CN203824993U - Improved dissolubility testing device - Google Patents
Improved dissolubility testing device Download PDFInfo
- Publication number
- CN203824993U CN203824993U CN201420243202.4U CN201420243202U CN203824993U CN 203824993 U CN203824993 U CN 203824993U CN 201420243202 U CN201420243202 U CN 201420243202U CN 203824993 U CN203824993 U CN 203824993U
- Authority
- CN
- China
- Prior art keywords
- stripping rotor
- water bath
- testing device
- dissolution rate
- rate testing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000012360 testing method Methods 0.000 title claims abstract description 40
- 239000007788 liquid Substances 0.000 claims abstract description 71
- 238000004090 dissolution Methods 0.000 claims abstract description 50
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 49
- 238000005070 sampling Methods 0.000 claims abstract description 24
- 238000007789 sealing Methods 0.000 claims abstract description 5
- 238000007599 discharging Methods 0.000 claims description 15
- 239000011229 interlayer Substances 0.000 claims description 13
- 239000001307 helium Substances 0.000 claims description 12
- 229910052734 helium Inorganic materials 0.000 claims description 12
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 claims description 12
- 239000007789 gas Substances 0.000 claims description 9
- 239000010410 layer Substances 0.000 claims description 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- 244000309464 bull Species 0.000 claims description 4
- 238000010276 construction Methods 0.000 claims description 3
- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 abstract description 7
- 239000003814 drug Substances 0.000 description 8
- 229940079593 drug Drugs 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000002351 wastewater Substances 0.000 description 1
Landscapes
- Sampling And Sample Adjustment (AREA)
Abstract
The utility model relates to an improved dissolubility testing device which comprises a fixed bracket, wherein a water bath is arranged on the fixed bracket, a positioning base station is arranged on an upper arm in the water bath, a dissolution cup is fixed in the water bath through the positioning base station, and a stirrer is arranged in the dissolution cup and connected with a motor through a rotating rod; the dissolution cup adopts a transparent sealing structure, a sample feed pipe attached to the left side wall is arranged on the left side of the dissolution cup, a sampling pipe is arranged on the right side of the dissolution cup, an outlet end of the sampling pipe is connected to a sample collecting cup, a seal cartridge is arranged in the connection position of the sampling pipe and the sample collecting cup, and the sample collecting cup is connected with a sampling injector through a drainage hose; and the bottom of the water bath is communicated with a drain pipe, an extending end of the drain pipe is connected to a liquid settling pond, and an outlet end of the liquid settling pond is communicated to the water bath through a liquid pump. According to the improved dissolubility testing device, stability of inside environment of the dissolution cup is improved, water scale is prevented from being deposited on the surface of a heating wire in the dissolubility testing device, and meanwhile, sampling is more accurate.
Description
Technical field
The utility model relates to pharmaceutical industry checkout equipment technical field, particularly a kind of modified Dissolution Rate Testing device.
Background technology
Dissolution rate also claims dissolution rate, refers under the solvent environment of specific condition and regulation speed and the degree of medicine stripping from the solid pharmaceutical preparations such as tablet, capsule, granule.The process of measuring solid pharmaceutical preparation dissolution rate is called Dissolution Rate Testing, and it is a kind of disintegration of oral solid formulation in intestines and stomach and in vitro test method of stripping simulated.Drug dissolution inspection is a kind of effective means of evaluating preparation quality and technological level, the difference that can reflect to a certain extent crystal formation, granularity, prescription composition, auxiliary material kind and character, the production technology etc. of main ingredient, also be a kind of effective standard of evaluating preparation active component bioavilability and preparation uniformity coefficient, can effectively distinguish the difference of same drug bioavailability, be therefore that drug dissolution detection is that drug quality is controlled one of essential items for inspection.
Drug dissolution detects and conventionally adopts dissolution tester, be that dissolution rate test unit carries out, in whole testing process, the stability of dissolution tester internal environment, the temperature uniformity of test instrument inside, stripping rotor sealing, sampling mode etc. all can have influence on dissolution rate test effect.In addition, while stripping rotor being implemented to temperature bath in existing dissolution tester, conventionally adopt the liquid in electric-heating-wire-heating temperature bath, then complete the heating to stripping rotor internal solvent, but in long-time use procedure, heating wire can produce incrustation scale in surface, causes the diffusion of heating wire surface heat inhomogeneous, easily cause that heater strip breaks or short circuit, cause serious potential safety hazard.
Summary of the invention
The purpose of this utility model is, for existing dissolution tester in dissolution rate test process, test instrument inside is heated, and inequality, internal liquid are easily volatilized, sampling mode is too extensive, the technical disadvantages of the easy short circuit of heater strip, a kind of modified Dissolution Rate Testing device is provided, solve above technical matters, promote dissolution rate measuring accuracy, the potential safety hazard of avoiding heating wire short circuit to cause.
The utility model is achieved through the following technical solutions:
A kind of modified Dissolution Rate Testing device, it is characterized in that, structure comprises fixed support (1), on fixed support (1), be provided with water bath (2), the interior upper arm of water bath (2) is provided with location base station (21), water bath (2) is inner is fixed with stripping rotor (3) by location base station (21), and stripping rotor (3) inside is provided with stirrer (4), and stirrer (4) is connected with motor (51) by bull stick (5); Described stripping rotor (3) is set to transparent hermetically-sealed construction, stripping rotor (3) left side is provided with the sample feeding pipe (6) being affixed with left side wall, stripping rotor (3) right side side is provided with stopple coupon (7), stopple coupon (7) endpiece is connected to collection sample cup (8), stopple coupon (7) is provided with sealing shroud (71) with collection sample cup (8) junction, and collection sample cup (8) is connected with sampling injector (9) by conduction hose (81); Water bath (2) bottom is communicated with discharging tube (10), and discharging tube (10) external part is connected to liquid sump (11), and liquid sump (11) endpiece is communicated to water bath (2) by drawing liquid pump (12).
Further, described stripping rotor (3) wall is provided with the interlayer (32) of hollow structure, and interlayer (32) is transported pipeline (15) by gas and is communicated with helium hold-up vessel (16).
Further, described interlayer (32) bottom is provided with the micropore (301) that can pass through for nitrogen near stirrer (4) one sides.
Further, described stripping rotor (3) sidewall is provided with the spacing line of liquid level (302).
Further, described stirrer (4) is provided with 3 groups of paddle wheels (41), one group of paddle wheel (41) in the middle of being positioned at is horizontally disposed with, near one group of impeller (41) of stripping rotor (3) bottom to stripping rotor (3) bottom deflection, away from one group of impeller (41) of nearly stripping rotor (3) bottom to stripping rotor (3) top deflection.
Further, described stripping rotor (3) outer rim is provided with locator card platform (31), and locator card platform (31) matches with the location base station (21) on water bath (2).
Further, described water bath (2) sidewall and bottom are provided with heater strip (201), and the heater strip (201) that is positioned at sidewall is set to dissymmetrical structure.
Further, described liquid sump (11) bottom is provided with incrustation scale adsorbed layer (14), between liquid sump (11) and drawing liquid pump (12), near liquid sump (11) one sides, is provided with filtrator (13).
Further, described discharging tube (10) is provided with the first operation valve (101) near water bath (2) one sides.
Further, described stopple coupon (7) is provided with the second operation valve (701) near stripping rotor (3) one sides, between the second operation valve (701) and stripping rotor (3), is provided with sampling pump (72).
The utility model relates to a kind of modified Dissolution Rate Testing device, and beneficial effect is:
1, 3 groups of paddle wheels of the utility model (41) extend to the different directions of stripping rotor, make the mixing effect of stirrer (4) better, that stirs is more even, meanwhile, stripping rotor (3) wall is provided with the interlayer (32) of hollow structure, interlayer (32) is transported pipeline (15) by gas and is communicated with helium hold-up vessel (16), helium in helium hold-up vessel (16) enters stripping rotor (3) by micropore (301), this kind of design, can avoid the inner stirring dead angle of stripping rotor (3), make inner liquid more even, in addition, also help the discharge of the water-soluble gas such as liquid internal oxygen.
2, stripping rotor of the present utility model (3) and collection sample cup (8) are all set to Semi-seal structure, and the volatilization of liquid has been avoided in this kind of design, has guaranteed to greatest extent the stability of internal environment, improve the accuracy of dissolution rate test.
3, the utility model collection sample cup (8) is connected with sampling injector (9) by conduction hose (81), during sampling and testing, extracts the sample liquid of predetermined amount by sampling injector (9), and this kind of sampling mode, samples more accurate.
4, the utility model water bath (2) bottom is communicated with discharging tube (10), discharging tube (10) external part is connected to liquid sump (11), liquid sump (11) endpiece is communicated to water bath (2) by drawing liquid pump (12), meanwhile, liquid sump (11) bottom is provided with incrustation scale adsorbed layer (14), between liquid sump (11) and drawing liquid pump (12), near liquid sump (11) one sides, be provided with filtrator (13), this kind of design makes this Dissolution Rate Testing device when duty not, liquid in water bath (2) can export in liquid sump (11) by discharging tube (10), avoid heater strip (201) to be immersed in for a long time in water, surface deposition incrustation scale, cause heater strip (201) surface radiating inequality or short circuit, simultaneously, the filtrator (13) increasing and incrustation scale adsorbed layer (14) can avoid the incrustation scale of precipitation again to enter water bath (2), extend the serviceable life of this dissolution rate proving installation.
5, the utility model stripping rotor (3) sidewall is provided with the spacing line of liquid level (302), the liquid of avoiding operator to add in stripping rotor is too much, help the location to the interior liquid level of water bath (2) simultaneously, guarantee that the interior liquid level of water bath (2), all the time higher than the liquid level in stripping rotor (3), guarantees the normal work of this Dissolution Rate Testing device.
Accompanying drawing explanation
Fig. 1 is the structural representation of the utility model modified Dissolution Rate Testing device.
Embodiment
Consulting 1 pair of the utility model of accompanying drawing is described further.
The utility model relates to a kind of modified Dissolution Rate Testing device, it is characterized in that, structure comprises fixed support (1), on fixed support (1), be provided with water bath (2), the interior upper arm of water bath (2) is provided with location base station (21), water bath (2) is inner is fixed with stripping rotor (3) by location base station (21), and stripping rotor (3) inside is provided with stirrer (4), and stirrer (4) is connected with motor (51) by bull stick (5); Described stripping rotor (3) is set to transparent hermetically-sealed construction, stripping rotor (3) left side is provided with the sample feeding pipe (6) being affixed with left side wall, stripping rotor (3) right side side is provided with stopple coupon (7), stopple coupon (7) endpiece is connected to collection sample cup (8), stopple coupon (7) is provided with sealing shroud (71) with collection sample cup (8) junction, and collection sample cup (8) is connected with sampling injector (9) by conduction hose (81); Water bath (2) bottom is communicated with discharging tube (10), and discharging tube (10) external part is connected to liquid sump (11), and liquid sump (11) endpiece is communicated to water bath (2) by drawing liquid pump (12).
Preferably, as improvement, described stripping rotor (3) wall is provided with the interlayer (32) of hollow structure, and interlayer (32) is transported pipeline (15) by gas and is communicated with helium hold-up vessel (16).
Preferably, as improvement, described interlayer (32) bottom is provided with the micropore (301) that can pass through for nitrogen near stirrer (4) one sides.
Preferably, as improvement, described stripping rotor (3) sidewall is provided with the spacing line of liquid level (302).
Preferably, as improvement, described stirrer (4) is provided with 3 groups of paddle wheels (41), one group of paddle wheel (41) in the middle of being positioned at is horizontally disposed with, near one group of impeller (41) of stripping rotor (3) bottom to stripping rotor (3) bottom deflection, away from one group of impeller (41) of nearly stripping rotor (3) bottom to stripping rotor (3) top deflection.
Preferably, as improvement, described stripping rotor (3) outer rim is provided with locator card platform (31), and locator card platform (31) matches with the location base station (21) on water bath (2).
Preferably, as improvement, described water bath (2) sidewall and bottom are provided with heater strip (201), and the heater strip (201) that is positioned at sidewall is set to dissymmetrical structure.
Preferably, as improvement, described liquid sump (11) bottom is provided with incrustation scale adsorbed layer (14), between liquid sump (11) and drawing liquid pump (12), near liquid sump (11) one sides, is provided with filtrator (13).
Preferably, as improvement, described discharging tube (10) is provided with the first operation valve (101) near water bath (2) one sides.
Preferably, as improvement, described stopple coupon (7) is provided with the second operation valve (701) near stripping rotor (3) one sides, between the second operation valve (701) and stripping rotor (3), is provided with sampling pump (72).
Compared with prior art, 3 groups of paddle wheels (41) that the utility model relates to extend to the different directions of stripping rotor, make the mixing effect of stirrer (4) better, that stirs is more even, meanwhile, stripping rotor (3) wall is provided with the interlayer (32) of hollow structure, interlayer (32) is transported pipeline (15) by gas and is communicated with helium hold-up vessel (16), helium in helium hold-up vessel (16) enters stripping rotor (3) by micropore (301), this kind of design, can avoid the inner stirring dead angle of stripping rotor (3), make inner liquid more even, in addition, also help the discharge of the water-soluble gas such as liquid internal oxygen.
Stripping rotor of the present utility model (3) and collection sample cup (8) are all set to Semi-seal structure, and the volatilization of liquid has been avoided in this kind of design, has guaranteed to greatest extent the stability of internal environment, improve the accuracy of dissolution rate test.
The utility model collection sample cup (8) is connected with sampling injector (9) by conduction hose (81), during sampling and testing, extracts the sample liquid of predetermined amount by sampling injector (9), and this kind of sampling mode, samples more accurate.
The utility model water bath (2) bottom is communicated with discharging tube (10), discharging tube (10) external part is connected to liquid sump (11), liquid sump (11) endpiece is communicated to water bath (2) by drawing liquid pump (12), meanwhile, liquid sump (11) bottom is provided with incrustation scale adsorbed layer (14), between liquid sump (11) and drawing liquid pump (12), near liquid sump (11) one sides, be provided with filtrator (13), this kind of design makes this Dissolution Rate Testing device when duty not, liquid in water bath (2) can export in liquid sump (11) by discharging tube (10), avoid heater strip (201) to be immersed in for a long time in water, surface deposition incrustation scale, cause heater strip (201) surface radiating inequality or short circuit, simultaneously, the filtrator (13) increasing and incrustation scale adsorbed layer (14) can avoid the incrustation scale of precipitation again to enter water bath (2), extend the serviceable life of this dissolution rate proving installation.
The utility model stripping rotor (3) sidewall is provided with the spacing line of liquid level (302), the liquid of avoiding operator to add in stripping rotor is too much, help the location to the interior liquid level of water bath (2) simultaneously, guarantee that the interior liquid level of water bath (2), all the time higher than the liquid level in stripping rotor (3), guarantees the normal work of this Dissolution Rate Testing device.
The utility model in use, in water bath (2), be injected with warm body lotion body, be generally pure water, utilize heater strip (201) to carry out constant heating, guarantee that the interior temperature of water bath (2) is within the scope of constant preset value, when Dissolution Rate Testing finishes, open the first operation valve (101), in warm body lotion in water bath (2) is exported to, when carrying out dissolution rate testing experiment, close the first operation valve (101), open drawing liquid pump (12), purifying waste water after filtrator (13) and incrustation scale adsorbed layer (14) purification exported in water bath (2), in dissolution rate testing experiment process, mixed liquor to be measured enters in stripping rotor (3) by sample feeding pipe (6), under the cooperation of bull stick (5) and motor (51), stirrer (4) at the uniform velocity rotates, the circulation of impeller (41) Spin-up stripping rotor (3) internal liquid and medicine particle dissolve, helium by helium hold-up vessel (16) output enters stripping rotor (3) through gas transhipment pipeline (15) and micropore (301) successively, helium bottom right moves upward, accelerate the circulation of stripping rotor internal liquid, accelerate to stir motion and the grain dissolution of liquid in dead angle, the gas that is dissolved in liquid in stripping rotor can be discharged to stripping rotor (3) by sample feeding pipe (6) simultaneously, medicine mixed liquor after dissolving is exported by stopple coupon (7), during sampling, open the second operation valve (701), utilize sampling pump (72) that the inner liquid of stripping rotor (3) is exported in collection sample cup (8), further utilize sampling injector (9) accurately to sample, carry out follow-up dependence test.
According to above explanation, can complete application of the present utility model.
The above; it is only preferably embodiment of the utility model; but protection domain of the present utility model is not limited to this; anyly be familiar with those skilled in the art in the technical scope that the utility model discloses; according to the technical solution of the utility model and utility model design thereof, be equal to replacement or changed, within all should being encompassed in protection domain of the present utility model.
Claims (10)
1. a modified Dissolution Rate Testing device, it is characterized in that, structure comprises fixed support (1), on fixed support (1), be provided with water bath (2), the interior upper arm of water bath (2) is provided with location base station (21), water bath (2) is inner is fixed with stripping rotor (3) by location base station (21), and stripping rotor (3) inside is provided with stirrer (4), and stirrer (4) is connected with motor (51) by bull stick (5); Described stripping rotor (3) is set to transparent hermetically-sealed construction, stripping rotor (3) left side is provided with the sample feeding pipe (6) being affixed with left side wall, stripping rotor (3) right side side is provided with stopple coupon (7), stopple coupon (7) endpiece is connected to collection sample cup (8), stopple coupon (7) is provided with sealing shroud (71) with collection sample cup (8) junction, and collection sample cup (8) is connected with sampling injector (9) by conduction hose (81); Water bath (2) bottom is communicated with discharging tube (10), and discharging tube (10) external part is connected to liquid sump (11), and liquid sump (11) endpiece is communicated to water bath (2) by drawing liquid pump (12).
2. modified Dissolution Rate Testing device according to claim 1, is characterized in that, described stripping rotor (3) wall is provided with the interlayer (32) of hollow structure, and interlayer (32) is transported pipeline (15) by gas and is communicated with helium hold-up vessel (16).
3. modified Dissolution Rate Testing device according to claim 2, is characterized in that, described interlayer (32) bottom is provided with the micropore (301) that can pass through for nitrogen near stirrer (4) one sides.
4. modified Dissolution Rate Testing device according to claim 1, is characterized in that, described stripping rotor (3) sidewall is provided with the spacing line of liquid level (302).
5. modified Dissolution Rate Testing device according to claim 1, it is characterized in that, described stirrer (4) is provided with 3 groups of paddle wheels (41), one group of paddle wheel (41) in the middle of being positioned at is horizontally disposed with, near one group of impeller (41) of stripping rotor (3) bottom to stripping rotor (3) bottom deflection, away from one group of impeller (41) of nearly stripping rotor (3) bottom to stripping rotor (3) top deflection.
6. modified Dissolution Rate Testing device according to claim 1, is characterized in that, described stripping rotor (3) outer rim is provided with locator card platform (31), and locator card platform (31) matches with the location base station (21) on water bath (2).
7. modified Dissolution Rate Testing device according to claim 1, is characterized in that, described water bath (2) sidewall and bottom are provided with heater strip (201), and the heater strip (201) that is positioned at sidewall is set to dissymmetrical structure.
8. modified Dissolution Rate Testing device according to claim 1, it is characterized in that, described liquid sump (11) bottom is provided with incrustation scale adsorbed layer (14), between liquid sump (11) and drawing liquid pump (12), near liquid sump (11) one sides, is provided with filtrator (13).
9. modified Dissolution Rate Testing device according to claim 1, is characterized in that, described discharging tube (10) is provided with the first operation valve (101) near water bath (2) one sides.
10. modified Dissolution Rate Testing device according to claim 1, it is characterized in that, described stopple coupon (7) is provided with the second operation valve (701) near stripping rotor (3) one sides, between the second operation valve (701) and stripping rotor (3), is provided with sampling pump (72).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420243202.4U CN203824993U (en) | 2014-05-13 | 2014-05-13 | Improved dissolubility testing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420243202.4U CN203824993U (en) | 2014-05-13 | 2014-05-13 | Improved dissolubility testing device |
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| Publication Number | Publication Date |
|---|---|
| CN203824993U true CN203824993U (en) | 2014-09-10 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420243202.4U Expired - Lifetime CN203824993U (en) | 2014-05-13 | 2014-05-13 | Improved dissolubility testing device |
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| Country | Link |
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| CN (1) | CN203824993U (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106442904A (en) * | 2016-09-23 | 2017-02-22 | 梁永革 | Test instrument for dissolution rate of drugs |
| CN108931616A (en) * | 2018-07-19 | 2018-12-04 | 天津赛普瑞实验设备有限公司 | A kind of temperature automatically controlled digestion instrument that can deaerate in real time to dissolution medium |
| CN109078665A (en) * | 2018-09-05 | 2018-12-25 | 江苏德威新材料股份有限公司 | Thermostatical oil bath |
| CN111474082A (en) * | 2020-06-04 | 2020-07-31 | 神华准格尔能源有限责任公司 | Research device for migration rule of elements in coal |
-
2014
- 2014-05-13 CN CN201420243202.4U patent/CN203824993U/en not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106442904A (en) * | 2016-09-23 | 2017-02-22 | 梁永革 | Test instrument for dissolution rate of drugs |
| CN106442904B (en) * | 2016-09-23 | 2018-08-17 | 梁永革 | A kind of drug dissolution tester |
| CN108931616A (en) * | 2018-07-19 | 2018-12-04 | 天津赛普瑞实验设备有限公司 | A kind of temperature automatically controlled digestion instrument that can deaerate in real time to dissolution medium |
| CN109078665A (en) * | 2018-09-05 | 2018-12-25 | 江苏德威新材料股份有限公司 | Thermostatical oil bath |
| CN111474082A (en) * | 2020-06-04 | 2020-07-31 | 神华准格尔能源有限责任公司 | Research device for migration rule of elements in coal |
| CN111474082B (en) * | 2020-06-04 | 2023-02-03 | 神华准格尔能源有限责任公司 | Research device for migration rule of elements in coal |
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| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20140910 |