CN205941517U - A constant temperature constant speed instrument for declining external release of medicine of nanometer preparation is tested - Google Patents
A constant temperature constant speed instrument for declining external release of medicine of nanometer preparation is tested Download PDFInfo
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- CN205941517U CN205941517U CN201620730307.1U CN201620730307U CN205941517U CN 205941517 U CN205941517 U CN 205941517U CN 201620730307 U CN201620730307 U CN 201620730307U CN 205941517 U CN205941517 U CN 205941517U
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- water bath
- heater
- drug release
- temperature
- constant speed
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Abstract
The utility model provides a constant temperature constant speed instrument for declining external release of medicine of nanometer preparation is tested, including the water bath system with be used for right the magnetism mixing system that stirs is carried out in drug release pond in the water bath system, wherein, the water bath system includes water bath and heater and circulating pump, the heater is used for rightly water bath tank's liquid heats, the circulating pump is used for rightly water bath tank's liquid circulates, the heater of heater for carrying out high accuracy temperature control. The utility model discloses a constant temperature constant speed instrument for declining external release of medicine of nanometer preparation is tested, the water bath in a plurality of release ponds can be held in the adoption, plus accuse temperature, temperature measurement and circulating device for the temperature of water bath tank portion liquid can be evenly, accurately control, simultaneously, adopt to set up the magnetism mixing system in the water bath below, the rotational speed of guaranteeing to be used for respectively to release each agitator disk in pond is the same.
Description
Technical field
The utility model is related to a kind of constant temperature constant speed instrument, particularly to a kind of medicine body being applied to micro-/ nano preparation
The constant temperature constant speed instrument of outer release test.
Background technology
For the prevailing quality assessment item release in vitro of micro-/ nano pharmaceutical preparation is tested, still lack at present
Standardized experiment and Testing Guideline；And there is no the release in vitro survey for micro-/ nano pharmaceutical preparation for the coordinates equipment
Examination.
Traditional dialysis are not suitable for the research application of micro-/ nano pharmaceutical preparation.Traditional dialysis are micro-/ nano preparation
Suspension is scattered in the bag filter with suitable molecular cut off, puts in suitable dissolution medium, different time after closing
Point takes dissolution medium to measure the concentration of medicine, thus calculating drug release rate.
Its drawback is：It is difficult to the parallel release conditions controlling each sample to be consistent, for example, dialysis membrane contact area
The heterogencity of fluid kinetics of diffusion environment residing for heterogencity, each sample, the difficult control of temperature of many experiments are same
One temperature etc..
It is, therefore, desirable to provide a kind of technical scheme, to ensure the uniformity of the release conditions of each micro-/ nano pharmaceutical preparation,
It is mainly the parallel control of temperature conditionss and stirring condition.
Utility model content
The purpose of this utility model is, provides a kind of constant temperature of the test of the drug release in vitro for micro-/ nano preparation
Multiple insoluble drug release ponds can be tested by constant speed instrument simultaneously, residing in test to ensure multiple insoluble drug release ponds
Temperature conditionss identical with stirring condition (or extremely approximate), thus ensure the uniformity of each micro-/ nano pharmaceutical preparation release conditions.
The constant temperature constant speed instrument of the drug release in vitro test for micro-/ nano preparation of the present utility model, including water-bath
System and the magnetic stirring system for being stirred to the insoluble drug release pond in described water-bath system, wherein, described water-bath system
Including water bath and heater and circulating pump, described heater is used for the liquid in described water bath is heated, described
Circulating pump is used for the liquid in described water bath is circulated, and described heater is to carry out adding of high accuracy temperature control
Hot device.
Preferably, described heater has overheat protective function.
In order to temperature is more accurately monitored and controlled, further, it is also equipped with temperature sensor in described water bath, use
In thermometric is carried out to the liquid in described water bath；Described water-bath system also includes display screen, for described temperature sensor
The temperature of the liquid in the described water bath of measurement is shown.
Further, described magnetic stirring system includes the structure of multiple downsides being arranged on described water bath and rotating speed is homogeneous
Same agitator disk.
Preferably, described agitator disk includes gear and is symmetrically fixedly installed on the magnetic patch of the upper surface of described gear；Institute
State magnetic stirring system and also include stepper motor and transmission belt, the driving wheel of described transmission belt and described stepper motor and each institute
The gear stating agitator disk all engages, so that moving under the drive of the driving wheel in described stepper motor for the described transmission belt and driving
Each described agitator disk rotates.
The constant temperature constant speed instrument of the drug release in vitro test for micro-/ nano preparation of the present utility model, adopting can
Accommodate the water bath in multiple insoluble drug release ponds, additional temperature control, thermometric and EGR are so that the temperature of water bath internal liquid
Can uniformly, control exactly；Meanwhile, using the magnetic stirring system being arranged on below water bath it is ensured that being used for each insoluble drug release
The rotating speed of each agitator disk in pond is identical.
Brief description
Fig. 1 is the knot of the constant temperature constant speed instrument of the test of the drug release in vitro for micro-/ nano preparation of the present utility model
Structure schematic diagram；
Fig. 2 is the top view of the magnetic stirring system in Fig. 1.
Specific embodiment
With reference to the accompanying drawings and detailed description to the drug release in vitro for micro-/ nano preparation of the present utility model
The constant temperature constant speed instrument of test is described in further detail, but not as to restriction of the present utility model.
Fig. 1 is the knot of the constant temperature constant speed instrument of the test of the drug release in vitro for micro-/ nano preparation of the present utility model
Structure schematic diagram.This constant temperature constant speed instrument includes water-bath system and for being stirred to the insoluble drug release pond 30 in water-bath system
Magnetic stirring system.
Wherein, water-bath system includes water bath 11 and heater 12 and circulating pump 13.This heater 12 is used for water-bath
Liquid 15 in groove 11 is heated.Preferably, heater 12 is to carry out high accuracy temperature control, so, can adopt
The high-precision microcomputer chip optimizing programming is controlled to this heater 12, and it is desired to be that temperature can be precisely controlled in
Temperature value or near.Additionally, it is further preferred that this heater 12 has overheat protective function, to ensure whole constant temperature constant speed
The safe operation of instrument.
While heating, circulating pump 13 is circulated to the liquid 15 in water bath 11, so that the liquid in water bath 11
The temperature of body 15 keeps uniformly, the unevenness of the temperature of water bath 11 entirety being controlled within the acceptable range, for example, controlling
System exists<In the range of ± 0.2 DEG C.
As shown in figure 1, liquid 15 flows into from the A mouth (water inlet) of water-bath system, heated up by heater 12, then
In the presence of circulating pump 13, through water pipe 121, flow out from B mouth (delivery port), flow into water bath 11.Liquid in water bath 11
Body 15 constantly flows out it is achieved that the circulation to the liquid 15 in water bath 11 is heated with uniform from B mouth after A mouth is heated.
Additionally, in order to be further ensured that temperature controlled accuracy, being also equipped with temperature sensor 14 in water bath 11, use
In thermometric is carried out to the liquid 15 in water bath 11.This water-bath system also includes display screen (not shown), for temperature
The temperature of the liquid 15 in the water bath 11 of sensor 14 measurement is shown, so that user can grasp water-bath in real time
The actual temperature of the liquid 15 in groove 11, is easy to user and in time heater 12 or circulating pump 13 is adjusted.
As shown in Figure 1, 2, magnetic stirring system includes downside, the structure that multiple (for example, 12) are arranged on water bath 11
Agitator disk 21 with rotating speed all same.The upper surface that each agitator disk 21 includes gear 211 and is fixedly installed on gear 211
Magnetic patch 212.If two magnetic patch 212 as shown in Fig. 2, this two magnetic patch 212 are symmetrical arranged.This magnetic stirring system also wraps
Include stepper motor 22 and transmission belt 23 synchronous cog belt of double cog (preferably), the active of transmission belt 23 and stepper motor 22
The gear 211 of wheel 221 and each agitator disk 21 all engages, thus, the band of the driving wheel 221 in stepper motor 22 for the transmission belt 23
Dynamic lower motion, and drive each agitator disk 21 to rotate simultaneously.
Fig. 2 show an example of this magnetic stirring system, and in this example, magnetic stirring system includes 12 agitator disks
21.In order that the set location optimization of 12 agitator disks 21, magnetic stirring system also includes a tensioning wheel 24, this tensioning wheel 24 with
The driving wheel 221 of stepper motor 22 is diagonally positioned, so that transmission belt 23 is tensioned takes turns 24 with driving wheel 221 diagonally opposed
Tensioning.12 agitator disks 21 are disposed alternately at the both sides of transmission belt 23 successively and are engaged with transmission belt 23.It is understood that figure
Magnetic stirring system shown in 2 be only a kind of implementation, the actual number that can design agitator disk 21 as needed, putting position,
Induced way, as long as make each agitator disk 21 be driven by same driving wheel 221 and conveyer belt 23, to ensure each agitator disk
21 rotating speed is essentially identical.
So, magnetic stirring system can be realized simultaneously to multiple (the number identical number with agitator disk 21) insoluble drug release
Pond 30 (it is placed in water bath 11 and carries out water-bath) carries out electromagnetic agitation.Because multiple agitator disks 21 of this magnetic stirring system are equal
Be rotated by same stepper motor 22 and same transmission belt 23, therefore, its rotating speed identical or extremely approximate it is ensured that
The corresponding mixing speed to individual insoluble drug release pond is identical.
Cooperation optimizes Motor drive and the control program of establishment, can make the rotating speed unevenness control between each agitator disk 21
System exists<It is achieved that the synchronization of magnetic speed of agitator and stable, thus it is multiple to realize Synchronization Control in the range of ± 0.1%rpm (≈ 0)
The rotating speed in insoluble drug release pond it is ensured that between group the uniformity of experiment condition and data reappearance.And, to each agitator disk 21
Rotating speed easy to adjust, directly perceived, in the allowed band of 25～600rpm can achieve any speed governing.
Further, the temperature of establishment and the control program of stepper motor will be optimized, concentrate design on one piece of wiring board,
Can also the running parameter such as displays temperature, magnetic speed of agitator, working time simultaneously on a display screen.
Above specific embodiment is only illustrative embodiments of the present utility model it is impossible to be used for limiting this practicality newly
Type, protection domain of the present utility model is defined by the claims.Those skilled in the art can be in essence of the present utility model
In protection domain, the utility model is made with various modifications or equivalent, these modifications or equivalent also should be regarded as
In protection domain of the present utility model.
Claims (5)
1. a kind of constant temperature constant speed instrument of the drug release in vitro test for micro-/ nano preparation is it is characterised in that include water-bath
System and the magnetic stirring system for being stirred to the insoluble drug release pond in described water-bath system, wherein,
Described water-bath system includes water bath and heater and circulating pump, and described heater is used for the liquid in described water bath
Body is heated, and described circulating pump is used for the liquid in described water bath is circulated, and described heater is to carry out height
The heater that accurate temperature controls.
2. the constant temperature constant speed instrument of the drug release in vitro test for micro-/ nano preparation according to claim 1, it is special
Levy and be, described heater has overheat protective function.
3. the constant temperature constant speed instrument of the drug release in vitro test for micro-/ nano preparation according to claim 1, it is special
Levy and be, in described water bath, be also equipped with temperature sensor, for thermometric is carried out to the liquid in described water bath；Described water
Bath system also includes display screen, and the temperature for the liquid in the described water bath to described temperature sensor measurement shows
Show.
4. the constant temperature constant speed instrument of the drug release in vitro test for micro-/ nano preparation according to claim 1, it is special
Levy and be, described magnetic stirring system includes the structure of multiple downsides being arranged on described water bath and the stirring of rotating speed all same
Disk.
5. the constant temperature constant speed instrument of the drug release in vitro test for micro-/ nano preparation according to claim 4, it is special
Levy and be, described agitator disk includes gear and is symmetrically fixedly installed on the magnetic patch of the upper surface of described gear；
Described magnetic stirring system also includes stepper motor and transmission belt, the driving wheel of described transmission belt and described stepper motor, with
And the gear of each described agitator disk all engages, so that moving under the drive of the driving wheel in described stepper motor for the described transmission belt
And drive each described agitator disk to rotate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620730307.1U CN205941517U (en) | 2016-07-12 | 2016-07-12 | A constant temperature constant speed instrument for declining external release of medicine of nanometer preparation is tested |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620730307.1U CN205941517U (en) | 2016-07-12 | 2016-07-12 | A constant temperature constant speed instrument for declining external release of medicine of nanometer preparation is tested |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205941517U true CN205941517U (en) | 2017-02-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201620730307.1U Active CN205941517U (en) | 2016-07-12 | 2016-07-12 | A constant temperature constant speed instrument for declining external release of medicine of nanometer preparation is tested |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108318646A (en) * | 2018-03-27 | 2018-07-24 | 苏州桓晨医疗科技有限公司 | A kind of dissolution medium of aids drug release in vitro |
-
2016
- 2016-07-12 CN CN201620730307.1U patent/CN205941517U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108318646A (en) * | 2018-03-27 | 2018-07-24 | 苏州桓晨医疗科技有限公司 | A kind of dissolution medium of aids drug release in vitro |
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| GR01 | Patent grant |