CN110907616B - Medicine dissolution instrument for analyzing medicine dissolution rate - Google Patents
Medicine dissolution instrument for analyzing medicine dissolution rate Download PDFInfo
- Publication number
- CN110907616B CN110907616B CN201911259005.5A CN201911259005A CN110907616B CN 110907616 B CN110907616 B CN 110907616B CN 201911259005 A CN201911259005 A CN 201911259005A CN 110907616 B CN110907616 B CN 110907616B
- Authority
- CN
- China
- Prior art keywords
- rod
- plate
- drug dissolution
- spring
- box body
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 53
- 238000004090 dissolution Methods 0.000 title claims abstract description 45
- 229940079593 drug Drugs 0.000 title claims abstract description 34
- 238000001514 detection method Methods 0.000 claims abstract description 29
- 238000004458 analytical method Methods 0.000 claims abstract description 18
- 238000010438 heat treatment Methods 0.000 claims abstract description 11
- 238000003756 stirring Methods 0.000 claims description 21
- 230000005540 biological transmission Effects 0.000 claims description 13
- 238000005192 partition Methods 0.000 claims description 13
- 230000003028 elevating effect Effects 0.000 claims description 8
- 238000009434 installation Methods 0.000 claims description 5
- 230000002349 favourable effect Effects 0.000 abstract description 6
- 239000007788 liquid Substances 0.000 abstract description 5
- 238000005094 computer simulation Methods 0.000 abstract description 2
- 230000007613 environmental effect Effects 0.000 abstract description 2
- 230000009286 beneficial effect Effects 0.000 description 6
- 230000001788 irregular Effects 0.000 description 6
- 238000007789 sealing Methods 0.000 description 6
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000011435 rock Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000012738 dissolution medium Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention discloses a drug dissolution instrument for drug dissolution analysis, which comprises a box body, a cover plate and a motor, wherein heating components are uniformly arranged at the bottom end inside the box body, the cover plate is arranged at the top end of the box body, a bearing net is arranged below a detection flask, a connecting ring is arranged on the inner side of a limiting structure, a clamping mechanism is arranged on the inner side of the cover plate, a fixing plug is arranged at the top of the inner side of the detection flask, driving wheels are arranged on the outer side of a driving rod at equal intervals, and a third spring is connected below a driven plate. This medicine is dissolved out appearance for dissolution analysis of medicine is convenient for bear the weight of the basket body, is favorable to guaranteeing the stability of basket body, and the basket body of equidimension not of being convenient for uses, is convenient for carry out stable fixed to the basket body, is convenient for guarantee the sealed of basket body, is favorable to guaranteeing the rapid heating, and is favorable to dynamic simulation human internal liquid environmental condition, is favorable to guaranteeing the accuracy of test structure.
Description
Technical Field
The invention relates to the technical field of medical treatment, in particular to a drug dissolution instrument for drug dissolution analysis.
Background
Before the oral medicament is put into use, a large number of test analyses are required to ensure the use safety of the medicament, the dissolution rate is the dissolution rate and degree of the medicament under specified conditions and is an important index for evaluating the quality of the medicament, so a medicament dissolution instrument is required to perform the test analysis on the medicament;
however, the drug dissolution device in the background of the prior art still has certain disadvantages when in use, such as:
1. the basket body is inconvenient to bear, the stability of the basket body is not guaranteed, and the basket bodies with different sizes are inconvenient to use;
2. the basket body is not convenient to be fixed stably, the sealing of the basket body is not convenient to be ensured, and the quick heating is not convenient to be ensured;
3. the device is not beneficial to dynamically simulating the internal liquid environment condition of the human body and ensuring the accuracy of the test structure.
Therefore, we propose a drug dissolution apparatus for drug dissolution analysis so as to solve the problems proposed in the above.
Disclosure of Invention
The invention aims to provide a drug dissolution instrument for drug dissolution analysis, which solves the problems that the existing drug dissolution instrument in the background art is inconvenient to bear a basket body, guarantee the stability of the basket body, use basket bodies with different sizes, stably fix the basket body, guarantee the sealing of the basket body, guarantee rapid heating, dynamically simulate the internal liquid environment condition of a human body and guarantee the accuracy of a test structure.
In order to achieve the purpose, the invention provides the following technical scheme: a medicine dissolving-out instrument for analyzing medicine dissolution rate comprises a box body, a cover plate and a motor, wherein heating assemblies are uniformly arranged at the bottom inside the box body, a lifting lead screw is connected to the rear side of the box body, supporting rods are arranged on the left side and the right side of the lifting lead screw, the top ends of the lifting lead screw and the supporting rods are connected with the bottom end face of a top plate, a telescopic rod is installed at the bottom end of the top plate, a lifting platform is connected with the bottom end of the telescopic rod, the cover plate is arranged at the top end of the box body, a detection flask is arranged on the inner side of the cover plate, a bearing net is installed below the detection flask, a limiting structure is connected to the bottom end of the bearing net, a connecting ring is arranged on the inner side of the connecting ring, a connecting rod is installed on the inner side of the connecting ring, a partition plate is fixedly welded inside the box body, and cavities located inside the box body are formed between the partition plate and the partition plate, clamping mechanism is installed to the inboard of apron, and clamping mechanism includes intermediate lever, punch holder, lower plate and second spring, the top and the end of intermediate lever are connected with punch holder and lower plate respectively, and the outside of intermediate lever is connected with the second spring, detect the inboard top of flask and install the fixed stopper, and the inboard of fixed stopper is provided with the puddler, the stirring leaf is installed to the bottom of puddler, and the outside of puddler is provided with the installation pipe that is located the fixed stopper top, the inside at the bracing piece is installed to the motor, and the output of motor is connected with the transfer line, the outside equidistant drive wheel that is provided with of transfer line, and the below of drive wheel is provided with the driven plate, the below of driven plate is connected with the third spring, and the below of driven plate still is connected with the fourth spring that is located the inboard of third spring.
Preferably, the lifting platform forms a lifting structure between the box body and the top plate, the lifting screw rod and the supporting rod penetrate through the lifting platform, and the telescopic rods are symmetrically arranged between the lifting platform and the top plate.
Preferably, the bottom avris of apron is pasted and is connected with sealed the pad, and the protruding structure and the groove structure of apron bottom avris all are right trapezoid structure to this protruding structure and groove structure parallel arrangement, the apron is connected through sealed inseparable block between filling up and the box simultaneously.
Preferably, the overlap joint between the bottom of detecting the flask and the bearing net, and the bearing net is network structure to welded fastening between bearing net and the limit structure, and limit structure includes loop bar, dead lever and the first spring of fixed connection between loop bar and dead lever.
Preferably, the bottom end of the loop bar is connected with the top end of the fixed bar in a telescopic mode through a first spring, the loop bar is connected with the connecting bar through a connecting ring, and the connecting bar is rotatably connected with the box body.
Preferably, the bottom of connecting rod is helicitic texture, and the bottom of connecting rod is gear column structure to the bottom of connecting rod and adjust the one-to-one meshing between the pole and be connected, adjust the pole setting simultaneously and in the left side of connecting rod.
Preferably, intermediate lever, punch holder and lower plate all are the arc structure, and the place plane of punch holder and lower plate is perpendicular with the place plane of intermediate lever to articulated between the outside intermediate position of intermediate lever and the apron, the outside top of intermediate lever passes through flexible connection between second spring and the apron moreover.
Preferably, the stirring rod comprises a lower stretching rod and a fixing ball, the lower stretching rod and the fixing ball are of an integrated structure, and the lower stretching rod is rotatably connected with the fixing plug through the fixing ball.
Preferably, the driving wheel and the motor form a driving structure through a driving rod, the driving wheel is in an eccentric wheel structure in shape, and the driving wheel and the driven plate are arranged in a one-to-one correspondence manner.
Preferably, the driven plate is connected with the lifting platform in a telescopic mode through a third spring, the driven plate is connected with a pressing plate in a telescopic mode through a fourth spring, and the pressing plate and the lower stretching rod are correspondingly arranged.
Compared with the prior art, the invention has the beneficial effects that: the medicine dissolution instrument for analyzing the medicine dissolution rate is convenient for bearing the basket body, is beneficial to ensuring the stability of the basket body, is convenient for using basket bodies with different sizes, is convenient for stably fixing the basket body, is convenient for ensuring the sealing of the basket body, is beneficial to ensuring rapid heating, is beneficial to dynamically simulating the liquid environment condition in a human body, and is beneficial to ensuring the accuracy of a test structure;
1. through a gear worm structure formed between the adjusting rod and the connecting rod, the lifting adjustment of the bearing net is facilitated through the threaded connection between the connecting rod and the connecting ring, so that the bearing of the detection flask is facilitated, and the stability of the basket body is ensured;
2. the cover plate is tightly clamped with the box body through the sealing gasket, and the upper clamping plate and the lower clamping plate are convenient to clamp the detection flask through the rotation between the middle rod and the cover plate, so that the stable fixation of the detection flask is convenient to guarantee;
3. through the fixed stopper with detect being connected between the flask, be convenient for guarantee the leakproofness of detecting the flask, and receive the irregular of striking back through third spring and fourth spring and rock, be convenient for make the clamp plate carry out irregular striking to the lower pole that stretches, so that the stirring leaf irregularly rocks, and then is favorable to the human inside liquid environmental condition of dynamic simulation, is favorable to guaranteeing the accuracy of test structure.
Drawings
FIG. 1 is a front sectional view of the present invention;
FIG. 2 is a schematic side view of the present invention;
FIG. 3 is an enlarged view of portion A of FIG. 1 according to the present invention;
FIG. 4 is a schematic view of a connecting structure of a connecting rod and an adjusting rod according to the present invention;
FIG. 5 is a schematic view of a sectional view of the case of the present invention;
FIG. 6 is an enlarged view of portion B of FIG. 1 according to the present invention;
FIG. 7 is a schematic view of the natural state structure of the clamping mechanism of the present invention;
FIG. 8 is an enlarged view of the portion C of FIG. 1 according to the present invention;
fig. 9 is a side sectional structure diagram of the elevating platform of the present invention.
In the figure: 1. a box body; 2. a heating assembly; 3. a lifting screw rod; 4. a support bar; 5. a lifting platform; 6. a top plate; 7. a telescopic rod; 8. a cover plate; 9. a gasket; 10. detecting the flask; 11. a carrying net; 12. a limiting structure; 1201. a loop bar; 1202. a first spring; 1203. fixing the rod; 13. a connecting ring; 14. a connecting rod; 15. adjusting a rod; 16. a partition plate; 17. a cavity; 18. a clamping mechanism; 1801. an intermediate lever; 1802. an upper splint; 1803. a lower splint; 1804. a second spring; 19. a fixed plug; 20. a stirring rod; 2001. a lower extension rod; 2002. fixing the ball; 21. stirring blades; 22. installing a pipe; 23. a motor; 24. a transmission rod; 25. a driving wheel; 26. a driven plate; 27. a third spring; 28. a fourth spring; 29. and (7) pressing a plate.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-9, the present invention provides a technical solution: a drug dissolution instrument for drug dissolution analysis comprises a box body 1, a heating component 2, a lifting screw rod 3, a support rod 4, a lifting table 5, a top plate 6, a telescopic rod 7, a cover plate 8, a sealing gasket 9, a detection flask 10, a bearing net 11, a limiting structure 12, a connecting ring 13, a connecting rod 14, an adjusting rod 15, a partition plate 16, a containing cavity 17, a clamping mechanism 18, a fixing plug 19, a stirring rod 20, a stirring blade 21, an installation pipe 22, a motor 23, a transmission rod 24, a transmission wheel 25, a driven plate 26, a third spring 27, a fourth spring 28 and a pressing plate 29, wherein the heating component 2 is uniformly arranged at the bottom end in the box body 1, the lifting screw rod 3 is connected with the rear side of the box body 1, the support rod 4 is arranged on the left side and the right side of the lifting screw rod 3, the top ends of the lifting screw rod 3 and the support rod 4 are connected with the bottom end face of the top plate 6, the telescopic rod 7 is arranged at the bottom end of the top plate 6, the bottom end of the telescopic rod 7 is connected with the lifting platform 5, the cover plate 8 is arranged at the top end of the box body 1, the inner side of the cover plate 8 is provided with a detection flask 10, a bearing net 11 is arranged below the detection flask 10, the bottom end of the bearing net 11 is connected with a limiting structure 12, the inner side of the limiting structure 12 is provided with a connecting ring 13, the inner side of the connecting ring 13 is provided with a connecting rod 14, the inner part of the box body 1 is fixedly welded with a partition plate 16, a containing cavity 17 positioned in the box body 1 is respectively arranged between the partition plate 16 and the box body 1 and between the partition plate 16 and the partition plate 16, the inner side of the cover plate 8 is provided with a clamping mechanism 18, the clamping mechanism 18 comprises an intermediate rod 1801, an upper clamping plate 1802, a lower clamping plate 1803 and a second spring 1804, the top end and the tail end of the intermediate rod 1801 are respectively connected with the upper clamping plate 1802 and the lower clamping plate 1803, the outer side of the intermediate rod 1801 is connected with the second spring 1804, the top of the inner side of the detection flask 10 is provided with a fixing plug 19, and the inner side of the fixed plug 19 is provided with a stirring rod 20, the bottom end of the stirring rod 20 is provided with a stirring blade 21, the outer side of the stirring rod 20 is provided with an installation pipe 22 positioned at the top end of the fixed plug 19, the motor 23 is installed inside the support rod 4, the output end of the motor 23 is connected with a transmission rod 24, the outer side of the transmission rod 24 is provided with transmission wheels 25 at equal intervals, a driven plate 26 is arranged below the transmission wheels 25, a third spring 27 is connected below the driven plate 26, and a fourth spring 28 positioned at the inner side of the third spring 27 is further connected below the driven plate 26.
Like in fig. 1 and 2 elevating platform 5 constitutes elevation structure between box 1 and roof 6, and lift lead screw 3 and bracing piece 4 all run through elevating platform 5, and telescopic link 7 is installed to the symmetry between elevating platform 5 and the roof 6, be convenient for go up and down, thereby be convenient for detect the installation dismantlement of flask 10, be convenient for operate, paste to be connected with sealed pad 9 as the bottom avris of apron 8 in fig. 1 and 7, and the protruding structure and the groove structure of 8 bottom avris of apron all are right trapezoid structure, and this protruding structure and groove structure parallel arrangement, apron 8 is connected through sealed inseparable block between 9 and the box 1 simultaneously, be convenient for install apron 8, be convenient for guarantee the leakproofness through sealed pad 9.
As shown in the figures 2 and 3, the bottom end of the detection flask 10 is lapped with the bearing net 11, the bearing net 11 is in a net structure, the bearing net 11 is welded and fixed with the limiting structure 12, the limiting structure 12 comprises a loop bar 1201, a fixing rod 1203 and a first spring 1202 fixedly connected between the loop bar 1201 and the fixing rod 1203, the detection flask 10 is conveniently supported, the bottom end of the loop bar 1201 is telescopically connected with the top end of the fixing rod 1203 through the first spring 1202, the loop bar 1201 is connected with the connecting rod 14 through a connecting ring 13, the connecting rod 14 is rotatably connected with the box body 1, the height of the bearing net 11 is conveniently adjusted, the deflection of the bearing net 11 is avoided, the bottom end of the connecting rod 14 is in a thread structure, the bottom end of the connecting rod 14 is in a gear-like structure, the bottom end of the connecting rod 14 is in one-to-one meshing connection with the adjusting rod 15, and the adjusting rod 15 is arranged at the left side of the connecting rod 14, is convenient to operate and adjust and use.
As shown in fig. 6 and 7, the middle rod 1801, the upper clamp plate 1802 and the lower clamp plate 1803 are all in an arc-shaped structure, the plane of the upper clamp plate 1802 and the plane of the lower clamp plate 1803 are perpendicular to the plane of the middle rod 1801, the middle position of the outer side of the middle rod 1801 is hinged to the cover plate 8, the top of the outer side of the middle rod 1801 is telescopically connected to the cover plate 8 through a second spring 1804, so that the detection flask 10 can be clamped and fixed through the upper clamp plate 1802 and the lower clamp plate 1803, the stirring rod 20 comprises a lower stretching rod 2001 and a fixing ball 2002, the lower stretching rod 2001 and the fixing ball 2002 are in an integrated structure, and the lower stretching rod 2001 is rotatably connected to the fixing plug 19 through the fixing ball 2002, so that irregular shaking of the lower stretching rod 2001 is facilitated.
As shown in fig. 8 and 9, the driving wheel 25 and the motor 23 form a driving structure through the driving rod 24, the driving wheel 25 is in an eccentric wheel structure, and the driving wheel 25 and the driven plate 26 are correspondingly arranged one by one, so as to facilitate the driving of the driven plate 26 through the driving wheel 25, the driven plate 26 is telescopically connected with the lifting platform 5 through the third spring 27, the driven plate 26 is telescopically connected with the pressing plate 29 through the fourth spring 28, and the pressing plate 29 and the downward extending rod 2001 are correspondingly arranged, so as to facilitate the impact of the downward extending rod 2001, so as to facilitate the irregular shaking of the medicine inside the detection flask 10 through the stirring blade 21.
The working principle is as follows: when the medicine dissolution instrument for analyzing the medicine dissolution rate is used, firstly, a proper amount of plasma water is added into the box body 1, according to different specifications of the used detection flask 10, the adjusting rod 15 is rotated, so that the adjusting rod 15 drives the connecting rod 14 to rotate through the meshing connection between the adjusting rod 15 and the connecting rod 14, the connecting rod 14 drives the connecting ring 13 to lift, the connecting ring 13 is connected with the bearing net 11 through the sleeve rod 1201, the bearing net 11 is lifted, and meanwhile, the sleeve rod 1201 is in telescopic connection with the first spring 1202 through the fixing rod 1203, the stability of the structure is ensured, and the adjustment and the use are facilitated;
then, water in the box body 1 is heated to 37 +/-0.5 ℃ through the heating assembly 2, dissolution media are poured into the detection flask 10, the detection flask 10 is placed on the bearing net 11, a through hole in the middle of the cover plate 8 penetrates through the detection flask 10, so that the cover plate 8 is tightly clamped at the top end of the box body 1 through the sealing gasket 9, the top of the detection flask 10 touches the upper clamping plate 1802 while the cover plate 8 is clamped, the middle rod 1801 rotates on the inner side of the cover plate 8, the upper clamping plate 1802 and the lower clamping plate 1803 are respectively attached to the outer sides of the detection flask 10, the detection flask 10 is clamped, and the stability of the middle rod 1801 is conveniently ensured through the elastic action of the second spring 1804, so that the detection flask 10 is conveniently fixed;
then, a downward extending rod 2001 of a stirring blade 21 with a flexible structure at the bottom is connected to the lower part of the lifting platform 5 through a fixing plug 19 and a mounting pipe 22 in a threaded manner, the lifting platform 5 descends through the rotation of the lifting screw rod 3, so that the downward extending rod 2001 connected with the bottom end of the lifting platform 5 is correspondingly inserted into the detection flask 10, and the flexible structure of the stirring blade 21 does not influence the in-and-out of the downward extending rod 2001, so that the fixing plug 19 is connected to the inner side of the detection flask 10, and the detection flask 10 is sealed, so that the test accuracy is ensured;
then the motor 23 with the model number of Y90S-2 is started to drive the transmission wheel 25 to rotate through the transmission rod 24, so as to impact the driven plate 26 through the eccentric wheel structure of the driving wheel 25, so that the driven plate 26 is telescopically shaken at the inner side of the lifting platform 5 through the third spring 27, and simultaneously the driven plate 26 drives the pressing plate 29 to telescopically shake through the fourth spring 28, so that the pressing plate 29 can impact the lower stretching rod 2001 irregularly, and the lower stretching rod 2001 can rotate irregularly through the fixing ball 2002, so as to facilitate the irregular movement of the stirring blade 21, so as to simulate irregular movement of effusion in a human body, which is the whole working process of the drug dissolution instrument for analyzing the drug dissolution rate, and the content which is not described in detail in the specification belongs to the prior art known by professionals in the field.
The standard parts used in the invention can be purchased from the market, the special-shaped parts can be customized according to the description of the specification and the accompanying drawings, the specific connection mode of each part adopts conventional means such as bolts, rivets, welding and the like mature in the prior art, the machines, the parts and equipment adopt conventional models in the prior art, and the circuit connection adopts the conventional connection mode in the prior art, so that the detailed description is omitted.
Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that various changes in the embodiments and/or modifications of the invention can be made, and equivalents and modifications of some features of the invention can be made without departing from the spirit and scope of the invention.
Claims (10)
1. The utility model provides a medicine is dissolved out appearance for analysis of medicine degree of dissolving, includes box (1), apron (8) and motor (23), its characterized in that: the heating components (2) are uniformly arranged at the bottom end inside the box body (1), the rear side of the box body (1) is connected with a lifting screw rod (3), supporting rods (4) are arranged on the left side and the right side of the lifting screw rod (3), the top ends of the lifting screw rod (3) and the supporting rods (4) are connected with the bottom end face of a top plate (6), a telescopic rod (7) is installed at the bottom end of the top plate (6), the bottom end of the telescopic rod (7) is connected with a lifting platform (5), a cover plate (8) is arranged at the top end of the box body (1), a detection flask (10) is arranged on the inner side of the cover plate (8), a bearing net (11) is installed below the detection flask (10), the bottom end of the bearing net (11) is connected with a limiting structure (12), a connecting ring (13) is arranged on the inner side of the limiting structure (12), and a connecting rod (14) is installed on the inner side of the connecting ring (13), the inner side of the box body (1) is fixedly welded with a partition plate (16), an accommodating cavity (17) located in the box body (1) is formed between the partition plate (16) and the box body (1) and between the partition plate (16) and the partition plate (16), a clamping mechanism (18) is installed on the inner side of the cover plate (8), the clamping mechanism (18) comprises an intermediate rod (1801), an upper clamping plate (1802), a lower clamping plate (1803) and a second spring (1804), the top end and the tail end of the intermediate rod (1801) are respectively connected with the upper clamping plate (1802) and the lower clamping plate (1803), the outer side of the intermediate rod (1801) is connected with the second spring (1804), a fixing plug (19) is installed at the top of the inner side of the detection flask (10), a stirring rod (20) is arranged on the inner side of the fixing plug (19), a stirring blade (21) is installed at the bottom end of the stirring rod (20), and an installation pipe (22) located at the top end of the fixing plug (19) is arranged on the outer side of the stirring rod (20), the motor (23) is installed in the supporting rod (4), the output end of the motor (23) is connected with a transmission rod (24), transmission wheels (25) are arranged on the outer side of the transmission rod (24) at equal intervals, a driven plate (26) is arranged below the transmission wheels (25), a third spring (27) is connected below the driven plate (26), and a fourth spring (28) located on the inner side of the third spring (27) is connected below the driven plate (26).
2. The drug dissolution apparatus for drug dissolution analysis of claim 1, wherein: elevating platform (5) constitute elevation structure between box (1) and roof (6), and elevating screw (3) and bracing piece (4) all run through elevating platform (5) to telescopic link (7) are installed to the symmetry between elevating platform (5) and roof (6).
3. The drug dissolution apparatus for drug dissolution analysis of claim 1, wherein: the bottom avris of apron (8) is pasted and is connected with sealed pad (9), and the protrusion structure and the groove structure of apron (8) bottom avris all are right trapezoid structure to this protrusion structure and groove structure parallel arrangement, apron (8) are connected through sealed inseparable block between (9) and box (1) simultaneously.
4. The drug dissolution apparatus for drug dissolution analysis of claim 1, wherein: the bottom of detecting flask (10) and bear the overlap joint between net (11), and bear net (11) and be network structure to bear between net (11) and limit structure (12) welded fastening, and limit structure (12) include loop bar (1201), dead lever (1203) and fixed connection at loop bar (1201) and dead lever (1203) between first spring (1202).
5. The drug dissolution apparatus for drug dissolution analysis of claim 4, wherein: the bottom end of the loop bar (1201) is connected with the top end of the fixing rod (1203) in a telescopic mode through a first spring (1202), the loop bar (1201) is connected with the connecting rod (14) through a connecting ring (13), and the connecting rod (14) is rotatably connected with the box body (1).
6. The drug dissolution apparatus for drug dissolution analysis of claim 1, wherein: the bottom of connecting rod (14) is helicitic texture, and the bottom of connecting rod (14) is gear column structure to the bottom of connecting rod (14) and adjust the one-to-one meshing between pole (15) and be connected, adjust pole (15) simultaneously and set up the left side at connecting rod (14).
7. The drug dissolution apparatus for drug dissolution analysis of claim 1, wherein: middle pole (1801), punch holder (1802) and lower plate (1803) all are the arc structure, and the place plane of punch holder (1802) and lower plate (1803) is perpendicular with the place plane of middle pole (1801), and articulated between the outside intermediate position of middle pole (1801) and apron (8), and the outside top of middle pole (1801) is through flexible connection between second spring (1804) and apron (8) moreover.
8. The drug dissolution apparatus for drug dissolution analysis of claim 1, wherein: the stirring rod (20) comprises a downward extending rod (2001) and a fixing ball (2002), the downward extending rod (2001) and the fixing ball (2002) are of an integrated structure, and the downward extending rod (2001) is rotatably connected with the fixing plug (19) through the fixing ball (2002).
9. The drug dissolution apparatus for drug dissolution analysis of claim 1, wherein: the driving wheel (25) and the motor (23) form a driving structure through the driving rod (24), the shape structure of the driving wheel (25) is an eccentric wheel structure, and the driving wheel (25) and the driven plate (26) are arranged in a one-to-one correspondence mode.
10. The drug dissolution apparatus for drug dissolution analysis of claim 1, wherein: the driven plate (26) is in telescopic connection with the lifting platform (5) through a third spring (27), the driven plate (26) is in telescopic connection with a pressing plate (29) through a fourth spring (28), and the pressing plate (29) and the lower extension rod (2001) are correspondingly arranged.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911259005.5A CN110907616B (en) | 2019-12-10 | 2019-12-10 | Medicine dissolution instrument for analyzing medicine dissolution rate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911259005.5A CN110907616B (en) | 2019-12-10 | 2019-12-10 | Medicine dissolution instrument for analyzing medicine dissolution rate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110907616A CN110907616A (en) | 2020-03-24 |
| CN110907616B true CN110907616B (en) | 2022-04-12 |
Family
ID=69824059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911259005.5A Expired - Fee Related CN110907616B (en) | 2019-12-10 | 2019-12-10 | Medicine dissolution instrument for analyzing medicine dissolution rate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110907616B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112326903A (en) * | 2020-11-02 | 2021-02-05 | 苏州安默医药科技有限公司 | Multi-dimensional bionic drug dissolution detection device and detection method |
Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100922184B1 (en) * | 2009-04-30 | 2009-10-19 | 정수영 | Dissolution tester for medicine |
| CN102375047A (en) * | 2011-07-15 | 2012-03-14 | 西南交通大学 | Method for determining release of chewing medicament and special chewing device thereof |
| CN202974998U (en) * | 2012-09-04 | 2013-06-05 | 天津创兴电子设备制造有限公司 | Drug dissolution tester with fourteen paddles and fourteen cups |
| CN103323393A (en) * | 2013-05-24 | 2013-09-25 | 新疆富科思生物技术发展有限公司 | A real-time optical-fiber medicine intrinsic dissolution determinator |
| CN104089879A (en) * | 2013-04-01 | 2014-10-08 | 上海富科思分析仪器有限公司 | Optical fiber-based drug dissolution rate and release rate process analyzer |
| CN106442904A (en) * | 2016-09-23 | 2017-02-22 | 梁永革 | Test instrument for dissolution rate of drugs |
| CN206788150U (en) * | 2017-04-10 | 2017-12-22 | 陈秀英 | A kind of instrument and equipment suitable for medicine dissolution detection |
| CN207457206U (en) * | 2017-11-30 | 2018-06-05 | 天津市医药集团技术发展有限公司 | A kind of new take-off basket for being used to detect drug dissolution |
| CN207816947U (en) * | 2017-12-04 | 2018-09-04 | 天津绿格瑞科技发展有限公司 | Damping type drug-eluting experiment instrument |
| CN208297294U (en) * | 2018-06-06 | 2018-12-28 | 天津赛普瑞实验设备有限公司 | It is a kind of can 12 paddle, 12 glasss of drug dissolution analyzers for using of subregion |
| CN208432531U (en) * | 2018-04-12 | 2019-01-25 | 开封明仁药业有限公司 | A kind of detection optical fiber drug dissolution the real time measure instrument |
| CN109917089A (en) * | 2019-03-27 | 2019-06-21 | 杭州谷典服饰有限公司 | Dissolution testing system |
| CN209215353U (en) * | 2018-11-14 | 2019-08-06 | 漯河医学高等专科学校 | A kind of pharmaceutical test medicament dissolution instrument |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11209410B2 (en) * | 2014-06-10 | 2021-12-28 | Logan Instruments Corporation | Dissolution tester assembly with integrated imaging system |
-
2019
- 2019-12-10 CN CN201911259005.5A patent/CN110907616B/en not_active Expired - Fee Related
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100922184B1 (en) * | 2009-04-30 | 2009-10-19 | 정수영 | Dissolution tester for medicine |
| CN102375047A (en) * | 2011-07-15 | 2012-03-14 | 西南交通大学 | Method for determining release of chewing medicament and special chewing device thereof |
| CN202974998U (en) * | 2012-09-04 | 2013-06-05 | 天津创兴电子设备制造有限公司 | Drug dissolution tester with fourteen paddles and fourteen cups |
| CN104089879A (en) * | 2013-04-01 | 2014-10-08 | 上海富科思分析仪器有限公司 | Optical fiber-based drug dissolution rate and release rate process analyzer |
| CN103323393A (en) * | 2013-05-24 | 2013-09-25 | 新疆富科思生物技术发展有限公司 | A real-time optical-fiber medicine intrinsic dissolution determinator |
| CN106442904A (en) * | 2016-09-23 | 2017-02-22 | 梁永革 | Test instrument for dissolution rate of drugs |
| CN206788150U (en) * | 2017-04-10 | 2017-12-22 | 陈秀英 | A kind of instrument and equipment suitable for medicine dissolution detection |
| CN207457206U (en) * | 2017-11-30 | 2018-06-05 | 天津市医药集团技术发展有限公司 | A kind of new take-off basket for being used to detect drug dissolution |
| CN207816947U (en) * | 2017-12-04 | 2018-09-04 | 天津绿格瑞科技发展有限公司 | Damping type drug-eluting experiment instrument |
| CN208432531U (en) * | 2018-04-12 | 2019-01-25 | 开封明仁药业有限公司 | A kind of detection optical fiber drug dissolution the real time measure instrument |
| CN208297294U (en) * | 2018-06-06 | 2018-12-28 | 天津赛普瑞实验设备有限公司 | It is a kind of can 12 paddle, 12 glasss of drug dissolution analyzers for using of subregion |
| CN209215353U (en) * | 2018-11-14 | 2019-08-06 | 漯河医学高等专科学校 | A kind of pharmaceutical test medicament dissolution instrument |
| CN109917089A (en) * | 2019-03-27 | 2019-06-21 | 杭州谷典服饰有限公司 | Dissolution testing system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110907616A (en) | 2020-03-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110907616B (en) | Medicine dissolution instrument for analyzing medicine dissolution rate | |
| CN208217122U (en) | A kind of auxiliary sack-filling device of feedbag | |
| CN207152964U (en) | A kind of limb rehabilitation training device | |
| CN210834596U (en) | Device for testing absorption rate of paper diaper | |
| CN211864778U (en) | Anesthesia reagent blending device for clinical medicine | |
| CN211577605U (en) | LCD module test fixture | |
| CN211583128U (en) | Intelligent step tester | |
| CN209846724U (en) | Art ceramic show shelf | |
| CN209453501U (en) | A kind of sphygmomanometer leakproofness maintenance detecting platform easy to remove | |
| CN111968456A (en) | Multi-functional teaching workstation of medical science | |
| CN210522413U (en) | Liquid preparation device for laboratory dialysis powder detection | |
| CN215608810U (en) | Eye wave physiotherapy equipment convenient to overhaul | |
| CN216870530U (en) | Medicine examination appearance that disintegrates convenient to it is clean | |
| CN215180109U (en) | Medicine dissolving-out instrument | |
| CN221148570U (en) | Textile pH value detection equipment | |
| CN220730986U (en) | Remote education device for education and training | |
| CN220213836U (en) | Adjustable multifunctional exercise training frame | |
| CN220001766U (en) | Shelter from structure convenient to children draw blood | |
| CN219982868U (en) | Sphygmomanometer calibrating device | |
| CN214108247U (en) | Transparent experimental cover for animals | |
| CN212697846U (en) | Dress designing is with convenient platemaking platform | |
| CN211553727U (en) | Quick check out test set of oral emulsion stability | |
| CN216963042U (en) | Liquid preparation equipment for pharmacy | |
| CN216286408U (en) | Electronic information display device for computer | |
| CN221229742U (en) | Infusion support with weighing function |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20220322 Address after: No. 4598 Jindu Road, Minhang District, Shanghai 201100 Applicant after: SHANGHAI XINYI TIANPING PHARMACEUTICAL CO.,LTD. Address before: 325000 room 219, Industrial Park Road, grape shed High-tech Industrial Park, Wenzhou, Zhejiang, China, 4 Applicant before: WENZHOU HONGLIANG MACHINERY TECHNOLOGY Co.,Ltd. |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20220412 |