CN208297481U - With the online dissolved oxygen measuring device of zero offset capability in a kind of digestion instrument - Google Patents
With the online dissolved oxygen measuring device of zero offset capability in a kind of digestion instrument Download PDFInfo
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- CN208297481U CN208297481U CN201820850500.8U CN201820850500U CN208297481U CN 208297481 U CN208297481 U CN 208297481U CN 201820850500 U CN201820850500 U CN 201820850500U CN 208297481 U CN208297481 U CN 208297481U
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- Prior art keywords
- dissolved oxygen
- stripping
- water bath
- control cabinet
- measuring device
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Abstract
The utility model discloses the online dissolved oxygen measuring devices in a kind of digestion instrument with zero offset capability, including water bath, electric box is provided with outside the water bath, circulation pipe is provided between the electric box and the water bath, several stripping rotors are provided in the water bath, the bottom end of the electric box is provided with damping base, equipment rack is fixedly connected with above the stripping rotor, the upper end of the equipment rack is connected with control cabinet, the agitating paddle connecting with the control cabinet is provided in the stripping rotor, machine shaft is connected between the agitating paddle and the control cabinet, control display device is provided in the control cabinet, several locking members are provided with above the control cabinet, the top of the stripping rotor is provided with stripping cup cap, the left and right ends of the stripping cup cap are provided with compression cup button, it is arranged on the stripping cup cap There is a vacuum air pump, the utility model not only the size of real-time detection dissolved oxygen amount but also has the function of real time correction, is worthy to be popularized.
Description
Technical field
It is online with zero offset capability in specially a kind of digestion instrument the utility model relates to digestion instrument technical field
Dissolved oxygen measuring device.
Background technique
Dissolution rate is also referred to as dissolution rate, refer to defined solvent and under the conditions of, drug is from tablet, capsule, granule
The speed and degree dissolved out in equal solid pharmaceutical preparations.The process of measurement solid pharmaceutical preparation dissolution rate is known as Dissolution Rate Testing, it is a kind of
Simulate the in vitro test method of oral solid formulation disintegration in the gastrointestinal tract and dissolution.Drug dissolution inspection is evaluation preparation
A kind of effective means of quality and technological level can reflect the crystal form of main ingredient, granularity, composition, auxiliary to a certain extent
The difference of item kind and property, production technology etc., and evaluation agent activity ingredients Biogenic availability and the preparation uniformity one
Kind effective standard, can effectively distinguish the difference of same drug bioavailability, thus be drug quality control essential items for inspection it
One.It is generally believed that slightly solubility (referring generally to slightly soluble in water or insoluble) drug, because of clinical treatment caused by preparation prescription and production technology
Imitate the drug (including soluble drug) that unstable drug and therapeutic dose are close with dosis toxica, oral solid formulation matter
Dissolution test item must be set in amount standard.In addition, during the prescription screening and the technological process of production of solid pharmaceutical preparation are worked out,
Also the dissolution rate to developed dosage form is needed to do comprehensive investigation.One feasible Dissolution Rate Testing method should be in different time, place
The measurement between dissolution determination or different operators to same preparation must all reach test result with good heavy
Existing property.When digestion instrument is tested, in whipping process, oxygen can generate bubble, influence the dissolution rate of solid pharmaceutical preparation, therefore, it is necessary to
Exclude the oxygen in medium.The existing usual structure of degassing method is more complex, higher cost；And it is typically not capable of and preferably removes
Oxygen effect.But remove oxygen simply and need great amount of cost, it can not have to handle when dissolved oxygen amount is lower, but existing equipment
Do not have a set of to effectively monitor equipment and control device.
Existing digestion instrument still has following defect:
The existing digestion instrument degassing usual structure of method is more complex, higher cost and is typically not capable of ideal deoxygenation effect
Fruit, the monitoring device without dissolved oxygen amount cannot make tune appropriate for the size of dissolved oxygen amount under different pressures different temperatures
Section.
Summary of the invention
In order to overcome the shortcomings of prior art, the utility model, which is provided in a kind of digestion instrument, has zero offset capability
Online dissolved oxygen measuring device, can effectively solve background technique propose the problem of.
The technical scheme adopted by the utility model to solve the technical problem is as follows:
With the online dissolved oxygen measuring device of zero offset capability, including water bath, the water bath in a kind of digestion instrument
It is provided with electric box outside, circulation pipe is provided between the electric box and the water bath, is provided in the water bath several
Stripping rotor, the bottom end of the electric box are provided with damping base, and equipment rack is fixedly connected with above the stripping rotor, described
The upper end of equipment rack is connected with control cabinet, and the agitating paddle connecting with the control cabinet is provided in the stripping rotor, described to stir
It mixes and is connected with machine shaft between paddle and the control cabinet, control display device, the control cabinet are provided in the control cabinet
Top be provided with several locking members, the top of the stripping rotor is provided with stripping cup cap, the left and right ends of the stripping cup cap
It is provided with compression cup button, is provided with vacuum air pump on the stripping cup cap.
Further, the stripping rotor includes the dissolution cup body of U-shaped, is provided with signal acquisition on wall in the stripping rotor body
Device, the bottom end of the agitating paddle are provided with the paddle head of symmetrical flat-shaped truncated cone-shaped.
Further, the control display device includes temperature indicator, pressure display unit, dissolved oxygen amount display and control
Keyboard.
Further, the online dissolved oxygen measuring device control module includes signal picker, and the signal picker is defeated
Signal end is connected on Digital Signal Processing and A/D converter out, and the output end of the Digital Signal Processing and A/D converter connects
It connects in the pin input end of PIC16F877A chip, the pin output end of the PIC16F877A is connected separately with LCD and shows
Device, relay control pump, WMOi3 module and keyboard setter.
Further, the signal picker includes dissolved oxygen sensor, temperature sensor and pressure sensor.
Compared with prior art, the utility model has the beneficial effects that
The utility model using online dissolved oxygen measuring device acquisition and data feedback control etc. module designs respectively by
Controller controls corresponding device element, not only accomplishes in real-time monitoring dissolution fluid the size of dissolved oxygen amount under given conditions, and
And real time calibration can also be carried out according to the standard of setting, it solves the problems, such as to propose in background technique.
Detailed description of the invention
Fig. 1 is the utility model overall structure diagram；
Fig. 2 is the single stripping rotor structural schematic diagram of the utility model；
Fig. 3 is the online dissolved oxygen measuring device module diagram of the utility model.
Figure label:
1- water bath；2- electric box；3- circulation pipe；4- stripping rotor；5- damping base；6- stripping cup cap；7- equipment rack；
8- agitating paddle；9- machine shaft；10- control cabinet；11- locking member；12- controls display device；13- vacuum air pump；14- signal is adopted
Storage；
401- dissolves out cup body；
601- compression cup button；
801- paddle head；
1201- temperature indicator；1202- pressure display unit；1203- dissolved oxygen amount display；1204- control keyboard.
Specific embodiment
The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model
Clearly and completely describe, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole
Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art are without making creative work
Every other embodiment obtained, fall within the protection scope of the utility model.
It is measured as shown in Figure 1, the utility model provides the online dissolved oxygen in a kind of digestion instrument with zero offset capability
Device includes water bath 1, is provided with electric box 2 outside the water bath 1, is provided between the electric box 2 and the water bath 1
Circulation pipe 3 is provided with several stripping rotors 4 in the water bath 1, and the bottom end of the electric box 2 is provided with damping base 5, described
The top of stripping rotor 4 is fixedly connected with equipment rack 7, and the upper end of the equipment rack 7 is connected with control cabinet 10, the stripping rotor
It is provided with the agitating paddle 8 connecting with the control cabinet 10 in 4, is connected with motor between the agitating paddle 8 and the control cabinet 10
Shaft 9 is provided with control display device 12 in the control cabinet 10, and the top of the control cabinet 10 is provided with several locking members
11, the top of the stripping rotor 4 is provided with stripping cup cap 6, and the left and right ends of the stripping cup cap 6 are provided with compression cup button 601,
Vacuum air pump 13 is provided on the stripping cup cap 6.
As shown in Fig. 2, the stripping rotor 4 includes the dissolution cup body 401 of U-shaped, it is provided on 401 inner wall of dissolution cup body
Signal picker 14, the bottom end of the agitating paddle 8 are provided with the paddle head 801 of symmetrical flat-shaped truncated cone-shaped.
Specific embodiment of the present utility model is that the stripping rotor 4 in water bath 1 is used as dissolution experiment, and circulation pipe 3 connects
Between electric box 2 and water bath 1, connection type is that the water outlet of water bath 1 is connected to the water inlet of electric box 2, electrically
The water outlet of case 2 is connected on the water inlet of water bath 1, guarantees that bath foam circulates, and agitating paddle 8 can cooperate motor driven to accelerate
The compression cup button 601 of dissolution, 6 left and right sides of stripping cup cap of the compression cup button 601 of 6 left and right sides of stripping cup cap guarantees entire stripping rotor
Closed environment in 4, but can generate oxygen under the action of agitating paddle 8 will generate bubble when dissolution fluid dissolved oxygen amount is excessively high
Result of extraction is influenced, experimentation is caused to fail.Dissolved oxygen information needs to acquire using signal picker 14 in entire stripping rotor 4.
The paddle head 801 of symmetrical flat-shaped truncated cone-shaped guarantees the stationarity uniformity of stirring, and more oxygen bubble is avoided to generate.
As shown in Figure 1, the control display device 12 includes temperature indicator 1201, pressure display unit 1202, dissolved oxygen amount
Display 1203 and control keyboard 1204.
Signal picker 14 is not only acquired dissolved oxygen amount but also is acquired to the temperature and pressure in stripping rotor 4,
Since it is desired that the size of comprehensive analysis different temperatures and dissolution fluid dissolved oxygen amount under pressure.Control keyboard 1204 can be by staff
The parameter of each physical quantity, such as temperature, pressure are freely set, can also carry out resetting the operation such as calibration.
As shown in figure 3, the online dissolved oxygen measuring device control module includes signal picker 14, the signal picker
14 output signal ends are connected on Digital Signal Processing and A/D converter, the output of the Digital Signal Processing and A/D converter
End is connected in the pin input end of PIC16F877A chip, and the pin output end of the PIC16F877A is connected separately with LCD
Display, relay control pump, WMOi3 module and keyboard setter.
As shown in figure 3, the signal picker 14 includes dissolved oxygen sensor, temperature sensor and pressure sensor.
Entire measurement and adjusting correction course are that dissolved oxygen sensor, temperature sensor and pressure sensor acquire respectively
The analog quantity of related physical quantity in stripping rotor 4, acquisition is converted into digital signal simultaneously by Digital Signal Processing and A/D converter
And relevant signal processing is carried out, treated, and useful signal is passed to progress discriminance analysis in PIC16F877A chip,
PIC16F877A chip processor number each to relevant interface LCD display real-time display is lifted, which is temperature display
Device 1201, pressure display unit 1202 and dissolved oxygen amount display 1203.When detecting dissolution fluid dissolved oxygen under specific temperature and pressure
When measuring excessively high, it will control relay control pump opens (pump of control is vacuum air pump 13) and excessive bubble is discharged, and guarantees
Each parameter balance or up to standard in stripping rotor 4.The utility model not only the size of real-time detection dissolved oxygen amount but also has real-time
The function of correction, is worthy to be popularized.
It is obvious to a person skilled in the art that the present invention is not limited to the details of the above exemplary embodiments, and
And without departing substantially from the spirit or essential attributes of the utility model, it can realize that this is practical new in other specific forms
Type.Therefore, in all respects, the present embodiments are to be considered as illustrative and not restrictive, this is practical new
The range of type is indicated by the appended claims rather than the foregoing description, it is intended that containing for the equivalent requirements of the claims will be fallen in
All changes in justice and range are embraced therein.It should not treat any reference in the claims as limiting
Related claim.
Claims (5)
1. with the online dissolved oxygen measuring device of zero offset capability in a kind of digestion instrument, it is characterised in that: including water bath
(1), it is provided with electric box (2) outside the water bath (1), is provided with circulation between the electric box (2) and the water bath (1)
It manages (3), is provided with several stripping rotors (4) in the water bath (1), the bottom end of the electric box (2) is provided with damping base
(5), it is fixedly connected with equipment rack (7) above the stripping rotor (4), the upper end of the equipment rack (7) is connected with control
Case (10), the stripping rotor (4) is interior to be provided with the agitating paddle (8) connecting with the control cabinet (10), the agitating paddle (8) and institute
It states and is connected between control cabinet (10) machine shaft (9), control display device (12) is provided in the control cabinet (10), it is described
It is provided with above control cabinet (10) several locking members (11), the top of the stripping rotor (4) is provided with stripping cup cap (6), institute
The left and right ends for stating stripping cup cap (6) are provided with compression cup button (601), are provided with vacuum air pump on the stripping cup cap (6)
(13)。
2. special with the online dissolved oxygen measuring device of zero offset capability in a kind of digestion instrument according to claim 1
Sign is: the stripping rotor (4) includes the dissolution cup body (401) of U-shaped, is provided with signal on dissolution cup body (401) inner wall
Collector (14), the bottom end of the agitating paddle (8) are provided with the paddle head (801) of symmetrical flat-shaped truncated cone-shaped.
3. special with the online dissolved oxygen measuring device of zero offset capability in a kind of digestion instrument according to claim 1
Sign is: the control display device (12) includes temperature indicator (1201), pressure display unit (1202), dissolved oxygen amount display
(1203) with control keyboard (1204).
4. special with the online dissolved oxygen measuring device of zero offset capability in a kind of digestion instrument according to claim 1
Sign is: the online dissolved oxygen measuring device control module includes signal picker (14), signal picker (14) output
Signal end is connected on Digital Signal Processing and A/D converter, and the output end of the Digital Signal Processing and A/D converter connects
In the pin input end of PIC16F877A chip, the pin output end of the PIC16F877A be connected separately with LCD display,
Relay control pump, WMOi3 module and keyboard setter.
5. there is the online dissolved oxygen measuring device of zero offset capability in a kind of digestion instrument according to claim 2 or 4,
Be characterized in that: the signal picker (14) includes dissolved oxygen sensor, temperature sensor and pressure sensor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820850500.8U CN208297481U (en) | 2018-06-04 | 2018-06-04 | With the online dissolved oxygen measuring device of zero offset capability in a kind of digestion instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820850500.8U CN208297481U (en) | 2018-06-04 | 2018-06-04 | With the online dissolved oxygen measuring device of zero offset capability in a kind of digestion instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208297481U true CN208297481U (en) | 2018-12-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201820850500.8U Expired - Fee Related CN208297481U (en) | 2018-06-04 | 2018-06-04 | With the online dissolved oxygen measuring device of zero offset capability in a kind of digestion instrument |
Country Status (1)
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| CN (1) | CN208297481U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112326903A (en) * | 2020-11-02 | 2021-02-05 | 苏州安默医药科技有限公司 | Multi-dimensional bionic drug dissolution detection device and detection method |
-
2018
- 2018-06-04 CN CN201820850500.8U patent/CN208297481U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112326903A (en) * | 2020-11-02 | 2021-02-05 | 苏州安默医药科技有限公司 | Multi-dimensional bionic drug dissolution detection device and detection method |
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20181228 |