CN202256307U - Dissolution tester - Google Patents
Dissolution tester Download PDFInfo
- Publication number
- CN202256307U CN202256307U CN201120365495XU CN201120365495U CN202256307U CN 202256307 U CN202256307 U CN 202256307U CN 201120365495X U CN201120365495X U CN 201120365495XU CN 201120365495 U CN201120365495 U CN 201120365495U CN 202256307 U CN202256307 U CN 202256307U
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- water bath
- control
- box
- control box
- test instrument
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Abstract
The utility model provides a dissolution tester, which comprises a water bath box, a plurality of dissolution cups arranged in the water bath box and an electrical box arranged on the outer side of the water bath box. A machine frame is further fixed on the water bath box, a control box is fixed on the machine frame, a plurality of paddle rods are arranged on the control box, and the paddle rods droop from the control box and are inserted in the dissolution cups. A precise control system composed of a single chip microcomputer performs centralized control of each part. The dissolution tester is high in automation degree, control accuracy and sensitivity, small in error, low in noise and convenient to operate.
Description
Technical field
The utility model relates to a kind of test instrument that is used for the detection of drugs dissolution rate.
Background technology
Drug dissolution is meant medicine in the regulation medium, under certain condition, and the degree of the speed of stripping and stripping from solid pharmaceutical preparations such as tablet or capsule.Drug dissolution directly influences medicine absorption in vivo and utilization, is an inherent index estimating drug quality.All to investigate this index in drug manufacture check, clinical efficacy investigation, stability of drug products check, new drug development, prescription screening, process modification etc. aspect many.
The drug dissolution inspection is a kind of effective means of estimating preparation quality and technological level; It also is a kind of effective standard of estimating preparation active component bioavilability and preparation uniformity coefficient; As long as can effectively distinguish the difference of same kind of drug bioavailability, therefore be one of industrial quality control essential items for inspection.It is through the experiment in vitro method of simulation oral solid formulation process in leaching in stomach; Although check and external assay can be not in full accord in the body; But has certain correlativity; And the external check of dissolution rate is simple than check in the body, can yet be regarded as a cost-effective quality testing, control device.
Therefore a kind of instrument that can simulate oral solid formulation process in leaching in stomach is very important with the instrument of measuring dissolution rate.
Summary of the invention
According to the demand, the utility model proposes a kind of dissolution rate test instrument, and said test instrument comprises water bath, is arranged at several stripping rotors electric box outside with being arranged at said water bath in the said water bath; Also be fixed with frame on the said water bath, be fixed with control box on the said frame, said control box is provided with several looms, and said loom hangs down on said control box, and inserts in the said stripping rotor.
Preferably, said loom runs through said control box, and is fixed in the top of said control box through locking member; Said control box is provided with temperature control panel, speed control panel, time control panel and supervisory keyboard; The side of said control box is provided with handrail; Said water bath bottom surface is provided with beam; The rim of a cup of said stripping rotor is provided with the stripping bowl cover.
The dissolution rate test instrument of the utility model can be formed precise control system by one chip microcomputer each parts is carried out centralized control; The automation equipment degree is high, and control accuracy is high, and highly sensitive, error is little, and noise is low, and is easy to operate.
Description of drawings
Accompanying drawing 1 is the structural representation of the utility model preferred embodiment.
Embodiment
Preferred embodiment below in conjunction with 1 pair of the utility model of accompanying drawing is done further explanation.
Referring to Fig. 1, the dissolution rate test instrument of the utility model comprises water bath 1, is arranged at several stripping rotors 3 and the electric box 2 that is arranged at said water bath 1 outside in the said water bath 1; Also be fixed with frame 4 on the said water bath 1, be fixed with control box 5 on the said frame 4, said control box 5 is provided with several looms 32, and said loom 32 hangs down on said control box 5, and inserts in the said stripping rotor 3.
In this preferred embodiment, said loom 32 runs through said control box 5, and is fixed in the top of said control box 5 through locking member 7; Said control box 1 is provided with temperature control panel 54, speed control panel 53, time control panel 52 and supervisory keyboard 51; Said temperature control panel 54 is provided with temperature control pilot lamp, temperature display device 541 and temperature control operating key 542; Speed control panel 53 is provided with speed display window 531 and rotates pilot lamp and speed control key 532, and time control panel 52 is provided with time showing window 521, timing controlled key 522 and timing indicator; Supervisory keyboard 51 is provided with numeric keypad 511, the operating key 513 of the operating key 512 and presetting of resetting/in real time.
The bottom surface of said water bath 1 is provided with beam 9; The rim of a cup of said stripping rotor 3 is provided with stripping bowl cover 31, and the cup Kong Zhonghou that stripping rotor 3 is put into water bath 1 fixes through the compression cup button.
The dissolution rate test instrument of the utility model should be placed on the firm horizontal table or desktop, and beam 9 is placed between water bath 1 and the table top, and through the AC in connector incoming transport power supply on the electric box 2.Be connected with plastic flexible pipe 10 between water bath 1 and the electric box 2, the water inlet of water bath 1 connects the water delivering orifice of electric box 2, and the water delivering orifice of water bath 1 connects the water inlet of electric box 2.Heating water tank is in the inside of electric box 2, and the water circulation system with a sealing such as composition such as water bath 1 grade generally circulates as water-bath liquid with distilled water, and regular situation can reach set point of temperature in following 30 minutes.
During work, the dissolution rate test instrument energized of the utility model, power light is bright, and instrument starts; After about 10 minutes of the preheating, can carry out parameters and preset.Press presetting on the supervisory keyboard 51/real-time operating key 513 and get into real-time statuss; The temperature control operating key of pressing again on the temperature control panel 54 542 gets into the A.T.C state, and the temperature control pilot lamp is bright, and electric heater begins heating; The instrument A.T.C, after about 30 minutes, temperature stabilization is at 37.0 ± 0.3 ℃.Can mercury thermometer be inserted in the water bath 1, treat that reading is stable after, the reading of the reading of mercury thermometer and instrument demonstration relatively; Regulate the temperature adjustment potentiometer knob on control box 5 rear panels then, the reading that instrument is shown reaches consistent with the reading of mercury thermometer.After treating instrument stabilizer running, repeat above step, make the two reading reach stable and consistent and get final product.
Instrument start and reset after, system is in preset condition, system presets parameter commonly used automatically: 37.0 ℃ of temperature, speed 100RPM, time 045min.If, can carry out preset temperature by temperature control operating key 542; If, can carry out speed and preset by speed control key 532; If, can carry out time preset by timing controlled key 522.Operand word keyboard 511 can preset the pharmacopeia parameter.
After preset parameter was accomplished, by presetting/real-time operating key 513, system was in real-time status; If press speed control key 532, loom 32 begins to rotate; By speed control key 532, loom 32 stops operating again.
During work, it is an amount of to measure the solvent of handling through the degassing, injects respectively in six stripping rotors 3 of the utility model preferred embodiment; The control temperature makes solvent temperature be stabilized in preset temperature; Materials six, drop into respectively in six stripping rotors 3; Loom 32 is fallen in the stripping rotor 3, and control is immediately rotated and the control timing; Behind preset time, regularly finish, the draw solution of taking a sample again is an amount of, filters through 0.8 μ m miillpore filter immediately; Get filtrating, measure and calculate the stripping quantity of each sample by prescriptive procedure.
Before carrying out the pipeline connection, can plastic flexible pipe 10 usefulness boiling water be soaked softness, so that plug connects; Also can be provided with handrail 6, so that operation and mobile in the side of said control box 5.
The dissolution rate test instrument of the utility model can be formed precise control system by one chip microcomputer each parts is carried out centralized control; The automation equipment degree is high, and control accuracy is high, and highly sensitive, error is little, and noise is low, and is easy to operate.
Claims (6)
1. dissolution rate test instrument, it is characterized in that: said test instrument comprises water bath, is arranged at several stripping rotors electric box outside with being arranged at said water bath in the said water bath; Also be fixed with frame on the said water bath, be fixed with control box on the said frame, said control box is provided with several looms, and said loom hangs down on said control box, and inserts in the said stripping rotor.
2. dissolution rate test instrument as claimed in claim 1 is characterized in that: said loom runs through said control box, and is fixed in the top of said control box through locking member.
3. dissolution rate test instrument as claimed in claim 1 is characterized in that: said control box is provided with temperature control panel, speed control panel, time control panel and supervisory keyboard.
4. dissolution rate test instrument as claimed in claim 1 is characterized in that: the side of said control box is provided with handrail.
5. dissolution rate test instrument as claimed in claim 1 is characterized in that: said water bath bottom surface is provided with beam.
6. dissolution rate test instrument as claimed in claim 1 is characterized in that: the rim of a cup of said stripping rotor is provided with the stripping bowl cover.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201120365495XU CN202256307U (en) | 2011-09-28 | 2011-09-28 | Dissolution tester |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201120365495XU CN202256307U (en) | 2011-09-28 | 2011-09-28 | Dissolution tester |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202256307U true CN202256307U (en) | 2012-05-30 |
Family
ID=46117528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201120365495XU Expired - Fee Related CN202256307U (en) | 2011-09-28 | 2011-09-28 | Dissolution tester |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202256307U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102944534A (en) * | 2012-11-06 | 2013-02-27 | 天津市天大天发科技有限公司 | Automatic medicine disintegration tester |
| WO2016101406A1 (en) * | 2014-12-22 | 2016-06-30 | 天津市天大天发科技有限公司 | Push-pull medicine dissolution tester accessory storage device |
| CN106442904A (en) * | 2016-09-23 | 2017-02-22 | 梁永革 | Test instrument for dissolution rate of drugs |
-
2011
- 2011-09-28 CN CN201120365495XU patent/CN202256307U/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102944534A (en) * | 2012-11-06 | 2013-02-27 | 天津市天大天发科技有限公司 | Automatic medicine disintegration tester |
| WO2016101406A1 (en) * | 2014-12-22 | 2016-06-30 | 天津市天大天发科技有限公司 | Push-pull medicine dissolution tester accessory storage device |
| CN106442904A (en) * | 2016-09-23 | 2017-02-22 | 梁永革 | Test instrument for dissolution rate of drugs |
| CN106442904B (en) * | 2016-09-23 | 2018-08-17 | 梁永革 | A kind of drug dissolution tester |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120530 Termination date: 20200928 |