CN106442904A - Test instrument for dissolution rate of drugs - Google Patents
Test instrument for dissolution rate of drugs Download PDFInfo
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- CN106442904A CN106442904A CN201610847759.2A CN201610847759A CN106442904A CN 106442904 A CN106442904 A CN 106442904A CN 201610847759 A CN201610847759 A CN 201610847759A CN 106442904 A CN106442904 A CN 106442904A
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- stripping
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
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Abstract
The invention discloses a test instrument for dissolution rate of drugs and mainly relates to the technical field of drug inspection. The test instrument comprises a base, wherein four adjusting bolts are arranged at the edge of the base; a reference block is arranged on the base; a level bubble is arranged on the reference block; a cylindrical lug boss and a heating box are arranged at the top of the base; an annular water bath box is arranged on the cylindrical lug boss in a sleeving manner; an annular cover is arranged at the top of the annular water bath box; a lifting mechanism is arranged on the cylindrical lug boss; a cylindrical shell is arranged at the top of the lifting mechanism; a driving motor is arranged at the top of the cylindrical shell; a plurality of rotating shafts are annularly arrayed on the cylindrical shell; stirring paddles are arranged at the bottom of the rotating shafts; a dissolving cup is arranged in the annular water bath box. The test instrument has the beneficial effects of reducing the interference factor of the dissolution rate test, guaranteeing the reliability of the test result, shortening the time for correcting the test instrument for dissolution rate and improving the working efficiency.
Description
Technical field
The present invention relates to drug inspection technical field, specifically a kind of drug dissolution test instrument.
Background technology
Dissolution rate refer to medicine from solid pharmaceutical preparations such as tablets the speed of dissolution and degree regulation solvent, dissolution rate is piece
One important indicator of agent quality control.At present, how the dissolution rate of medicine is tested using dissolution tester, dissolution
The testing result of degree test instrument is easily affected by many factors, the axle center line skew of the axial line of rotating shaft and stripping rotor, dissolution rate
Test instrument does not place level, the perpendicularity of rotating shaft offset big city and causes stripping quantity to increase, and for solving such interference, needs
Before experiment, using level meter, square etc., dissolution tester is corrected, trimming process occupies substantial amounts of time, work
Make that efficiency is low, and the water bath of existing dissolution tester is using the electric-heating-wire-heating being arranged on bottom, heating wire is long-time
During use, its surface can produce incrustation scale, and the water temperature easily causing diverse location in water bath produces difference, and then affects dissolution
The testing result of degree test instrument.
Content of the invention
It is an object of the invention to provide a kind of drug dissolution test instrument, it can reduce the interference of Dissolution Rate Testing because
Element, ensure that the confidence level of testing result, can reduce dissolution tester and be corrected the required time, it is possible to increase work
Make efficiency.
The present invention for achieving the above object, is achieved through the following technical solutions：
A kind of drug dissolution test instrument, including base, the edge of described base arranges four regulating bolts, described base
Upper setting reference block, described reference block is provided with air level, and the top of described base arranges cylindrical boss, heater box, described
Annular water bath is arranged with cylindrical boss, described heater box is wound with heating coil, described heating coil is connected with
Relay, described heater box arranges circulating pump, connects structure by pipeline between described circulating pump, annular water bath, heater box
Become closed circuit, in described annular water bath, be provided with temperature sensor, the annular lid of top setting of described annular water bath, institute
State setting elevating mechanism on cylindrical boss, the top of described elevating mechanism arranges cylindrical housings, described cylindrical housings
Top arranges motor, and described motor is located at the center of cylindrical housings, circular array in described cylindrical housings
Row are provided with several rotating shafts, and the axial line of described rotating shaft is vertical with the top surface of reference block, and the top of described cylindrical housings is provided with
The first support tube being adapted with rotating shaft, described rotating shaft is connected with the first support tube by clutch shaft bearing, described cylindrical housings
Bottom be provided with rotating shaft be adapted the second support tube, described rotating shaft is connected with the second support tube by second bearing, described
On motor, first bevel gear is set, described rotating shaft arranges second bevel gear, described first bevel gear, second bevel gear are equal
It is provided with power transmission shaft, described power transmission shaft and the circle being adapted with rotating shaft in the inside of cylindrical housings, described circular cylindrical shell body
Cylindrical shell rotates and connects, and one end of described power transmission shaft is provided with the third hand tap gear engaging with first bevel gear, and the other end is provided with
The 4th bevel gear engaging with second bevel gear, described rotating shaft bottom setting stirring slurry, described annular water bath in be provided with
The stripping rotor that stirring slurry is adapted, described annular lid is provided with the through hole being adapted with stripping rotor, the top of described stripping rotor
Be provided with through hole be adapted collar stop, described collar stop bottom setting locating piece, described annular lid be provided with
The location hole that locating piece is adapted, described rotating shaft is provided with the stripping cup cap being adapted with stripping rotor, the bottom of described stripping cup cap
The groove that portion's setting is adapted with collar stop, the axial line of described stripping cup cap is conllinear with the axial line of rotating shaft, described dissolution
Bowl cover is slidably connected with rotating shaft, and described cylindrical housings arrange setting Single-chip Controlling in touch-screen, described circular cylindrical shell body
Device, described relay, temperature sensor, motor, touch-screen are all connected with singlechip controller signal.
Described circulating pump is provided with filter screen.
Draw-in groove is arranged on described cylindrical boss, described annular water bath is provided with the first fixture block being adapted with draw-in groove,
Described annular lid is provided with the second fixture block being adapted with draw-in groove.
The bottom setting lead of described cylindrical housings, described cylindrical boss is provided with and leading that lead is adapted
To set.
In described rotating shaft arrange stop nut, described stop nut be located at stripping cup cap top, described stop nut with
Spring is set between stripping cup cap, and one end of described spring is contacted with stop nut, and the other end is contacted with stripping cup cap, described bullet
Spring is set in rotating shaft.
Contrast prior art, the beneficial effects of the present invention is：
1st, the temperature sensor of the present invention is for detecting the temperature in annular water bath and testing result being sent to monolithic
Machine controller, singlechip controller controls heating coil to work by the adhesive of control relay, and heating coil is to heater box
Interior water heating, connects and composes closed circuit by pipeline between circulating pump, annular water bath, heater box, can be annular water
Bath cabinet provides constant water temperature, it can be avoided that the impact to testing result for the water temperature difference, reference block is as the horizontal base of the present invention
Standard, adjusts different regulating bolts, can determine that the top surface whether level of reference block by air level, the first support tube, second
Support tube can increase the support distances of rotating shaft, ensure that the perpendicularity of rotating shaft, the bottom setting of stripping cup cap and annular gear
The groove that block is adapted, the axial line of stripping cup cap is conllinear with the axial line of rotating shaft, ensure that axial line and the dissolution of rotating shaft
The axial line of cup is conllinear, can reduce the disturbing factor of Dissolution Rate Testing, ensure that the confidence level of testing result, can reduce
Dissolution tester is corrected the required time, it is possible to increase operating efficiency.
2nd, the motor of the present invention can drive multiple axis of rotation by Bevel Gear Transmission, ensure that annular water-bath
The uniformity of mixing speed in multiple stripping rotors in case, it can be avoided that in different stripping rotor the rotating speed difference of rotating shaft bring dry
Disturb, locating piece is matched with location hole, it can be avoided that stripping rotor skew in checkout procedure.
3rd, the circulating pump of the present invention is provided with filter screen, can filter to entering the water in annular water bath, can keep away
Exempt from incrustation scale and enter annular water bath.
The 4th, draw-in groove is arranged on the cylindrical boss of the present invention, described annular water bath is provided with first being adapted with draw-in groove
Fixture block, described annular lid is provided with the second fixture block being adapted with draw-in groove, and the first fixture block, the second fixture block snap in draw-in groove, energy
Annular water bath and annular lid in process of the test is enough avoided to rock, it can be avoided that rocking the interference to assay.
5th, the bottom setting lead of the cylindrical housings of the present invention, described cylindrical boss is provided with is fitted with lead phase
The fairlead answered, ensure that rotating shaft is vertically moved, it is possible to increase the axial line of rotating shaft is same with the axial line of stripping rotor
Heart degree.
6th, stop nut is arranged on the rotating shaft of the present invention, described stop nut is located at the top of stripping cup cap, described spacing
Spring is set between nut and stripping cup cap, and one end of described spring is contacted with stop nut, and the other end is contacted with stripping cup cap,
Described spring is set in rotating shaft, can adjust the thrust of spring by stop nut, and elevating mechanism is by circular cylindrical shell body drop
When lower, stripping cup cap is firmly pressed on stripping rotor spring, can be prevented effectively from the evaporation of the liquid in stripping rotor.
Brief description
Accompanying drawing 1 is the structural representation of the present invention；
Accompanying drawing 2 is the structural representation of annular water bath in embodiment；
Accompanying drawing 3 is the structural representation of annular lid in embodiment；
Accompanying drawing 4 is the internal drive structure chart of cylindrical housings in embodiment；
Accompanying drawing 5 is the structural representation of stripping rotor in embodiment.
Label in accompanying drawing：1st, base；2nd, regulating bolt；3rd, reference block；4th, cylindrical boss；5th, heater box；6th, annular water
Bath cabinet；7th, circulating pump；8th, temperature sensor；9th, annular lid；10th, elevating mechanism；11st, cylindrical housings；12nd, motor；
13rd, rotating shaft；14th, the first support tube；15th, the second support tube；16th, first bevel gear；17th, second bevel gear；18th, power transmission shaft；19、
Third hand tap gear；20th, the 4th bevel gear；21st, stirring slurry；22nd, stripping rotor；23rd, through hole；24th, collar stop；25th, locating piece；
26th, location hole；27th, stripping cup cap；28th, touch-screen；29th, the first fixture block；30th, the second fixture block；31st, lead；32nd, fairlead；
33rd, stop nut；34th, spring.
Specific embodiment
With reference to specific embodiment, the present invention is expanded on further.It should be understood that these embodiments are merely to illustrate the present invention
Rather than restriction the scope of the present invention.In addition, it is to be understood that after having read the content of present invention instruction, people in the art
Member can make various changes or modifications to the present invention, and these equivalent form of values equally fall within scope defined herein.
Of the present invention is a kind of drug dissolution test instrument, and including base 1, the edge of described base 1 arranges four tune
Section bolt 2, described base 1 arranges reference block 3, the upper surface of reference block 3 is as the horizontal reference of the present invention, described reference block
3 are provided with air level, adjust different regulating bolts 2, can determine that the top surface whether level of reference block 3 by air level.Institute
State top setting cylindrical boss 4, the heater box 5 of base 1, described cylindrical boss 4 is arranged with annular water bath 6, described
It is wound with heating coil in heater box 5, described heating coil is connected with relay, described heater box 5 arranges circulating pump 7,
Between described circulating pump 7, annular water bath 6, heater box 5, closed circuit is connected and composed by pipeline, in described annular water bath 6
It is provided with temperature sensor 8, temperature sensor 8 is for detecting the temperature in annular water bath 6 and testing result being sent to monolithic
Machine controller, singlechip controller controls heating coil to work by the adhesive of control relay, and heating coil is to heater box 5
Interior water heating, connects and composes closed circuit by pipeline between circulating pump 7, annular water bath 6, heater box 5, can be annular
Water bath 6 provides constant water temperature, it can be avoided that the impact to testing result for the water temperature difference.The top of described annular water bath 6
The annular lid 9 of setting, described cylindrical boss 4 arranges elevating mechanism 10, and the top setting of described elevating mechanism 10 is cylindrical
Housing 11, elevating mechanism 10 is used for driving cylindrical housings 11 to move up and down.The top setting of described cylindrical housings 11 drives
Motor 12, described motor 12 is located at the center of cylindrical housings 11, and in described cylindrical housings 11, annular array sets
There are several rotating shafts 13, the axial line of described rotating shaft 13 is vertical with the top surface of reference block 3, and the top of described cylindrical housings 11 sets
There is the first support tube 14 being adapted with rotating shaft 13, described rotating shaft 13 is connected with the first support tube 14 by clutch shaft bearing, described
The bottom of cylindrical housings 11 is provided with the second support tube 15 being adapted with rotating shaft 13, and second bearing and the is passed through in described rotating shaft 13
Two support tubes 15 connect, and the first support tube 14, the second support tube 15 can increase the support distances of rotating shaft 13, ensure that rotating shaft
13 perpendicularity.On described motor 12, first bevel gear 16 is set, described rotating shaft 13 arranges second bevel gear 17, described
First bevel gear 16, second bevel gear 17 are respectively positioned on the inside of cylindrical housings 11, be provided with and turn in described cylindrical housings 11
The power transmission shaft 18 that axle 13 is adapted, described power transmission shaft 18 is rotated with cylindrical housings 11 and is connected, and one end of described power transmission shaft 18 sets
There is the third hand tap gear 19 engaging with first bevel gear 16, the other end is provided with the 4th bevel gear engaging with second bevel gear 17
20, motor 12 can drive multiple rotating shafts 13 to rotate by Bevel Gear Transmission, can reducing energy consumption, ensure that annular water
The uniformity of mixing speed in multiple stripping rotors 22 in bath cabinet 6, it can be avoided that the rotating speed of rotating shaft 13 is different in different stripping rotor 22
The interference bringing.The bottom setting stirring slurry 21 of described rotating shaft 13, is provided with described annular water bath 6 and is adapted with stirring slurry 21
Stripping rotor 22, described annular lid 9 be provided with stripping rotor 22 be adapted through hole 23, the top of described stripping rotor 22 is provided with
The collar stop 24 being adapted with through hole 23, collar stop 24 is it can be avoided that stripping rotor 22 landing.The bottom of described collar stop 24
Portion arranges locating piece 25, and described annular lid 9 is provided with location hole 26, locating piece 25 and the location hole being adapted with locating piece 25
26 match, it can be avoided that stripping rotor 22 offsets in checkout procedure.Described rotating shaft 13 is provided with molten with what stripping rotor 22 was adapted
Go out bowl cover 27, the bottom of described stripping cup cap 27 arranges the groove being adapted with collar stop 24, the axle of described stripping cup cap 27
Heart line is conllinear with the axial line of rotating shaft 13, and described stripping cup cap 27 and rotating shaft 13 are slidably connected, and stripping cup cap 27 falls, annular gear
Block 24 snaps in groove, ensure that the axial line of rotating shaft 13 is conllinear with the axial line of stripping rotor 22, can reduce dissolution rate examination
The disturbing factor tested, ensure that the confidence level of testing result, can reduce dissolution tester and be corrected the required time,
Operating efficiency can be improved.Touch-screen 28 is arranged on described cylindrical housings 11, setting single-chip microcomputer in described cylindrical housings 11
Controller, described relay, temperature sensor 8, motor 12, touch-screen 28 are all connected with singlechip controller signal, lead to
Cross touch-screen 28 and can carry out man-machine interaction with the present invention.
In order to avoid incrustation scale enters annular water bath 6, described circulating pump 7 is provided with filter screen, being capable of the annular water-bath to entrance
Water in case 6 is filtered, it can be avoided that incrustation scale enters annular water bath 6.
In order to avoid rocking the interference to assay, described cylindrical boss 4 arranges draw-in groove, described annular water bath
6 are provided with the first fixture block 29 being adapted with draw-in groove, and described annular lid 9 is provided with the second fixture block 30 being adapted with draw-in groove,
First fixture block 29, the second fixture block 30 snap in draw-in groove, it can be avoided that annular water bath 6 and annular lid 9 rock in process of the test,
It can be avoided that rocking the interference to assay.
In order to improve the concentricity of the axial line of rotating shaft 13 and the axial line of stripping rotor 22, the bottom of described cylindrical housings 11
Portion arranges lead 31, and described cylindrical boss 4 is provided with the fairlead 32 being adapted with lead 31, ensure that rotating shaft 13
Vertically move, it is possible to increase the concentricity of the axial line of the axial line of rotating shaft 13 and stripping rotor 22.
In order to be prevented effectively from the evaporation of the liquid in stripping rotor 22, described rotating shaft 13 arranges stop nut 33, described limit
Position nut 33 is located at the top of stripping cup cap 27, arranges spring 34, described bullet between described stop nut 33 and stripping cup cap 27
One end of spring 34 is contacted with stop nut 33, and the other end is contacted with stripping cup cap 27, and described spring 34 is set in rotating shaft 13, leads to
The position crossing stop nut 33 can adjust the thrust of spring 34, when cylindrical housings 11 are fallen by elevating mechanism 10, spring
Stripping cup cap 27 is firmly pressed on the evaporation that can be prevented effectively from the liquid in stripping rotor 22 on stripping rotor 22 by 34.
Embodiment：Of the present invention is a kind of drug dissolution test instrument, including base 1, the edge setting of described base 1
Four regulating bolts 2, four regulating bolts 2 are uniformly arranged at the edge of base 1, and described base 1 arranges reference block 3, benchmark
The upper surface of block 3 is inlaid with air level, adjusts different tune as the horizontal reference of the present invention, the upper surface of described reference block 3
Section bolt 2, can determine that the top surface whether level of reference block 3 by air level.The top setting cylindrical boss of described base 1
4th, heater box 5, described cylindrical boss 4 is arranged with annular water bath 6, and the top of described cylindrical boss 4 is machined with and base
The parallel top surface of quasi- block 3, described cylindrical boss 4 arranges draw-in groove, and draw-in groove is vertical with the top surface of cylindrical boss 4, described ring
Shape water bath 6 is provided with the first fixture block 29 being adapted with draw-in groove, in the first fixture block 29 insertion draw-in groove, it can be avoided that annular water-bath
Case 6 rocks, and ensure that the bottom surface level of annular water bath 6.It is wound with heating coil, described heating in described heater box 5
It is connected with relay on coil, described heater box 5 arranges circulating pump 7, in the water inlet end insertion heater box 5 of described circulating pump 7,
Water side connect with the top of annular water bath 6, the bottom of annular water bath 6 away from circulating pump 7 water side side be provided with and
The communicating pipe of heater box 5 connection, connected and composed by pipeline between described circulating pump 7, annular water bath 6, heater box 5 and loop back
Road, installs four temperature sensors 8 in described annular water bath 6, four temperature sensor 8 arrays in annular water bath set
Put, temperature sensor 8 is for detecting the temperature in annular water bath 6 and testing result being sent to singlechip controller, monolithic
Machine controller controls heating coil to work by the adhesive of control relay, and heating coil heats to the water in heater box 5, follows
Between ring pump 7, annular water bath 6, heater box 5, closed circuit is connected and composed by pipeline, perseverance can be provided for annular water bath 6
Fixed water temperature, it can be avoided that the impact to testing result for the water temperature difference.The water inlet end of described circulating pump 7 is provided with filter screen, can
Filter to entering the water in annular water bath 6, it can be avoided that incrustation scale enters annular water bath 6.Described annular water bath 6
The annular lid 9 of top setting, described annular lid 9 is provided with the second fixture block 30 being adapted with draw-in groove, and the second fixture block 30 snaps in
In draw-in groove, it can be avoided that annular lid 9 rocks, and ensure that the upper surface level of annular lid 9.Described cylindrical boss 4
Upper setting elevating mechanism 10, elevating mechanism 10 can adopt jack, and the upper and lower surface of elevating mechanism 10 is parallel, described elevating mechanism
10 top setting cylindrical housings 11, the center of the bottom of cylindrical housings 11 is machined with and is connected with elevating mechanism 10
Horizontal plane, elevating mechanism 10 is used for driving cylindrical housings 11 to move up and down.The bottom of described cylindrical housings 11 arranges four
Lead 31, described cylindrical boss 4 is provided with the fairlead 32 being adapted with lead 31, ensure that in rotating shaft 13 vertically
Lower movement, it is possible to increase the concentricity of the axial line of the axial line of rotating shaft 13 and stripping rotor 22.The top of described cylindrical housings 11
Motor 12 is installed in portion, and described motor 12 is located at the center of cylindrical housings 11, in described cylindrical housings 11
Annular array is provided with four rotating shafts 13, and the axial line of described rotating shaft 13 is vertical with the top surface of reference block 3, described cylindrical housings 11
Top be provided with the first support tube 14 being adapted with rotating shaft 13, clutch shaft bearing and the first support tube 14 company is passed through in described rotating shaft 13
Connect, the bottom of described cylindrical housings 11 is provided with the second support tube 15 being adapted with rotating shaft 13, and described rotating shaft 13 passes through second
Bearing is connected with the second support tube 15, and the first support tube 14, the second support tube 15 can increase the support distances of rotating shaft 13, can
Ensure the perpendicularity of rotating shaft 13.On described motor 12, first bevel gear 16 is set, setting the second cone tooth in described rotating shaft 13
Wheel 17, described first bevel gear 16, second bevel gear 17 are respectively positioned on the inside of cylindrical housings 11, in described cylindrical housings 11
It is provided with the power transmission shaft 18 being adapted with rotating shaft 13, described power transmission shaft 18 is rotated with cylindrical housings 11 and is connected, described power transmission shaft 18
One end be provided with the third hand tap gear 19 engaging with first bevel gear 16, the other end is provided with the 4th engaging with second bevel gear 17
Bevel gear 20, motor 12 can drive multiple rotating shafts 13 to rotate by Bevel Gear Transmission, can reducing energy consumption, ensure that
The uniformity of mixing speed in multiple stripping rotors 22 in annular water bath 6, it can be avoided that the turning of rotating shaft 13 in different stripping rotor 22
The interference that fast difference is brought.Stirring slurry 21 is installed in the bottom of described rotating shaft 13, is provided with and stirring slurry 21 in described annular water bath 6
Adaptable stripping rotor 22, described annular lid 9 is provided with the through hole 23 being adapted with stripping rotor 22, the top of described stripping rotor 22
Portion is provided with the collar stop 24 being adapted with through hole 23, and collar stop 24 is it can be avoided that stripping rotor 22 landing.Described collar stop
24 bottom setting locating piece 25, described annular lid 9 is provided with the location hole 26 being adapted with locating piece 25, locating piece 25 with
Location hole 26 matches, it can be avoided that stripping rotor 22 offsets in checkout procedure, ensure that the perpendicularity of stripping rotor 22.Described turn
Axle 13 is provided with the stripping cup cap 27 being adapted with stripping rotor 22, bottom setting and collar stop 24 phase of described stripping cup cap 27
The groove adapting to, the axial line of described stripping cup cap 27 and the axial line of rotating shaft 13 are conllinear, described stripping cup cap 27 and rotating shaft 13
It is slidably connected, stripping cup cap 27 falls, collar stop 24 snaps in groove, ensure that axial line and the stripping rotor 22 of rotating shaft 13
Axial line conllinear, the disturbing factor of Dissolution Rate Testing can be reduced, ensure that the confidence level of testing result, can reduce molten
Out-degree test instrument is corrected the required time, it is possible to increase operating efficiency.Described rotating shaft 13 is multidiameter, in described rotating shaft 13
Setting stop nut 33, described stop nut 33 is located at the top of stripping cup cap 27, described stop nut 33 and stripping cup cap 27
Between spring 34 is set, one end of described spring 34 contacted with stop nut 33, and the other end is contacted with stripping cup cap 27, described bullet
Spring 34 is set in rotating shaft 13, can adjust the thrust of spring 34 by the position of stop nut 33, and elevating mechanism 10 will be justified
When cylindrical shell 11 falls, stripping cup cap 27 is firmly pressed on stripping rotor 22 spring 34, can be prevented effectively from stripping rotor
The evaporation of the liquid in 22.Touch-screen 28 is arranged on described cylindrical housings 11, setting single-chip microcomputer in described cylindrical housings 11
Controller, described touch-screen 28, temperature sensor 8 are connected with the input of singlechip controller, described relay, motor
12 are connected with the output end of singlechip controller, can carry out man-machine interaction with the present invention by touch-screen 28.
Claims (5)
1. a kind of drug dissolution test instrument, including base (1), is characterized in that：The edge of described base (1) arranges four regulations
Bolt (2), described base (1) is upper to arrange reference block (3), and described reference block (3) is provided with air level, the top of described base (1)
Portion's setting cylindrical boss (4), heater box (5), described cylindrical boss (4) is arranged with annular water bath (6), described heating
Case is wound with heating coil on (5), and described heating coil is connected with relay, and described heater box (5) is upper to arrange circulating pump
(7), described circulating pump (7), annular water bath (6), heater box connect and compose closed circuit by pipeline between (5), described ring
It is provided with temperature sensor (8), the annular lid (9) of top setting of described annular water bath (6), described circle in shape water bath (6)
Cylindrical end tangs (4) are upper to arrange elevating mechanism (10), top setting cylindrical housings (11) of described elevating mechanism (10), described circle
Top setting motor (12) of cylindrical shell (11), described motor (12) is located at the centre bit of cylindrical housings (11)
Put, the upper annular array of described cylindrical housings (11) is provided with several rotating shafts (13), the axial line of described rotating shaft (13) and benchmark
The top surface of block (3) is vertical, and the top of described cylindrical housings (11) is provided with the first support tube (14) being adapted with rotating shaft (13),
Described rotating shaft (13) is connected with the first support tube (14) by clutch shaft bearing, and the bottom of described cylindrical housings (11) is provided with and turns
The second support tube (15) that axle (13) is adapted, described rotating shaft (13) is connected with the second support tube (15) by second bearing, institute
State motor (12) upper setting first bevel gear (16), described rotating shaft (13) upper setting second bevel gear (17), described first
Bevel gear (16), second bevel gear (17) are respectively positioned on the inside of cylindrical housings (11), are provided with described cylindrical housings (11)
The power transmission shaft (18) being adapted with rotating shaft (13), described power transmission shaft (18) is rotated with cylindrical housings (11) and is connected, described transmission
One end of axle (18) is provided with the third hand tap gear (19) engaging with first bevel gear (16), and the other end is provided with and second bevel gear
(17) the 4th bevel gear (20) engaging, bottom setting stirring slurry (21) of described rotating shaft (13), in described annular water bath (6)
It is provided with the stripping rotor (22) being adapted with stirring slurry (21), described annular lid (9) is provided with adaptable with stripping rotor (22)
Through hole (23), the top of described stripping rotor (22) is provided with the collar stop (24) being adapted with through hole (23), described collar stop
(24) bottom setting locating piece (25), described annular lid (9) is provided with the location hole (26) being adapted with locating piece (25),
Described rotating shaft (13) is provided with the stripping cup cap (27) being adapted with stripping rotor (22), the bottom setting of described stripping cup cap (27)
The groove being adapted with collar stop (24), the axial line of described stripping cup cap (27) is conllinear with the axial line of rotating shaft (13), institute
State stripping cup cap (27) to be slidably connected with rotating shaft (13), described cylindrical housings (11) are upper to arrange touch-screen (28), described cylinder
Setting singlechip controller, described relay, temperature sensor (8), motor (12), touch-screen (28) in shape housing (11)
All it is connected with singlechip controller signal.
2. a kind of drug dissolution test instrument according to claim 1, is characterized in that：Described circulating pump (7) is provided with filter
Net.
3. a kind of drug dissolution test instrument according to claim 1, is characterized in that：Set on described cylindrical boss (4)
Put draw-in groove, described annular water bath (6) is provided with the first fixture block (29) being adapted with draw-in groove, and described annular lid (9) sets
There is the second fixture block (30) being adapted with draw-in groove.
4. a kind of drug dissolution test instrument according to claim 1, is characterized in that：The bottom of described cylindrical housings (11)
Portion's setting lead (31), described cylindrical boss (4) is provided with the fairlead (32) being adapted with lead (31).
5. a kind of drug dissolution test instrument according to claim 1, is characterized in that：The upper setting of described rotating shaft (13) is spacing
Nut (33), described stop nut (33) is located at top, described stop nut (33) and the stripping cup cap of stripping cup cap (27)
(27) setting spring (34) between, one end of described spring (34) contacted with stop nut (33), the other end and stripping cup cap
(27) contact, described spring (34) is set in rotating shaft (13).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610847759.2A CN106442904B (en) | 2016-09-23 | 2016-09-23 | A kind of drug dissolution tester |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610847759.2A CN106442904B (en) | 2016-09-23 | 2016-09-23 | A kind of drug dissolution tester |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106442904A true CN106442904A (en) | 2017-02-22 |
| CN106442904B CN106442904B (en) | 2018-08-17 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610847759.2A Active CN106442904B (en) | 2016-09-23 | 2016-09-23 | A kind of drug dissolution tester |
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| CN (1) | CN106442904B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107020170A (en) * | 2017-05-13 | 2017-08-08 | 宁波智正伟盈信息科技有限公司 | A kind of monitor station of medical treatment detection culture dish |
| CN109164015A (en) * | 2018-08-23 | 2019-01-08 | 沈阳奥吉娜药业有限公司 | PH meter drives calibration assemblies |
| CN110907616A (en) * | 2019-12-10 | 2020-03-24 | 温州宏量机械科技有限公司 | Medicine dissolution instrument for analyzing medicine dissolution rate |
| CN113019213A (en) * | 2021-03-04 | 2021-06-25 | 天津拓至明实验仪器设备有限公司 | Water bath test or inspection device |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202256307U (en) * | 2011-09-28 | 2012-05-30 | 苏州瑞纳生化技术有限公司 | Dissolution tester |
| CN202676690U (en) * | 2012-05-28 | 2013-01-16 | 禄根仪器（镇江）有限公司（中外合资） | Universal dissolution instrument |
| CN203824993U (en) * | 2014-05-13 | 2014-09-10 | 四川美大康华康药业有限公司 | Improved dissolubility testing device |
| CN204008621U (en) * | 2014-05-15 | 2014-12-10 | 新疆富科思生物技术发展有限公司 | A kind of high-precision intelligent dissolution rate instrument |
| CN204347014U (en) * | 2015-01-26 | 2015-05-20 | 内蒙古工业大学 | Novel dissolution test system |
| CN204536313U (en) * | 2015-03-17 | 2015-08-05 | 张西强 | A kind of drug dissolution instrument rack |
| US20150358587A1 (en) * | 2014-06-10 | 2015-12-10 | Logan Instruments Corporation | Dissolution tester assembly with integrated imaging system |
| CN205374284U (en) * | 2016-01-13 | 2016-07-06 | 杨雪芳 | A novel degree of dissolving out tester for medicine inspection |
| CN105784952A (en) * | 2016-05-25 | 2016-07-20 | 延边大学 | Simple type test device for dissolution rate of flowing pool |
| CN205538936U (en) * | 2016-06-01 | 2016-08-31 | 奥星衡迅生命科技（上海）有限公司 | Medicine degree of dissolving out detecting system |
-
2016
- 2016-09-23 CN CN201610847759.2A patent/CN106442904B/en active Active
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202256307U (en) * | 2011-09-28 | 2012-05-30 | 苏州瑞纳生化技术有限公司 | Dissolution tester |
| CN202676690U (en) * | 2012-05-28 | 2013-01-16 | 禄根仪器（镇江）有限公司（中外合资） | Universal dissolution instrument |
| CN203824993U (en) * | 2014-05-13 | 2014-09-10 | 四川美大康华康药业有限公司 | Improved dissolubility testing device |
| CN204008621U (en) * | 2014-05-15 | 2014-12-10 | 新疆富科思生物技术发展有限公司 | A kind of high-precision intelligent dissolution rate instrument |
| US20150358587A1 (en) * | 2014-06-10 | 2015-12-10 | Logan Instruments Corporation | Dissolution tester assembly with integrated imaging system |
| CN204347014U (en) * | 2015-01-26 | 2015-05-20 | 内蒙古工业大学 | Novel dissolution test system |
| CN204536313U (en) * | 2015-03-17 | 2015-08-05 | 张西强 | A kind of drug dissolution instrument rack |
| CN205374284U (en) * | 2016-01-13 | 2016-07-06 | 杨雪芳 | A novel degree of dissolving out tester for medicine inspection |
| CN105784952A (en) * | 2016-05-25 | 2016-07-20 | 延边大学 | Simple type test device for dissolution rate of flowing pool |
| CN205538936U (en) * | 2016-06-01 | 2016-08-31 | 奥星衡迅生命科技（上海）有限公司 | Medicine degree of dissolving out detecting system |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107020170A (en) * | 2017-05-13 | 2017-08-08 | 宁波智正伟盈信息科技有限公司 | A kind of monitor station of medical treatment detection culture dish |
| CN109164015A (en) * | 2018-08-23 | 2019-01-08 | 沈阳奥吉娜药业有限公司 | PH meter drives calibration assemblies |
| CN110907616A (en) * | 2019-12-10 | 2020-03-24 | 温州宏量机械科技有限公司 | Medicine dissolution instrument for analyzing medicine dissolution rate |
| CN110907616B (en) * | 2019-12-10 | 2022-04-12 | 上海信谊天平药业有限公司 | Medicine dissolution instrument for analyzing medicine dissolution rate |
| CN113019213A (en) * | 2021-03-04 | 2021-06-25 | 天津拓至明实验仪器设备有限公司 | Water bath test or inspection device |
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| Publication number | Publication date |
|---|---|
| CN106442904B (en) | 2018-08-17 |
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