CN205538936U - Medicine degree of dissolving out detecting system - Google Patents
Medicine degree of dissolving out detecting system Download PDFInfo
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- CN205538936U CN205538936U CN201620524166.8U CN201620524166U CN205538936U CN 205538936 U CN205538936 U CN 205538936U CN 201620524166 U CN201620524166 U CN 201620524166U CN 205538936 U CN205538936 U CN 205538936U
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- stripping rotor
- dissolution
- medicine
- sampling
- slide
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Abstract
The utility model provides a medicine degree of dissolving out detecting system. It is including dissolving out appearance, sampling device and discharging equipment. Dissolve out the appearance and have base and a plurality of subassembly that dissolves out, dissolve out the subassembly and can dismantle and connect in the base, dissolve out the subassembly and have body, slide, pivot, stirring component, dissolve out cup and heating device, head end swivelling joint in slide, tail end swivelling joint in the stirring component of pivot, the body is located to the slide cunning, the bottom of body is formed with the appearance cavity, dissolves out the cup and locates in the appearance cavity, heating device is used for heating dissolving out the cup, and heating device has power, a plurality of heating element and a heating jacket, and the internal face that holds the cavity is located in the outer wall subsides of heating jacket, and the equipartition has a plurality of heating element on the internal face of heating jacket, and a plurality of heating element electricity are connected in the power and are covered and locate the outer wall that dissolves out the cup, the equal sealing connection of sampling device and discharging equipment is in dissolving out the cup. This medicine degree of dissolving out detecting system can the rapid heating, convenient operation.
Description
Technical field
This utility model relates to a kind of dissolution testing system.
Background technology
The dissolution of medicine generally uses digestion instrument to measure.Use digestion instrument that the dissolution of medicine is entered
When row is measured, need to include being passed through solvent to stripping rotor, heating stripping rotor, input medicine, sampling detection
And detection terminate after the solution being made up of solvent and medicine in stripping rotor is poured out.Wherein, existing
In technology, stripping rotor is heated and generally uses heating in water bath, time-consuming long, the use inconvenience of heating；Take
Sample detection generally uses manually sampling, operation inconvenience；After having detected, need stripping rotor is taken out rear
Solution can be poured out, operation inconvenience.
Utility model content
The technical problems to be solved in the utility model is to overcome stripping rotor heating in prior art time-consuming
Defect long, unhandy, it is provided that a kind of dissolution testing system.
This utility model is to solve above-mentioned technical problem by following technical proposals:
A kind of dissolution testing system, including a digestion instrument, its feature is, described digestion instrument has
Having a base and enclose the multiple dissolution assemblies being located at described base, each described dissolution assembly removably connects
In described base, each described dissolution assembly have a body, a slide, a rotating shaft, an agitating element,
One stripping rotor and a heater, the head end of described rotating shaft is rotatably connected and rotates even in described slide, tail end
Being connected to described agitating element, described slide is slidedly arranged on described body along the length direction of described body；
The bottom of described body is formed with a reservoir body, and described stripping rotor is located in described reservoir body, described
The center of stripping rotor and described rotating shaft are centrally located on same straight line, and described stripping rotor is used for holding solvent
With medicine to be detected；
Described heater for described stripping rotor is heated, described heater have a power supply,
Multiple heating element heaters and a heating mantle, the outside wall surface of described heating mantle is attached at the internal face of described reservoir body,
Being evenly equipped with multiple described heating element heater on the internal face of described heating mantle, multiple described heating element heaters electrically connect
In described power supply and cover in the outside wall surface of described stripping rotor；
Described dissolution testing system also includes:
One sampler, is sealedly attached to described stripping rotor, and described sampler is for medicine to be detected
The solution formed after being dissolved in solvent carries out automatic sampling；
One tapping equipment, is sealedly attached to described stripping rotor, and described tapping equipment is for when medicine to be detected
Detect the solution in stripping rotor described in rear automatic-discharging.
Multiple described dissolution assemblies are each other without directly contact, for each described dissolution assembly, described
Detecting system in digestion instrument can be independently controlled every with monitoring while controlling described rotating shaft lifting
Mixing speed in individual described stripping rotor.
Produce heat after the energising of described heating element heater, and transfer heat to described stripping rotor, thus realize
Heating to described stripping rotor.The effect of described heating mantle includes fixing multiple described heating element heaters, avoids
Or reduce heat diffusion.When actually used, described heating mantle is not complete annular, but for having
The annular of an opening, the graduation mark of described stripping rotor is had to be positioned at the region that the opening of described heating mantle is corresponding,
Primarily to the dissolved state of medicine to be detected and stirring in being easy to observe described stripping rotor.It addition,
Use described heating mantle that described stripping rotor is heated, it is possible to by solvent from room temperature liter in 15 minutes
To 37 DEG C, thus, it is possible to realize quickly heating, it is simple to use.
Described sampler and described tapping equipment it has been directly connected to, it is possible to realize automatically on described digestion instrument
Sampling carries out detecting and solution in stripping rotor described in automatic-discharging, easy to operate.
It is preferred that be detachably connected with a bowl cover on described stripping rotor, described bowl cover is provided with a sampling
Mouth and a floss hole, described sampler is sealedly attached to described stripping rotor by described sample tap, described
Tapping equipment is sealedly attached to described stripping rotor by described floss hole.
Described sampler and described tapping equipment are all sealedly attached to described stripping rotor, it is to avoid or outside reducing
Boundary's environment impact on medicine to be detected in described stripping rotor, it is possible to increase the dissolution of medicine to be detected
Accuracy of detection.
It is preferred that described sampler has a sampling cup, a sampling catheter, a sampling pump and one first
Control valve, described sampling catheter connects and has described sampling pump and described first control valve, and described sampling is led
The head end of pipe is connected to described sampling cup, and the tail end of described sampling catheter is arranged with one first potted component,
The tail end of described sampling catheter is tightly connected by described first potted component is embedded at described sample tap
In described stripping rotor.
When needing the solution in described stripping rotor is sampled, regulate described first control valve so that
It is connected between described sampling cup and described stripping rotor such that it is able to be sampled more conveniently.
It is preferred that described tapping equipment has a discharge cup, a discharge tube, an emptying pump and one second
Control valve, described discharge tube connects and has described emptying pump and described second control valve, and described discharge is led
The head end of pipe is connected to described discharge cup, and the tail end of described discharge tube is arranged with one second potted component,
The tail end of described discharge tube is tightly connected by described second potted component is embedded at described floss hole
In described stripping rotor.
After detection terminates, when needing to pour out the solution in described stripping rotor, regulate described second and control
Valve so that be connected between described discharge cup and described stripping rotor such that it is able to arrange more conveniently
Put.
It is preferred that when medicine to be detected is flake drug, described agitating element is a rotation oar, described
Being additionally provided with a medicine dispensing port on bowl cover, described medicine dispensing port is used for throwing in described flake drug, described
A lid it is installed with on medicine dispensing port.
Throw in when described flake drug and terminate afterwards or when not carrying out described flake drug and throwing in, described lid
Described medicine dispensing port is located in all rotations, and minimizing external environment is on the impact within described stripping rotor further,
Thus, it is possible to improve the accuracy of detection of the dissolution of medicine to be detected further.
It is preferred that when medicine to be detected is pharmaceutical capsules, described agitating element is a spin basket, described
Spin basket has a connecting element and a basket body, and the head end of described connecting element is rotatably connected in described rotating shaft
Tail end, the tail end of described connecting element is arranged with described basket body, and described basket body is used for placing described capsule
Medicine, and the outer surface of described basket body is evenly equipped with multiple through hole, multiple described through holes are used for making described capsule
Medicine contacts with the solvent in described stripping rotor.
It is preferred that be provided with a temperature sensor in described rotating shaft.
Described temperature sensor can monitor the temperature in each described stripping rotor in real time, sustainably.
It is preferred that described slide is slidedly arranged on described body by a driving means, described driving means includes
One drives motor, a leading screw and a slide block, and described driving motor is connected to described leading screw, and described slide block is even
Being connected to described leading screw, described slide block is connected to described slide, and described slide block and described slide are positioned at described
The both sides of body.
It is preferred that described body is provided with two guide rails being oppositely arranged, described slide is slidedly arranged on described in two and leads
Rail, has a scale area between guide rail described in two, described scale area is slidably equipped with a pointer, described pointer
Between the bottom surface aliging to illustrate described agitating element and described base with described agitating element away from
From.
When described flake drug and described pharmaceutical capsules are detected, described agitating element and described dissolution
The relative altitude of cup is typically different, described scale area and the existence of described pointer so that described dissolution
Instrument has preset height regulatory function, can according to described pointer position on described scale area easily
The described agitating element distance relative to the bottom surface of described base is shown.Thus to described lamellar
When medicine and described pharmaceutical capsules carry out transition detection, it is not necessary to readjust height.
On the basis of meeting common sense in the field, above-mentioned each optimum condition, can combination in any, obtain this reality
By novel each preferred embodiments.
Positive progressive effect of the present utility model is:
Dissolution testing system in this utility model includes digestion instrument, sampler and tapping equipment,
Described sampler and described tapping equipment are directly connected in described digestion instrument, it is possible to realize automatic sampling and
Automatic-discharging, easy to operate；In described digestion instrument use heating mantle, heating element heater combination to stripping rotor
Heat, it is possible to quickly the solvent in described stripping rotor is heated to the temperature needed, improve detection effect
Rate, easy to use.
Accompanying drawing explanation
Fig. 1 be this utility model one preferred embodiment dissolution testing system in the knot of dissolution assembly
Structure schematic diagram.
Fig. 2 be this utility model one preferred embodiment dissolution testing system in stripping rotor and sampling
Device, the attachment structure schematic diagram of tapping equipment.
Description of reference numerals:
1: sampler
11: sampling cup
12: sampling catheter
13: sampling pump
14: the first control valves
2: tapping equipment
21: discharge cup
22: discharge tube
23: emptying pump
24: the second control valves
3: dissolution assembly
31: body
311: guide rail
32: slide
33: rotating shaft
34: agitating element
35: stripping rotor
Detailed description of the invention
Name preferred embodiment, and combine accompanying drawing and become apparent from intactly illustrating this utility model.
As shown in Figure 1-2, a kind of dissolution testing system includes a digestion instrument (not shown), takes
Sampling device 1 and tapping equipment 2, described digestion instrument has a base (not shown) and is located at the described end with enclosing
Multiple dissolution assemblies 3 of seat, each dissolution assembly 3 is removably connected to described base, each dissolution group
Part 3 has body 31, slide 32, rotating shaft 33,34, stirring unit, stripping rotor 35 and heater
(not shown), the head end of rotating shaft 33 is rotatably connected and is rotatably connected in agitating element in slide 32, tail end
34, slide 32 is slidedly arranged on body 31 along the length direction of body 31.Wherein, sampler 1 is for right
The solution that medicine to be detected is formed after being dissolved in solvent carries out automatic sampling；Tapping equipment 2 is for when to be detected
Drug detection complete after solution in automatic-discharging stripping rotor 35.
Sampler 1, tapping equipment 2 can be the most each molten according to the number corresponding configuration of dissolution assembly 3
Go out assembly 3 and be respectively provided with sampler 1 and tapping equipment 2, it is possible to do not enter according to the number of dissolution assembly 3
Row is arranged, and sampler 1 and tapping equipment 2 can be used alternatingly between different dissolution assemblies 3.
Multiple dissolution assemblies 3 are each other without directly contact, for each dissolution assembly 3, described dissolution
Detecting system in instrument can be independently controlled each molten with monitoring while controlling rotating shaft 33 lifting
Go out the mixing speed in cup 35.
Sampler 1 and tapping equipment 2 it has been directly connected to, it is possible to realize automatic sampling on described digestion instrument
Carry out detecting and solution in automatic-discharging stripping rotor 35, easy to operate.
In the present embodiment, the bottom of body 31 is formed with a reservoir body (not shown), stripping rotor 35
It is located in described reservoir body, as it is shown in figure 1, the center of stripping rotor 35 and rotating shaft 33 are centrally located at same
On one straight line, stripping rotor 35 is used for holding solvent and medicine to be detected.Described heater is for molten
Going out cup 35 to heat, described heater has a power supply, multiple heating element heater and a heating mantle,
The outside wall surface of described heating mantle is attached at the internal face of described reservoir body, on the internal face of described heating mantle all
Being furnished with multiple described heating element heater, multiple described heating element heaters are electrically connected to described power supply and cover in dissolution
The outside wall surface of cup 35.
Produce heat after the energising of described heating element heater, and transfer heat to stripping rotor 35, thus realize right
The heating of stripping rotor 35.The effect of described heating mantle includes fixing multiple described heating element heaters, avoid or
Reduce heat diffusion.In the present embodiment, described heating mantle is not complete annular, but for having
Having the annular (not shown) of an opening, the opening that the graduation mark of stripping rotor 35 is positioned at described heating mantle is corresponding
Region in, primarily to be easy to observe dissolved state and the stirring of medicine to be detected in stripping rotor 35
State.It addition, use described heating mantle that stripping rotor 35 is heated, it is possible to by molten in 15 minutes
Matchmaker rises to 37 DEG C from room temperature, thus, it is possible to realize quickly heating, it is simple to use.
In the present embodiment, medicine to be detected is flake drug, and agitating element 34 is for rotating oar, molten
Go out and on cup 35, be covered with a bowl cover (not shown).Wherein, described bowl cover is arranged at intervals with a medicine to throw
Put mouth, a sample tap and a floss hole, as in figure 2 it is shown, sampler 1 is sealed by described sample tap
Being connected to stripping rotor 35, tapping equipment 2 is sealedly attached to stripping rotor 35 by described floss hole.Described
Medicine dispensing port is used for throwing in described flake drug, described medicine dispensing port is installed with a lid and (does not shows
Go out).Throw in when described flake drug and terminate afterwards or when not carrying out described flake drug and throwing in, described lid
Body all revolves is located at described medicine dispensing port, and minimizing external environment is on the impact within stripping rotor 35 further,
Thus, it is possible to improve the accuracy of detection of the dissolution of medicine to be detected further.
Sampler 1 and tapping equipment 2 are all sealedly attached to stripping rotor 35, it is to avoid or reduce external environment
Impact on medicine to be detected in stripping rotor 35, it is possible to increase the detection essence of the dissolution of medicine to be detected
Degree.
As in figure 2 it is shown, sampler 1 has sampling cup 11, sampling catheter 12, sampling pump
13 and one first control valve 14, sampling catheter 12 connects and has sampling pump 13 and the first control valve 14,
The head end of sampling catheter 12 is connected to sampling cup 11, and the tail end of sampling catheter 12 is arranged with one first sealing
Element (not shown), the tail end of sampling catheter 12 takes described in being embedded at by described first potted component
Sample mouth is sealedly attached to stripping rotor 35.Tapping equipment 2 have discharge cup 21, discharge tube 22,
One emptying pump 23 and one second control valve 24, discharge tube 22 connects and has emptying pump 23 and the second control
Valve 24 processed, the head end of discharge tube 22 is connected to discharge cup 21, and the tail end of discharge tube 22 is arranged with
One second potted component (not shown), the tail end of discharge tube 22 is by by embedding for described second potted component
It is located at described floss hole and is sealedly attached to stripping rotor 35.
When needing the solution in stripping rotor 35 is sampled, regulate the first control valve 14 so that take
It is connected between sample cup 11 and stripping rotor 35 such that it is able to be sampled more conveniently.Detection terminates
After, when needing to pour out the solution in stripping rotor 35, regulate the second control valve 24 so that discharge cup
It is connected between 21 and stripping rotor 35 such that it is able to discharge more conveniently.
In other embodiments, when medicine to be detected is pharmaceutical capsules, agitating element 34 is a rotation
Turning basket, described spin basket has a connecting element and a basket body, and the head end of described connecting element is rotatably connected
In the tail end of rotating shaft 33, the tail end of described connecting element is arranged with described basket body, and described basket body is used for putting
Putting described pharmaceutical capsules, and the outer surface of described basket body is evenly equipped with multiple through hole, multiple described through holes are used for
Described pharmaceutical capsules is made to contact with the solvent in stripping rotor 35.
In the present embodiment, a temperature sensor (not shown) it is provided with in rotating shaft 33.Described temperature passes
Sensor can monitor the temperature in each stripping rotor 35 in real time, sustainably.
In the present embodiment, slide 32 is slidedly arranged on body 31 by a driving means (not shown),
It is described that described driving means includes that a driving motor, a leading screw and a slide block, described driving motor are connected to
Leading screw, described slide block is connected to described leading screw, and described slide block is connected to slide 32, and described slide block and cunning
Seat 32 is positioned at the both sides of body 31.It addition, as it is shown in figure 1, body 31 is provided with two is oppositely arranged
Guide rail 311, slide 32 is slidedly arranged on two guide rails 311, has a scale area (not between two guide rails 311
Illustrate), described scale area is slidably equipped with a pointer (not shown), described pointer is used for and agitating element 34
Align the distance between the bottom surface of agitating element 34 and described base is shown.
Described scale area and the existence of described pointer so that described digestion instrument has preset height regulatory function,
Agitating element 34 can be conveniently shown relative to institute according to described pointer position on described scale area
State the distance of the bottom surface of base.Thus so that described flake drug and described pharmaceutical capsules are carried out turn
When changing detection, it is not necessary to readjust height.
Although the foregoing describing detailed description of the invention of the present utility model, but those skilled in the art should
Working as understanding, these are merely illustrative of, and protection domain of the present utility model is to be limited by appended claims
Fixed.Those skilled in the art is on the premise of without departing substantially from principle of the present utility model and essence, permissible
These embodiments are made various changes or modifications, but these changes and amendment each fall within this utility model
Protection domain.
Claims (9)
1. a dissolution testing system, including a digestion instrument, it is characterised in that described dissolution
Instrument has a base and encloses the multiple dissolution assemblies being located at described base, and each described dissolution assembly is detachable
Being connected to described base, each described dissolution assembly has a body, a slide, a rotating shaft, a stirring
Element, a stripping rotor and a heater, the head end of described rotating shaft is rotatably connected in described slide, tail end
Being rotatably connected in described agitating element, described slide is slidedly arranged on described body along the length direction of described body；
The bottom of described body is formed with a reservoir body, and described stripping rotor is located in described reservoir body, described
The center of stripping rotor and described rotating shaft are centrally located on same straight line, and described stripping rotor is used for holding solvent
With medicine to be detected；
Described heater for described stripping rotor is heated, described heater have a power supply,
Multiple heating element heaters and a heating mantle, the outside wall surface of described heating mantle is attached at the internal face of described reservoir body,
Being evenly equipped with multiple described heating element heater on the internal face of described heating mantle, multiple described heating element heaters electrically connect
In described power supply and cover in the outside wall surface of described stripping rotor；
Described dissolution testing system also includes:
One sampler, is sealedly attached to described stripping rotor, and described sampler is for medicine to be detected
The solution formed after being dissolved in solvent carries out automatic sampling；
One tapping equipment, is sealedly attached to described stripping rotor, and described tapping equipment is for when medicine to be detected
Detect the solution in stripping rotor described in rear automatic-discharging.
2. dissolution testing system as claimed in claim 1, it is characterised in that described dissolution
Being detachably connected with a bowl cover on Bei, described bowl cover is provided with a sample tap and a floss hole, described in take
Sampling device is sealedly attached to described stripping rotor by described sample tap, and described tapping equipment is by described discharge
Mouth is sealedly attached to described stripping rotor.
3. dissolution testing system as claimed in claim 2, it is characterised in that described sampling
Device has a sampling cup, a sampling catheter, a sampling pump and one first control valve, described sampling catheter
Upper connection has described sampling pump and described first control valve, the head end of described sampling catheter be connected to described in take
Sample cup, the tail end of described sampling catheter is arranged with one first potted component, and the tail end of described sampling catheter leads to
Cross and described first potted component is embedded at described sample tap is sealedly attached to described stripping rotor.
4. dissolution testing system as claimed in claim 2, it is characterised in that described discharge
Device has a discharge cup, a discharge tube, an emptying pump and one second control valve, described discharge tube
Upper connection has described emptying pump and described second control valve, and the head end of described discharge tube is connected to described row
Putting cup, the tail end of described discharge tube is arranged with one second potted component, and the tail end of described discharge tube leads to
Cross and described second potted component is embedded at described floss hole is sealedly attached to described stripping rotor.
5. dissolution testing system as claimed in claim 2, it is characterised in that when to be detected
When medicine is flake drug, described agitating element is a rotation oar, described bowl cover is additionally provided with a medicine and throws
Putting mouth, described medicine dispensing port is used for throwing in described flake drug, and described medicine dispensing port is installed with one
Lid.
6. dissolution testing system as claimed in claim 1, it is characterised in that when to be detected
When medicine is pharmaceutical capsules, described agitating element is a spin basket, and described spin basket has a connecting element
With a basket body, the head end of described connecting element is rotatably connected in the tail end of described rotating shaft, described connecting element
Tail end be arranged with described basket body, described basket body is used for placing outside described pharmaceutical capsules, and described basket body
Surface is evenly equipped with multiple through hole, and multiple described through holes are in making described pharmaceutical capsules and described stripping rotor
Solvent contacts.
7. dissolution testing system as claimed in claim 1, it is characterised in that described rotating shaft
Inside it is provided with a temperature sensor.
8. dissolution testing system as claimed in claim 1, it is characterised in that described slide
Be slidedly arranged on described body by a driving means, described driving means include a driving motor, a leading screw and
One slide block, described driving motor is connected to described leading screw, and described slide block is connected to described leading screw, described cunning
Block is connected to described slide, and described slide block and described slide are positioned at the both sides of described body.
9. the dissolution testing system as described in claim 1-8 any one, it is characterised in that
Described body is provided with two guide rails being oppositely arranged, and described slide is slidedly arranged on guide rail described in two, leads described in two
Having a scale area between rail, described scale area is slidably equipped with a pointer, described pointer is for stirring with described
Mix component alignment to illustrate the distance between the bottom surface of described agitating element and described base.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620524166.8U CN205538936U (en) | 2016-06-01 | 2016-06-01 | Medicine degree of dissolving out detecting system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620524166.8U CN205538936U (en) | 2016-06-01 | 2016-06-01 | Medicine degree of dissolving out detecting system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205538936U true CN205538936U (en) | 2016-08-31 |
Family
ID=56795573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201620524166.8U Active CN205538936U (en) | 2016-06-01 | 2016-06-01 | Medicine degree of dissolving out detecting system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN205538936U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106442904A (en) * | 2016-09-23 | 2017-02-22 | 梁永革 | Test instrument for dissolution rate of drugs |
-
2016
- 2016-06-01 CN CN201620524166.8U patent/CN205538936U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106442904A (en) * | 2016-09-23 | 2017-02-22 | 梁永革 | Test instrument for dissolution rate of drugs |
| CN106442904B (en) * | 2016-09-23 | 2018-08-17 | 梁永革 | A kind of drug dissolution tester |
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