CN109847857A - A kind of pharmacy drug grinding device - Google Patents
A kind of pharmacy drug grinding device Download PDFInfo
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- CN109847857A CN109847857A CN201811263647.8A CN201811263647A CN109847857A CN 109847857 A CN109847857 A CN 109847857A CN 201811263647 A CN201811263647 A CN 201811263647A CN 109847857 A CN109847857 A CN 109847857A
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Abstract
The invention belongs to medicament disintegrating technical fields, a kind of pharmacy drug grinding device is disclosed, the pharmacy drug grinding device includes: be used as medicine mouth, cylinder, motor, broken impeller, filter plate, receipts medicine-chest, central control module, coding module, quality detection module, connecting tube.The present invention by coding module can be recorded according to the medicine information of successful match in pharmacology level code and common name level code autocoding is carried out to the nomenclature of drug sequence code of newly-increased drug, the code efficiency of drug can be effectively improved；Simultaneously, disintegration time limited and dissolution rate is combined to detect the quality of drug by quality detection module, under the premise of the detection method of drug quality of the present invention reaches same level of to the accuracy in detection of drug and existing quality determining method, the detection method of drug quality of the present invention can reduce the quality testing cost of drug.
Description
Technical field
The invention belongs to medicament disintegrating technical field more particularly to a kind of pharmacy drug grinding devices.
Background technique
Drug refers to the disease for preventing, treating, diagnosing people, and purposefully the physiological function of adjusting people and regulation have suitable
Answer the substance of disease or major function, usage and dosage, including Chinese medicine, the prepared slices of Chinese crude drugs, Chinese patent drug, medicinal chemicals and its system
Agent, antibiotic, biochemical drug, radioactive drugs, serum, vaccine, blood product and diagnostic aid etc..Kind quasi-complexity: specific
Kind, the whole world about more than 20000, about more than 4000 kinds of Western medicine preparation, thus may be used by about more than 5000 kinds of China's Chinese materia medica preparation
See, the type of drug is complicated, various in style；The medical specificity of drug: drug is not a kind of independent commodity, it is tight with medicine
Close combination, complements each other.Patient only passes through the inspection diagnosis of doctor, and rationally uses under the guidance of doctor and licensed pharmacist
Medicine can be only achieved the purpose for preventing disease, protection health；The stringency of drug quality: drug is directly related to the body of people
Health even life living or death, therefore, quality must not have the least bit careless.We have to make sure that drug safely, effectively, it is uniform,
Stablize.It needs to take considerable time, occupy however, existing pharmacy carries out h coding with drug of the drug grinding device to crushing
A large amount of labo r resources, the efficiency for thus causing medicine coding to work are very low；Meanwhile, testing number at high cost to the quality inspection of drug
According to inaccuracy.
In conclusion problem of the existing technology is: existing pharmacy is carried out with drug of the drug grinding device to crushing
H coding's needs take considerable time, occupy a large amount of labo r resources, and the efficiency for thus causing medicine coding to work is very low；Together
When, at high cost to the quality inspection of drug, prohibited data detection is true.
Summary of the invention
In view of the problems of the existing technology, the present invention provides a kind of pharmacy drug grinding devices.
The invention is realized in this way a kind of pharmacy drug grinding device includes:
Mouth, cylinder, motor, broken impeller, filter plate, receipts medicine-chest, central control module, coding module, the quality of being used as medicine are examined
Survey module, connecting tube；
Upper end is socketed with the mouth that is used as medicine on the left of cylinder；Cylinder top surface has been screwed motor；Inner barrel is crushed impeller
It is engaged on motor；Broken wheel bottom is socketed with filter plate；Cylinder body bottom is connected by connecting tube and receives medicine-chest；
Central control module is connect, for passing through single-chip microcontroller control with motor, receipts medicine-chest, coding module, quality detection module
Modules processed and equipment work normally；
Coding module is connect with central control module, for carrying out information coding to smashed drug；
Quality detection module is connect with central control module, for detecting to drug quality.
Further, the coding module coding method is as follows:
(1) the pharmaceutical products name of newly-increased drug is obtained；
(2) medicine information record is obtained, the medicine information record includes Drug generic name；
(3) it searches the Drug generic name and the matched medicine information of the pharmaceutical products name records；
(4) when the medicine information for finding the Drug generic name and the pharmaceutical products name successful match records
When, the medicine coding in the medicine information record is obtained, includes pharmacology level code, common name level in the medicine coding
Code and nomenclature of drug sequence code；
(5) lookup and the first nomenclature of drug sequence code corresponding to the pharmacology level code, the common name level code,
The second nomenclature of drug sequence code is generated according to the first nomenclature of drug sequence code, according to the pharmacology level code, described logical
The medicine coding of the newly-increased drug is generated with name level code and the second nomenclature of drug sequence code.
Further, described to search the Drug generic name and the matched medicine information record of the pharmaceutical products name
Step includes:
Search whether that there are the Drug generic name medicine information records identical with the pharmaceutical products name；
It, will be described when medicine information record identical with the pharmaceutical products name there is no the Drug generic name
The ultimate character of pharmaceutical products name is cut off, and searches whether that there are the pharmaceutical products famous prime ministers after the Drug generic name and excision
Same medicine information record；
When medicine information record identical with the current production name there is no the Drug generic name, then by institute
Two, the end character for stating pharmaceutical products name is cut off, and searches whether that there are the pharmaceutical products after the Drug generic name and excision
The identical medicine information record afterwards, and so on, it is described after finding the Drug generic name and excision character
Successful match when the identical medicine information of current production name records.
Further, described to search the Drug generic name and the matched medicine information record of the pharmaceutical products name
Step includes:
Calculate the character match rate of the pharmaceutical products name Yu the Drug generic name；
The first preset matching rate threshold value and the second preset matching rate threshold value are obtained, the first preset matching rate threshold value is greater than
The second preset matching rate threshold value；
Medicine information record when being not less than the first preset matching rate threshold value there are the character match rate
When successful match；
Medicine information note when being not less than the first preset matching rate threshold value there is no the character match rate
When record, screening go out the character match rate more than the medicine information of the second preset matching rate threshold value record to obtain to
With set of records ends；
The character in the pharmaceutical products name is searched in the set of records ends to be matched, and to completely include the drug general
The medicine information record of character in name；
When the drug for completely including the character in the Drug generic name there are the character in the pharmaceutical products name
Successful match when information records.
Further, the quality detection module detection method is as follows:
1) disintegration time limited of the tested medicine in the disintegration liquid of three kinds of different acidities is measured respectively, by each of tested medicine
Disintegration time limited corresponding with Consult drug disintegration time limited is compared, and the disintegration liquid of three kinds of different acidities is respectively that pH value is 1.16
To 1.20 aqueous hydrochloric acid solution, pH value be 3.52 to 3.59 Acetic acid-sodium acetate buffer and pH value be 5.53 to 5.91 water；
2) the drug accumulation dissolution percentage that real-time online measurement tested medicine changes over time, at any time by tested medicine
The drug accumulation dissolution percentage of variation obtains the dissolution song of tested medicine after carrying out data fitting using Weibull distribution model
The form parameter of line；
It 3) is that mass percent is 50% by the form parameter of the dissolution curve of tested medicine, the amount of dissolution of tested medicine
The amount of dissolution of time and tested medicine is that these three parameters of time that mass percent is 63.2% carry out t inspection；
4) in t checkout procedure, the shape of the dissolution curve of the form parameter and Consult drug of the dissolution curve of tested medicine
Shape parameter is compared, and the amount of dissolution of tested medicine is that the amount of dissolution of the time that mass percent is 50% and Consult drug is matter
The time that amount percentage is 50% is compared, and the amount of dissolution of tested medicine is the time and reference that mass percent is 63.2%
The amount of dissolution of drug is to be compared the time that mass percent is 63.2%, wherein real-time online measures tested medicine at any time
Between change drug accumulation dissolution percentage when, the dissolution medium of tested medicine and the dissolution medium of Consult drug are identical, tested
The dissolution medium of drug is the phosphate buffer that pH value is 7.6, and dissolving-out method is slurry processes, and revolving speed is 50 revs/min；
5) t of the comparison result and three parameters of tested medicine that combine the disintegration time limited of tested medicine and Consult drug is examined
As a result the difference between the quality of tested medicine and the quality of Consult drug is obtained.
Advantages of the present invention and good effect are as follows: the present invention by coding module by the pharmaceutical products name of newly-increased drug with
The Drug generic name of the medicine information record of storage is matched, and is recorded when finding the matched medicine information of Drug generic name
When, can be recorded according to the medicine information of successful match in pharmacology level code and common name level code to the medicine of newly-increased drug
The name of an article claims sequence code to carry out autocoding, and according to nomenclature of drug sequence code after autocoding and pharmacology level code, general
Name level code generates the complete medicine coding of newly-increased drug, so that need to only carry out matching to nomenclature of drug can be realized newly-increased drug
Full automatic coding, the workload of coding work greatly reduces, and can effectively improve the code efficiency of drug；Meanwhile passing through matter
Amount detection module combines disintegration time limited and dissolution rate to detect the quality of drug, the detection of drug quality of the present invention
Under the premise of method reaches same level of to the accuracy in detection of drug and existing quality determining method, drug of the present invention
The detection method of quality can reduce the quality testing cost of drug, in addition, the detection method of drug quality of the present invention
It can be improved to drug quality accuracy in detection, furthermore, the detection method of drug quality of the present invention can identify drug
Preparation process difference be so that the detection method of drug quality of the present invention detects the quality of drug more fully hereinafter
The monitoring and improvement of drug quality provide an important basis.
Detailed description of the invention
Fig. 1 is pharmacy drug grinding device structural block diagram provided in an embodiment of the present invention.
In figure: 1, be used as medicine mouth；2, cylinder；3, motor；4, it is crushed impeller；5, filter plate；6, medicine-chest is received；7, center control mould
Block；8, coding module；9, quality detection module；10, connecting tube.
Specific embodiment
In order to further understand the content, features and effects of the present invention, the following examples are hereby given, and cooperate attached drawing
Detailed description are as follows.
Structure of the invention is explained in detail with reference to the accompanying drawing.
As shown in Figure 1, pharmacy drug grinding device provided by the invention includes: the mouth 1, cylinder 2, motor 3, broken of being used as medicine
Impeller 4, receives medicine-chest 6, central control module 7, coding module 8, quality detection module 9, connecting tube 10 at filter plate 5.
2 left side upper end of cylinder is socketed with the mouth 1 that is used as medicine；2 top surface of cylinder has been screwed motor 3；2 internal fracture of cylinder
Impeller 4 is engaged on motor 3；Broken 4 bottom of impeller is socketed with filter plate 5；2 bottom of cylinder medicine-chest is received by the connection of connecting tube 10
6；
Central control module 7 is connect, for passing through list with motor 3, receipts medicine-chest 6, coding module 8, quality detection module 9
Piece machine controls modules and equipment works normally；
Coding module 8 is connect with central control module 7, for carrying out information coding to smashed drug；
Quality detection module 9 is connect with central control module 7, for detecting to drug quality.
8 coding method of coding module provided by the invention is as follows:
(1) the pharmaceutical products name of newly-increased drug is obtained；
(2) medicine information record is obtained, the medicine information record includes Drug generic name；
(3) it searches the Drug generic name and the matched medicine information of the pharmaceutical products name records；
(4) when the medicine information for finding the Drug generic name and the pharmaceutical products name successful match records
When, the medicine coding in the medicine information record is obtained, includes pharmacology level code, common name level in the medicine coding
Code and nomenclature of drug sequence code；
(5) lookup and the first nomenclature of drug sequence code corresponding to the pharmacology level code, the common name level code,
The second nomenclature of drug sequence code is generated according to the first nomenclature of drug sequence code, according to the pharmacology level code, described logical
The medicine coding of the newly-increased drug is generated with name level code and the second nomenclature of drug sequence code.
It is provided by the invention to search the Drug generic name and the matched medicine information record of the pharmaceutical products name
The step of include:
Search whether that there are the Drug generic name medicine information records identical with the pharmaceutical products name；
It, will be described when medicine information record identical with the pharmaceutical products name there is no the Drug generic name
The ultimate character of pharmaceutical products name is cut off, and searches whether that there are the pharmaceutical products famous prime ministers after the Drug generic name and excision
Same medicine information record；
When medicine information record identical with the current production name there is no the Drug generic name, then by institute
Two, the end character for stating pharmaceutical products name is cut off, and searches whether that there are the pharmaceutical products after the Drug generic name and excision
The identical medicine information record afterwards, and so on, it is described after finding the Drug generic name and excision character
Successful match when the identical medicine information of current production name records.
It is provided by the invention to search the Drug generic name and the matched medicine information record of the pharmaceutical products name
The step of include:
Calculate the character match rate of the pharmaceutical products name Yu the Drug generic name；
The first preset matching rate threshold value and the second preset matching rate threshold value are obtained, the first preset matching rate threshold value is greater than
The second preset matching rate threshold value；
Medicine information record when being not less than the first preset matching rate threshold value there are the character match rate
When successful match；
Medicine information note when being not less than the first preset matching rate threshold value there is no the character match rate
When record, screening go out the character match rate more than the medicine information of the second preset matching rate threshold value record to obtain to
With set of records ends；
The character in the pharmaceutical products name is searched in the set of records ends to be matched, and to completely include the drug general
The medicine information record of character in name；
When the drug for completely including the character in the Drug generic name there are the character in the pharmaceutical products name
Successful match when information records.
9 detection method of quality detection module provided by the invention is as follows:
1) disintegration time limited of the tested medicine in the disintegration liquid of three kinds of different acidities is measured respectively, by each of tested medicine
Disintegration time limited corresponding with Consult drug disintegration time limited is compared, and the disintegration liquid of three kinds of different acidities is respectively that pH value is 1.16
To 1.20 aqueous hydrochloric acid solution, pH value be 3.52 to 3.59 Acetic acid-sodium acetate buffer and pH value be 5.53 to 5.91 water；
2) the drug accumulation dissolution percentage that real-time online measurement tested medicine changes over time, at any time by tested medicine
The drug accumulation dissolution percentage of variation obtains the dissolution song of tested medicine after carrying out data fitting using Weibull distribution model
The form parameter of line；
It 3) is that mass percent is 50% by the form parameter of the dissolution curve of tested medicine, the amount of dissolution of tested medicine
The amount of dissolution of time and tested medicine is that these three parameters of time that mass percent is 63.2% carry out t inspection；
4) in t checkout procedure, the shape of the dissolution curve of the form parameter and Consult drug of the dissolution curve of tested medicine
Shape parameter is compared, and the amount of dissolution of tested medicine is that the amount of dissolution of the time that mass percent is 50% and Consult drug is matter
The time that amount percentage is 50% is compared, and the amount of dissolution of tested medicine is the time and reference that mass percent is 63.2%
The amount of dissolution of drug is to be compared the time that mass percent is 63.2%, wherein real-time online measures tested medicine at any time
Between change drug accumulation dissolution percentage when, the dissolution medium of tested medicine and the dissolution medium of Consult drug are identical, tested
The dissolution medium of drug is the phosphate buffer that pH value is 7.6, and dissolving-out method is slurry processes, and revolving speed is 50 revs/min；
5) t of the comparison result and three parameters of tested medicine that combine the disintegration time limited of tested medicine and Consult drug is examined
As a result the difference between the quality of tested medicine and the quality of Consult drug is obtained.
When the invention works, motor 3 is started using single-chip microcontroller control by central control module 7, drug to be comminuted is passed through
The mouth 1 that is used as medicine pours into cylinder 2；Motor 3 controls broken impeller 4 and carries out crushing operation to drug；Drug powder is flowed by filter plate 5
Receive medicine-chest 6；Then, information coding is carried out to smashed drug by coding module 8；Finally, right by quality detection module 9
Drug quality is detected.
The above is only the preferred embodiments of the present invention, and is not intended to limit the present invention in any form,
Any simple modification made to the above embodiment according to the technical essence of the invention, equivalent variations and modification, belong to
In the range of technical solution of the present invention.
Claims (5)
1. a kind of pharmacy drug grinding device, which is characterized in that the pharmacy drug grinding device includes:
Be used as medicine mouth, cylinder, motor, broken impeller, filter plate, receipts medicine-chest, central control module, coding module, quality testing mould
Block, connecting tube；
Upper end is socketed with the mouth that is used as medicine on the left of cylinder；Cylinder top surface has been screwed motor；Inner barrel is crushed impeller linking
On motor；Broken wheel bottom is socketed with filter plate；Cylinder body bottom is connected by connecting tube and receives medicine-chest；
Central control module is connect with motor, receipts medicine-chest, coding module, quality detection module, each for being controlled by single-chip microcontroller
A module and equipment work normally；
Coding module is connect with central control module, for carrying out information coding to smashed drug；
Quality detection module is connect with central control module, for detecting to drug quality.
2. pharmacy as described in claim 1 drug grinding device, which is characterized in that the coding module coding method is as follows:
(1) the pharmaceutical products name of newly-increased drug is obtained；
(2) medicine information record is obtained, the medicine information record includes Drug generic name；
(3) it searches the Drug generic name and the matched medicine information of the pharmaceutical products name records；
(4) it when the medicine information for finding the Drug generic name and the pharmaceutical products name successful match records, obtains
Take the medicine information record in medicine coding, include in the medicine coding pharmacology level code, common name level code and
Nomenclature of drug sequence code；
(5) lookup and the first nomenclature of drug sequence code corresponding to the pharmacology level code, the common name level code, according to
The first nomenclature of drug sequence code generates the second nomenclature of drug sequence code, according to the pharmacology level code, the common name
Level code and the second nomenclature of drug sequence code generate the medicine coding of the newly-increased drug.
3. pharmacy as claimed in claim 2 drug grinding device, which is characterized in that described to search the Drug generic name and institute
Stating the step of matched medicine information of pharmaceutical products name records includes:
Search whether that there are the Drug generic name medicine information records identical with the pharmaceutical products name；
When medicine information record identical with the pharmaceutical products name there is no the Drug generic name, by the drug
The ultimate character of ProductName is cut off, and it is identical with the pharmaceutical products name after excision to search whether that there are the Drug generic names
The medicine information record；
When medicine information record identical with the current production name there is no the Drug generic name, then by the medicine
Two, the end character of product ProductName is cut off, and searches whether that there are the Drug generic names and phase after the pharmaceutical products after excision
With medicine information record, and so on, until finding the Drug generic name and cutting off described current after character
Successful match when the identical medicine information of ProductName records.
4. pharmacy as claimed in claim 2 drug grinding device, which is characterized in that described to search the Drug generic name and institute
Stating the step of matched medicine information of pharmaceutical products name records includes:
Calculate the character match rate of the pharmaceutical products name Yu the Drug generic name；
The first preset matching rate threshold value and the second preset matching rate threshold value are obtained, the first preset matching rate threshold value is greater than described
Second preset matching rate threshold value；
When there are the character match rate be not less than the first preset matching rate threshold value when the medicine information record when
With success；
When the medicine information when being not less than the first preset matching rate threshold value there is no the character match rate records,
Screening goes out the character match rate and records to obtain note to be matched more than the medicine information of the second preset matching rate threshold value
Record set；
The character searched in the pharmaceutical products name in the set of records ends to be matched completely includes in the Drug generic name
Character the medicine information record；
When the medicine information for completely including the character in the Drug generic name there are the character in the pharmaceutical products name
Successful match when record.
5. pharmacy as described in claim 1 drug grinding device, which is characterized in that the quality detection module detection method is such as
Under:
1) disintegration time limited of the tested medicine in the disintegration liquid of three kinds of different acidities is measured respectively, by each disintegration of tested medicine
Disintegration time limited corresponding with Consult drug in time limit is compared, the disintegration liquid of three kinds of different acidities be respectively pH value be 1.16 to
The water that the Acetic acid-sodium acetate buffer and pH value that 1.20 aqueous hydrochloric acid solution, pH value are 3.52 to 3.59 are 5.53 to 5.91；
2) the drug accumulation dissolution percentage that real-time online measurement tested medicine changes over time, tested medicine is changed over time
Drug accumulation dissolution percentage data fittings is carried out using Weibull distribution model after obtain the dissolution curve of tested medicine
Form parameter；
It 3) is time that mass percent is 50% by the form parameter of the dissolution curve of tested medicine, the amount of dissolution of tested medicine
The amount of dissolution with tested medicine is that these three parameters of time that mass percent is 63.2% carry out t inspection；
4) in t checkout procedure, the shape of the dissolution curve of the form parameter and Consult drug of the dissolution curve of tested medicine is joined
Number is compared, and the amount of dissolution of tested medicine is that the amount of dissolution of the time that mass percent is 50% and Consult drug is quality hundred
Divide than being compared for 50% time, the amount of dissolution of tested medicine is the time and Consult drug that mass percent is 63.2%
The amount of dissolution be to be compared the time that mass percent is 63.2%, wherein real-time online measurement tested medicine become at any time
When the drug accumulation of change dissolves out percentage, the dissolution medium of tested medicine and the dissolution medium of Consult drug are identical, tested medicine
Dissolution medium be phosphate buffer that pH value is 7.6, dissolving-out method is slurry processes, and revolving speed is 50 revs/min；
5) comparison result of the disintegration time limited of tested medicine and Consult drug and the t inspection result of three parameters of tested medicine are combined
Obtain the difference between the quality of tested medicine and the quality of Consult drug.
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| CN201811263647.8A CN109847857A (en) | 2018-10-28 | 2018-10-28 | A kind of pharmacy drug grinding device |
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| CN201811263647.8A CN109847857A (en) | 2018-10-28 | 2018-10-28 | A kind of pharmacy drug grinding device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111203303A (en) * | 2020-01-13 | 2020-05-29 | 杨老又 | Machine for preparing medicine particles |
| WO2022104953A1 (en) * | 2020-11-20 | 2022-05-27 | 山东妙迪食品有限公司 | Jujube powder extraction and processing device |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH0924285A (en) * | 1995-07-07 | 1997-01-28 | Yamawa Eng:Kk | Solid matter crushing and drying device |
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Application publication date: 20190607 |