning finishes, the rotational response rotating disk, make it forward the measured place to, fall measuring head, cooperate owing to design the chimb that designs on fluted and the black reaction cup on the measuring head, perhaps design has chimb on measuring head, design is fluted on the black reaction cup, thereby the sealing that guarantees light makes extraneous light can not enter reaction cup.The light of cycle chemistry or biochemical reaction institute output is handled via sending into computing machine after optically detecting and the converting system
Placing response cup on the described rotating disk mechanism;
Described reaction cup is made up of the black light screening material, the edge that protrusion is arranged on the reaction cup, the incubation of reaction cup, cleaning, measurement are all carried out in this rotating disk, adopt the bayonet type measuring head to combine with reaction cup, guarantee the sealing of light to external world, adopt catoptron or other light conducting systems that the light of reaction cup output is transmitted to optical measurement unit.
Owing to adopted above technical scheme, the utlity model has following beneficial effect: can satisfy the request for utilization of middle and small hospital, can reduce cost again, reduce failure rate, be convenient to reviewer's operation and maintenance.
Description of drawings
Fig. 1 is a structural representation of the present utility model.
In the drawings: 1-left arm, 2-right arm, 3-fluid filling pump, 4-reagent storehouse, 5-kit, 6-sample disk, 7-sample tube, 8-reaction rotating disk, 9-reaction cup, 10-incubation groove, 11-magnetic chorista, 12-cleaning support, 13-scavenging pump, 14-waste drains pump, 15-excite reagent pump, 16-measuring head, 17-photon survey unit, 18-catoptron, 19-sample needle, 20-computing machine
Embodiment
As shown in Figure 1, the full-automatic immunoluminescence analytic system of a kind of rotating disk direct-reading that the utility model provides comprises left arm 1 and right arm 2, fluid filling pump 3, reagent storehouse 4, kit 5, sample disk 6, sample tube 7, reaction rotating disk 8, reaction cup 9, incubation groove 10, the magnetic chorista 11 that can carry out XYZ motion, cleans support 12, scavenging pump 13, waste drains pump 14, excites reagent pump 15, measuring head 16, photon survey unit 17, catoptron 18, sampling probe 19 and computing machine 20.During measurement, XYZ motion and fluid filling pump 3 by left and right arms are added to the sample in reagent in the kit 5 and the sample tube 7 in the reaction cup 9, reaction cup 9 is carried out incubation in keeping the incubation groove 10 of constant temperature, behind the incubation certain hour, rotational response rotating disk 8, make it pass through magnetic chorista 11 and realize that magnetic separates, reaction cup 9 is cleaned by the cleaning needle that cleans on the support 12 by scavenging pump 13, waste liquid is taken away by waste drains pump 14, after cleaning finishes, forward reaction cup 9 to measured place again, fall measuring head 16, make extraneous light can not enter reaction cup 9.Program according to the rules excites reagent by exciting reagent pump 15 to add then, and the light of institute's output is measured by photon survey unit 17, and the result of measurement sends into computing machine 20 and handles.
Left arm 1 and right arm 2 can side-to-side movements on X-axis, X-axis is mounted on the left and right sides support on the system backplane, Y-axis motion and Z shaft movement mechanism are installed on left arm 1 and right arm 2, thereby realize the motion of the XYZ axle of left and right arms, sample needle 19 is installed on the Z axle, sample needle 19 links to each other with fluid filling pump by plastic tube, thereby reagent in the kit and the sample in the sample tube can be added in the reaction cup 9.The reagent storehouse is installed on the base plate in system left side, kit is placed in the reagent storehouse 4, sample disk 6, reaction rotating disk 8, incubation groove 10, magnetic chorista 11 as an integral installation on the base plate on system right side, sample tube 7 puts into sample disk 6, reaction cup 9 is put into the incubation groove at place, reaction rotating disk 8 back, and can rotate along with reaction rotating disk 8, arrive magnetic separation, cleaning and measuring position.The magnetic separation is to realize by the magnet that is installed on the incubation groove 10, at cleaning positions, by being installed in the scavenging pump 13 on the machine bed plate and cleaning support 12, the contents in the reaction cup 9 is cleaned, and waste liquid is taken away by the waste drains pump 14 that is installed on the machine.After cleaning finished, rotational response changeed 8 dishes, makes it forward the measured place to, falls measuring head, because chimb fluted and the black reaction cup cooperates on the measuring head, made extraneous light can not enter reaction cup.The light of cycle chemistry or biochemical reaction institute output is handled via sending into computing machine 20 after optically detecting and the converting system.
Claims (5)
1. full-automatic immunoluminescence analytic system of rotating disk direct-reading, comprise: the left arm and the right arm that can carry out the XYZ motion, fluid filling pump, sample needle, the reagent storehouse, kit, sample disk, sample tube, the reaction rotating disk, reaction cup, the incubation groove, the magnetic chorista, clean support, scavenging pump, waste drains pump, excite reagent pump, measuring head, the photon survey unit, catoptron, sampling probe and computing machine, it is characterized in that: left arm and right arm can side-to-side movements on X-axis, X-axis is mounted on the left and right sides support on the system backplane, and Y-axis motion and Z shaft movement mechanism are installed on left arm and right arm.
2. the full-automatic immunoluminescence analytic system of a kind of rotating disk direct-reading as claimed in claim 1, it is characterized in that: on the Z axle sample needle is installed, sample needle links to each other with fluid filling pump by plastic tube.
3. the full-automatic immunoluminescence analytic system of a kind of rotating disk direct-reading as claimed in claim 1, it is characterized in that: the reagent storehouse is installed on the base plate in system left side, kit is placed in the reagent storehouse, sample disk, reaction rotating disk, incubation groove, magnetic chorista as an integral installation on the base plate on system right side, sample tube puts into sample disk, reaction cup is put into the residing incubation groove of reaction rotating disk.
4. the full-automatic immunoluminescence analytic system of a kind of rotating disk direct-reading as claimed in claim 1 is characterized in that: on the measuring head design fluted, design has a chimb on the black reaction cup; Also can design chimb on measuring head, design is fluted on the black reaction cup.
5. the full-automatic immunoluminescence analytic system of a kind of rotating disk direct-reading as claimed in claim 1, it is characterized in that: placing response cup on the described rotating disk mechanism, described reaction cup is made up of the black light screening material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010201535472U CN201765226U (en) | 2010-04-06 | 2010-04-06 | Dial type direct-reading fully-automatic immune luminescence analysis system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010201535472U CN201765226U (en) | 2010-04-06 | 2010-04-06 | Dial type direct-reading fully-automatic immune luminescence analysis system |
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| CN201765226U true CN201765226U (en) | 2011-03-16 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2010201535472U Expired - Fee Related CN201765226U (en) | 2010-04-06 | 2010-04-06 | Dial type direct-reading fully-automatic immune luminescence analysis system |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102608129A (en) * | 2012-03-16 | 2012-07-25 | 北京勤邦生物技术有限公司 | Shimmer detecting system |
| CN103941032A (en) * | 2014-05-06 | 2014-07-23 | 北京中勤世帝生物技术有限公司 | Automatic detector for biological samples |
| CN104111328A (en) * | 2013-04-16 | 2014-10-22 | 深圳迈瑞生物医疗电子股份有限公司 | Sample detection apparatus and sample detection method |
| CN104297498A (en) * | 2013-07-16 | 2015-01-21 | 合肥运涛光电科技有限公司 | Fully automatic biochemical and luminescent immunoassay system |
| CN106018784A (en) * | 2016-07-05 | 2016-10-12 | 深圳普门科技有限公司 | Small electrochemical luminescence immunoassay analyzer and analysis method thereof |
| CN106959334A (en) * | 2017-05-08 | 2017-07-18 | 湖州市环境保护监测中心站 | A kind of ion measurement device of multitask |
| CN110076154A (en) * | 2018-01-25 | 2019-08-02 | 深圳市新产业生物医学工程股份有限公司 | The reaction cup cleaning method of rotating disc type reaction cup cleaning device |
-
2010
- 2010-04-06 CN CN2010201535472U patent/CN201765226U/en not_active Expired - Fee Related
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102608129A (en) * | 2012-03-16 | 2012-07-25 | 北京勤邦生物技术有限公司 | Shimmer detecting system |
| CN102608129B (en) * | 2012-03-16 | 2014-07-09 | 北京勤邦生物技术有限公司 | Shimmer detecting system |
| CN104111328A (en) * | 2013-04-16 | 2014-10-22 | 深圳迈瑞生物医疗电子股份有限公司 | Sample detection apparatus and sample detection method |
| CN104297498A (en) * | 2013-07-16 | 2015-01-21 | 合肥运涛光电科技有限公司 | Fully automatic biochemical and luminescent immunoassay system |
| CN104297498B (en) * | 2013-07-16 | 2016-05-25 | 合肥运涛光电科技有限公司 | A kind of full-automatic biochemical and luminescence immunoassay system |
| CN103941032A (en) * | 2014-05-06 | 2014-07-23 | 北京中勤世帝生物技术有限公司 | Automatic detector for biological samples |
| CN103941032B (en) * | 2014-05-06 | 2016-09-07 | 北京中勤世帝生物技术有限公司 | A kind of biological sample automatic detecting instrument |
| CN106018784A (en) * | 2016-07-05 | 2016-10-12 | 深圳普门科技有限公司 | Small electrochemical luminescence immunoassay analyzer and analysis method thereof |
| CN106018784B (en) * | 2016-07-05 | 2019-02-22 | 深圳普门科技股份有限公司 | Small electrical chemical illumination immunity analysis instrument and its analysis method |
| CN106959334A (en) * | 2017-05-08 | 2017-07-18 | 湖州市环境保护监测中心站 | A kind of ion measurement device of multitask |
| CN110076154A (en) * | 2018-01-25 | 2019-08-02 | 深圳市新产业生物医学工程股份有限公司 | The reaction cup cleaning method of rotating disc type reaction cup cleaning device |
| CN110076154B (en) * | 2018-01-25 | 2021-01-19 | 深圳市新产业生物医学工程股份有限公司 | Reaction cup cleaning method of rotating disc type reaction cup cleaning device |
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Legal Events
| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110316 Termination date: 20140406 |