CN209460264U - A kind of isolated organ isothermal experiments device - Google Patents
A kind of isolated organ isothermal experiments device Download PDFInfo
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- CN209460264U CN209460264U CN201821942648.0U CN201821942648U CN209460264U CN 209460264 U CN209460264 U CN 209460264U CN 201821942648 U CN201821942648 U CN 201821942648U CN 209460264 U CN209460264 U CN 209460264U
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Abstract
The utility model discloses a kind of isolated organ isothermal experiments devices, including outer bath, and the L-type hook of the interior bath in outer bath slot and fixed isolated organ is arranged in；Wherein, the cavity that can encapsulate isothermal liquid is collectively formed in the cell wall of the cell wall of interior bath and outer bath；Outer bath is provided with the inlet and liquid outlet being connected with cavity；Interior bath bottom is provided with the tapping channel through outer bath bottom；Interior bath top is equipped with and the liquid feeding slot that is connected in interior bath slot, and liquid feeding slot is outside the interior bath.Experimental provision in the utility model can reduce external factor when liquid is added and shake to isolated organ bring, create a further reduction the interference that liquid feeding or dosing detect experimental data, so that experimental data is more accurate reliable.
Description
Technical field
The utility model relates to medical experiment devices, more specifically, being related to a kind of isolated organ isothermal experiments device.
Background technique
Gastrointestinal smooth muscle physiological property and drug are to the warp that the effect of in vitro intestinal segment is in the experiment of medicine function assessment
Allusion quotation experiment records the influence of the physiological property and drug of intestinal segment to it by tonotransducer.As shown in Figure 1, to be normal at present
The experiment schematic diagram for being used to carry out in vitro intestinal segment of rule.Magnus' bath 1 is contained into Rockwell liquid, takes in vitro intestinal segment 2, suture needle is used at both ends
Threading, one section is fixed on L-type hook 3, is put into Magnus' bath 1 rapidly, the other end is connected to tonotransducer 4 and keeps vertical and suitable
Suitable elasticity makes in vitro intestinal segment 2 keep the afterload tension of about 1g.Magnus' bath 1 the disadvantage is that: pass through 1 upper port of Magnus' bath
Hand, which is easy to encounter line segment, when changing liquid and dosing leads to tension change, eventually leads to experimental data inaccuracy.
Utility model content
The purpose of the utility model is to provide a kind of isolated organ isothermal experiments devices, solve existing Magnus' bath and change
Interference is generated to isolated organ when liquid and dosing, leads to the problem of experimental data inaccuracy.
In order to solve the above technical problems, the utility model provides a kind of isolated organ isothermal experiments device, including outer bath,
The L-type hook of interior bath in the outer bath slot and fixed isolated organ is set；
Wherein, the cavity that can encapsulate isothermal liquid is collectively formed in the cell wall of the cell wall of the interior bath and the outer bath；
The outer bath is provided with the inlet and liquid outlet being connected with the cavity；
The interior bath bottom is provided with the tapping channel through the outer bath bottom；The interior bath top be equipped with and
The liquid feeding slot being connected in the interior bath slot, and the liquid feeding slot is set to outside the interior bath.
Wherein, the liquid feeding groove bottom is higher than the interior bath highest liquid level line.
Wherein, big equipped with the communication port aperture is adjusted at the communication port that the liquid feeding slot is connected with the interior bath
Small valve.
Wherein, the communication port is equipped with mesh members.
Wherein, snorkel is provided on the side wall that the tapping channel extends to outside the outer bath.
Wherein, the interior bath and the outer bath are transparent glass slot, and are provided on the cell wall of the interior bath
Graduation mark.
Wherein, L-type hook bottom end is provided with multiple cable clamping interfaces, for fixing the connecting line of isolated organ.
Wherein, the concaveconvex structure that the cell wall of the cable clamping interface has, and the concaveconvex structure of two cell walls of the cable clamping interface
Cooperate fitting.
Isolated organ isothermal experiments device provided by the utility model, including outer bath are arranged in outer bath slot
The L-type hook of interior bath and fixed isolated organ；Wherein, the cell wall of the cell wall of interior bath and outer bath, which is collectively formed, to encapsulate
The cavity of isothermal liquid；Outer bath is provided with the inlet and liquid outlet being connected with cavity；Interior bath bottom, which is provided with, to be run through
The tapping channel of outer bath bottom；Interior bath top is equipped with and the liquid feeding slot that is connected in interior bath slot, and in liquid feeding slot is set to
Outside bath.Liquid feeding slot is set on the top of interior bath in the utility model, by the liquid feeding slot for extending to side from interior bath
Liquid feeding or dosing in inside bath, the line that effectively can avoid the problem that and hang isolated organ are touched, while in addition
Liquid in bath is flowed by liquid feeding slot from the inner sidewall of interior bath, rather than is instilled from interior bath upper vertical, is reduced
It is shaken when liquid is added to isolated organ bring, creates a further reduction the interference that liquid feeding or dosing detect experimental data,
So that experimental data is more accurate.
Detailed description of the invention
For the clearer technical solution for illustrating the utility model embodiment or the prior art, below will to embodiment or
Attached drawing needed to be used in the description of the prior art is briefly described, it should be apparent that, the accompanying drawings in the following description is only
Some embodiments of the utility model, for those of ordinary skill in the art, without creative efforts,
It is also possible to obtain other drawings based on these drawings.
Fig. 1 is in the prior art for carrying out the experimental provision schematic diagram of in vitro intestinal segment；
Fig. 2 is the structural schematic diagram of isolated organ isothermal experiments device provided by the embodiment of the utility model；
Fig. 3 is the structural schematic diagram of L-type provided by the embodiment of the utility model hook；
In attached drawing, 1 it is Magnus' bath, 2 is isolated organ, 3 is L-type hook, 31 is cable clamping interface, 4 is tonotransducer, 5
For tapping channel, 51 be snorkel, 6 be rubber sleave, 7 be ventilation needle tubing, 8 be outer bath, 9 be interior bath, 10 be liquid outlet,
11 it is inlet, 12 be liquid feeding slot, 13 is valve.
Specific embodiment
In order to make those skilled in the art better understand the scheme of the utility model, with reference to the accompanying drawing and specific implementation
The utility model is described in further detail for mode.Obviously, described embodiment is only the utility model a part
Embodiment, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not doing
Every other embodiment obtained under the premise of creative work out, fall within the protection scope of the utility model.
As shown in Fig. 2, Fig. 2 is the structural representation of isolated organ isothermal experiments device provided by the embodiment of the utility model
Figure, comprising:
The L-type hook 3 of the interior bath 9 in outer 8 slot of bath and fixed isolated organ 2 is arranged in outer bath 8；
Wherein, the cavity that can encapsulate isothermal liquid is collectively formed in the cell wall of interior bath 9 and the cell wall of outer bath 8；Outer bath 8
It is provided with the inlet 11 and liquid outlet 10 being connected with cavity；
Interior 9 bottom of bath is provided with the tapping channel 5 through outer 8 bottom of bath；Interior 9 top of bath is equipped with and interior bath 9
The liquid feeding slot 12 being connected in slot, and liquid feeding slot 12 is set to outside interior bath 9.
Specifically, as shown in Fig. 2, in cavity isothermal liquid, usually thermostatted water, then ring can be injected by inlet 11
It flows, is finally flowed out by liquid outlet 10, so that around the isothermal liquid of flowing around interior bath 9, to protect around interior 9 wall of bath
It is constant temperature in interior bath 9 has been demonstrate,proved.
Carry drug in interior bath 9, immersed with isolated organ 2 in drug, the upper end of isolated organ 2 passes through on bracket
Connecting line suspension, lower end is connected by connecting line L-type hook 3, so that the state substantially in a vertical shape of isolated organ 2.And on interior bath 9
New drug, the releasable extra liquid in the tapping channel 5 of lower end can be added in end.
Gastrointestinal smooth muscle physiological property and drug are to the classical reality that the effect of in vitro intestinal segment is in function assessment experiment
It tests, the influence of the physiological property and drug of intestinal segment to it is recorded by tonotransducer.Just illustrate by taking the experiment as an example below
The usage mode of isolated organ isothermal experiments device.
Debugging apparatus and instrument connection, tonotransducer 4 connect biological signal collecting and processing system, interior bath before testing
9 contain into Rockwell liquid 20ml, 37 DEG C of constant temperature, mark liquid level.One section of above-mentioned ileum is taken, both ends are threaded with suture needle, and one end is solid
3 are linked up with due to L-type, is put into interior bath 9 rapidly, the other end is connected to tonotransducer 4 and keeps vertical and suitable elasticity, makes back
The afterload tension of intestinal segment holding about 1g.
It needs to be added different drugs during the experiment into Rockwell liquid, and ileum is detected by tonotransducer 4
Tension variation, to verify the effect that various different pharmaceuticals generate ileum.It can be seen that when testing detection, tension transducing
Connecting line and ileum between device 4 and ileum require to keep vertical state, and can not be disturbed, the data otherwise detected
With regard to inaccuracy.
As shown in Figure 1, being directly to be dripped at the top of interior bath 9 in inside bath 9 when dosing object at present in conventional experiment
Enter, it is easy to and the connecting line of ileum upper end generates touching, while the drug dripped also can bring vibration interference to ileum, so that
The reliability of experimental data reduces.
Therefore, it is provided with the liquid feeding slot 12 for extending to interior 9 side of bath in the upper end of interior bath 9 in the present embodiment,
When drug being added in inside bath 9, drug can be added by the liquid feeding slot 12 being connected with interior bath 9, can effectively kept away
Exempt from surprisingly to touch connecting line, and the drug being added can be flowed into inside interior bath 9 by liquid feeding slot 12 by interior 9 inner wall of bath,
When reducing addition drug, the disturbance of liquid environment in internal bath 9.
It should be noted that the isolated organ isothermal experiments device provided in the utility model, it is not limited to alimentary canal
Smooth muscle physiological property and drug are also used as other isolated organs, do class to using in the use of the effect of in vitro intestinal segment
As functional living being test.It is not listed one by one in this utility model.
Experimental provision provided in the utility model can largely reduce feeding operations during the experiment
To the interference effect that the experimental data of isolated organ generates, the accuracy of experimental data is improved.And this experimental provision structure
Simply, structure is simply at low cost, also reduces the operation difficulty of feeding operations.
For the ease of understanding isolated organ isothermal experiments device provided by the utility model, below with specific embodiment pair
Experimental provision various pieces, which are done, specifically to be introduced.
In a kind of specific embodiment of the utility model, the bottom surface of the liquid feeding slot 12 is higher than interior 9 highest liquid level line of bath.
Because the drug in liquid feeding slot 12 finally needs to be added in interior bath 9, if the bottom surface position of liquid feeding slot 12
Set it is lower, when in interior bath 9 liquid level reach certain altitude when, interior bath 9 and liquid feeding slot 12 just will form linker, inevitable shadow
Ring the speed that drug is added in liquid feeding slot 12.
Optionally, in the another specific embodiment of the utility model, can also further include:
The valve 13 of adjustable communication port pore size is set at the communication port that liquid feeding slot 12 is connected with interior bath 9.
As previously mentioned, the liquid in the internal bath 9 of meeting generates disturbance when drug is added in inside bath 9, influence to test
The accuracy of data.Therefore, valve 13 is set between liquid feeding slot 12 and interior bath 9 in the present embodiment, it is straight for adjusting the two
The pore size of port in succession, and then control the speed that the 12 Chinese medicine logistics of liquid feeding slot enters interior 9 speed of bath.When in liquid feeding slot 12
When 9 speed of bath is slower in drug inflow, it will be able to reduce the disturbance of liquid in internal bath 9.
Optionally, in the another specific embodiment of the utility model, can also further include:
Mesh members are set in communication port.
As previously mentioned, valve 13 is arranged in communication port, the size in communication port aperture can be controlled, but be unable to control
The flow velocity of drug in flowing at communication port in bath 9 is located at 12 bottom end of liquid feeding slot when the medication amount in liquid feeding slot 12 is more
Communication port it is hydraulic also bigger, in order to avoid drug in spurting flow into bath 9, net can be set at communication port
Shape component, effective buffered pharmaceutical flow into the speed of interior bath 9, further reduce 3 DATA REASONING of isolated organ in internal bath 9
Interference.
Optionally, in the another specific embodiment of the utility model, can also further include:
Snorkel 51 is provided on the side wall that tapping channel 5 extends to outside outer bath 8.
As shown in Figure 1, a rubber sleave 6 is arranged below tapping channel 5, and in rubber in traditional Magnus' bath 1
The side of leather sheath 6 penetrates a ventilation needle tubing 7, oxygen is passed through into Magnus' bath 1 by the ventilation needle tubing 7, to simulate people
Body environment.But when needing to carry out tapping to the liquid in Magnus' bath 1, it is necessary to extract ventilation needle tubing 7, wait tapping
After could continue to ventilate, it is cumbersome, and can not continue to ventilate into Magnus' bath 1.
As shown in Fig. 2, no matter experimental provision in the present invention, be arranged snorkel 51 in the side in tapping channel 5
Tapping channel 5 whether is needed to carry out tapping operation, it can be constantly to be passed through oxygen in interior bath 9, and to a certain extent
Simplify the operating procedure of experimenter.
Optionally, in the another specific embodiment of the utility model, can also further include:
Interior bath 9 and outer bath 8 are transparent glass slot, and are provided with graduation mark on 9 cell wall of interior bath.
It should be noted that glass, resin etc. are more common materials in experiment equipment.Interior bath in the present embodiment
9 and outer bath 8 can be glass and be also possible to other materials, in the present embodiment and with no restrictions, but bath 9 and outer bath in requiring
Slot 8 is necessary for transparent bath, so as to clearly be read according to the liquid level in the internal bath 9 of graduation mark.
In conventional bath, interior bath 9 be without graduation mark, in interior bath 9 dosage number, completely by testing
Person rule of thumb assesses, and accuracy is poor.Graduation mark is set on interior bath in the present embodiment, experimenter can be effectively improved
To the precision of the addition of various medication amounts in operating process, and then improve the accuracy of experimental data.
Optionally, in the another specific embodiment of the utility model, can also include:
L-type links up with 3 bottom ends and is provided with multiple cable clamping interfaces 31, for fixing the connecting line of isolated organ 2.
In view of the connecting line of 2 lower end of isolated organ needs to be fixed on L-type hook 3, and the connecting line is generally relatively thin, real
The person of testing, which needs the connecting line and L-type linking up with 3 lower endes, to knot, and practical operation is more difficult.
Therefore, as shown in figure 3, for the structural schematic diagram that L-type provided by the embodiment of the utility model is linked up with, L-type hook 3
Lower end be provided with several cable clamping interfaces 3, can by the connecting line of 2 lower end of isolated organ L-type hook on wind several circles so that
Connecting wire card, without knotting to connecting line, reduces the fixation difficulty of connecting line lower end inside cable clamping interface 3.
In addition, L-type, which is linked up with 3 lower ends, is arranged multiple cable clamping interfaces 31, then position of the connecting wire card in cable clamping interface 31 is just
It can adjust in the horizontal direction, guarantee that connecting line keeps vertical.
Further, as shown in figure 3, in order to guarantee that connecting line lower end is connected in the cable clamping interface 31 of L-type hook lower end not
It can skid off, the concaveconvex structure that the cell wall of cable clamping interface 31 has, and the concaveconvex structure of two cell walls of cable clamping interface 31 cooperates and pastes
It closes.
31 inner wall of cable clamping interface is arranged to rough structure, is conducive to the friction for increasing connecting line and 31 wall of cable clamping interface
Power can be largely avoided the problem of connecting line falls off.
Each embodiment in this specification is described in a progressive manner, the highlights of each of the examples are with it is other
The difference of embodiment, same or similar part may refer to each other between each embodiment.For being filled disclosed in embodiment
For setting, since it is corresponded to the methods disclosed in the examples, so being described relatively simple, related place is referring to method part
Explanation.
Claims (8)
1. a kind of isolated organ isothermal experiments device, which is characterized in that including outer bath, be arranged in the outer bath slot in
The L-type hook of bath and fixed isolated organ；
Wherein, the cavity that can encapsulate isothermal liquid is collectively formed in the cell wall of the cell wall of the interior bath and the outer bath；It is described
Outer bath is provided with the inlet and liquid outlet being connected with the cavity；
The interior bath bottom is provided with the tapping channel through the outer bath bottom；The interior bath top be equipped with and it is described
The liquid feeding slot being connected in interior bath slot, and the liquid feeding slot is set to outside the interior bath.
2. isolated organ isothermal experiments device as described in claim 1, which is characterized in that the liquid feeding groove bottom is higher than described
Interior bath highest liquid level line.
3. isolated organ isothermal experiments device as claimed in claim 2, which is characterized in that the liquid feeding slot and the interior bath
The valve that the communication port pore size is adjusted is equipped at the communication port being connected.
4. isolated organ isothermal experiments device as claimed in claim 3, which is characterized in that the communication port is equipped with reticular part
Part.
5. isolated organ isothermal experiments device as described in claim 1, which is characterized in that the tapping channel extends to described
Snorkel is provided on side wall outside outer bath.
6. isolated organ isothermal experiments device as described in claim 1, which is characterized in that the interior bath and the outer bath
It is transparent glass slot, and be provided with graduation mark on the cell wall of the interior bath.
7. such as isolated organ isothermal experiments device as claimed in any one of claims 1 to 6, which is characterized in that the L-type links up with bottom
End is provided with multiple cable clamping interfaces, for fixing the connecting line of isolated organ one end.
8. isolated organ isothermal experiments device as claimed in claim 7, which is characterized in that the cell wall of the cable clamping interface had
Concaveconvex structure, and the concaveconvex structure of two cell walls of the cable clamping interface cooperates and is bonded.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201821942648.0U CN209460264U (en) | 2018-11-23 | 2018-11-23 | A kind of isolated organ isothermal experiments device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201821942648.0U CN209460264U (en) | 2018-11-23 | 2018-11-23 | A kind of isolated organ isothermal experiments device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112772632A (en) * | 2020-12-31 | 2021-05-11 | 重庆北部宽仁医院 | Isolated liver perfusion device |
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2018
- 2018-11-23 CN CN201821942648.0U patent/CN209460264U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112772632A (en) * | 2020-12-31 | 2021-05-11 | 重庆北部宽仁医院 | Isolated liver perfusion device |
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