CN207147830U - Digestion instrument sampler with liquid replenishing function - Google Patents
Digestion instrument sampler with liquid replenishing function Download PDFInfo
- Publication number
- CN207147830U CN207147830U CN201720838921.4U CN201720838921U CN207147830U CN 207147830 U CN207147830 U CN 207147830U CN 201720838921 U CN201720838921 U CN 201720838921U CN 207147830 U CN207147830 U CN 207147830U
- Authority
- CN
- China
- Prior art keywords
- fluid infusion
- cup
- triple valve
- stripping rotor
- digestion instrument
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Sampling And Sample Adjustment (AREA)
Abstract
The utility model provides a kind of digestion instrument sampler with liquid replenishing function, including stripping rotor, specimen cup and fluid infusion cup, stripping rotor is externally provided with triple valve, the first interface of stripping rotor and triple valve is connected by main pipe, the second interface of triple valve is connected with specimen cup by sampling catheter, 3rd interface of triple valve is connected with fluid infusion cup by fluid infusion conduit, and sampling catheter is provided with sampling pump, and fluid infusion conduit is provided with fluid infusion pump.The utility model realizes the multi-functional of stirring, sampling and fluid infusion, have the advantages that simple in construction, easy to use, measurement result is more accurate, the utility model is applied to the tests of the scientific research department to dissolution rate such as each universities, medical treatment, health and epidemic prevention, environmental monitoring, pharmaceutical industry.
Description
Technical field
It the utility model is related to a kind of digestion instrument, more particularly to a kind of digestion instrument sampler with liquid replenishing function.
Background technology
Drug dissolution refers to medicine in regulation medium, under certain condition, from the solid pharmaceutical preparation such as tablet or capsule
The speed of dissolution and the degree of dissolution.Drug dissolution directly affects the absorption and utilization of medicine in vivo, is evaluation medicinal substances
In index in one of amount.In medicine production testing, clinical efficacy investigation, stability of drug products inspection, new drug development, prescription sieve
Many aspects such as choosing, process modification will investigate this index.Drug dissolution inspection is evaluation preparation quality and technological level
A kind of effective means, and evaluation agent activity ingredients Biogenic availability and the preparation uniformity a kind of effective standard, can have
Effect distinguishes the difference of same drug bioavailability, therefore is one of Drug's control essential items for inspection.
It is generally believed that insoluble drug, caused by preparation prescription and production technology the unstable medicine of clinical efficacy and
The medicine that therapeutic dose and dosis toxica are close, dissolution test item must be set in its oral solid formulation quality standard.In addition,
During the prescription screening and the technological process of production of solid pharmaceutical preparation are worked out, also need to do the dissolution rate of developed formulation and examine comprehensively
Examine.The process of measure solid pharmaceutical preparation dissolution rate is referred to as Dissolution Rate Testing, and it is that one kind simulates oral solid formulation in the gastrointestinal tract
Disintegration and dissolution in vitro test method.One feasible Dissolution Rate Testing method should be to same system in different time, place
Measure between the dissolution determination of agent or different operators, which must all reach result of the test, has good reappearance.
Therefore, there is very high requirement to the digestion instrument for dissolution rate test, should to each small details
This has good design, when digestion instrument tests stripping curve, because sample volume is big, in order to ensure the essence of test result
Really, fluid infusion is generally required, but operator is to be manually pushed back into stripping rotor with syringe mostly in practice, fluid infusion is relatively difficult, behaviour
It is inconvenient to make.
The content of the invention
In order to solve the above technical problems, the utility model provides a kind of digestion instrument sampler with liquid replenishing function.
The technical solution of the utility model is：Digestion instrument sampler with liquid replenishing function, including stripping rotor, specimen cup
With fluid infusion cup, the stripping rotor is externally provided with triple valve, and the first interface of the stripping rotor and the triple valve is connected by main pipe
Connect, the second interface of the triple valve is connected with the specimen cup by sampling catheter, the 3rd interface of the triple valve and institute
State fluid infusion cup to connect by fluid infusion conduit, the sampling catheter is provided with sampling pump, and the fluid infusion conduit is provided with fluid infusion pump.
Above technical scheme, it is preferred that agitator is provided with inside the stripping rotor, the agitator includes and the dissolution
The puddler of the concentric setting of cup and the stirring-head being connected with the puddler bottom.
Above technical scheme, it is preferred that the puddler and the stirring-head clamping.
Above technical scheme, it is preferred that the stripping rotor rim of a cup is provided with cup lid, and the cup lid center position is provided with center
Hole, the puddler upper end are connected through the output end of the centre bore and motor, and the off-center opening position of cup lid is provided with
Eccentric orfice, the main pipe are stretched in the stripping rotor through the eccentric orfice.
Above technical scheme, it is preferred that the specimen cup connects dissolution rate detection means.
The utility model has the advantages and positive effects of：The utility model provides a kind of dissolution with liquid replenishing function
Instrument sampler, fluid infusion conduit, fluid infusion cup are connected with the main pipe of liquid taking device by triple valve, and set on fluid infusion conduit
There is a fluid infusion pump, open the interface of triple valve the 3rd, open fluid infusion pump and replenish regulations into stripping rotor the dissolution medium of volume, complete benefit
Liquid, the utility model realize the multi-functional of stirring, sampling and fluid infusion, have simple in construction, easy to use, measurement result more
The advantages that accurate, the utility model are applied to the scientific researches such as each universities, medical treatment, health and epidemic prevention, environmental monitoring, pharmaceutical industry
Test of the department to dissolution rate.
Brief description of the drawings
Fig. 1 represents the structural representation of the utility model embodiment.
In figure：
1st, stripping rotor 2, agitator 21, puddler
22nd, stirring-head 3, centre bore 4, eccentric orfice
5th, motor 6, triple valve 7, sampling pump
8th, fluid infusion pump 9, specimen cup 10, fluid infusion cup
11st, main pipe 12, fluid infusion conduit 13, sampling catheter
14th, cup lid
Embodiment
In order that technical problem to be solved in the utility model, technical scheme and beneficial effect are more clearly understood, under
A kind of embodiment of the present utility model is made with reference to accompanying drawing and being illustrated in face.
Digestion instrument sampler with liquid replenishing function as shown in Figure 1, including stripping rotor 1, specimen cup 9 and fluid infusion cup
10, stripping rotor is externally provided with triple valve 6, and the first interface of stripping rotor and triple valve is connected by main pipe 11, and the second of triple valve
Interface is connected with specimen cup by sampling catheter 13, and the 3rd interface of triple valve is connected with fluid infusion cup by fluid infusion conduit 12, is taken
Sample conduit is provided with sampling pump 7, and fluid infusion conduit is provided with fluid infusion pump 8.
The inside of stripping rotor 1 is provided with agitator 2, agitator including the puddler 21 with the concentric setting of stripping rotor and with stirring
The type of attachment of the stirring-head 22 of bar bottom connection, puddler and stirring-head is clamping or threaded connection etc..
The rim of a cup of stripping rotor 1 is provided with cup lid 14, and the center position of cup lid 14 is provided with centre bore 3, and puddler upper end passes through center
Hole is connected with the output end of motor 5, and the off-center opening position of cup lid is provided with eccentric orfice 4, and main pipe 11 stretches to through eccentric orfice
In stripping rotor.Specimen cup 9 connects dissolution rate detection means.Sampling pump and fluid infusion pump are the pumps with distribution, change traffic engineering capability
Body, such as peristaltic pump.
The course of work of the present embodiment：Agitator carries out sampling operation under motor driven after the operating provisions time, when taking
When sample volume is big, in order to ensure the accurate of test result, fluid infusion is generally required, after completing primary sample, closes triple valve second
Interface, the interface of triple valve the 3rd is opened, open fluid infusion pump and replenish regulations into stripping rotor the dissolution medium of volume, after completion fluid infusion
The interface of triple valve the 3rd is closed, waits next sub-sampling.The present apparatus needs digestion instrument control system such as microcomputer, carrys out controlled motor
Operation, the keying of sampling pump, fluid infusion pump, the setting of pump discharge is the setting of sample volume and fluid replacement volume, triple valve valve road
Opening and closing etc..
The digestion instrument sampler with liquid replenishing function described in above example, by triple valve by fluid infusion conduit,
Fluid infusion cup is connected with the main pipe of liquid taking device, and fluid infusion pump is provided with fluid infusion conduit, opens the interface of triple valve the 3rd, is opened
Fluid infusion pump supplements dissolution medium into stripping rotor, completes fluid infusion, and the utility model realizes the multiple work(of stirring, sampling and fluid infusion
Can, have the advantages that simple in construction, easy to use, measurement result is more accurate, the utility model is applied to each universities, doctor
Test of the scientific research departments such as treatment, health and epidemic prevention, environmental monitoring, pharmaceutical industry to dissolution rate.
One embodiment of the present utility model is described in detail above, but the content is only of the present utility model
Preferred embodiment, it is impossible to be considered as being used to limit practical range of the present utility model.It is all to be made according to present utility model application scope
Equivalent change with improve etc., all should still belong within patent covering scope of the present utility model.
Claims (6)
1. the digestion instrument sampler with liquid replenishing function, including stripping rotor, specimen cup and fluid infusion cup, the stripping rotor are externally provided with
Triple valve, the stripping rotor are connected with the first interface of the triple valve by main pipe, the second interface of the triple valve with
The specimen cup is connected by sampling catheter, and the 3rd interface of the triple valve is connected with the fluid infusion cup by fluid infusion conduit,
The sampling catheter is provided with sampling pump, and the fluid infusion conduit is provided with fluid infusion pump.
2. the digestion instrument sampler according to claim 1 with liquid replenishing function, it is characterised in that：In the stripping rotor
Portion is provided with agitator, and the agitator includes and the puddler of the concentric setting of the stripping rotor and can with the puddler bottom
The stirring-head of dismantling connection.
3. the digestion instrument sampler according to claim 2 with liquid replenishing function, it is characterised in that：The puddler with
The stirring-head clamping.
4. the digestion instrument sampler with liquid replenishing function according to Claims 2 or 3, it is characterised in that：The dissolution
Cup rim of a cup is provided with cup lid, and the cup lid center position is provided with centre bore, and the puddler upper end passes through the centre bore and electricity
The output end connection of machine, the off-center opening position of cup lid are provided with eccentric orfice, and the main pipe stretches into through the eccentric orfice
In to the stripping rotor.
5. the digestion instrument sampler with liquid replenishing function according to any one of claims 1 to 3, it is characterised in that：
The specimen cup connects dissolution rate detection means.
6. the digestion instrument sampler according to claim 4 with liquid replenishing function, it is characterised in that：The specimen cup connects
Connect dissolution rate detection means.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720838921.4U CN207147830U (en) | 2017-07-12 | 2017-07-12 | Digestion instrument sampler with liquid replenishing function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720838921.4U CN207147830U (en) | 2017-07-12 | 2017-07-12 | Digestion instrument sampler with liquid replenishing function |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207147830U true CN207147830U (en) | 2018-03-27 |
Family
ID=61675176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720838921.4U Expired - Fee Related CN207147830U (en) | 2017-07-12 | 2017-07-12 | Digestion instrument sampler with liquid replenishing function |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207147830U (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108956913A (en) * | 2018-07-19 | 2018-12-07 | 天津赛普瑞实验设备有限公司 | A kind of real-time fluid infusion digestion instrument of controllable temperature |
| CN110459384A (en) * | 2019-09-11 | 2019-11-15 | 国网福建省电力有限公司检修分公司 | Capacitance type potential transformer electromagnetic unit takes oil and recharging oil device and working method |
| CN111983086A (en) * | 2020-08-24 | 2020-11-24 | 浙江圣兆药物科技股份有限公司 | Dissolution instrument for sustained-release medicine of suspension and application |
| CN112284822A (en) * | 2020-09-30 | 2021-01-29 | 深圳市锐拓仪器设备有限公司 | Automatic sampling device of dissolution instrument by flow cell method |
-
2017
- 2017-07-12 CN CN201720838921.4U patent/CN207147830U/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108956913A (en) * | 2018-07-19 | 2018-12-07 | 天津赛普瑞实验设备有限公司 | A kind of real-time fluid infusion digestion instrument of controllable temperature |
| CN110459384A (en) * | 2019-09-11 | 2019-11-15 | 国网福建省电力有限公司检修分公司 | Capacitance type potential transformer electromagnetic unit takes oil and recharging oil device and working method |
| CN111983086A (en) * | 2020-08-24 | 2020-11-24 | 浙江圣兆药物科技股份有限公司 | Dissolution instrument for sustained-release medicine of suspension and application |
| CN112284822A (en) * | 2020-09-30 | 2021-01-29 | 深圳市锐拓仪器设备有限公司 | Automatic sampling device of dissolution instrument by flow cell method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN207147830U (en) | Digestion instrument sampler with liquid replenishing function | |
| TWI471563B (en) | Delivery device for dispensing pharmaceutical dosage forms into dissolution testing apparatus | |
| JP5586098B2 (en) | Improved dissolution test equipment | |
| Searl et al. | The biopharmaceutical properties of solid dosage forms: I. An evaluation of 23 brands of phenylbutazone tablets | |
| CN207430070U (en) | A kind of gas dilution device | |
| CN205958587U (en) | Checkout stand device | |
| CN207147802U (en) | A kind of drug inspection sampler | |
| CN217953996U (en) | Anti-pollution sampling equipment of pharmaceutical analysis sample | |
| CN215296367U (en) | Pharmacy ration counter | |
| CN109847857A (en) | A kind of pharmacy drug grinding device | |
| CN103048166A (en) | Dissolution tester sampling device with automatically stirring function | |
| CN213467591U (en) | Hospital pharmacy pharmacology analysis experimental apparatus | |
| CN209423512U (en) | A kind of clinical examination solid reagent instant device | |
| CN202582943U (en) | Dissolution test sampling device adopting automatic control process | |
| CN208968871U (en) | A kind of vaporization prevention deoxygenation digestion instrument | |
| CN208297481U (en) | With the online dissolved oxygen measuring device of zero offset capability in a kind of digestion instrument | |
| CN202582944U (en) | Dissolver sampling device with automatic stirring function | |
| CN207996587U (en) | A kind of pharmaceutical purpose dispensing mixing arrangement | |
| CN110082464A (en) | A kind of inspection pretreatment unit and preprocess method | |
| CN205774546U (en) | The accurate drug-supplying system of unicellular nanometer | |
| CN207187578U (en) | A kind of component accurate formulation device of external diagnosis reagent case | |
| CN213284381U (en) | Device for checking dosage of mixture medicine | |
| CN202255965U (en) | Sampling device for dissolution test | |
| CN208350429U (en) | A kind of digestion instrument sampler | |
| CN112337340A (en) | Special medicament configuration equipment of medical care branch of academic or vocational study |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180327 Termination date: 20200712 |