CN202582972U - High-efficiency oxygen removal device for dissolution rate tester - Google Patents
High-efficiency oxygen removal device for dissolution rate tester Download PDFInfo
- Publication number
- CN202582972U CN202582972U CN 201220211145 CN201220211145U CN202582972U CN 202582972 U CN202582972 U CN 202582972U CN 201220211145 CN201220211145 CN 201220211145 CN 201220211145 U CN201220211145 U CN 201220211145U CN 202582972 U CN202582972 U CN 202582972U
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- China
- Prior art keywords
- stirrer
- valve
- stripping rotor
- bull stick
- stirring
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Abstract
The utility model discloses a high-efficiency oxygen removal device for a dissolution rate tester. The device comprises a dissolution cup. A stirrer is arranged in the dissolution cup, and is connected with a three-way valve which is communicated with a helium supply device and a sample cup respectively. A motor is arranged outside the dissolution cup, and is connected with the stirrer. By the stirrer with a cavity, an oxygen removal function, the function of a sampling tube and a function of driving the stirring of a stirring head are realized at the same time, so that the device is ingenious in design, and working efficiency is improved.
Description
Technical field
The utility model belongs to the checkout equipment of pharmaceutical industry, and the high-level efficiency that particularly relates to digestion instrument is removed oxygen unit.
Background technology
Dissolution rate (Dissolution rate) also claim dissolution rate, is meant under specified solvent and condition the speed and the degree of medicine stripping from solid pharmaceutical preparations such as tablet, capsule, granule.The process of measuring the solid pharmaceutical preparation dissolution rate is called dissolution rate test (Dissolution test), and it is a kind of disintegration of oral solid formulation in intestines and stomach and in vitro test method of stripping simulated.The drug dissolution inspection is a kind of effective means of estimating preparation quality and technological level; The difference that can reflect crystal formation, granularity, prescription composition, auxiliary material kind and character, the production technology etc. of main ingredient to a certain extent; It also is a kind of effective standard of estimating preparation active component bioavilability and preparation uniformity coefficient; Can effectively distinguish the difference of same kind of drug bioavailability, therefore be one of drug quality control essential items for inspection.
It is generally acknowledged; Slightly solubility (referring generally to slightly soluble or insoluble in water) medicine; Because of the medicine (comprising soluble drug) that preparation prescription and production technology cause unsettled medicine of clinical efficacy and therapeutic dose and dosis toxica to be close, must set the dissolution test item in its oral solid formulation quality standard.In addition, in the prescription screening of solid pharmaceutical preparation and the technological process of production formulation process, also need the dissolution rate of exploitation formulation is done comprehensive investigation.Feasible dissolution rate test method(s) should be all must reach test findings at different time, place to the dissolution determination of same preparation or the mensuration between the different operation person to have good reappearance.
During the digestion instrument test, in whipping process, oxygen can produce bubble, influences the dissolution rate of solid pharmaceutical preparation, therefore, must get rid of the oxygen in the medium.The common structure of existing degas method is complicated, and cost is higher; And do not reach desirable deaerating effect usually.
Therefore, the digestion instrument that is used for the dissolution rate test is had very high requirement, all good design should be arranged each small details.
The utility model content
The utility model technical matters to be solved provides the high-level efficiency of digestion instrument and removes oxygen unit, and this oxygen unit that removes combines stirrer, stopple coupon together, and can reach the effect except that oxygen simultaneously, can be applied to existing digestion instrument support equipment; Therefore not only simple in structure, and easy to use.
The utility model solves the problems of the technologies described above the technical scheme that is adopted: the high-level efficiency of digestion instrument is removed oxygen unit; Comprise stripping rotor; The inside of said stripping rotor is provided with stirrer, and said stirrer is connected with T-valve, and T-valve is communicated with helium feeding mechanism and sample cup respectively; The stripping rotor outer setting has motor, and motor is connected with stirrer.
Said stirrer comprises along the bull stick of stripping rotor shaft core position setting, the stirring-head that is connected with bull stick; The bull stick of said stirrer is a hollow-core construction.
Said motor is connected with stirring-head.
First interface of the T-valve that the inner chamber of said hollow-core construction is outer with being arranged on stripping rotor is communicated with; Second interface of said T-valve connects the helium feeding mechanism, and the 3rd interface of said T-valve is connected to sample cup.
In the technique scheme, the dissolution medium (being generally deionized water) of in stripping rotor, packing into.When needs remove oxygen; Stripping rotor is heated under 37 ℃, rotating speed of agitator 100rpm condition; The swivel tee valve; Second interface that connects the helium feeding mechanism in the T-valve is connected with the bull stick in the stripping rotor, and the cavity through bull stick promptly can reach desirable except that the oxygen effect after stripping rotor feeds certain hour.This structure can be used considerably less helium, reaches the desirable oxygen effect of removing, and therefore, cost is also lower.When needs were taken a sample from stripping rotor, the swivel tee valve was connected the 3rd interface and the bull stick in the stripping rotor that connect sample cup in the T-valve, from stripping rotor, draws sample in sample cup through the cavity of bull stick.Therefore, this stirrer with cavity has been realized removing oxygen, stopple coupon and driving three kinds of functions that stirring-head stirs simultaneously, designs very ingenious.
The rim of a cup of said stripping rotor is provided with bowl cover, and the through hole that said bull stick passes the bowl cover center is connected with T-valve.
Said sample cup connects the dissolution rate pick-up unit.
The bull stick of said stirrer and stirring-head are through being threaded.
This dismountable thread connecting mode of the bull stick of stirrer and stirring-head is convenient to replacing and installation to stirring-head.
In sum, the utility model compared with prior art has following advantage:
(1), the utility model is provided with simple in structurely, manufacturing cost is lower, is applicable to the test of scientific research departments such as each big-and-middle universities and colleges, medical treatment, health and epidemic prevention, environmental monitoring, pharmaceutical industry to dissolution rate.
(2), the stirrer that the utlity model has cavity realized removing oxygen, stopple coupon and driving three kinds of functions that stirring-head stirs simultaneously, designs very ingeniously, improved work efficiency.
Description of drawings
Fig. 1 is the structural representation of the utility model embodiment 1.
The corresponding name of each parts is called among the figure: 1-stripping rotor, 2-stirrer, 3-bull stick, 4-stirring-head; The 5-T-valve, 6-helium feeding mechanism, 7-sample cup, 8-bowl cover, 9-motor.
Embodiment
Below in conjunction with embodiment and accompanying drawing, the utility model is done further to specify, but the embodiment of the utility model is not limited thereto.
Embodiment 1:
As shown in Figure 1; The high-level efficiency of digestion instrument is removed oxygen unit, comprises stripping rotor 1, and the inside of said stripping rotor 1 is provided with stirrer 2; Said stirrer is connected with T-valve 5; T-valve 5 is communicated with helium feeding mechanism 6 and sample cup 7 respectively, and stripping rotor 1 outer setting has motor 9, and motor 9 is connected with stirrer 2.
Said stirrer 2 comprises along the bull stick 3 of stripping rotor 1 shaft core position setting, the stirring-head 4 that is connected with bull stick 3; The bull stick 3 of said stirrer 2 is a hollow-core construction.
Said motor 9 is connected with stirring-head 4.Rotation through motor 9 drives the rotation of stirring-head 4, makes that the dissolved efficiency in the stripping rotor 1 is higher.
The inner chamber of said hollow-core construction is communicated with first interface that is arranged on stripping rotor 1 T-valve 5 outward; Second interface of said T-valve 5 connects helium feeding mechanism 6, and the 3rd interface of said T-valve 5 is connected to sample cup 7.At 1 li dissolution medium of packing into of stripping rotor (being generally deionized water).When needs remove oxygen; Stripping rotor 1 is heated under 37 ℃, rotating speed of agitator 100rpm condition; Swivel tee valve 5; Second interface that connects helium feeding mechanisms 6 in the T-valve 5 is connected with the bull sticks 3 in the stripping rotor 1, and the cavity through bull stick 3 promptly can reach desirable except that the oxygen effect after stripping rotor 1 feeds certain hour.This structure can be used considerably less helium, reaches the desirable oxygen effect of removing, and therefore, cost is also lower.When needs were taken a sample from stripping rotor 1, swivel tee valve 5 was connected the 3rd interface and the bull stick in the stripping rotor 13 that connect sample cup 7 in the T-valve 5, from stripping rotor 1, draws sample in sample cup through the cavity of bull stick 3.Therefore, this stirrer with cavity has been realized removing oxygen, stopple coupon and driving three kinds of functions that stirring-head stirs simultaneously, designs very ingenious.
The rim of a cup of said stripping rotor 1 is provided with bowl cover 8, and the through hole that said bull stick 3 passes bowl cover 8 centers is connected with T-valve.
Said sample cup 7 connects the dissolution rate pick-up unit.
The bull stick 3 of said stirrer 2 and stirring-head 4 are through being threaded.This dismountable thread connecting mode of the bull stick of stirrer and stirring-head is convenient to replacing and installation to stirring-head.
As stated, just can realize the utility model preferably.
Claims (7)
1. the high-level efficiency of digestion instrument is removed oxygen unit; It is characterized in that: comprise stripping rotor (1); The inside of said stripping rotor (1) is provided with stirrer (2), and said stirrer is connected with T-valve (5), and T-valve (5) is communicated with helium feeding mechanism (6) and sample cup (7) respectively; Stripping rotor (1) outer setting has motor (9), and motor (9) is connected with stirrer (2).
2. the high-level efficiency of digestion instrument according to claim 1 is removed oxygen unit, it is characterized in that: said stirrer (2) comprises along the bull stick (3) of stripping rotor (1) shaft core position setting, the stirring-head (4) that is connected with bull stick (3); The bull stick (3) of said stirrer (2) is a hollow-core construction.
3. the high-level efficiency of digestion instrument according to claim 2 is removed oxygen unit, and it is characterized in that: said motor (9) is connected with stirring-head (4).
4. the high-level efficiency of digestion instrument according to claim 2 is removed oxygen unit, it is characterized in that: first interface of the T-valve (5) that the inner chamber of said hollow-core construction is outer with being arranged on stripping rotor (1) is communicated with; Second interface of said T-valve (5) connects helium feeding mechanism (6), and the 3rd interface of said T-valve (5) is connected to sample cup (7).
5. the high-level efficiency of digestion instrument according to claim 4 is removed oxygen unit, and it is characterized in that: the rim of a cup of said stripping rotor (1) is provided with bowl cover (8), and the through hole that said bull stick (3) passes bowl cover (8) center is connected with T-valve.
6. the high-level efficiency of digestion instrument according to claim 4 is removed oxygen unit, it is characterized in that: said sample cup (7) connects the dissolution rate pick-up unit.
7. the high-level efficiency of digestion instrument according to claim 1 is removed oxygen unit, and it is characterized in that: the bull stick (3) of said stirrer (2) and stirring-head (4) are through being threaded.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220211145 CN202582972U (en) | 2012-05-11 | 2012-05-11 | High-efficiency oxygen removal device for dissolution rate tester |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220211145 CN202582972U (en) | 2012-05-11 | 2012-05-11 | High-efficiency oxygen removal device for dissolution rate tester |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202582972U true CN202582972U (en) | 2012-12-05 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220211145 Expired - Fee Related CN202582972U (en) | 2012-05-11 | 2012-05-11 | High-efficiency oxygen removal device for dissolution rate tester |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202582972U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108088874A (en) * | 2017-12-12 | 2018-05-29 | 西南石油大学 | A kind of leaching method of black shale soluble salt |
-
2012
- 2012-05-11 CN CN 201220211145 patent/CN202582972U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108088874A (en) * | 2017-12-12 | 2018-05-29 | 西南石油大学 | A kind of leaching method of black shale soluble salt |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20121205 Termination date: 20130511 |